Pf4 (platelet factor 4) - Rat Genome Database

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Gene: Pf4 (platelet factor 4) Rattus norvegicus
Analyze
Symbol: Pf4
Name: platelet factor 4
RGD ID: 3305
Description: Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in several processes, including negative regulation of T-helper 17 cell differentiation; negative regulation of inflammatory response; and response to aldosterone. Located in platelet alpha granule. Part of protein-containing complex. Biomarker of acute myocardial infarction; anti-basement membrane glomerulonephritis; diabetic retinopathy; and retinal degeneration. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to several human genes including PF4 (platelet factor 4); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Cxcl4; PF-4; Pf4a; RATPF4A
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,582,477 - 17,583,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,582,477 - 17,583,392 (-)EnsemblGRCr8
mRatBN7.21417,298,304 - 17,299,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,298,308 - 17,299,365 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1417,298,559 - 17,299,267 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,617,480 - 18,618,188 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,309,831 - 17,310,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,848,549 - 18,849,258 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,848,549 - 18,849,258 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,758,191 - 18,758,900 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,812,550 - 18,813,259 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,674,419 - 16,675,127 (-)NCBICelera
RGSC_v3.11418,813,312 - 18,815,140 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
barium sulfate  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoic acid  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brevianamide A  (ISO)
bucladesine  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
cangrelor  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
ceric oxide  (EXP)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt atom  (ISO)
cocaine  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichloromethane  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethylbenzene  (EXP)
fentanyl  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
glucose  (ISO)
griseofulvin  (ISO)
heparin  (ISO)
hydrogen cyanide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
icariin  (ISO)
isobutyl nitrite  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
melatonin  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
nortriptyline  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paroxetine  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenformin  (EXP)
phenylarsine oxide  (ISO)
poly(styrene)  (ISO)
potassium cyanide  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
Silidianin  (ISO)
silychristin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Platelet factor 4 limits Th17 differentiation and ischaemia-reperfusion injury after liver transplantation in mice. Guo H, etal., Scand J Immunol. 2015 Feb;81(2):129-34. doi: 10.1111/sji.12257.
4. Immunogold probing of platelet factor 4 in different ploidy classes of rat megakaryocytes sorted by flow cytometry. Hegyi E, etal., Exp Hematol. 1990 Aug;18(7):789-93.
5. Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model. Horioka K, etal., J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.
6. Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis. Jiang Z, etal., J Dermatol Sci. 2021 Oct;104(1):63-73. doi: 10.1016/j.jdermsci.2021.07.006. Epub 2021 Jul 14.
7. Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats. Khazaei F, etal., Cell J. 2020 Oct;22(3):302-309. doi: 10.22074/cellj.2020.6703. Epub 2019 Dec 15.
8. Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Koenen RR, etal., Nat Med. 2009 Jan;15(1):97-103. doi: 10.1038/nm.1898. Epub 2009 Jan 4.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy. Nawaz MI, etal., Exp Eye Res. 2013 Apr;109:67-76. doi: 10.1016/j.exer.2013.01.008. Epub 2013 Jan 22.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
13. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Pitsilos S, etal., Thromb Haemost. 2003 Dec;90(6):1112-20. doi: 10.1160/TH03-02-0069.
16. Biochemical characterization of the serum fetuin-mineral complex. Price PA, etal., J Biol Chem. 2003 Jun 13;278(24):22153-60. Epub 2003 Apr 3.
17. Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site. Ravid K, etal., Mol Cell Biol 1991 Dec;11(12):6116-27.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Incidence and clinical relevance of anti-platelet factor 4/heparin antibodies before cardiac surgery. Selleng S, etal., Am Heart J. 2010 Aug;160(2):362-9. doi: 10.1016/j.ahj.2010.05.026.
22. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Shi G, etal., Blood. 2013 May 23;121(21):4417-27. doi: 10.1182/blood-2012-09-454710. Epub 2013 Apr 8.
23. Platelet factor 4 and β-thromboglobulin mRNAs in circulating microparticles of trauma patients as diagnostic markers for deep vein thrombosis. Su Y, etal., J Thromb Thrombolysis. 2020 Oct;50(3):525-532. doi: 10.1007/s11239-020-02124-5.
24. Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells. Suzuki R, etal., Peptides 2002 Oct;23(10):1713-7.
25. Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats. Tang J, etal., Biochim Biophys Acta. 2010 Sep;1804(9):1895-901. doi: 10.1016/j.bbapap.2010.06.018. Epub 2010 Jun 28.
26. Chemokine gene expression in anti-glomerular basement membrane antibody glomerulonephritis. Tang WW, etal., Am J Physiol. 1995 Sep;269(3 Pt 2):F323-30. doi: 10.1152/ajprenal.1995.269.3.F323.
27. rLj-RGD3, a novel recombinant toxin protein from Lampetra japonica, prevents coronary thrombosis-induced acute myocardial infarction by inhibiting platelet functions in rats. Wang S, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):240-245. doi: 10.1016/j.bbrc.2018.02.021. Epub 2018 Feb 3.
28. Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo. Yang L, etal., BMC Cancer. 2011 Jun 21;11:261. doi: 10.1186/1471-2407-11-261.
29. Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro. Yang M, etal., Blood. 2006 Mar 15;107(6):2262-70. doi: 10.1182/blood-2005-08-3365. Epub 2005 Nov 22.
30. Platelet factor 4 protects kidney allograft in a rat kidney transplantation model. Zhang L, etal., Inflammation. 2015 Apr;38(2):520-6. doi: 10.1007/s10753-014-9958-2.
31. [Changes of platelet rheological behavior and the interventional effects of ulinastatin in rats with high-voltage electrical burns]. Zhang QF, etal., Zhonghua Shao Shang Za Zhi. 2017 Dec 20;33(12):744-749. doi: 10.3760/cma.j.issn.1009-2587.2017.12.005.
Additional References at PubMed
PMID:1688470   PMID:2140694   PMID:3821732   PMID:6945600   PMID:8033893   PMID:9531587   PMID:10666185   PMID:10877842   PMID:11685038   PMID:12041672   PMID:12609849   PMID:12782716  
PMID:15187018   PMID:16797058   PMID:17244792   PMID:22206666   PMID:23245326   PMID:28053995   PMID:38174673  


