Id3 (inhibitor of DNA binding 3) - Rat Genome Database

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Gene: Id3 (inhibitor of DNA binding 3) Rattus norvegicus
Analyze
Symbol: Id3
Name: inhibitor of DNA binding 3
RGD ID: 2860
Description: Predicted to enable several functions, including bHLH transcription factor binding activity; leptomycin B binding activity; and transcription regulator inhibitor activity. Involved in neuron differentiation; positive regulation of apoptotic process; and regulation of DNA replication. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ID3 (inhibitor of DNA binding 3); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding protein inhibitor ID-3; inhibitor of differentiation 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; inhibitor of DNA binding 3, HLH protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,656,253 - 153,657,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,630,498 - 153,657,856 (+)EnsemblGRCr8
mRatBN7.25148,372,784 - 148,374,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,372,762 - 148,374,349 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5151,069,678 - 151,071,250 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,843,951 - 152,845,523 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,825,974 - 152,827,546 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,489,603 - 154,491,172 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,489,590 - 154,491,223 (+)Ensemblrn6Rnor6.0
Rnor_5.05158,263,323 - 158,264,892 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,934,138 - 154,935,707 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,776,457 - 146,778,028 (+)NCBICelera
RGSC_v3.15154,944,176 - 154,945,745 (+)NCBI
RH 3.4 Map51002.7RGD
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-pantothenic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
Actein  (EXP)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonic acid  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
calciol  (ISO)
calyculin A  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
Cyclopamine  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
diquat  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
iodoacetic acid  (ISO)
Iopanoic acid  (ISO)
iron dichloride  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
mestranol  (ISO)
methamphetamine  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
Monobutylphthalate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
PhIP  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triacsin C  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hormonal regulation and differential actions of the helix-loop-helix transcriptional inhibitors of differentiation (Id1, Id2, Id3, and Id4) in Sertoli cells. Chaudhary J, etal., Endocrinology 2001 May;142(5):1727-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Vascular injury induces posttranscriptional regulation of the Id3 gene: cloning of a novel Id3 isoform expressed during vascular lesion formation in rat and human atherosclerosis. Matsumura ME, etal., Arterioscler Thromb Vasc Biol 2001 May;21(5):752-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation. Nagata Y and Todokoro K, Biochem Biophys Res Commun 1994 Mar 30;199(3):1355-62.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Characterization of inhibitor of differentiation (Id3) gene expression in the developing cochlear tissue of rats. Ozeki M, etal., Acta Otolaryngol 2005 Mar;125(3):244-9.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Expression and functional role of the Id HLH family in cultured astrocytes. Tzeng SF and de Vellis J, Brain Res Mol Brain Res. 1997 Jun;46(1-2):136-42.
16. Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury. Tzeng SF, etal., J Neurosci Res. 2001 Dec 15;66(6):1161-72.
Additional References at PubMed
PMID:2000388   PMID:7655079   PMID:7864897   PMID:8083744   PMID:8759016   PMID:9013644   PMID:9418957   PMID:10567574   PMID:14627819   PMID:15159391   PMID:15161906   PMID:15219810  
PMID:15321928   PMID:15472070   PMID:15489334   PMID:15564458   PMID:16304207   PMID:16407553   PMID:17681138   PMID:18498089   PMID:19217292   PMID:19618124   PMID:23523789   PMID:23824195  
PMID:24499487  


Genomics

Comparative Map Data
Id3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,656,253 - 153,657,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5153,630,498 - 153,657,856 (+)EnsemblGRCr8
mRatBN7.25148,372,784 - 148,374,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,372,762 - 148,374,349 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5151,069,678 - 151,071,250 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,843,951 - 152,845,523 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,825,974 - 152,827,546 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,489,603 - 154,491,172 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,489,590 - 154,491,223 (+)Ensemblrn6Rnor6.0
