Eloa (elongin A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Eloa (elongin A) Rattus norvegicus
Analyze
Symbol: Eloa
Name: elongin A
RGD ID: 3827
Description: Predicted to enable double-stranded DNA binding activity. Involved in regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Located in site of DNA damage. Part of transcription elongation factor complex. Orthologous to human ELOA (elongin A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: El; elongin 110 kDa subunit; elongin-A; MGC93501; RNA polymerase II transcription factor elongin subunit A; RNA polymerase II transcription factor elongin subunit A (110 kDa); RNA polymerase II transcription factor SIII subunit A; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Tceb3; transcription elongation factor B (SIII) polypeptide 3 (110kD); transcription elongation factor B (SIII), polypeptide 3; transcription elongation factor B (SIII), polypeptide 3 (110kD); transcription elongation factor B polypeptide 3; transcription elongation factor B subunit 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,513,246 - 153,530,819 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,515,066 - 153,530,916 (-)EnsemblGRCr8
mRatBN7.25148,231,600 - 148,246,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,231,596 - 148,246,765 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,930,953 - 150,946,130 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,705,222 - 152,720,399 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,687,235 - 152,702,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5153,137,944 - 153,153,132 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5155,126,763 - 155,141,951 (-)NCBILyon_Normotensive
Lyon_Hypertensive5154,302,904 - 154,318,092 (-)NCBILyon_Hypertensive
F344_StmMcwi5147,874,736 - 147,889,923 (-)NCBIF344_StmMcwi
Rnor_6.05154,348,167 - 154,363,324 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,347,391 - 154,363,329 (-)Ensemblrn6Rnor6.0
Rnor_5.05158,113,019 - 158,128,176 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,784,631 - 154,799,759 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,637,979 - 146,653,167 (-)NCBICelera
RGSC_v3.15154,793,893 - 154,809,803 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
CGP 52608  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
fenthion  (ISO)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex. Aso T, etal., EMBO J. 1996 Oct 15;15(20):5557-66.
2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Aso T, etal., Science 1995 Sep 8;269(5229):1439-43.
3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. Bradsher JN, etal., J Biol Chem 1993 Dec 5;268(34):25587-93.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. Weems JC, etal., J Biol Chem. 2017 Apr 21;292(16):6431-6437. doi: 10.1074/jbc.C117.777946. Epub 2017 Mar 14.
Additional References at PubMed
PMID:10224134   PMID:11384984   PMID:12943681   PMID:19037258   PMID:22664934   PMID:23828199   PMID:25931508  


Genomics

Comparative Map Data
Eloa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,513,246 - 153,530,819 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,515,066 - 153,530,916 (-)EnsemblGRCr8
mRatBN7.25148,231,600 - 148,246,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,231,596 - 148,246,765 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,930,953 - 150,946,130 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,705,222 - 152,720,399 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,687,235 - 152,702,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5153,137,944 - 153,153,132 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5155,126,763 - 155,141,951 (-)NCBILyon_Normotensive
Lyon_Hypertensive5154,302,904 - 154,318,092 (-)NCBILyon_Hypertensive
F344_StmMcwi5147,874,736 - 147,889,923 (-)NCBIF344_StmMcwi
Rnor_6.05154,348,167 - 154,363,324 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,347,391 - 154,363,329 (-)Ensemblrn6Rnor6.0
Rnor_5.05158,113,019 - 158,128,176 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,784,631 - 154,799,759 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,637,979 - 146,653,167 (-)NCBICelera
RGSC_v3.15154,793,893 - 154,809,803 (-)NCBI
Cytogenetic Map5q36NCBI
ELOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,743,471 - 23,762,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,743,448 - 23,762,059 (+)Ensemblhg38GRCh38
GRCh37124,069,961 - 24,088,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,942,549 - 23,958,974 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34123,815,267 - 23,831,689NCBI
Celera122,399,409 - 22,418,102 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,327,072 - 22,340,121 (+)NCBIHuRef
CHM1_1124,182,608 - 24,201,320 (+)NCBICHM1_1
T2T-CHM13v2.0123,578,438 - 23,597,030 (+)NCBIT2T-CHM13v2.0
Eloa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,730,681 - 135,748,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,730,679 - 135,749,074 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384136,003,370 - 136,021,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,003,368 - 136,021,763 (-)Ensemblmm10GRCm38
MGSCv374135,559,285 - 135,577,564 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364135,275,446 - 135,293,725 (-)NCBIMGSCv36mm8
Celera4134,204,043 - 134,223,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.34NCBI
Eloa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,668,864 - 3,681,481 (+)Ensembl
ChiLan1.0NW_0049554523,668,868 - 3,681,506 (+)NCBIChiLan1.0ChiLan1.0
ELOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,179,052 - 203,197,800 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,282,030 - 202,300,763 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,934,975 - 22,953,666 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,919,531 - 23,938,402 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,919,531 - 23,938,402 (+)EnsemblpanPan2panpan1.1
ELOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,730,467 - 75,746,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,732,725 - 75,741,999 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha272,300,524 - 72,317,278 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0276,289,730 - 76,306,509 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,289,729 - 76,344,987 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,112,070 - 73,128,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,118,686 - 74,135,598 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,124,330 - 75,141,004 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eloa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,075,243 - 43,091,005 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,903,880 - 8,916,189 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,903,753 - 8,915,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,566,801 - 81,582,048 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1681,564,792 - 81,582,049 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,444,800 - 75,460,040 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,922,500 - 108,940,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,921,707 - 108,940,459 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660337,393,195 - 7,412,071 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eloa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,295,770 - 8,312,590 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247648,295,713 - 8,312,293 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Eloa
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,213,836 - 22,230,647 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eloa
123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:595
Count of miRNA genes:248
Interacting mature miRNAs:309
Transcripts:ENSRNOT00000064596
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH139056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,236,569 - 148,236,696 (+)MAPPERmRatBN7.2
Rnor_6.05154,353,136 - 154,353,262NCBIRnor6.0
Rnor_5.05158,117,988 - 158,118,114UniSTSRnor5.0
RGSC_v3.45154,789,600 - 154,789,726UniSTSRGSC3.4
Celera5146,642,985 - 146,643,111UniSTS
RH 3.4 Map51003.5UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064596   ⟹   ENSRNOP00000059109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,516,472 - 153,530,916 (-)Ensembl
mRatBN7.2 Ensembl5148,231,596 - 148,246,765 (-)Ensembl
Rnor_6.0 Ensembl5154,347,391 - 154,363,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101125   ⟹   ENSRNOP00000097263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,515,066 - 153,530,516 (-)Ensembl
mRatBN7.2 Ensembl5148,231,596 - 148,246,765 (-)Ensembl
RefSeq Acc Id: NM_017103   ⟹   NP_058799
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,515,130 - 153,530,286 (-)NCBI
mRatBN7.25148,231,600 - 148,246,760 (-)NCBI
Dahl_SR_JrHsd5153,137,944 - 153,153,132 (-)NCBI
Lyon_Normotensive5155,126,763 - 155,141,951 (-)NCBI
Lyon_Hypertensive5154,302,904 - 154,318,092 (-)NCBI
F344_StmMcwi5147,874,736 - 147,889,923 (-)NCBI
Rnor_6.05154,348,167 - 154,363,324 (-)NCBI
Rnor_5.05158,113,019 - 158,128,176 (-)NCBI
RGSC_v3.45154,784,631 - 154,799,759 (-)RGD
Celera5146,637,979 - 146,653,167 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287194   ⟹   XP_063143264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,513,246 - 153,530,819 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058799 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143264 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA82095 (Get FASTA)   NCBI Sequence Viewer  
  AAH81815 (Get FASTA)   NCBI Sequence Viewer  
  EDL80794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059109
  ENSRNOP00000097263
GenBank Protein Q63187 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058799   ⟸   NM_017103
- UniProtKB: Q63187 (UniProtKB/Swiss-Prot),   Q66HK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059109   ⟸   ENSRNOT00000064596
Ensembl Acc Id: ENSRNOP00000097263   ⟸   ENSRNOT00000101125
RefSeq Acc Id: XP_063143264   ⟸   XM_063287194
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GMG0 (UniProtKB/TrEMBL)
Protein Domains
F-box   TFIIS N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63187-F1-model_v2 AlphaFold Q63187 1-773 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694165
Promoter ID:EPDNEW_R4689
Type:multiple initiation site
Name:Eloa_1
Description:elongin A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,363,291 - 154,363,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3827 AgrOrtholog
BioCyc Gene G2FUF-39519 BioCyc
Ensembl Genes ENSRNOG00000010902 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064596 ENTREZGENE
  ENSRNOT00000101125 ENTREZGENE
Gene3D-CATH 1.20.930.10 UniProtKB/Swiss-Prot
  6.10.250.3180 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110428 IMAGE-MGC_LOAD
InterPro Elongin-A_domain UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  RNA_pol_II_trans_fac_SIII_A UniProtKB/Swiss-Prot
  TFIIS/CRSP70_N_sub UniProtKB/Swiss-Prot
  TFIIS/LEDGF_dom_sf UniProtKB/Swiss-Prot
  TFIIS_N UniProtKB/Swiss-Prot
MGC_CLONE MGC:93501 IMAGE-MGC_LOAD
NCBI Gene 25562 ENTREZGENE
PANTHER ELONGIN-A UniProtKB/Swiss-Prot
  TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 UniProtKB/Swiss-Prot
Pfam Elongin_A UniProtKB/Swiss-Prot
  Med26 UniProtKB/Swiss-Prot
PhenoGen Eloa PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot
  TFIIS_N UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010902 RatGTEx
SMART TFS2N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47676 UniProtKB/Swiss-Prot
TIGR TC233158
UniProt A0A8I6GMG0 ENTREZGENE, UniProtKB/TrEMBL
  ELOA1_RAT UniProtKB/Swiss-Prot
  F7FK45_RAT UniProtKB/TrEMBL
  Q63187 ENTREZGENE
  Q66HK4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-09 Eloa  elongin A  Tceb3  transcription elongation factor B subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-16 Tceb3  transcription elongation factor B subunit 3  Tceb3  transcription elongation factor B (SIII), polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tceb3  transcription elongation factor B (SIII), polypeptide 3     transcription elongation factor B (SIII), polypeptide 3 (110kD)  Name updated 629478 APPROVED
2001-10-22 Tceb3  transcription elongation factor B (SIII), polypeptide 3 (11kD)      Name withdrawn 68913 WITHDRAWN
2001-10-22 Tceb3  transcription elongation factor B (SIII), polypeptide 3 (110kD)      Name updated 68913 APPROVED
2001-07-23 Tceb3  RNA polymerase II transcription factor elongin subunit A (110 kDa)      Name withdrawn 67952 WITHDRAWN
2001-07-23 Tceb3  transcription elongation factor B (SIII), polypeptide 3 (11kD)      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein protein masses 110 kDa 730012