Genomics

Comparative Map Data
Pf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,582,477 - 17,583,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,582,477 - 17,583,392 (-)EnsemblGRCr8
mRatBN7.21417,298,304 - 17,299,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,298,308 - 17,299,365 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1417,298,559 - 17,299,267 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,617,480 - 18,618,188 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,309,831 - 17,310,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,848,549 - 18,849,258 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,848,549 - 18,849,258 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,758,191 - 18,758,900 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,812,550 - 18,813,259 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,674,419 - 16,675,127 (-)NCBICelera
RGSC_v3.11418,813,312 - 18,815,140 (-)NCBI
Cytogenetic Map14p22NCBI
PF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,980,811 - 73,982,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,980,811 - 73,982,027 (-)Ensemblhg38GRCh38
GRCh37474,846,528 - 74,847,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,065,660 - 75,066,541 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34475,211,830 - 75,212,712NCBI
Celera472,206,939 - 72,207,858 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,657,501 - 70,658,800 (-)NCBIHuRef
CHM1_1474,882,437 - 74,883,736 (-)NCBICHM1_1
T2T-CHM13v2.0477,324,459 - 77,325,772 (-)NCBIT2T-CHM13v2.0
Pf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,920,362 - 90,921,242 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,920,294 - 90,921,242 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38590,772,435 - 90,773,383 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,772,435 - 90,773,383 (+)Ensemblmm10GRCm38
MGSCv37591,201,461 - 91,202,409 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36591,847,713 - 91,848,583 (+)NCBIMGSCv36mm8
Celera588,924,056 - 88,925,004 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
PF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,076,726 - 56,078,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,265,831 - 56,267,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,208,806 - 50,210,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,041,833 - 56,043,133 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,041,833 - 56,043,750 (+)EnsemblpanPan2panpan1.1