Rnor_5.05158,263,323 - 158,264,892 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,934,138 - 154,935,707 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5146,776,457 - 146,778,028 (+)NCBICelera
RGSC_v3.15154,944,176 - 154,945,745 (+)NCBI
RH 3.4 Map51002.7RGD
Cytogenetic Map5q36NCBI
ID3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,557,926 - 23,559,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,557,917 - 23,559,883 (-)Ensemblhg38GRCh38
GRCh37123,884,417 - 23,885,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,756,996 - 23,758,909 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34123,629,761 - 23,631,591NCBI
Celera122,214,113 - 22,216,026 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef122,134,776 - 22,136,609 (-)NCBIHuRef
CHM1_1123,997,097 - 23,998,961 (-)NCBICHM1_1
T2T-CHM13v2.0123,392,495 - 23,394,070 (-)NCBIT2T-CHM13v2.0
Id3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,871,133 - 135,872,703 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,870,808 - 135,873,066 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384136,143,822 - 136,145,392 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,143,497 - 136,145,755 (+)Ensemblmm10GRCm38
MGSCv374135,699,737 - 135,701,307 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364135,415,898 - 135,417,463 (+)NCBIMGSCv36mm8
Celera4134,340,192 - 134,341,762 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.34NCBI
Id3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,537,021 - 3,560,954 (-)Ensembl
ChiLan1.0NW_0049554523,537,352 - 3,538,921 (-)NCBIChiLan1.0ChiLan1.0
ID3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,379,403 - 203,384,318 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,485,663 - 202,487,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,748,714 - 22,750,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,734,263 - 23,736,175 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,734,263 - 23,736,175 (-)EnsemblpanPan2panpan1.1
ID3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,880,659 - 75,881,786 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,880,657 - 75,882,010 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha272,450,690 - 72,451,818 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0276,440,035 - 76,441,163 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,440,029 - 76,441,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,262,350 - 73,263,478 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,269,394 - 74,270,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,274,965 - 75,276,093 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Id3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,933,316 - 42,934,892 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,758,030 - 8,759,823 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,758,098 - 8,759,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,422,546 - 81,424,075 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1681,422,541 - 81,424,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ID3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,120,403 - 109,122,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,120,691 - 109,123,210 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660337,205,391 - 7,212,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,175,372 - 8,177,451 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247648,175,841 - 8,177,444 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Id3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,091,879 - 22,093,472 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Id3
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:219
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000035788
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH133827  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,373,983 - 148,374,203 (+)MAPPERmRatBN7.2
Rnor_6.05154,490,803 - 154,491,022NCBIRnor6.0
Rnor_5.05158,264,523 - 158,264,742UniSTSRnor5.0
RGSC_v3.45154,935,338 - 154,935,557UniSTSRGSC3.4
Celera5146,777,659 - 146,777,878UniSTS
RH 3.4 Map51004.4UniSTS
Cytogenetic Map5q36UniSTS
RH94538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,373,871 - 148,373,964 (+)MAPPERmRatBN7.2
Rnor_6.05154,490,691 - 154,490,783NCBIRnor6.0
Rnor_5.05158,264,411 - 158,264,503UniSTSRnor5.0
RGSC_v3.45154,935,226 - 154,935,318UniSTSRGSC3.4
Celera5146,777,547 - 146,777,639UniSTS
RH 3.4 Map51002.7UniSTS
Cytogenetic Map5q36UniSTS
PMC305683P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,372,820 - 148,373,295 (+)MAPPERmRatBN7.2
Rnor_6.05154,489,640 - 154,490,114NCBIRnor6.0
