Prph2 (peripherin 2) - Rat Genome Database

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Gene: Prph2 (peripherin 2) Rattus norvegicus
Analyze
Symbol: Prph2
Name: peripherin 2
RGD ID: 3549
Description: Predicted to enable protein homodimerization activity. Involved in response to low light intensity stimulus. Predicted to be located in photoreceptor outer segment. Predicted to be active in plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2); PARTICIPATES IN retinitis pigmentosa pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; C60 fullerene; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Peripherin (retinal degradation slow); peripherin-2; Rds; retinal degeneration slow protein; retinal degeneration, slow; RSRDS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,563,770 - 21,579,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,563,777 - 21,579,074 (-)EnsemblGRCr8
mRatBN7.2914,066,149 - 14,081,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,066,156 - 14,081,454 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,647,971 - 22,663,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,711,982 - 27,727,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,011,338 - 26,026,628 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,085,933 - 16,386,176 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0915,002,816 - 15,006,668 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.499,251,024 - 9,272,513 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,815,281 - 11,829,854 (-)NCBICelera
RGSC_v3.199,248,345 - 9,269,835 (-)NCBI
RH 3.4 Map960.5RGD
Cytogenetic Map9q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Ali RR, etal., Nat Genet. 2000 Jul;25(3):306-10.
2. Nucleotide and predicted protein sequence of rat retinal degeneration slow (rds). Begy C and Bridges CD, Nucleic Acids Res 1990 May 25;18(10):3058.
3. Peripherin/RDS gene in Indonesian patients with retinitis pigmentosa: geographic comparison of polymorphic variations. Budu, etal., Hiroshima J Med Sci. 2005 Sep;54(3):73-6.
4. Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome. Chakraborty D, etal., PLoS One. 2013 May 1;8(5):e63321. doi: 10.1371/journal.pone.0063321. Print 2013.
5. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
6. Phenotypic expression of autosomal dominant retinitis pigmentosa in a Swedish family expressing a Phe-211-Leu variant of peripherin/RDS. Ekstrom U, etal., Ophthalmic Genet. 1998 Mar;19(1):27-37.
7. Combination of retinitis pigmentosa and hearing loss caused by a novel mutation in PRPH2 and a known mutation in GJB2: importance for differential diagnosis of Usher syndrome. Fakin A, etal., Vision Res. 2012 Dec 15;75:71-6. doi: 10.1016/j.visres.2012.07.011. Epub 2012 Jul 25.
8. Adult vitelliform macular dystrophy is frequently associated with mutations in the peripherin/RDS gene. Felbor U, etal., Hum Mutat. 1997;10(4):301-9.
9. Serine-27-phenylalanine mutation within the peripherin/RDS gene in a family with cone dystrophy. Fishman GA, etal., Ophthalmology. 1997 Feb;104(2):299-306.
10. Analysis of peripherin/RDS gene for Japanese retinal dystrophies. Fujiki K, etal., Jpn J Ophthalmol. 1998 May-Jun;42(3):186-92.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. Gorin MB, etal., Ophthalmology. 1995 Feb;102(2):246-55.
14. Autosomal dominant central areolar choroidal dystrophy caused by a mutation in codon 142 in the peripherin/RDS gene. Hoyng CB, etal., Am J Ophthalmol. 1996 Jun;121(6):623-9.
15. A null mutation in the human peripherin/RDS gene in a family with autosomal dominant retinitis punctata albescens. Kajiwara K, etal., Nat Genet. 1993 Mar;3(3):208-12.
16. Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosa. Kajiwara K, etal., Nature. 1991 Dec 12;354(6353):480-3.
17. Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors. Kedzierski W, etal., Invest Ophthalmol Vis Sci. 1997 Feb;38(2):498-509.
18. Clinical findings in a multigeneration family with autosomal dominant central areolar choroidal dystrophy associated with an Arg195Leu mutation in the peripherin/RDS gene. Keilhauer CN, etal., Arch Ophthalmol. 2006 Jul;124(7):1020-7.
19. Autosomal dominant pattern dystrophy: identification of a novel splice site mutation in the peripherin/RDS gene. Khoubian FJ, etal., Retina. 2005 Dec;25(8):999-1004.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. McNally N, etal., Hum Mol Genet. 2002 May 1;11(9):1005-16.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Ocular findings in patients with autosomal dominant retinitis pigmentosa and transversion mutation in codon 244 (Asn244Lys) of the peripherin/RDS gene. Nakazawa M, etal., Arch Ophthalmol. 1994 Dec;112(12):1567-73.
