Rabggtb (Rab geranylgeranyltransferase subunit beta) - Rat Genome Database

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Gene: Rabggtb (Rab geranylgeranyltransferase subunit beta) Rattus norvegicus
Analyze
Symbol: Rabggtb
Name: Rab geranylgeranyltransferase subunit beta
RGD ID: 3530
Description: Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: geranylgeranyl transferase type II subunit beta; geranylgeranyl transferase type-2 subunit beta; GGTase-II-beta; rab geranyl-geranyltransferase subunit beta; Rab geranylgeranyl transferase componenet, subunit beta; RAB geranylgeranyl transferase, b subunit; Rab geranylgeranyltransferase, beta subunit; rab GG transferase beta; rab GGTase beta; type II protein geranyl-geranyltransferase subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,504,586 - 245,510,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2245,504,586 - 245,510,774 (-)EnsemblGRCr8
mRatBN7.22242,844,758 - 242,850,951 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,844,762 - 242,851,050 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2250,667,563 - 250,673,774 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,561,386 - 248,567,597 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,459,951 - 243,466,163 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2245,436,568 - 245,442,779 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2245,560,508 - 245,566,719 (-)NCBILyon_Normotensive
Lyon_Hypertensive2245,247,868 - 245,254,079 (-)NCBILyon_Hypertensive
F344_StmMcwi2245,310,849 - 245,317,060 (-)NCBIF344_StmMcwi
Rnor_6.02260,110,309 - 260,115,574 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,110,309 - 260,115,577 (-)Ensemblrn6Rnor6.0
Rnor_5.02278,774,376 - 278,779,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42251,852,549 - 251,857,811 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2234,777,191 - 234,782,459 (-)NCBICelera
RGSC_v3.12251,867,151 - 251,872,419 (-)NCBI
Cytogenetic Map2q45NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
farnesol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrimidifen  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin K  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, etal., J Biol Chem 1993 Jun 5;268(16):12221-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, etal., Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795.
5. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, etal., EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Pylypenko O, etal., Mol Cell. 2003 Feb;11(2):483-94.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10745007   PMID:23114750  


Genomics

Comparative Map Data
Rabggtb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,504,586 - 245,510,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2245,504,586 - 245,510,774 (-)EnsemblGRCr8
mRatBN7.22242,844,758 - 242,850,951 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,844,762 - 242,851,050 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2250,667,563 - 250,673,774 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,561,386 - 248,567,597 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,459,951 - 243,466,163 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2245,436,568 - 245,442,779 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2245,560,508 - 245,566,719 (-)NCBILyon_Normotensive
Lyon_Hypertensive2245,247,868 - 245,254,079 (-)NCBILyon_Hypertensive
F344_StmMcwi2245,310,849 - 245,317,060 (-)NCBIF344_StmMcwi
Rnor_6.02260,110,309 - 260,115,574 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,110,309 - 260,115,577 (-)Ensemblrn6Rnor6.0
Rnor_5.02278,774,376 - 278,779,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42251,852,549 - 251,857,811 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2234,777,191 - 234,782,459 (-)NCBICelera
RGSC_v3.12251,867,151 - 251,872,419 (-)NCBI
Cytogenetic Map2q45NCBI
RABGGTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,786,194 - 75,795,090 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,786,188 - 75,795,086 (+)Ensemblhg38GRCh38
GRCh37176,251,879 - 76,260,775 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,024,474 - 76,033,352 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34175,963,906 - 75,972,785NCBI
Celera174,491,796 - 74,500,671 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef174,381,711 - 74,390,606 (+)NCBIHuRef
CHM1_1176,367,172 - 76,376,066 (+)NCBICHM1_1
T2T-CHM13v2.0175,622,856 - 75,631,751 (+)NCBIT2T-CHM13v2.0