Rnor_5.05158,263,360 - 158,263,834UniSTSRnor5.0
RGSC_v3.45154,934,175 - 154,934,649UniSTSRGSC3.4
Celera5146,776,494 - 146,776,968UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:235067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,372,869 - 148,372,956 (+)MAPPERmRatBN7.2
Rnor_6.05154,489,689 - 154,489,775NCBIRnor6.0
Rnor_5.05158,263,409 - 158,263,495UniSTSRnor5.0
RGSC_v3.45154,934,224 - 154,934,310UniSTSRGSC3.4
Celera5146,776,543 - 146,776,629UniSTS
Cytogenetic Map5q36UniSTS
PMC133998P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85153,656,327 - 153,656,799 (+)Marker Load Pipeline
mRatBN7.25148,372,820 - 148,373,292 (+)MAPPERmRatBN7.2
Rnor_6.05154,489,640 - 154,490,111NCBIRnor6.0
Rnor_5.05158,263,360 - 158,263,831UniSTSRnor5.0
RGSC_v3.45154,934,175 - 154,934,646UniSTSRGSC3.4
Celera5146,776,494 - 146,776,965UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:256941  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85153,656,330 - 153,656,826 (+)Marker Load Pipeline
mRatBN7.25148,372,823 - 148,373,319 (+)MAPPERmRatBN7.2
Rnor_6.05154,489,643 - 154,490,138NCBIRnor6.0
Rnor_5.05158,263,363 - 158,263,858UniSTSRnor5.0
RGSC_v3.45154,934,178 - 154,934,673UniSTSRGSC3.4
Celera5146,776,497 - 146,776,992UniSTS
Cytogenetic Map5q36UniSTS
Id3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,372,760 - 148,374,224 (+)MAPPERmRatBN7.2
Rnor_6.05154,489,580 - 154,491,043NCBIRnor6.0
Rnor_5.05158,263,300 - 158,264,763UniSTSRnor5.0
Celera5146,776,434 - 146,777,899UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 90 59 6 354 190 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035788   ⟹   ENSRNOP00000035270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,630,498 - 153,657,856 (+)Ensembl
mRatBN7.2 Ensembl5148,372,762 - 148,374,349 (+)Ensembl
Rnor_6.0 Ensembl5154,489,590 - 154,491,223 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159467   ⟹   ENSRNOP00000105136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5153,634,943 - 153,657,856 (+)Ensembl
RefSeq Acc Id: NM_013058   ⟹   NP_037190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,656,291 - 153,657,860 (+)NCBI
mRatBN7.25148,372,784 - 148,374,353 (+)NCBI
Rnor_6.05154,489,603 - 154,491,172 (+)NCBI
Rnor_5.05158,263,323 - 158,264,892 (+)NCBI
RGSC_v3.45154,934,138 - 154,935,707 (+)RGD
Celera5146,776,457 - 146,778,028 (+)RGD
Sequence:
RefSeq Acc Id: XM_063287199   ⟹   XP_063143269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,656,253 - 153,657,860 (+)NCBI
RefSeq Acc Id: NP_037190   ⟸   NM_013058
- UniProtKB: P41138 (UniProtKB/Swiss-Prot),   A6IT99 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035270   ⟸   ENSRNOT00000035788
RefSeq Acc Id: XP_063143269   ⟸   XM_063287199
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000105136   ⟸   ENSRNOT00000159467
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41138-F1-model_v2 AlphaFold P41138 1-119 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694167
Promoter ID:EPDNEW_R4692
Type:single initiation site
Name:Id3_1
Description:inhibitor of DNA binding 3, HLH protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,489,581 - 154,489,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2860 AgrOrtholog
BioCyc Gene G2FUF-39512 BioCyc
Ensembl Genes ENSRNOG00000026124 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035788.6 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623701 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot
  DNA-bd_prot-inh UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:25585 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72531 IMAGE-MGC_LOAD
NCBI Gene 25585 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-3 UniProtKB/Swiss-Prot
  PTHR11723 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Id3 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026124 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
TIGR TC204264
  TC204265
UniProt A0ABK0LHT2_RAT UniProtKB/TrEMBL
  A6IT99 ENTREZGENE, UniProtKB/TrEMBL
  ID3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-13 Id3  inhibitor of DNA binding 3  Id3  inhibitor of DNA binding 3, HLH protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Id3  inhibitor of DNA binding 3, HLH protein  Id3  inhibitor of DNA binding 3, dominant negative helix-loop-helix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Id3  inhibitor of DNA binding 3, dominant negative helix-loop-helix protein  Id3  inhibitor of DNA binding 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Id3  inhibitor of DNA binding 3    Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein  Name updated 1299863 APPROVED
2002-06-10 Id3  Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression of Id3a isoform results in increased apoptotic activity in smooth muscle cells following vascular lesion 727315