24. Autosomal dominant cone-rod dystrophy associated with a Val200Glu mutation of the peripherin/RDS gene. Nakazawa M, etal., Retina. 1996;16(5):405-10.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Butterfly-shaped pigment dystrophy of the fovea caused by a point mutation in codon 167 of the RDS gene. Nichols BE, etal., Nat Genet. 1993 Mar;3(3):202-7.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. A novel complex mutation event in the peripherin/RDS gene in a family with retinal pattern dystrophy. Pajic B, etal., Retina. 2006 Oct;26(8):947-53.
29. Phenotypic intrafamilial variability associated with S212G mutation in the RDS/peripherin gene. Passerini I, etal., Eur J Ophthalmol. 2007 Nov-Dec;17(6):1000-3.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype. Poloschek CM, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4253-65. doi: 10.1167/iovs.09-4655. Epub 2010 Mar 24.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. A novel Cys-214-Ser mutation in the peripherin/RDS gene in a Japanese family with autosomal dominant retinitis pigmentosa. Saga M, etal., Hum Genet. 1993 Nov;92(5):519-21.
36. Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina. Sarra GM, etal., Hum Mol Genet 2001 Oct 1;10(21):2353-61.
37. Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Travis GH, etal., Nature. 1989 Mar 2;338(6210):70-3.
38. A peculiar autosomal dominant macular dystrophy caused by an asparagine deletion at codon 169 in the peripherin/RDS gene. van Lith-Verhoeven JJ, etal., Arch Ophthalmol. 2003 Oct;121(10):1452-7.
39. Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. Wang X, etal., J Med Genet. 2013 Oct;50(10):674-88. doi: 10.1136/jmedgenet-2013-101558. Epub 2013 Jul 11.
40. Demonstration of peripherin/rds mRNA in normal and light-damaged rat retinas by in situ hybridization histochemistry. Yanagita T, etal., Jpn J Ophthalmol. 1993;37(1):1-8.
41. [The study of RDS gene mutation and clinical phenotype in a family with primary retinitis pigmentosa]. Yang H, etal., Zhonghua Yan Ke Za Zhi. 2000 Jan;36(1):52-5, 6, 7.
42. A novel mutation in the RDS/Peripherin gene causes adult-onset foveomacular dystrophy. Yang Z, etal., Am J Ophthalmol. 2003 Feb;135(2):213-8.
43. A novel RDS/peripherin gene mutation associated with diverse macular phenotypes. Yang Z, etal., Ophthalmic Genet. 2004 Jun;25(2):133-45.
Additional References at PubMed
PMID:15964665   PMID:21052544   PMID:22183407  


Genomics

Comparative Map Data
Prph2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,563,770 - 21,579,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,563,777 - 21,579,074 (-)EnsemblGRCr8
mRatBN7.2914,066,149 - 14,081,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,066,156 - 14,081,454 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,647,971 - 22,663,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,711,982 - 27,727,288 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,011,338 - 26,026,628 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,085,933 - 16,386,176 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0915,002,816 - 15,006,668 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.499,251,024 - 9,272,513 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,815,281 - 11,829,854 (-)NCBICelera
RGSC_v3.199,248,345 - 9,269,835 (-)NCBI
RH 3.4 Map960.5RGD
Cytogenetic Map9q12NCBI
PRPH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,696,598 - 42,722,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,696,598 - 42,722,597 (-)Ensemblhg38GRCh38
GRCh37642,664,336 - 42,690,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36642,772,314 - 42,798,287 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34642,772,317 - 42,798,287NCBI
Celera644,216,617 - 44,242,609 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,382,731 - 42,408,581 (-)NCBIHuRef
CHM1_1642,666,888 - 42,692,860 (-)NCBICHM1_1
T2T-CHM13v2.0642,525,027 - 42,556,549 (-)NCBIT2T-CHM13v2.0
Prph2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,221,404 - 47,235,859 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,221,385 - 47,235,859 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,910,478 - 46,924,933 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,910,459 - 46,924,933 (+)Ensemblmm10GRCm38
MGSCv371747,047,434 - 47,061,875 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361746,373,676 - 46,388,117 (+)NCBIMGSCv36mm8
Celera1750,346,402 - 50,360,871 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.91NCBI
Prph2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,782,183 - 8,795,017 (-)Ensembl
ChiLan1.0NW_0049554378,784,211 - 8,794,789 (-)NCBIChiLan1.0ChiLan1.0
PRPH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,192,804 - 57,219,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,060,828 - 53,089,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,284,818 - 42,316,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,582,317 - 43,608,011 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,582,317 - 43,608,011 (-)EnsemblpanPan2panpan1.1