Rabggtb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393153,612,926 - 153,618,603 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3153,612,924 - 153,618,646 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383153,907,289 - 153,912,966 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3153,907,287 - 153,913,009 (-)Ensemblmm10GRCm38
MGSCv373153,570,253 - 153,575,930 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363153,844,841 - 153,849,445 (-)NCBIMGSCv36mm8
Celera3160,370,948 - 160,376,625 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map378.76NCBI
Rabggtb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,152,380 - 17,162,310 (-)Ensembl
ChiLan1.0NW_00495542317,155,161 - 17,162,237 (-)NCBIChiLan1.0ChiLan1.0
RABGGTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21151,097,980 - 151,106,943 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,258,522 - 150,267,454 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,001,443 - 75,010,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,973,158 - 76,982,083 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,973,158 - 76,982,083 (+)EnsemblpanPan2panpan1.1
RABGGTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1670,824,822 - 70,834,958 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl670,825,188 - 70,835,238 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha673,489,614 - 73,499,688 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0671,417,955 - 71,428,054 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,417,956 - 71,428,066 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1670,913,867 - 70,923,901 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0670,859,305 - 70,869,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,352,611 - 71,362,696 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rabggtb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505887,302,500 - 87,310,667 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365712,812,871 - 2,821,053 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365712,812,902 - 2,821,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RABGGTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6137,410,691 - 137,534,233 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16137,525,063 - 137,534,132 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26127,497,462 - 127,506,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RABGGTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12057,398,684 - 57,407,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2057,398,327 - 57,407,712 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603360,102,783 - 60,111,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rabggtb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474221,168,290 - 21,175,923 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rabggtb
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:32
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000065997
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat

Markers in Region
RH127932  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82245,504,684 - 245,504,901 (+)Marker Load Pipeline
mRatBN7.22242,844,856 - 242,845,073 (+)MAPPERmRatBN7.2
Rnor_6.02260,110,408 - 260,110,624NCBIRnor6.0
Rnor_5.02278,774,475 - 278,774,691UniSTSRnor5.0
RGSC_v3.42251,852,644 - 251,852,860UniSTSRGSC3.4
Celera2234,777,290 - 234,777,506UniSTS
RH 3.4 Map21629.8UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010063585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC060536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065997   ⟹   ENSRNOP00000061541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2245,504,586 - 245,509,890 (-)Ensembl
mRatBN7.2 Ensembl2242,844,762 - 242,850,951 (-)Ensembl
Rnor_6.0 Ensembl2260,110,309 - 260,115,577 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099311   ⟹   ENSRNOP00000086870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2245,504,588 - 245,510,774 (-)Ensembl
mRatBN7.2 Ensembl2242,844,762 - 242,851,050 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109806   ⟹   ENSRNOP00000096722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2245,504,586 - 245,510,052 (-)Ensembl
mRatBN7.2 Ensembl2242,844,839 - 242,850,204 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144515   ⟹   ENSRNOP00000101139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2245,507,937 - 245,509,853 (-)Ensembl
RefSeq Acc Id: NM_138708   ⟹   NP_619715
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,504,586 - 245,510,779 (-)NCBI
