Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) - Rat Genome Database

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Gene: Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) Rattus norvegicus
Analyze
Symbol: Ppm1b
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1B
RGD ID: 3374
Description: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including N-terminal protein myristoylation; negative regulation of interferon-beta production; and regulation of signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PP2C-beta; Pp2c2; protein phosphatase 1B; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C isoform beta; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,399,559 - 15,460,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,399,562 - 15,460,756 (-)EnsemblGRCr8
mRatBN7.269,646,695 - 9,707,471 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx69,935,440 - 9,996,111 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,244,815 - 10,305,488 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,766,465 - 9,827,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)Ensemblrn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,370,886 - 9,431,637 (-)NCBICelera
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetazolamide  (ISO)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. Kato S, etal., FEBS Lett 1996 Nov 4;396(2-3):293-7.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The mouse protein phosphatase 2Cbeta (Ppm1b) gene maps to the distal part of mouse chromosome 17. Watanabe T, etal., Genomics 1996 Apr 1;33(1):147-9.
Additional References at PubMed
PMID:1312947   PMID:7532404   PMID:8889548   PMID:12477932   PMID:18930133   PMID:20801214   PMID:22750291   PMID:23088624   PMID:35352799  


Genomics

Comparative Map Data
Ppm1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,399,559 - 15,460,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,399,562 - 15,460,756 (-)EnsemblGRCr8
mRatBN7.269,646,695 - 9,707,471 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx69,935,440 - 9,996,111 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,244,815 - 10,305,488 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,766,465 - 9,827,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)Ensemblrn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,370,886 - 9,431,637 (-)NCBICelera
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Cytogenetic Map6q12NCBI
PPM1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,168,875 - 44,246,928 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,167,969 - 44,244,384 (+)Ensemblhg38GRCh38
GRCh37244,396,014 - 44,461,785 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,249,504 - 44,315,246 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34244,307,666 - 44,370,261NCBI
Celera244,234,958 - 44,300,689 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,132,461 - 44,198,020 (+)NCBIHuRef
CHM1_1244,325,419 - 44,391,185 (+)NCBICHM1_1
T2T-CHM13v2.0244,174,224 - 44,253,771 (+)NCBIT2T-CHM13v2.0
Ppm1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,264,169 - 85,331,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,264,169 - 85,331,419 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381784,956,741 - 85,023,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,956,741 - 85,023,991 (+)Ensemblmm10GRCm38
MGSCv371785,356,081 - 85,423,332 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361784,866,341 - 84,925,447 (+)NCBIMGSCv36mm8
Celera1789,319,953 - 89,386,219 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.13NCBI
Ppm1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,276,525 - 11,352,095 (+)Ensembl
ChiLan1.0NW_00495544111,276,525 - 11,338,586 (+)NCBIChiLan1.0ChiLan1.0
PPM1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,182,330 - 82,253,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,186,287 - 82,257,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,254,168 - 44,325,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,230,001 - 45,262,587 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,230,001 - 45,262,587 (+)EnsemblpanPan2panpan1.1
PPM1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,590,110 - 46,680,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,590,079 - 46,665,866 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1046,450,255 - 46,538,849 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01047,467,776 - 47,557,210 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,468,700 - 47,547,566 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,175,538 - 47,264,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,466,410 - 47,555,184 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,649,226 - 47,737,813 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppm1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,292,532 - 36,376,368 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,722,396 - 7,805,036 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,732,724 - 7,804,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,221,873 - 96,317,247 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1396,237,660 - 96,317,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,392,133 - 102,472,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,003,885 - 63,093,584 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,016,553 - 63,093,592 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604548,789,555 - 48,865,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,656,755 - 25,723,236 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473825,657,084 - 25,738,913 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppm1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v177,907,651 - 7,965,953 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppm1b
371 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:115
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000040509, ENSRNOT00000048656
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
BE112607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,706,372 - 9,706,532 (-)MAPPERmRatBN7.2
Rnor_6.068,220,324 - 8,220,483NCBIRnor6.0
Rnor_5.068,152,936 - 8,153,095UniSTSRnor5.0
RGSC_v3.468,319,625 - 8,319,784UniSTSRGSC3.4
Celera69,430,539 - 9,430,698UniSTS
Cytogenetic Map6q12UniSTS
RH141215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,653,748 - 9,653,953 (-)MAPPERmRatBN7.2
Rnor_6.068,272,867 - 8,273,071NCBIRnor6.0
Rnor_5.068,205,479 - 8,205,683UniSTSRnor5.0
RGSC_v3.468,373,116 - 8,373,320UniSTSRGSC3.4
Celera69,377,939 - 9,378,143UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ780970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV110469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV777419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM042005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM075941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM108050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM141620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN800175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S90449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040509   ⟹   ENSRNOP00000041472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,219,385 - 8,280,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000048656   ⟹   ENSRNOP00000048342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,220,228 - 8,273,549 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079279   ⟹   ENSRNOP00000074301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,408,631 - 15,460,756 (-)Ensembl
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)Ensembl
Rnor_6.0 Ensembl68,220,228 - 8,271,054 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083470   ⟹   ENSRNOP00000074150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,417,917 - 15,429,873 (-)Ensembl
mRatBN7.2 Ensembl69,665,052 - 9,677,022 (-)Ensembl
Rnor_6.0 Ensembl68,218,696 - 8,270,293 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122241   ⟹   ENSRNOP00000100456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,400,464 - 15,459,460 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151256   ⟹   ENSRNOP00000109449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,406,137 - 15,459,460 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154745   ⟹   ENSRNOP00000099191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,408,631 - 15,459,460 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167508   ⟹   ENSRNOP00000102147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,399,562 - 15,460,301 (-)Ensembl
RefSeq Acc Id: NM_001270619   ⟹   NP_001257548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,408,631 - 15,459,460 (-)NCBI
mRatBN7.269,655,765 - 9,706,628 (-)NCBI
Rnor_6.068,220,228 - 8,271,055 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,379,955 - 9,430,794 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270620   ⟹   NP_001257549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,399,559 - 15,460,301 (-)NCBI
mRatBN7.269,646,695 - 9,707,471 (-)NCBI
Rnor_6.068,219,385 - 8,280,124 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033096   ⟹   NP_149087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,406,137 - 15,459,460 (-)NCBI
mRatBN7.269,653,271 - 9,706,628 (-)NCBI
Rnor_6.068,220,228 - 8,273,549 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
RGSC_v3.468,319,544 - 8,373,795 (+)RGD
Celera69,377,461 - 9,430,794 (-)NCBI
Sequence:
RefSeq Acc Id: NP_149087   ⟸   NM_033096
- Peptide Label: isoform 1
- UniProtKB: Q546R0 (UniProtKB/Swiss-Prot),   Q64046 (UniProtKB/Swiss-Prot),   P35815 (UniProtKB/Swiss-Prot),   A6H9H9 (UniProtKB/TrEMBL),   A6H9H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257549   ⟸   NM_001270620
- Peptide Label: isoform 3
- UniProtKB: Q642F2 (UniProtKB/TrEMBL),   D3ZLY2 (UniProtKB/TrEMBL),   A6H9H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257548   ⟸   NM_001270619
- Peptide Label: isoform 2
- UniProtKB: Q99ND8 (UniProtKB/TrEMBL),   A6H9I0 (UniProtKB/TrEMBL),   A0A0G2K7Q5 (UniProtKB/TrEMBL),   Q6P6W5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074301   ⟸   ENSRNOT00000079279
Ensembl Acc Id: ENSRNOP00000048342   ⟸   ENSRNOT00000048656
Ensembl Acc Id: ENSRNOP00000074150   ⟸   ENSRNOT00000083470
Ensembl Acc Id: ENSRNOP00000041472   ⟸   ENSRNOT00000040509
Ensembl Acc Id: ENSRNOP00000099191   ⟸   ENSRNOT00000154745
Ensembl Acc Id: ENSRNOP00000100456   ⟸   ENSRNOT00000122241
Ensembl Acc Id: ENSRNOP00000102147   ⟸   ENSRNOT00000167508
Ensembl Acc Id: ENSRNOP00000109449   ⟸   ENSRNOT00000151256
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35815-F1-model_v2 AlphaFold P35815 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694378
Promoter ID:EPDNEW_R4903
Type:multiple initiation site
Name:Ppm1b_1
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,226 - 8,220,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3374 AgrOrtholog
BioCyc Gene G2FUF-38652 BioCyc
Ensembl Genes ENSRNOG00000030667 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000151256 ENTREZGENE
  ENSRNOT00000154745 ENTREZGENE
  ENSRNOT00000167508 ENTREZGENE
Gene3D-CATH 1.10.10.430 UniProtKB/Swiss-Prot
  3.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599216 IMAGE-MGC_LOAD
  IMAGE:7113731 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot
  PP2C_BS UniProtKB/Swiss-Prot
  PP2C_C UniProtKB/Swiss-Prot
  PP2C_C_sf UniProtKB/Swiss-Prot
  PPM-type_dom_sf UniProtKB/Swiss-Prot
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot
KEGG Report rno:24667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72371 IMAGE-MGC_LOAD
  MGC:93319 IMAGE-MGC_LOAD
NCBI Gene 24667 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam PP2C UniProtKB/Swiss-Prot
  PP2C_C UniProtKB/Swiss-Prot
PhenoGen Ppm1b PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot
  PPM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030667 RatGTEx
SMART PP2Cc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81601 UniProtKB/Swiss-Prot
  SSF81606 UniProtKB/Swiss-Prot
UniProt A0A0G2K7C6_RAT UniProtKB/TrEMBL
  A0A0G2K7Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFW6_RAT UniProtKB/TrEMBL
  A0ABK0LG38_RAT UniProtKB/TrEMBL
  A6H9H5 ENTREZGENE, UniProtKB/TrEMBL
  A6H9H8 ENTREZGENE, UniProtKB/TrEMBL
  A6H9H9 ENTREZGENE, UniProtKB/TrEMBL
  A6H9I0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLY2 ENTREZGENE
  P35815 ENTREZGENE, UniProtKB/Swiss-Prot
  Q546R0 ENTREZGENE
  Q64046 ENTREZGENE
  Q642F2 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6W5 ENTREZGENE, UniProtKB/TrEMBL
  Q99ND8 ENTREZGENE
UniProt Secondary Q546R0 UniProtKB/Swiss-Prot
  Q64046 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Ppm1b  protein phosphatase, Mg2+/Mn2+ dependent, 1B  Ppm1b  protein phosphatase 1B, magnesium dependent, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppm1b  Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform      Symbol and Name status set to approved 70586 APPROVED