Lypla1 (lysophospholipase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lypla1 (lysophospholipase 1) Rattus norvegicus
Analyze
Symbol: Lypla1
Name: lysophospholipase 1
RGD ID: 3025
Description: Enables phosphatidylcholine lysophospholipase activity. Predicted to be involved in several processes, including negative regulation of Golgi to plasma membrane protein transport; negative regulation of aggrephagy; and protein depalmitoylation. Predicted to act upstream of or within aggrephagy and protein targeting to vacuole involved in autophagy. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and nuclear membrane. Predicted to be active in mitochondrion. Orthologous to human LYPLA1 (lysophospholipase 1); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25KDL; acyl-protein thioesterase 1; APT-1; LPL-I; lysophospholipase I; lysoPLA; lysoPLA I; palmitoyl-protein hydrolase; Pla1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8519,477,408 - 19,506,568 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl519,477,409 - 19,506,522 (-)EnsemblGRCr8
mRatBN7.2514,679,605 - 14,708,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl514,679,606 - 14,708,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx516,873,890 - 16,902,965 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0518,487,392 - 18,516,463 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0518,208,564 - 18,237,635 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0514,559,333 - 14,588,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl514,559,334 - 14,588,422 (-)Ensemblrn6Rnor6.0
Rnor_5.0519,341,836 - 19,370,929 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4514,882,196 - 14,911,284 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera514,050,814 - 14,079,913 (-)NCBICelera
RGSC_v3.1514,882,195 - 14,911,284 (-)NCBI
Cytogenetic Map5q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
Diisodecyl phthalate  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
lithocholic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenylpropanolamine  (ISO)
phenytoin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
mitochondrion  (IEA,ISO)
nuclear membrane  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Phospholipase and lysophospholipase activity of rat eosinophil leukocytes. Ottolenghi A and Rowland JT, Arch Biochem Biophys 2002 Oct 15;406(2):190-202.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. cDNA cloning and expression of a novel family of enzymes with calcium-independent phospholipase A2 and lysophospholipase activities. Portilla D, etal., J Am Soc Nephrol 1998 Jul;9(7):1178-86.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Purification, cDNA cloning, and regulation of lysophospholipase from rat liver. Sugimoto H, etal., J Biol Chem 1996 Mar 29;271(13):7705-11.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9624183   PMID:12477932   PMID:14651853   PMID:15489334   PMID:15555596   PMID:19439193   PMID:20418879   PMID:21393252   PMID:22399288   PMID:23376485   PMID:23533145   PMID:24682756  
PMID:27307232   PMID:31505169   PMID:34800366  


Genomics

Comparative Map Data
Lypla1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8519,477,408 - 19,506,568 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl519,477,409 - 19,506,522 (-)EnsemblGRCr8
mRatBN7.2514,679,605 - 14,708,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl514,679,606 - 14,708,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx516,873,890 - 16,902,965 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0518,487,392 - 18,516,463 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0518,208,564 - 18,237,635 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0514,559,333 - 14,588,447 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl514,559,334 - 14,588,422 (-)Ensemblrn6Rnor6.0
Rnor_5.0519,341,836 - 19,370,929 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4514,882,196 - 14,911,284 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera514,050,814 - 14,079,913 (-)NCBICelera
RGSC_v3.1514,882,195 - 14,911,284 (-)NCBI
Cytogenetic Map5q12NCBI
LYPLA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38854,042,987 - 54,101,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl854,046,367 - 54,102,017 (-)Ensemblhg38GRCh38
GRCh37854,955,547 - 55,014,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36855,121,491 - 55,177,130 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34855,121,490 - 55,177,130NCBI
Celera850,949,236 - 51,005,140 (-)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef850,427,322 - 50,482,732 (-)NCBIHuRef
CHM1_1855,010,550 - 55,065,879 (-)NCBICHM1_1
T2T-CHM13v2.0854,420,379 - 54,479,027 (-)NCBIT2T-CHM13v2.0
Lypla1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914,878,046 - 4,916,958 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14,878,011 - 4,918,633 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3814,807,823 - 4,846,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14,807,788 - 4,848,410 (+)Ensemblmm10GRCm38
