Tcp1 (t-complex 1) - Rat Genome Database

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Gene: Tcp1 (t-complex 1) Rattus norvegicus
Analyze
Symbol: Tcp1
Name: t-complex 1
RGD ID: 3832
Description: Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in positive regulation of telomerase RNA localization to Cajal body; protein folding; and protein stabilization. Predicted to act upstream of with a positive effect on scaRNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in heterochromatin. Orthologous to human TCP1 (t-complex 1); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CCT-alpha; CCTalpha; t-complex protein 1; T-complex protein 1 subunit alpha; Tcp-1; TCP-1-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tcp1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,376,848 - 50,384,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,376,848 - 50,384,527 (-)EnsemblGRCr8
mRatBN7.2147,829,061 - 47,836,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,520,703 - 48,528,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,506,599 - 54,514,346 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,596,232 - 48,603,911 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,025,664 - 48,033,343 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,025,663 - 48,033,396 (-)Ensemblrn6Rnor6.0
Rnor_5.0151,719,055 - 51,726,734 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,103,543 - 42,111,222 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera143,629,524 - 43,637,203 (-)NCBICelera
RGSC_v3.1142,106,487 - 42,114,167 (-)NCBI
RH 3.4 Map1537.31RGD
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
elemental selenium  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
quartz  (ISO)
raloxifene  (EXP)
rotenone  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
T-2 toxin  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. Ishibashi K, etal., Biochem Biophys Res Commun 2000 Apr 13;270(2):370-6.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Cloning of cDNA encoding rat TCP-1. Morita T, etal., Biochim Biophys Acta 1991 Dec 2;1129(1):96-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells. Soues S, etal., Exp Cell Res 2003 Aug 15;288(2):363-73.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1495973   PMID:1937024   PMID:2655925   PMID:7828721   PMID:7953530   PMID:17110338   PMID:17634366   PMID:18694933   PMID:19056867   PMID:19684306   PMID:20080638   PMID:20131911  
PMID:20193073   PMID:20458337   PMID:21525035   PMID:21753002   PMID:21880732   PMID:22681889   PMID:22871113   PMID:23011926   PMID:23533145   PMID:23716698   PMID:23904609   PMID:24625528  
PMID:25002582   PMID:25467444   PMID:30053369  


