Ramp1 (receptor activity modifying protein 1) - Rat Genome Database

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Gene: Ramp1 (receptor activity modifying protein 1) Rattus norvegicus
Analyze
Symbol: Ramp1
Name: receptor activity modifying protein 1
RGD ID: 61870
Description: Enables coreceptor activity. Involved in receptor internalization. Located in extracellular space. Is active in glutamatergic synapse and synaptic membrane. Orthologous to human RAMP1 (receptor activity modifying protein 1); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor activity-modifying protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,213,031 - 99,263,696 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2991,765,481 - 91,816,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,192,341 - 100,242,910 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,328,109 - 105,378,678 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,693,378 - 103,742,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,313,632 - 98,364,206 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)Ensemblrn6Rnor6.0
Rnor_5.0997,995,669 - 98,041,719 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,402,493 - 90,450,038 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,308,226 - 89,359,459 (+)NCBICelera
RGSC_v3.1990,607,261 - 90,654,807 (+)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (EXP,ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (EXP)
L-methionine  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrates  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Bomberger JM, etal., J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
2. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. Mallee JJ, etal., J Biol Chem 2002 Apr 19;277(16):14294-8. Epub 2002 Feb 14.
6. Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors. Marvizón JC, etal., Neuroscience. 2007 Aug 10;148(1):250-65. doi: 10.1016/j.neuroscience.2007.05.036. Epub 2007 Jul 5.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
11. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.
Additional References at PubMed
PMID:1299114   PMID:1299115   PMID:9620797   PMID:10854696   PMID:10882736   PMID:11804624   PMID:12626334   PMID:12801991   PMID:12837925   PMID:14715154   PMID:14722252   PMID:15193773  
PMID:15643132   PMID:16458982   PMID:16713642   PMID:17310067   PMID:18039931   PMID:18186028   PMID:18241048   PMID:18434369   PMID:18599553   PMID:18655130   PMID:20596610   PMID:21034462  
PMID:21040789   PMID:22038237   PMID:22208649   PMID:22500019   PMID:26927337  