MGSCv3714,797,974 - 4,836,816 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614,797,974 - 4,836,816 (+)NCBIMGSCv36mm8
Celera14,819,711 - 4,858,108 (+)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.79NCBI
Lypla1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545413,354,721 - 13,385,142 (-)Ensembl
ChiLan1.0NW_00495545413,356,851 - 13,385,110 (-)NCBIChiLan1.0ChiLan1.0
LYPLA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2769,685,881 - 69,740,846 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1845,410,670 - 45,465,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0850,474,238 - 50,529,167 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1847,850,592 - 47,905,377 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl847,850,592 - 47,905,367 (-)EnsemblpanPan2panpan1.1
LYPLA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1295,656,376 - 5,696,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl295,616,961 - 5,697,284 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha296,031,347 - 6,072,546 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0295,732,636 - 5,773,863 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl295,691,587 - 5,773,875 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1295,669,309 - 5,710,546 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0295,874,942 - 5,916,139 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,957,952 - 5,999,169 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lypla1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530373,814,174 - 73,848,519 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936496936,763 - 971,710 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936496937,918 - 971,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYPLA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,083,548 - 77,102,408 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1477,083,624 - 77,102,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,154,849 - 84,172,657 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LYPLA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1850,120,930 - 50,171,517 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603991,764,068 - 91,814,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lypla1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247351,582,169 - 1,622,307 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lypla1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11140,181,938 - 140,210,689 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lypla1
144 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir138-2rno-miR-138-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20064393

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:191
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000011312
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)51297048025683802Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat

Markers in Region
RH128529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2514,679,665 - 14,679,881 (+)MAPPERmRatBN7.2
Rnor_6.0514,559,390 - 14,559,605NCBIRnor6.0
Rnor_5.0519,341,892 - 19,342,107UniSTSRnor5.0
RGSC_v3.4514,882,252 - 14,882,467UniSTSRGSC3.4
Celera514,050,870 - 14,051,085UniSTS
Cytogenetic Map5q12UniSTS
RH132667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2514,704,984 - 14,705,193 (+)MAPPERmRatBN7.2
Rnor_6.0514,584,709 - 14,584,917NCBIRnor6.0
Rnor_5.0519,367,210 - 19,367,418UniSTSRnor5.0
RGSC_v3.4514,907,571 - 14,907,779UniSTSRGSC3.4
Celera514,076,202 - 14,076,410UniSTS
Cytogenetic Map5q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U97146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011312   ⟹   ENSRNOP00000011312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,477,409 - 19,506,491 (-)Ensembl
mRatBN7.2 Ensembl514,679,617 - 14,708,746 (-)Ensembl
Rnor_6.0 Ensembl514,559,334 - 14,588,422 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094380   ⟹   ENSRNOP00000095255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,477,409 - 19,506,491 (-)Ensembl
mRatBN7.2 Ensembl514,679,606 - 14,708,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094682   ⟹   ENSRNOP00000082375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,477,409 - 19,506,420 (-)Ensembl
mRatBN7.2 Ensembl514,679,609 - 14,708,627 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108888   ⟹   ENSRNOP00000077801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,482,692 - 19,506,522 (-)Ensembl
mRatBN7.2 Ensembl514,684,893 - 14,708,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110893   ⟹   ENSRNOP00000076457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl514,679,609 - 14,708,651 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117962   ⟹   ENSRNOP00000083839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,481,003 - 19,506,522 (-)Ensembl
mRatBN7.2 Ensembl514,679,609 - 14,708,651 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118190   ⟹   ENSRNOP00000083046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl519,477,409 - 19,506,095 (-)Ensembl
mRatBN7.2 Ensembl514,679,612 - 14,708,399 (-)Ensembl