mRatBN7.22242,844,758 - 242,850,951 (-)NCBI
Dahl_SR_JrHsd2245,436,568 - 245,442,779 (-)NCBI
Lyon_Normotensive2245,560,508 - 245,566,719 (-)NCBI
Lyon_Hypertensive2245,247,868 - 245,254,079 (-)NCBI
F344_StmMcwi2245,310,849 - 245,317,060 (-)NCBI
Rnor_6.02260,110,309 - 260,115,574 (-)NCBI
Rnor_5.02278,774,376 - 278,779,641 (-)NCBI
RGSC_v3.42251,852,549 - 251,857,811 (-)RGD
Celera2234,777,191 - 234,782,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281366   ⟹   XP_063137436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,504,590 - 245,510,878 (-)NCBI
RefSeq Acc Id: XM_063281367   ⟹   XP_063137437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,504,590 - 245,510,783 (-)NCBI
RefSeq Acc Id: XM_063281368   ⟹   XP_063137438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,504,590 - 245,510,777 (-)NCBI
RefSeq Acc Id: XM_063281369   ⟹   XP_063137439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,504,590 - 245,508,022 (-)NCBI
RefSeq Acc Id: XR_010063585
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82245,505,544 - 245,510,831 (-)NCBI
RefSeq Acc Id: NP_619715   ⟸   NM_138708
- UniProtKB: Q08603 (UniProtKB/Swiss-Prot),   Q68G48 (UniProtKB/TrEMBL),   A6HWN7 (UniProtKB/TrEMBL),   A0A8I6GFF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061541   ⟸   ENSRNOT00000065997
Ensembl Acc Id: ENSRNOP00000086870   ⟸   ENSRNOT00000099311
Ensembl Acc Id: ENSRNOP00000096722   ⟸   ENSRNOT00000109806
RefSeq Acc Id: XP_063137436   ⟸   XM_063281366
- Peptide Label: isoform X1
- UniProtKB: Q08603 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137437   ⟸   XM_063281367
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137438   ⟸   XM_063281368
- Peptide Label: isoform X3
- UniProtKB: Q08603 (UniProtKB/Swiss-Prot),   A6HWN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137439   ⟸   XM_063281369
- Peptide Label: isoform X4
- UniProtKB: A6HWP3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101139   ⟸   ENSRNOT00000144515
Protein Domains
Prenyltransferase alpha-alpha toroid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08603-F1-model_v2 AlphaFold Q08603 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691831
Promoter ID:EPDNEW_R2355
Type:single initiation site
Name:Rabggtb_1
Description:Rab geranylgeranyltransferase, beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02260,115,586 - 260,115,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3530 AgrOrtholog
BioCyc Gene G2FUF-50774 BioCyc
Ensembl Genes ENSRNOG00000009992 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065997 ENTREZGENE
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918640 IMAGE-MGC_LOAD
  IMAGE:7135106 IMAGE-MGC_LOAD
InterPro PFTB_repeat UniProtKB/Swiss-Prot
  PGGT1B-like UniProtKB/Swiss-Prot
  Ptb1 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
KEGG Report rno:25533 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72651 IMAGE-MGC_LOAD
  MGC:93047 IMAGE-MGC_LOAD
NCBI Gene 25533 ENTREZGENE
PANTHER GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR11774 UniProtKB/Swiss-Prot
Pfam Prenyltrans UniProtKB/Swiss-Prot
PhenoGen Rabggtb PhenoGen
RatGTEx ENSRNOG00000009992 RatGTEx
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
TIGR TC217759
UniProt A0A8I6GFF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLQ7_RAT UniProtKB/TrEMBL
  A0ABK0L7Z1_RAT UniProtKB/TrEMBL
  A0ABZ3NN91_RAT UniProtKB/TrEMBL
  A6HWN7 ENTREZGENE, UniProtKB/TrEMBL
  A6HWN8_RAT UniProtKB/TrEMBL
  A6HWN9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWP2_RAT UniProtKB/TrEMBL
  A6HWP3 ENTREZGENE, UniProtKB/TrEMBL
  A6HWP4_RAT UniProtKB/TrEMBL
  A6HWP5_RAT UniProtKB/TrEMBL
  F1LSM6_RAT UniProtKB/TrEMBL
  PGTB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G48 ENTREZGENE
  Q6P9Y2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-04 Rabggtb  Rab geranylgeranyltransferase subunit beta  Rabggtb  Rab geranylgeranyltransferase, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rabggtb  Rab geranylgeranyltransferase, beta subunit  Rabggtb  RAB geranylgeranyl transferase, b subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Rabggtb  RAB geranylgeranyl transferase, b subunit    Rab geranylgeranyl transferase componenet, subunit beta  Name updated 1299863 APPROVED
2002-06-10 Rabggtb  Rab geranylgeranyl transferase componenet, subunit beta      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction combines with alpha subunit Rabggta to form Component B of the Rab geranylgeranyl transferase, which combines with an additional Component A for enzyme activity 69952