Genomics

Comparative Map Data
Ramp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,213,031 - 99,263,696 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2991,765,481 - 91,816,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,192,341 - 100,242,910 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,328,109 - 105,378,678 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,693,378 - 103,742,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,313,632 - 98,364,206 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)Ensemblrn6Rnor6.0
Rnor_5.0997,995,669 - 98,041,719 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,402,493 - 90,450,038 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,308,226 - 89,359,459 (+)NCBICelera
RGSC_v3.1990,607,261 - 90,654,807 (+)NCBI
Cytogenetic Map9q36NCBI
RAMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,858,880 - 237,912,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,858,893 - 237,912,111 (+)Ensemblhg38GRCh38
GRCh372238,768,266 - 238,820,748 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,432,926 - 238,485,495 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342238,550,286 - 238,602,746NCBI
Celera2232,481,221 - 232,533,800 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,560,137 - 230,612,778 (+)NCBIHuRef
CHM1_12238,773,978 - 238,826,564 (+)NCBICHM1_1
T2T-CHM13v2.02238,348,771 - 238,402,144 (+)NCBIT2T-CHM13v2.0
Ramp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,107,544 - 91,152,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,107,544 - 91,152,918 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38191,179,822 - 91,225,196 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,179,822 - 91,225,196 (+)Ensemblmm10GRCm38
MGSCv37193,076,399 - 93,121,773 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,010,447 - 93,054,085 (+)NCBIMGSCv36mm8
Celera194,117,772 - 94,162,742 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.08NCBI
Ramp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555422,530,349 - 2,564,072 (-)NCBIChiLan1.0ChiLan1.0
RAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,492,353 - 140,558,565 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,507,320 - 140,573,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,092,164 - 125,144,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B243,942,771 - 243,995,221 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,942,771 - 243,995,221 (+)EnsemblpanPan2panpan1.1
RAMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,431,136 - 48,466,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,437,919 - 48,466,070 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2548,924,771 - 48,962,496 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02548,813,868 - 48,851,604 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2548,813,905 - 48,851,525 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,689,424 - 48,727,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,477,911 - 48,515,642 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,710,077 - 48,748,033 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ramp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,399,529 - 190,436,574 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525503,070 - 540,281 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936525503,119 - 540,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,490,356 - 137,535,553 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115137,490,440 - 137,535,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,914,286 - 151,944,914 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110123,873,597 - 123,931,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10123,873,351 - 123,931,248 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604075,479,406 - 75,535,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,169,360 - 3,202,389 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248473,169,339 - 3,202,393 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ramp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14163,173,856 - 163,222,253 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ramp1
200 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:107
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000027012
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH137956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,776,803 - 91,776,946 (+)MAPPERmRatBN7.2
Rnor_6.0999,520,938 - 99,521,080NCBIRnor6.0
Rnor_6.0998,324,875 - 98,325,017NCBIRnor6.0
Rnor_5.0998,006,912 - 98,007,054UniSTSRnor5.0
Rnor_5.0999,190,621 - 99,190,763UniSTSRnor5.0
RGSC_v3.4990,413,736 - 90,413,878UniSTSRGSC3.4
Celera989,319,465 - 89,319,607UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000027012   ⟹   ENSRNOP00000027012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,785,098 - 91,816,151 (+)Ensembl
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095283   ⟹   ENSRNOP00000083989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)Ensembl
RefSeq Acc Id: NM_031645   ⟹   NP_113833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,116 - 99,263,696 (+)NCBI
mRatBN7.2991,765,561 - 91,816,151 (+)NCBI
Rnor_6.0998,313,632 - 98,364,205 (+)NCBI
Rnor_5.0997,995,669 - 98,041,719 (+)NCBI
RGSC_v3.4990,402,493 - 90,450,038 (+)RGD
Celera989,308,226 - 89,359,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_017596613   ⟹   XP_017452102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,214,018 - 99,263,692 (+)NCBI
mRatBN7.2991,766,463 - 91,816,152 (+)NCBI
Rnor_6.0998,313,729 - 98,364,206 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084148   ⟹   XP_038940076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,031 - 99,263,256 (+)NCBI
mRatBN7.2991,765,481 - 91,815,705 (+)NCBI
RefSeq Acc Id: XM_063267661   ⟹   XP_063123731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,031 - 99,241,541 (+)NCBI
RefSeq Acc Id: NP_113833   ⟸   NM_031645
- Peptide Label: precursor
- UniProtKB: Q9JJ74 (UniProtKB/Swiss-Prot),   A6JQP8 (UniProtKB/TrEMBL),   Q9JMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452102   ⟸   XM_017596613
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEF6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027012   ⟸   ENSRNOT00000027012
RefSeq Acc Id: XP_038940076   ⟸   XM_039084148
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000083989   ⟸   ENSRNOT00000095283
RefSeq Acc Id: XP_063123731   ⟸   XM_063267661
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ74-F1-model_v2 AlphaFold Q9JJ74 1-148 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696855
Promoter ID:EPDNEW_R7380
Type:initiation region
Name:Ramp1_1
Description:receptor activity modifying protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,313,621 - 98,313,681EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61870 AgrOrtholog
BioCyc Gene G2FUF-26728 BioCyc
Ensembl Genes ENSRNOG00000019926 Ensembl
  ENSRNOG00000089232 ENTREZGENE
Ensembl Transcript ENSRNOT00000122624 ENTREZGENE
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot
InterPro RAMP UniProtKB/Swiss-Prot
  RAMP_sf UniProtKB/Swiss-Prot
KEGG Report rno:58965 UniProtKB/Swiss-Prot
NCBI Gene 58965 ENTREZGENE
PANTHER PTHR14076 UniProtKB/Swiss-Prot
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam RAMP UniProtKB/Swiss-Prot
PhenoGen Ramp1 PhenoGen
RatGTEx ENSRNOG00000019926 RatGTEx
  ENSRNOG00000089232 RatGTEx
TIGR TC205211
UniProt A0A8L2QEF6 ENTREZGENE
  A0ABK0L603_RAT UniProtKB/TrEMBL
  A0ABK0LB47_RAT UniProtKB/TrEMBL
  A0ABK0LH29_RAT UniProtKB/TrEMBL
  A0ABK0LRM9_RAT UniProtKB/TrEMBL
  A0ABK0LS10_RAT UniProtKB/TrEMBL
  A0ABK0M5I0_RAT UniProtKB/TrEMBL
  A0ABK0M5R0_RAT UniProtKB/TrEMBL
  A6JQP8 ENTREZGENE, UniProtKB/TrEMBL
  A6JQP9_RAT UniProtKB/TrEMBL
  Q9JJ74 ENTREZGENE
  Q9JMD9 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVQ4_RAT UniProtKB/TrEMBL
  RAMP1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ramp1  receptor activity modifying protein 1  Ramp1  receptor (G protein-coupled) activity modifying protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ramp1  receptor (G protein-coupled) activity modifying protein 1  Ramp1  receptor (calcitonin) activity modifying protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ramp1  receptor (calcitonin) activity modifying protein 1       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in chronic heart failure 625420
gene_expression mRNA and protein expressed in both atria and ventricles with a 3-fold increase in expression in chronic heart failure models 625420
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state 61729
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state 68902
gene_physical_interaction forms a complex with calcitonin receptor-like receptor (CRLR) to form functional calcitonin gene-related peptide (CGRP) receptor 625420
gene_process mediates increased lipid synthesis, triglyceride accumulation, mesangial expansion, glomerulosclerosis, and proteinuria by increasing the expression of transforming growth factor and vascular endothelial growth factor 625420