RefSeq Acc Id: NM_013006   ⟹   NP_037138
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,477,409 - 19,506,491 (-)NCBI
mRatBN7.2514,679,610 - 14,708,698 (-)NCBI
Rnor_6.0514,559,334 - 14,588,422 (-)NCBI
Rnor_5.0519,341,836 - 19,370,929 (-)NCBI
RGSC_v3.4514,882,196 - 14,911,284 (-)RGD
Celera514,050,814 - 14,079,913 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109305   ⟹   XP_038965233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,478,860 - 19,506,568 (-)NCBI
mRatBN7.2514,679,605 - 14,708,746 (-)NCBI
RefSeq Acc Id: XM_039109306   ⟹   XP_038965234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,481,080 - 19,506,568 (-)NCBI
mRatBN7.2514,683,282 - 14,708,746 (-)NCBI
RefSeq Acc Id: XM_039109308   ⟹   XP_038965236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,483,761 - 19,506,568 (-)NCBI
mRatBN7.2514,685,962 - 14,708,722 (-)NCBI
RefSeq Acc Id: XM_063287186   ⟹   XP_063143256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,482,113 - 19,506,568 (-)NCBI
RefSeq Acc Id: XM_063287187   ⟹   XP_063143257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,478,860 - 19,505,837 (-)NCBI
RefSeq Acc Id: XM_063287188   ⟹   XP_063143258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,477,408 - 19,503,329 (-)NCBI
RefSeq Acc Id: XM_063287189   ⟹   XP_063143259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,477,408 - 19,506,560 (-)NCBI
RefSeq Acc Id: XM_063287190   ⟹   XP_063143260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8519,478,860 - 19,506,562 (-)NCBI
RefSeq Acc Id: NP_037138   ⟸   NM_013006
- UniProtKB: P70470 (UniProtKB/Swiss-Prot),   A6JFJ3 (UniProtKB/TrEMBL),   A0A8I5ZTV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011312   ⟸   ENSRNOT00000011312
RefSeq Acc Id: XP_038965233   ⟸   XM_039109305
- Peptide Label: isoform X2
- UniProtKB: A0A8I6APY4 (UniProtKB/TrEMBL),   A0A8I5ZTV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965234   ⟸   XM_039109306
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZTV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965236   ⟸   XM_039109308
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000076457   ⟸   ENSRNOT00000110893
Ensembl Acc Id: ENSRNOP00000077801   ⟸   ENSRNOT00000108888
Ensembl Acc Id: ENSRNOP00000082375   ⟸   ENSRNOT00000094682
Ensembl Acc Id: ENSRNOP00000083046   ⟸   ENSRNOT00000118190
Ensembl Acc Id: ENSRNOP00000095255   ⟸   ENSRNOT00000094380
Ensembl Acc Id: ENSRNOP00000083839   ⟸   ENSRNOT00000117962
RefSeq Acc Id: XP_063143259   ⟸   XM_063287189
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZYI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143258   ⟸   XM_063287188
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZYI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143260   ⟸   XM_063287190
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063143257   ⟸   XM_063287187
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZYI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143256   ⟸   XM_063287186
- Peptide Label: isoform X1
Protein Domains
Phospholipase/carboxylesterase/thioesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70470-F1-model_v2 AlphaFold P70470 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693543
Promoter ID:EPDNEW_R4068
Type:initiation region
Name:Lypla1_1
Description:lysophospholipase I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0514,588,381 - 14,588,441EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3025 AgrOrtholog
BioCyc Gene G2FUF-42152 BioCyc
Ensembl Genes ENSRNOG00000008320 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011312 ENTREZGENE
  ENSRNOT00000117962 ENTREZGENE
  ENSRNOT00000117962.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190638 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  AB_hydrolase_domain UniProtKB/Swiss-Prot
  PLipase/COase/thioEstase UniProtKB/Swiss-Prot
KEGG Report rno:25514 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93566 IMAGE-MGC_LOAD
NCBI Gene 25514 ENTREZGENE
PANTHER ACYL-PROTEIN THIOESTERASE 1 UniProtKB/Swiss-Prot
  LYSOPHOSPHOLIPASE-RELATED UniProtKB/Swiss-Prot
Pfam Abhydrolase_2 UniProtKB/Swiss-Prot
PhenoGen Lypla1 PhenoGen
RatGTEx ENSRNOG00000008320 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
TIGR TC229522
UniProt A0A8I5Y1L5_RAT UniProtKB/TrEMBL
  A0A8I5YBB3 ENTREZGENE
  A0A8I5ZTV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q511 ENTREZGENE, UniProtKB/TrEMBL
  A6JFJ3 ENTREZGENE, UniProtKB/TrEMBL
  LYPA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Lypla1  lysophospholipase 1  Lypla1  lysophospholipase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-22 Lypla1  lysophospholipase I  Lypla1  lysophospholipase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-06-12 Lypla1  Lysophospholipase 1      Name updated 62408 APPROVED
2001-06-12 Pla1a  Lysophospholipase      Symbol withdrawn, duplicate of Lypla1 (RGD:3025) 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains contains a consensus sequence of arboxylesterases 633195
gene_expression ubiquitously expressed; enriched in the kidney and small intestine 633195
gene_protein 24 kDa 633195