Tspy1 (testis specific protein, Y-linked 1) - Rat Genome Database

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Gene: Tspy1 (testis specific protein, Y-linked 1) Rattus norvegicus
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Symbol: Tspy1
Name: testis specific protein, Y-linked 1
RGD ID: 3912
Description: Enables histone binding activity. Involved in spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including TSPY1 (testis specific protein Y-linked 1); TSPY4 (testis specific protein Y-linked 4); and TSPY9 (testis specific protein Y-linked 9); INTERACTS WITH fenvalerate; benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: rTSPY; Testis specific protein on Y; testis specific protein, Y-linked; testis-specific protein TSPY; testis-specific Y-encoded protein 1; Tspy
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y213,710 - 218,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblY215,352 - 218,667 (-)EnsemblGRCr8
UTH_Rnor_SHR_UtxY1,585,543 - 1,588,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0Y1,745,092 - 1,748,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0Y601,048 - 604,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0Y151,941 - 156,587 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY151,937 - 155,263 (+)Ensemblrn6Rnor6.0
Cytogenetic MapYq11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (IBA)
cytoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Organization and expression of rat Tspy. Dechend F, etal., Cytogenet Cell Genet 1998;83(3-4):270-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Kido T and Lau YF, Biochem Biophys Res Commun. 2006 Nov 10;350(1):56-67. Epub 2006 Sep 14.
5. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Li Y, etal., Hum Pathol. 2007 Oct;38(10):1470-81. Epub 2007 May 22.
6. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Mazeyrat S and Mitchell MJ, Hum Mol Genet 1998 Mar;7(3):557-62.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Detection of recurrent copy number loss at Yp11.2 involving TSPY gene cluster in prostate cancer using array-based comparative genomic hybridization. Vijayakumar S, etal., Cancer Res. 2006 Apr 15;66(8):4055-64.
10. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Yin YH, etal., Br J Cancer. 2005 Aug 22;93(4):458-63.

Genomics

Comparative Map Data
Tspy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8Y213,710 - 218,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblY215,352 - 218,667 (-)EnsemblGRCr8
UTH_Rnor_SHR_UtxY1,585,543 - 1,588,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0Y1,745,092 - 1,748,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0Y601,048 - 604,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0Y151,941 - 156,587 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblY151,937 - 155,263 (+)Ensemblrn6Rnor6.0
Cytogenetic MapYq11NCBI
TSPY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y9,466,955 - 9,469,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblY9,466,955 - 9,469,749 (+)Ensemblhg38GRCh38
GRCh37Y9,304,564 - 9,307,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y9,914,564 - 9,917,358 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34Y9,958,849 - 9,961,645NCBI
Cytogenetic MapYp11.2NCBI
T2T-CHM13v2.0Y9,653,822 - 9,656,636 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Tspy1
16 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 5 27 51 40 41 27 29 27 2 123 65 46 21 38 14

Sequence


Ensembl Acc Id: ENSRNOT00000077988   ⟹   ENSRNOP00000071386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblY215,352 - 218,564 (-)Ensembl
Rnor_6.0 EnsemblY151,937 - 154,657 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083382   ⟹   ENSRNOP00000075045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblY215,352 - 218,667 (-)Ensembl
Rnor_6.0 EnsemblY151,948 - 155,263 (+)Ensembl
RefSeq Acc Id: NM_022923   ⟹   NP_075212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y215,352 - 218,667 (-)NCBI
Rnor_6.0Y151,948 - 155,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773672   ⟹   XP_008771894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y215,352 - 218,709 (-)NCBI
Rnor_6.0Y151,941 - 156,587 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100721   ⟹   XP_038956649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y215,352 - 218,718 (-)NCBI
RefSeq Acc Id: XR_005498751
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8Y213,710 - 218,709 (-)NCBI
RefSeq Acc Id: XP_008771894   ⟸   XM_008773672
- Peptide Label: isoform X1
- UniProtKB: O70602 (UniProtKB/Swiss-Prot),   Q9R1M4 (UniProtKB/Swiss-Prot),   Q9R1M3 (UniProtKB/Swiss-Prot),   A0A8L2R474 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_075212   ⟸   NM_022923
- UniProtKB: Q9R1M3 (UniProtKB/Swiss-Prot),   O70602 (UniProtKB/Swiss-Prot),   Q9R1M4 (UniProtKB/Swiss-Prot),   A0A8L2R474 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071386   ⟸   ENSRNOT00000077988
Ensembl Acc Id: ENSRNOP00000075045   ⟸   ENSRNOT00000083382
RefSeq Acc Id: XP_038956649   ⟸   XM_039100721
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1M3-F1-model_v2 AlphaFold Q9R1M3 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3912 AgrOrtholog
BioCyc Gene G2FUF-425 BioCyc
Ensembl Genes ENSRNOG00000054648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083382 ENTREZGENE
  ENSRNOT00000083382.3 UniProtKB/Swiss-Prot
  ENSRNOT00000116666.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.1500 UniProtKB/Swiss-Prot
  Nucleosome assembly protein UniProtKB/Swiss-Prot
InterPro NAP-like_sf UniProtKB/Swiss-Prot
  NAP_family UniProtKB/Swiss-Prot
KEGG Report rno:25223 UniProtKB/Swiss-Prot
NCBI Gene 25223 ENTREZGENE
PANTHER PTHR11875 UniProtKB/Swiss-Prot
Pfam NAP UniProtKB/Swiss-Prot
PhenoGen Tspy1 PhenoGen
RatGTEx ENSRNOG00000054648 RatGTEx
Superfamily-SCOP SSF143113 UniProtKB/Swiss-Prot
UniProt A0A8L2R474 ENTREZGENE, UniProtKB/TrEMBL
  O70602 ENTREZGENE
  Q9R1M3 ENTREZGENE
  Q9R1M4 ENTREZGENE
  TSPY1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70602 UniProtKB/Swiss-Prot
  Q9R1M4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Tspy1  testis specific protein, Y-linked 1  Tspy  testis specific protein, Y-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tspy  testis specific protein, Y-linked    Testis specific protein on Y  Name updated 629478 APPROVED
2002-06-10 Tspy  Testis specific protein on Y      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 47% amino acid identity to human homolog 634385