Sstr4 (somatostatin receptor 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Sstr4 (somatostatin receptor 4) Rattus norvegicus
Analyze
Symbol: Sstr4
Name: somatostatin receptor 4
RGD ID: 3764
Description: Enables somatostatin receptor activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of arachidonate secretion; and regulation of signal transduction. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Biomarker of status epilepticus. Orthologous to human SSTR4 (somatostatin receptor 4); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Smstr4; Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA; somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,307,992 - 156,309,855 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3156,307,093 - 156,550,348 (+)EnsemblGRCr8
mRatBN7.23135,854,826 - 135,856,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3139,797,830 - 139,799,693 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,381,963 - 148,383,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,080,466 - 146,082,329 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3154,405,129 - 154,406,992 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3161,371,145 - 161,373,008 (+)NCBILyon_Normotensive
Lyon_Hypertensive3153,231,164 - 153,233,027 (+)NCBILyon_Hypertensive
F344_StmMcwi3134,539,268 - 134,541,131 (+)NCBIF344_StmMcwi
Rnor_6.03142,739,781 - 142,741,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)Ensemblrn6Rnor6.0
Rnor_5.03149,151,003 - 149,152,866 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43137,150,419 - 137,152,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3134,698,650 - 134,700,513 (+)NCBICelera
RGSC_v3.13137,055,991 - 137,057,857 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. Bito H, etal., J Biol Chem. 1994 Apr 29;269(17):12722-30.
2. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. Bologna E and Leroux P, J Comp Neurol. 2000 May 15;420(4):466-80.
3. Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Braun H, etal., Brain Res. 2002 Mar 15;930(1-2):191-9.
4. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Bruno JF, etal., Proc Natl Acad Sci U S A 1992 Dec 1;89(23):11151-5.
5. Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. Christenn M, etal., FEBS Lett. 2007 Nov 13;581(27):5173-7. Epub 2007 Oct 12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. A potential role of somatostatin and its receptor SSTR4 in the migration of hepatic oval cells. Jung Y, etal., Lab Invest. 2006 May;86(5):477-89.
9. Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. Kubota A, etal., J Clin Invest. 1994 Mar;93(3):1321-5.
10. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy. Kumar U, etal., Endocrinology. 1997 Oct;138(10):4473-6.
11. The expression of somatostatin receptors in the hippocampus of pilocarpine-induced rat epilepsy model. Kwak SE, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):569-83. Epub 2008 Oct 31.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. O'Carroll AM, etal., Mol Pharmacol 1992 Dec;42(6):939-46.
15. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Park S, etal., Neuroendocrinology. 2003 Sep;78(3):163-75.
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Vasculoprotective effects of somatostatin receptor subtypes. Tigerstedt NM, etal., Mol Cell Endocrinol. 2007 Dec 15;279(1-2):34-8. Epub 2007 Sep 11.
21. Ligand Binding and Functional Properties of the Rat Somatostatin Receptor SSTR4 Stably Expressed in Chinese Hamster Ovary Cells. Xu Y, etal., Mol Cell Neurosci. 1993 Jun;4(3):245-9.
Additional References at PubMed
PMID:17617126   PMID:20573967   PMID:22098068   PMID:23233668   PMID:24416361   PMID:24769416   PMID:25926390   PMID:30291955  


Genomics

Comparative Map Data
Sstr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,307,992 - 156,309,855 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3156,307,093 - 156,550,348 (+)EnsemblGRCr8
mRatBN7.23135,854,826 - 135,856,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3139,797,830 - 139,799,693 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,381,963 - 148,383,826 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,080,466 - 146,082,329 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3154,405,129 - 154,406,992 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3161,371,145 - 161,373,008 (+)NCBILyon_Normotensive
Lyon_Hypertensive3153,231,164 - 153,233,027 (+)NCBILyon_Hypertensive
F344_StmMcwi3134,539,268 - 134,541,131 (+)NCBIF344_StmMcwi
Rnor_6.03142,739,781 - 142,741,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)Ensemblrn6Rnor6.0
Rnor_5.03149,151,003 - 149,152,866 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43137,150,419 - 137,152,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3134,698,650 - 134,700,513 (+)NCBICelera
RGSC_v3.13137,055,991 - 137,057,857 (+)NCBI
Cytogenetic Map3q41NCBI
SSTR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,035,312 - 23,039,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,035,312 - 23,039,237 (+)Ensemblhg38GRCh38
GRCh372023,015,949 - 23,019,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,964,057 - 22,965,314 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342022,964,120 - 22,965,287NCBI
Celera2023,089,437 - 23,090,694 (+)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2022,977,578 - 22,978,835 (+)NCBIHuRef