Variants

.
Variants in Pf4
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:118
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000033406
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
D14Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,300,125 - 17,300,272 (+)MAPPERmRatBN7.2
Rnor_6.01418,850,235 - 18,850,381NCBIRnor6.0
Rnor_5.01418,759,877 - 18,760,023UniSTSRnor5.0
RGSC_v3.41418,814,236 - 18,814,382UniSTSRGSC3.4
Celera1416,676,104 - 16,676,250UniSTS
Cytogenetic Map14p22UniSTS
D14Mgh10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,584,240 - 17,584,467 (+)Marker Load Pipeline
mRatBN7.21417,300,069 - 17,300,296 (+)MAPPERmRatBN7.2
Rnor_6.01418,850,179 - 18,850,405NCBIRnor6.0
Rnor_5.01418,759,821 - 18,760,047UniSTSRnor5.0
RGSC_v3.41418,814,180 - 18,814,406UniSTSRGSC3.4
RGSC_v3.41418,814,179 - 18,814,406RGDRGSC3.4
Celera1416,676,048 - 16,676,274UniSTS
RGSC_v3.11418,814,179 - 18,814,406RGD
RH 3.4 Map14213.6RGD
RH 3.4 Map14213.6UniSTS
RH 2.0 Map14215.5RGD
Cytogenetic Map14p22UniSTS
D14Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,583,416 - 17,583,700 (+)Marker Load Pipeline
mRatBN7.21417,299,244 - 17,299,529 (+)MAPPERmRatBN7.2
Rnor_6.01418,849,355 - 18,849,638NCBIRnor6.0
Rnor_5.01418,758,997 - 18,759,280UniSTSRnor5.0
RGSC_v3.41418,813,356 - 18,813,639UniSTSRGSC3.4
RGSC_v3.41418,813,355 - 18,813,639RGDRGSC3.4
Celera1416,675,224 - 16,675,507UniSTS
RGSC_v3.11418,813,355 - 18,813,639RGD
SHRSP x BN Map146.9UniSTS
SHRSP x BN Map146.9RGD
Cytogenetic Map14p22UniSTS
RH129105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,298,308 - 17,298,460 (+)MAPPERmRatBN7.2
Rnor_6.01418,848,420 - 18,848,571NCBIRnor6.0
Rnor_5.01418,758,062 - 18,758,213UniSTSRnor5.0
RGSC_v3.41418,812,421 - 18,812,572UniSTSRGSC3.4
Celera1416,674,290 - 16,674,441UniSTS
Cytogenetic Map14p22UniSTS
Pf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,582,666 - 17,582,887 (+)Marker Load Pipeline
mRatBN7.21417,298,493 - 17,298,715 (+)MAPPERmRatBN7.2
Rnor_6.01418,848,605 - 18,848,825NCBIRnor6.0
Rnor_5.01418,758,247 - 18,758,467UniSTSRnor5.0
RGSC_v3.41418,812,606 - 18,812,826UniSTSRGSC3.4
Celera1416,674,475 - 16,674,694UniSTS
Cytogenetic Map14p22UniSTS
Pf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,582,872 - 17,583,312 (+)Marker Load Pipeline
mRatBN7.21417,298,700 - 17,299,140 (+)MAPPERmRatBN7.2
Rnor_6.01418,848,811 - 18,849,250NCBIRnor6.0
Rnor_5.01418,758,453 - 18,758,892UniSTSRnor5.0
RGSC_v3.41418,812,812 - 18,813,251UniSTSRGSC3.4
Celera1416,674,680 - 16,675,119UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 92 59 6 356 192 11 134 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000033406   ⟹   ENSRNOP00000032276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1417,582,477 - 17,583,392 (-)Ensembl
mRatBN7.2 Ensembl1417,298,308 - 17,299,365 (-)Ensembl
Rnor_6.0 Ensembl1418,848,549 - 18,849,258 (-)Ensembl
RefSeq Acc Id: NM_001007729   ⟹   NP_001007730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,582,477 - 17,583,392 (-)NCBI
mRatBN7.21417,298,304 - 17,299,220 (-)NCBI
Rnor_6.01418,848,549 - 18,849,258 (-)NCBI
Rnor_5.01418,758,191 - 18,758,900 (-)NCBI
RGSC_v3.41418,812,550 - 18,813,259 (-)RGD
Celera1416,674,419 - 16,675,127 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41832 (Get FASTA)   NCBI Sequence Viewer  
  EDL88566 (Get FASTA)   NCBI Sequence Viewer  
  EDL88567 (Get FASTA)   NCBI Sequence Viewer  
  EDL88568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032276
  ENSRNOP00000032276.1
GenBank Protein P06765 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007730   ⟸   NM_001007729
- Peptide Label: precursor
- UniProtKB: P06765 (UniProtKB/Swiss-Prot),   A6KKE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032276   ⟸   ENSRNOT00000033406
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06765-F1-model_v2 AlphaFold P06765 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699229
Promoter ID:EPDNEW_R9752
Type:multiple initiation site
Name:Pf4_1
Description:platelet factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,849,331 - 18,849,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3305 AgrOrtholog
BioCyc Gene G2FUF-16205 BioCyc
Ensembl Genes ENSRNOG00000028015 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033406 ENTREZGENE
  ENSRNOT00000033406.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:360918 UniProtKB/Swiss-Prot
NCBI Gene Pf4 ENTREZGENE
PANTHER PLATELET FACTOR 4 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Pf4 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028015 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A6KKE3 ENTREZGENE, UniProtKB/TrEMBL
  P06765 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-19 Pf4  platelet factor 4  Cxcl4  chemokine (C-X-C motif) ligand 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cxcl4  chemokine (C-X-C motif) ligand 4  Pf4  platelet factor 4  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pf4  Platelet factor 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process induces histamine release from peritoneal mast cells 724612