Prss2 (protease, serine, 2) - Rat Genome Database

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Gene: Prss2 (protease, serine, 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss2
Name: protease, serine, 2
RGD ID: 3418
Description: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Involved in response to nutrient. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1) and PRSS2 (serine protease 2); PARTICIPATES IN influenza A pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anionic trypsin II; anionic trypsin-2; pancreatic trypsin 2; Pancreatic trypsin II; pretrypsinogen II; Ptryss2; serine protease 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Candidate Gene For: Bp116
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,244,964 - 71,250,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl471,244,964 - 71,250,043 (+)EnsemblGRCr8
mRatBN7.2470,278,304 - 70,283,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx475,187,220 - 75,192,253 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,101,091 - 71,106,156 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,517,199 - 69,522,232 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,689,737 - 70,694,816 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)Ensemblrn6Rnor6.0
Rnor_5.04135,480,753 - 135,485,777 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4469,088,288 - 69,093,312 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera465,243,567 - 65,248,645 (+)NCBICelera
RGSC_v3.1469,288,085 - 69,369,442 (+)NCBI
Cytogenetic Map4q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Brinen LS, etal., Biochemistry. 1996 May 14;35(19):5999-6009.
2. Structure of two related rat pancreatic trypsin genes. Craik CS, etal., J Biol Chem 1984 Nov 25;259(22):14255-64.
3. Regulation by a protein-free carbohydrate-rich diet of rat pancreatic mRNAs encoding trypsin and elastase isoenzymes. Dakka N, etal., Biochem J. 1990 Jun 1;268(2):471-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Gillmor SA, etal., J Mol Biol. 2000 Jun 16;299(4):993-1003.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas. Hedstrom J, etal., Int J Cancer. 1996 May 3;66(3):326-31.
8. Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy. Lauhio A, etal., Ann Med. 2008;40(4):312-20.
9. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. Lucas JM, etal., J Pathol. 2008 Jun;215(2):118-25.
10. Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs. MacDonald RJ, etal., J Biol Chem 1982 Aug 25;257(16):9724-32.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Pasternak A, etal., Protein Sci. 1999 Jan;8(1):253-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1881877   PMID:3112942   PMID:11685246   PMID:18815551   PMID:23650361   PMID:31904090  


Genomics

Variants

.
Variants in Prss2
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000018852, ENSRNOT00000066789
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
D4Mgh32  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,245,453 - 71,245,857 (+)Marker Load Pipeline
mRatBN7.2470,278,793 - 70,279,197 (+)MAPPERmRatBN7.2
Rnor_6.0470,690,227 - 70,690,630NCBIRnor6.0
Rnor_5.04135,481,243 - 135,481,646UniSTSRnor5.0
Rnor_5.04135,420,192 - 135,420,595UniSTSRnor5.0
RGSC_v3.4469,088,777 - 69,089,181RGDRGSC3.4
RGSC_v3.4469,088,778 - 69,089,181UniSTSRGSC3.4
Celera465,244,057 - 65,244,460UniSTS
RGSC_v3.1469,364,907 - 69,365,311RGD
RH 3.4 Map4419.12UniSTS
RH 3.4 Map4419.12RGD
RH 2.0 Map4470.7RGD
Cytogenetic Map4q22UniSTS
D4Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,249,116 - 71,249,285 (+)Marker Load Pipeline
mRatBN7.2470,282,456 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,890 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,932UniSTSRnor5.0
Rnor_5.04135,484,906 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,440 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,441 - 69,092,609UniSTSRGSC3.4
Celera465,247,719 - 65,247,887UniSTS
RGSC_v3.1469,368,570 - 69,368,739RGD
RH 3.4 Map4403.82RGD
RH 3.4 Map4403.82UniSTS
RH 2.0 Map4440.8RGD
Cytogenetic Map4q22UniSTS
D4Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2470,279,628 - 70,279,998 (+)MAPPERmRatBN7.2
Rnor_6.0470,691,062 - 70,691,431NCBIRnor6.0
Rnor_5.04135,482,078 - 135,482,447UniSTSRnor5.0
RGSC_v3.4469,089,613 - 69,089,982UniSTSRGSC3.4
Celera465,244,892 - 65,245,260UniSTS
FHH x ACI Map444.65RGD
FHH x ACI Map444.65UniSTS
Cytogenetic Map4q22UniSTS
D4Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8471,249,115 - 71,249,285 (+)Marker Load Pipeline
mRatBN7.2470,282,455 - 70,282,627 (+)MAPPERmRatBN7.2
Rnor_6.0470,693,889 - 70,694,058NCBIRnor6.0
Rnor_5.04135,416,764 - 135,416,933UniSTSRnor5.0
Rnor_5.04135,484,905 - 135,485,074UniSTSRnor5.0
RGSC_v3.4469,092,439 - 69,092,609RGDRGSC3.4
RGSC_v3.4469,092,440 - 69,092,609UniSTSRGSC3.4
Celera465,247,718 - 65,247,887UniSTS
RGSC_v3.1469,368,569 - 69,368,739RGD
SHRSP x BN Map434.06RGD
SHRSP x BN Map434.06UniSTS
FHH x ACI Map444.65RGD
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 7 6 13 26 30 10 31 10 68 43 8 6 18 20

Sequence


Ensembl Acc Id: ENSRNOT00000018852   ⟹   ENSRNOP00000018853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl470,689,737 - 70,694,761 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095908   ⟹   ENSRNOP00000082459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl471,244,964 - 71,250,043 (+)Ensembl
mRatBN7.2 Ensembl470,278,304 - 70,283,385 (+)Ensembl
RefSeq Acc Id: NM_012729   ⟹   NP_036861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,244,964 - 71,250,043 (+)NCBI
mRatBN7.2470,278,304 - 70,283,385 (+)NCBI
Rnor_6.0470,689,737 - 70,694,816 (+)NCBI
Rnor_5.04135,480,753 - 135,485,777 (+)NCBI
RGSC_v3.4469,088,288 - 69,093,312 (+)RGD
Celera465,243,567 - 65,248,645 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036861 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98517 (Get FASTA)   NCBI Sequence Viewer  
  CAA24581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082459
  ENSRNOP00000082459.1
GenBank Protein P00763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036861   ⟸   NM_012729
- Peptide Label: precursor
- UniProtKB: P00763 (UniProtKB/Swiss-Prot),   A6IF27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018853   ⟸   ENSRNOT00000018852
Ensembl Acc Id: ENSRNOP00000082459   ⟸   ENSRNOT00000095908
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00763-F1-model_v2 AlphaFold P00763 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692997
Promoter ID:EPDNEW_R3521
Type:single initiation site
Name:Prss2_1
Description:protease, serine, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,689,724 - 70,689,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3418 AgrOrtholog
BioCyc Gene G2FUF-45121 BioCyc
Ensembl Genes ENSRNOG00000032916 Ensembl
  ENSRNOG00000064731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000095908 ENTREZGENE
  ENSRNOT00000095908.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Serine_Proteases_S1 UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:25052 UniProtKB/Swiss-Prot
NCBI Gene 25052 ENTREZGENE
PANTHER PROTEASE, SERINE 1 (TRYPSIN 1)-RELATED UniProtKB/Swiss-Prot
  TRYPSIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032916 RatGTEx
  ENSRNOG00000064731 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6IF27 ENTREZGENE, UniProtKB/TrEMBL
  P00763 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prss2  protease, serine, 2    pancreatic trypsin 2  Name updated 1299863 APPROVED
2003-04-09 Prss2  pancreatic trypsin 1    Pancreatic trypsin II  Name updated 629478 APPROVED
2002-06-10 Prss2  Pancreatic trypsin II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology nucleotide sequence is 88% homologous with that of trypsinogen I mRNA 633744
gene_homology preproenzyme has 89% amino acid sequence identity with trypsinogen I 633744