CHM1_12023,016,757 - 23,018,014 (+)NCBICHM1_1
T2T-CHM13v2.02023,094,793 - 23,098,718 (+)NCBIT2T-CHM13v2.0
Sstr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,237,297 - 148,238,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,237,264 - 148,238,687 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382148,395,377 - 148,396,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,395,344 - 148,396,767 (+)Ensemblmm10GRCm38
MGSCv372148,221,113 - 148,222,500 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362148,086,783 - 148,092,384 (+)NCBIMGSCv36mm8
Celera2149,668,860 - 149,670,247 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.44NCBI
SSTR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22123,913,464 - 23,917,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12023,910,298 - 23,914,353 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02022,982,009 - 22,986,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,333,445 - 23,334,933 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,333,320 - 23,334,766 (+)EnsemblpanPan2panpan1.1
Sstr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,149,383 - 149,157,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366202,576,598 - 2,577,761 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366202,575,880 - 2,577,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSTR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,027,241 - 52,034,777 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,031,021 - 52,032,187 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660786,842,484 - 6,846,721 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sstr4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15127,960,551 - 127,963,139 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sstr4
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:72
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000006181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 8 65 138 62 61 32 62 32 6 268 155 9 113 64 84 29 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000006181   ⟹   ENSRNOP00000066231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3156,307,127 - 156,550,348 (+)Ensembl
mRatBN7.2 Ensembl3135,854,826 - 135,856,689 (+)Ensembl
Rnor_6.0 Ensembl3142,739,781 - 142,741,644 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133452   ⟹   ENSRNOP00000101562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3156,307,190 - 156,511,207 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158555   ⟹   ENSRNOP00000105163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3156,307,093 - 156,314,504 (+)Ensembl
RefSeq Acc Id: NM_013036   ⟹   NP_037168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,307,992 - 156,309,855 (+)NCBI
mRatBN7.23135,854,826 - 135,856,689 (+)NCBI
Dahl_SR_JrHsd3154,405,129 - 154,406,992 (+)NCBI
Lyon_Normotensive3161,371,145 - 161,373,008 (+)NCBI
Lyon_Hypertensive3153,231,164 - 153,233,027 (+)NCBI
F344_StmMcwi3134,539,268 - 134,541,131 (+)NCBI
Rnor_6.03142,739,781 - 142,741,644 (+)NCBI
Rnor_5.03149,151,003 - 149,152,866 (+)NCBI
RGSC_v3.43137,150,419 - 137,152,284 (+)RGD
Celera3134,698,650 - 134,700,513 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037168 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA17519 (Get FASTA)   NCBI Sequence Viewer  
  AAA42180 (Get FASTA)   NCBI Sequence Viewer  
  EDL95103 (Get FASTA)   NCBI Sequence Viewer  
  EDL95104 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066231
  ENSRNOP00000066231.1
GenBank Protein P30937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037168   ⟸   NM_013036
- UniProtKB: P30937 (UniProtKB/Swiss-Prot),   A6K7B6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066231   ⟸   ENSRNOT00000006181
Ensembl Acc Id: ENSRNOP00000101562   ⟸   ENSRNOT00000133452
Ensembl Acc Id: ENSRNOP00000105163   ⟸   ENSRNOT00000158555
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30937-F1-model_v2 AlphaFold P30937 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3764 AgrOrtholog
BioCyc Gene G2FUF-47510 BioCyc
Ensembl Genes ENSRNOG00000004641 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006181 ENTREZGENE
  ENSRNOT00000006181.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Somatstn_rcpt UniProtKB/Swiss-Prot
  Somatstn_rcpt_4 UniProtKB/Swiss-Prot
KEGG Report rno:25555 UniProtKB/Swiss-Prot
NCBI Gene 25555 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
  SOMATOSTATIN RECEPTOR TYPE 4 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Sstr4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  SOMATOSTATNR UniProtKB/Swiss-Prot
  SOMATOSTTN4R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004641 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC211734
UniProt A6K7B6 ENTREZGENE, UniProtKB/TrEMBL
  P30937 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sstr4  somatostatin receptor 4    Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA  Symbol and Name updated 629477 APPROVED
2002-06-10 Sstr4  Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in various brain regions, particularly in cortex and hippocampus 727543
gene_physical_interaction higher affinity for somatostatin 14 than for somatostatin 28 727543
gene_product member of the seven transmembrane domain superfamily of G-protein coupled receptors 727543
gene_protein predicted protein contains 384 aa residues 727543