Genomics

Comparative Map Data
Tcp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,376,848 - 50,384,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,376,848 - 50,384,527 (-)EnsemblGRCr8
mRatBN7.2147,829,061 - 47,836,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,520,703 - 48,528,382 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,506,599 - 54,514,346 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,596,232 - 48,603,911 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,025,664 - 48,033,343 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,025,663 - 48,033,396 (-)Ensemblrn6Rnor6.0
Rnor_5.0151,719,055 - 51,726,734 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,103,543 - 42,111,222 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera143,629,524 - 43,637,203 (-)NCBICelera
RGSC_v3.1142,106,487 - 42,114,167 (-)NCBI
RH 3.4 Map1537.31RGD
Cytogenetic Map1q11NCBI
TCP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,778,498 - 159,789,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,778,498 - 159,789,703 (-)Ensemblhg38GRCh38
GRCh376160,199,530 - 160,210,634 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,119,520 - 160,130,725 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346160,169,941 - 160,181,146NCBI
Celera6160,845,607 - 160,856,819 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,669,773 - 157,680,978 (-)NCBIHuRef
CHM1_16160,461,821 - 160,473,042 (-)NCBICHM1_1
T2T-CHM13v2.06161,024,115 - 161,035,234 (-)NCBIT2T-CHM13v2.0
Tcp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,135,216 - 13,143,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,134,588 - 13,143,954 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381712,916,329 - 12,925,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,915,701 - 12,925,067 (+)Ensemblmm10GRCm38
MGSCv371713,109,331 - 13,117,933 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361712,759,446 - 12,767,497 (+)NCBIMGSCv36mm8
Celera1712,948,013 - 12,956,616 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.72NCBI
Tcp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543921,114,038 - 21,124,379 (+)NCBIChiLan1.0ChiLan1.0
TCP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,877,363 - 179,888,668 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,781,864 - 177,793,622 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,661,409 - 157,672,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,673,050 - 162,684,261 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,673,596 - 162,683,985 (-)EnsemblpanPan2panpan1.1
TCP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,029,260 - 49,038,023 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,029,282 - 49,038,020 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha149,871,249 - 49,879,992 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0149,213,974 - 49,222,681 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,213,961 - 49,222,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,096,311 - 49,105,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,967,408 - 48,976,160 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,582,581 - 49,591,336 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tcp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,021,338 - 144,030,784 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,273,331 - 11,282,811 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,273,335 - 11,282,811 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,590,140 - 7,601,795 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.117,590,140 - 7,600,709 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,389,098 - 9,399,667 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,377,452 - 87,388,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,377,996 - 87,388,568 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604059,776,464 - 59,787,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,121,274 - 3,133,640 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tcp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12191,644,267 - 191,651,978 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tcp1
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000019531
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
AI528772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,186 - 47,829,332 (+)MAPPERmRatBN7.2
mRatBN7.24120,706,024 - 120,706,170 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,789 - 48,025,934NCBIRnor6.0
Rnor_6.04120,180,744 - 120,180,889NCBIRnor6.0
Rnor_5.04185,422,198 - 185,422,343UniSTSRnor5.0
RGSC_v3.44122,326,785 - 122,326,930UniSTSRGSC3.4
RGSC_v3.4142,103,668 - 42,103,813UniSTSRGSC3.4
Celera143,629,649 - 43,629,794UniSTS
Celera4109,662,385 - 109,662,530UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS
RH94518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,061 - 47,829,145 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,664 - 48,025,747NCBIRnor6.0
Rnor_5.0151,726,651 - 51,726,734UniSTSRnor5.0
RGSC_v3.4142,103,543 - 42,103,626UniSTSRGSC3.4
Celera143,629,524 - 43,629,607UniSTS
RH 3.4 Map1537.31UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019531   ⟹   ENSRNOP00000019531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,376,848 - 50,384,389 (-)Ensembl
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)Ensembl
Rnor_6.0 Ensembl148,025,663 - 48,033,343 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076422   ⟹   ENSRNOP00000068050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,376,848 - 50,384,527 (-)Ensembl
mRatBN7.2 Ensembl147,829,077 - 47,836,752 (-)Ensembl
Rnor_6.0 Ensembl148,025,667 - 48,033,396 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl148,027,007 - 48,030,554 (-)Ensembl
RefSeq Acc Id: NM_012670   ⟹   NP_036802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,376,848 - 50,384,527 (-)NCBI
mRatBN7.2147,829,062 - 47,836,744 (-)NCBI
Rnor_6.0148,025,664 - 48,033,343 (-)NCBI
Rnor_5.0151,719,055 - 51,726,734 (+)NCBI
RGSC_v3.4142,103,543 - 42,111,222 (-)RGD
Celera143,629,524 - 43,637,203 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA14357 (Get FASTA)   NCBI Sequence Viewer  
  EDL83041 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019531.1
  ENSRNOP00000068050
GenBank Protein P28480 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036802   ⟸   NM_012670
- UniProtKB: P28480 (UniProtKB/Swiss-Prot),   A6KJV3 (UniProtKB/TrEMBL),   A0A096MJA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019531   ⟸   ENSRNOT00000019531
Ensembl Acc Id: ENSRNOP00000068050   ⟸   ENSRNOT00000076422

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28480-F1-model_v2 AlphaFold P28480 1-556 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689615
Promoter ID:EPDNEW_R139
Type:initiation region
Name:Tcp1_1
Description:t-complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,033,371 - 48,033,431EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3832 AgrOrtholog
BioCyc Gene G2FUF-61585 BioCyc
Ensembl Genes ENSRNOG00000014160 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019531.5 UniProtKB/Swiss-Prot
  ENSRNOT00000076422 ENTREZGENE
Gene3D-CATH 1.10.560.10 UniProtKB/Swiss-Prot
  3.30.260.10 UniProtKB/Swiss-Prot
  3.50.7.10 UniProtKB/Swiss-Prot
InterPro Chap_CCT_alpha UniProtKB/Swiss-Prot
  Chaperone_TCP-1 UniProtKB/Swiss-Prot
  Chaperonin_TCP-1_CS UniProtKB/Swiss-Prot
  Cpn60/TCP-1 UniProtKB/Swiss-Prot
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot
  GROEL-like_equatorial_sf UniProtKB/Swiss-Prot
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot
  TCP-1_chaperonin UniProtKB/Swiss-Prot
  thermosome_alpha UniProtKB/Swiss-Prot
KEGG Report rno:24818 UniProtKB/Swiss-Prot
NCBI Gene 24818 ENTREZGENE
PANTHER PTHR11353 UniProtKB/Swiss-Prot
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot
PhenoGen Tcp1 PhenoGen
PRINTS TCOMPLEXTCP1 UniProtKB/Swiss-Prot
PROSITE TCP1_1 UniProtKB/Swiss-Prot
  TCP1_2 UniProtKB/Swiss-Prot
  TCP1_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014160 RatGTEx
Superfamily-SCOP SSF48592 UniProtKB/Swiss-Prot
  SSF52029 UniProtKB/Swiss-Prot
  SSF54849 UniProtKB/Swiss-Prot
TIGR TC204340
UniProt A0A096MJA0 ENTREZGENE, UniProtKB/TrEMBL
  A6KJV3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJV4_RAT UniProtKB/TrEMBL
  P28480 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tcp1  t-complex 1  Tcp1  t-complex protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tcp1  T-complex 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference