Polb (DNA polymerase beta) - Rat Genome Database

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Gene: Polb (DNA polymerase beta) Rattus norvegicus
Analyze
Symbol: Polb
Name: DNA polymerase beta
RGD ID: 3363
Description: Enables DNA-directed DNA polymerase activity; damaged DNA binding activity; and metal ion binding activity. Involved in several processes, including pyrimidine dimer repair; response to gamma radiation; and response to hyperoxia. Predicted to be located in cytoplasm and spindle microtubule. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta); PARTICIPATES IN base excision repair pathway; INTERACTS WITH (15Z)-tetracosenoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5'-deoxyribose-phosphate lyase; 5'-dRP lyase; AP lyase; DNA pol beta; DNA-directed DNA polymerase beta; polymerase (DNA directed), beta; polymerase (DNA) beta; polymerase-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,081,903 - 76,105,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,081,864 - 76,108,180 (+)EnsemblGRCr8
mRatBN7.21669,379,438 - 69,402,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,379,400 - 69,404,812 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1674,653,139 - 74,676,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,084,728 - 78,107,983 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,333,927 - 73,357,182 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,237,001 - 74,260,272 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,237,001 - 74,260,271 (+)Ensemblrn6Rnor6.0
Rnor_5.01673,869,828 - 73,893,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41673,864,702 - 73,888,011 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1667,272,411 - 67,295,648 (+)NCBICelera
RGSC_v3.11673,864,971 - 73,890,378 (+)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(15Z)-tetracosenoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2'-deoxyadenosine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
2-nitropropane  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-chlorouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
capsaicin  (EXP)
chlorpyrifos  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
diamminedichloroplatinum  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
dioxygen  (ISO)
Epolactaene  (EXP)
epoxiconazole  (ISO)
ethene  (EXP)
flutamide  (EXP)
folic acid  (ISO)
Honokiol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lithocholic acid  (EXP)
melatonin  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
Methoxyamine  (ISO)
methyl methanesulfonate  (ISO)
methyl tert-butyl ether  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrates  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxirane  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rotenone  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
tamoxifen  (EXP)
taurine  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
transplatin  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
microtubule  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)
spindle microtubule  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes. Arndt JW, etal., Biochemistry. 2001 May 8;40(18):5368-75.
2. Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. Bhupanapadu Sunkesula SR, etal., Neurochem Res. 2008 Jun;33(6):1117-28. Epub 2008 Feb 8.
3. Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Cortina MS, etal., Exp Eye Res. 2005 Dec;81(6):742-50. Epub 2005 Jun 24.
4. Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase beta binding affinity. Cuneo MJ and London RE, Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6805-10. doi: 10.1073/pnas.0914077107. Epub 2010 Mar 29.
5. Regenerating rat liver DNA polymerases: disimilitude or relationship between nuclear and cytoplasmic enzymes? de Recondo AM and Abadiedebat J, Nucleic Acids Res. 1976 Aug;3(8):1823-37.
6. Characterization of the redox transition of the XRCC1 N-terminal domain. Gabel SA, etal., Structure. 2014 Dec 2;22(12):1754-63. doi: 10.1016/j.str.2014.09.012. Epub 2014 Nov 13.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters. Holmes EW, etal., Exp Mol Pathol 2002 Dec;73(3):209-19.
10. Kinetic mechanisms of rat polymerase beta-ssDNA interactions. Quantitative fluorescence stopped-flow analysis of the formation of the (Pol beta)(16) and (Pol beta)(5) ssDNA binding mode. Jezewska MJ, etal., J Mol Biol 2001 Nov 9;313(5):977-1002.
11. Induction of DNA polymerase beta and gamma in the lungs of age-related oxygen tolerant rats. Jinno S, etal., Mech Ageing Dev. 1995 Nov 24;85(2-3):95-107.
12. Interaction of DNA polymerase beta with GRIP1 during meiosis. Jonason AS, etal., Chromosoma. 2001 Nov;110(6):402-10. Epub 2001 Sep 12.
13. Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray irradiation. Kaneko T, etal., Mech Ageing Dev. 2002 Sep;123(11):1521-8.
14. Cloning and characterization of the 5' part of the high molecular weight transcript of rat DNA polymerase beta. Konopinski R, etal., Acta Biochim Pol 1995;42(2):253-8.
15. Hormonal regulation of DNA polymerase beta activity and expression in rat adrenal glands and testes. Kotake M, etal., Mol Cell Endocrinol 2002 Jun 28;192(1-2):127-32.
16. Effects of base excision repair gene polymorphisms on pancreatic cancer survival. Li D, etal., Int J Cancer. 2007 Apr 15;120(8):1748-54.
17. Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair. Li N, etal., DNA Repair (Amst). 2007 Sep 1;6(9):1297-306. Epub 2007 Apr 6.
18. Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase. Matsukage A, etal., J Biol Chem 1987 Jul 5;262(19):8960-2.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. A role for DNA polymerase beta in mutagenic UV lesion bypass. Servant L, etal., J Biol Chem 2002 Dec 20;277(51):50046-53.
27. Structure of rat DNA polymerase beta revealed by partial amino acid sequencing and cDNA cloning. Zmudzka BZ, etal., Proc Natl Acad Sci U S A 1986 Jul;83(14):5106-10.
Additional References at PubMed
PMID:1408801   PMID:1420147   PMID:2036395   PMID:2198936   PMID:2404980   PMID:3042024   PMID:3600656   PMID:7516581   PMID:8137427   PMID:8639559   PMID:8841120   PMID:9207062  
PMID:10197627   PMID:10656829   PMID:12477932   PMID:12741854   PMID:14563842   PMID:15177179   PMID:15248749   PMID:15311928   PMID:15485914   PMID:15725623   PMID:15751954   PMID:15794655  
PMID:15901725   PMID:16001017   PMID:16042415   PMID:16600869   PMID:16996474   PMID:19013261   PMID:19231836   PMID:19421423   PMID:19713937   PMID:20108981   PMID:20227374   PMID:21362556  
PMID:22010960   PMID:22219134   PMID:22651551   PMID:23651085   PMID:24388753   PMID:25378300   PMID:27996060   PMID:33087265  


Genomics

Comparative Map Data
Polb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,081,903 - 76,105,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,081,864 - 76,108,180 (+)EnsemblGRCr8
mRatBN7.21669,379,438 - 69,402,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,379,400 - 69,404,812 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1674,653,139 - 74,676,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,084,728 - 78,107,983 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,333,927 - 73,357,182 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,237,001 - 74,260,272 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,237,001 - 74,260,271 (+)Ensemblrn6Rnor6.0
Rnor_5.01673,869,828 - 73,893,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41673,864,702 - 73,888,011 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1667,272,411 - 67,295,648 (+)NCBICelera
RGSC_v3.11673,864,971 - 73,890,378 (+)NCBI
Cytogenetic Map16q12.5NCBI
POLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,338,494 - 42,371,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,338,454 - 42,371,808 (+)Ensemblhg38GRCh38
GRCh37842,196,012 - 42,229,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,315,187 - 42,348,470 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34842,315,186 - 42,348,470NCBI
Celera841,140,732 - 41,174,028 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,719,534 - 40,752,550 (+)NCBIHuRef
CHM1_1842,242,875 - 42,276,239 (+)NCBICHM1_1
T2T-CHM13v2.0842,608,570 - 42,642,104 (+)NCBIT2T-CHM13v2.0
Polb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,118,135 - 23,143,482 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,118,142 - 23,143,451 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38822,628,119 - 22,653,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,628,126 - 22,653,435 (-)Ensemblmm10GRCm38
MGSCv37823,738,591 - 23,763,909 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36824,093,810 - 24,118,959 (-)NCBIMGSCv36mm8
Celera824,118,302 - 24,143,706 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Polb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536540,836 - 595,198 (-)Ensembl
ChiLan1.0NW_004955536542,179 - 595,198 (-)NCBIChiLan1.0ChiLan1.0
POLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,790,457 - 60,824,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,507,601 - 36,541,429 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,582,370 - 41,615,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,026,991 - 39,060,464 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,026,991 - 39,060,464 (+)EnsemblpanPan2panpan1.1
POLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,306,359 - 23,335,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,306,367 - 23,335,322 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1623,810,815 - 23,839,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01625,054,877 - 25,083,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,054,893 - 25,083,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,426,046 - 23,455,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,988,955 - 24,018,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,039,745 - 24,068,768 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Polb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,368,259 - 46,394,119 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785323,941 - 350,539 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936785324,655 - 350,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,356,129 - 11,388,821 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11711,356,130 - 11,388,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,109,577 - 13,131,807 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,332,165 - 40,368,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,332,208 - 40,372,582 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660521,415,871 - 1,455,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624780884,896 - 941,587 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Polb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11363,779,772 - 63,803,237 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Polb
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:172
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026039
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat

Markers in Region
RH130718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,404,421 - 69,404,619 (+)MAPPERmRatBN7.2
Rnor_6.01674,261,984 - 74,262,181NCBIRnor6.0
Rnor_5.01673,894,818 - 73,895,015UniSTSRnor5.0
RGSC_v3.41673,889,723 - 73,889,920UniSTSRGSC3.4
Celera1667,297,360 - 67,297,557UniSTS
RH 3.4 Map16664.21UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026039   ⟹   ENSRNOP00000026039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1676,081,864 - 76,108,180 (+)Ensembl
mRatBN7.2 Ensembl1669,379,400 - 69,402,708 (+)Ensembl
Rnor_6.0 Ensembl1674,237,001 - 74,260,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113772   ⟹   ENSRNOP00000094599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,379,443 - 69,404,812 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118956   ⟹   ENSRNOP00000079289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1676,081,864 - 76,108,180 (+)Ensembl
mRatBN7.2 Ensembl1669,379,443 - 69,404,812 (+)Ensembl
RefSeq Acc Id: NM_017141   ⟹   NP_058837
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,081,903 - 76,105,174 (+)NCBI
mRatBN7.21669,379,438 - 69,402,710 (+)NCBI
Rnor_6.01674,237,001 - 74,260,272 (+)NCBI
Rnor_5.01673,869,828 - 73,893,106 (+)NCBI
RGSC_v3.41673,864,702 - 73,888,011 (+)RGD
Celera1667,272,411 - 67,295,648 (+)RGD
Sequence:
RefSeq Acc Id: NP_058837   ⟸   NM_017141
- UniProtKB: Q4G081 (UniProtKB/Swiss-Prot),   P06766 (UniProtKB/Swiss-Prot),   A6IW62 (UniProtKB/TrEMBL),   A0A8L2QFD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026039   ⟸   ENSRNOT00000026039
Ensembl Acc Id: ENSRNOP00000079289   ⟸   ENSRNOT00000118956
Ensembl Acc Id: ENSRNOP00000094599   ⟸   ENSRNOT00000113772
Protein Domains
DNA-directed DNA polymerase X   Helix-hairpin-helix DNA-binding motif class

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06766-F1-model_v2 AlphaFold P06766 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700187
Promoter ID:EPDNEW_R10709
Type:multiple initiation site
Name:Polb_1
Description:DNA polymerase beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,236,962 - 74,237,022EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3363 AgrOrtholog
BioCyc Gene G2FUF-10880 BioCyc
Ensembl Genes ENSRNOG00000019150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026039 ENTREZGENE
  ENSRNOT00000113772.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.110 UniProtKB/Swiss-Prot
  3.30.210.10 UniProtKB/Swiss-Prot
  3.30.460.10 UniProtKB/Swiss-Prot
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7386894 IMAGE-MGC_LOAD
InterPro DNA-dir_DNA_pol_X UniProtKB/Swiss-Prot
  DNA_pol-X_BS UniProtKB/Swiss-Prot
  DNA_pol_b-like_N UniProtKB/Swiss-Prot
  DNA_pol_B_palm_palm UniProtKB/Swiss-Prot
  DNA_pol_lambd_fingers_domain UniProtKB/Swiss-Prot
  DNA_pol_lamdba_lyase_dom_sf UniProtKB/Swiss-Prot
  DNA_Pol_thumb_sf UniProtKB/Swiss-Prot
  DNA_pol_X UniProtKB/Swiss-Prot
  DNA_pol_X_beta-like UniProtKB/Swiss-Prot
  Hlx-hairpin-Hlx_DNA-bd_motif UniProtKB/Swiss-Prot
  NT_sf UniProtKB/Swiss-Prot
  PolB_thumb UniProtKB/Swiss-Prot
KEGG Report rno:29240 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112619 IMAGE-MGC_LOAD
NCBI Gene 29240 ENTREZGENE
PANTHER DNA POLYMERASE BETA UniProtKB/Swiss-Prot
  PTHR11276 UniProtKB/Swiss-Prot
Pfam DNA_pol_B_palm UniProtKB/Swiss-Prot
  DNA_pol_B_thumb UniProtKB/Swiss-Prot
  DNA_pol_lambd_f UniProtKB/Swiss-Prot
  HHH_8 UniProtKB/Swiss-Prot
PharmGKB POLB RGD
PhenoGen Polb PhenoGen
PRINTS DNAPOLX UniProtKB/Swiss-Prot
  DNAPOLXBETA UniProtKB/Swiss-Prot
PROSITE DNA_POLYMERASE_X UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019150 RatGTEx
SMART HhH1 UniProtKB/Swiss-Prot
  POLXc UniProtKB/Swiss-Prot
Superfamily-SCOP PsbU/PolX domain-like UniProtKB/Swiss-Prot
  SSF47802 UniProtKB/Swiss-Prot
  SSF81301 UniProtKB/Swiss-Prot
UniProt A0A8I6G330_RAT UniProtKB/TrEMBL
  A0A8L2QFD3 ENTREZGENE, UniProtKB/TrEMBL
  A6IW62 ENTREZGENE, UniProtKB/TrEMBL
  DPOLB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G081 ENTREZGENE
  Q64619_RAT UniProtKB/TrEMBL
UniProt Secondary Q4G081 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Polb  DNA polymerase beta  Polb  polymerase (DNA) beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Polb  polymerase (DNA) beta  Polb  polymerase (DNA directed), beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Polb  polymerase (DNA directed), beta    DNA polymerase beta  Name updated 1299863 APPROVED
2002-06-10 Polb  DNA polymerase beta      Name updated 70584 APPROVED