PRPH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,299,236 - 11,316,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,299,236 - 11,316,175 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1211,326,457 - 11,343,396 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01211,780,500 - 11,797,719 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,780,500 - 11,797,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,308,736 - 11,325,675 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,393,617 - 11,410,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,487,294 - 11,504,233 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prph2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,785,976 - 46,800,438 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,160,016 - 17,173,981 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,159,756 - 17,174,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,790,178 - 37,805,142 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1737,788,547 - 37,805,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,265,462 - 43,270,328 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRPH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,429,876 - 29,456,013 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,430,545 - 29,453,636 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604442,728,399 - 42,754,586 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prph2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,685,378 - 16,700,111 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475416,685,512 - 16,699,145 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prph2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1482,949,508 - 82,963,872 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prph2
149 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:42
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000061500
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH94646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,066,171 - 14,066,339 (+)MAPPERmRatBN7.2
Rnor_6.0916,085,956 - 16,086,123NCBIRnor6.0
Rnor_5.0915,002,839 - 15,003,006UniSTSRnor5.0
RGSC_v3.499,251,047 - 9,251,214UniSTSRGSC3.4
Celera911,815,304 - 11,815,471UniSTS
RH 3.4 Map960.5UniSTS
Cytogenetic Map9q12UniSTS
RH136756  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8921,563,791 - 21,564,008 (+)Marker Load Pipeline
mRatBN7.2914,066,170 - 14,066,387 (+)MAPPERmRatBN7.2
Rnor_6.0916,085,955 - 16,086,171NCBIRnor6.0
Rnor_5.0915,002,838 - 15,003,054UniSTSRnor5.0
RGSC_v3.499,251,046 - 9,251,262UniSTSRGSC3.4
Celera911,815,303 - 11,815,519UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
nervous system
renal system
reproductive system
sensory system
visual system
1 17 3 17 2 3 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000108165   ⟹   ENSRNOP00000095739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl921,563,777 - 21,579,074 (-)Ensembl
mRatBN7.2 Ensembl914,066,156 - 14,081,454 (-)Ensembl
RefSeq Acc Id: NM_013021   ⟹   NP_037153
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,563,770 - 21,579,074 (-)NCBI
mRatBN7.2914,066,149 - 14,081,454 (-)NCBI
Rnor_6.0916,085,933 - 16,386,176 (-)NCBI
Rnor_5.0915,002,816 - 15,006,668 (-)NCBI
RGSC_v3.499,251,024 - 9,272,513 (-)RGD
Celera911,815,281 - 11,829,854 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037153 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA36603 (Get FASTA)   NCBI Sequence Viewer  
  EDM18867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095739
  ENSRNOP00000095739.1
GenBank Protein P17438 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037153   ⟸   NM_013021
- UniProtKB: P17438 (UniProtKB/Swiss-Prot),   A6JIL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000095739   ⟸   ENSRNOT00000108165

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17438-F1-model_v2 AlphaFold P17438 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3549 AgrOrtholog
BioCyc Gene G2FUF-28251 BioCyc
Ensembl Genes ENSRNOG00000068377 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000108165 ENTREZGENE
  ENSRNOT00000108165.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1450.10 UniProtKB/Swiss-Prot
InterPro Peripherin/rom-1 UniProtKB/Swiss-Prot
  Peripherin/rom-1_CS UniProtKB/Swiss-Prot
  Peripherin_LEL UniProtKB/Swiss-Prot
  Tetraspanin/Peripherin UniProtKB/Swiss-Prot
  Tetraspanin_EC2_sf UniProtKB/Swiss-Prot
KEGG Report rno:25534 UniProtKB/Swiss-Prot
NCBI Gene 25534 ENTREZGENE
PANTHER PERIPHERIN-2 UniProtKB/Swiss-Prot
  PTHR19282 UniProtKB/Swiss-Prot
Pfam Tetraspanin UniProtKB/Swiss-Prot
PhenoGen Prph2 PhenoGen
PRINTS PERIPHERNRDS UniProtKB/Swiss-Prot
PROSITE RDS_ROM1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000068377 RatGTEx
Superfamily-SCOP SSF48652 UniProtKB/Swiss-Prot
UniProt A6JIL5 ENTREZGENE, UniProtKB/TrEMBL
  P17438 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Prph2  peripherin 2  Rds  retinal degeneration, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rds  retinal degeneration, slow  Prph2  peripherin 2  Symbol and Name updated 1299863 APPROVED
2003-04-09 Prph2  peripherin 2  Rds  Peripherin (retinal degradation slow)  Symbol and Name updated 629477 APPROVED
2002-06-10 Rds  Peripherin (retinal degradation slow)      Symbol and Name status set to approved 70586 APPROVED