Crybb2 (crystallin, beta B2) - Rat Genome Database

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Gene: Crybb2 (crystallin, beta B2) Rattus norvegicus
Analyze
Symbol: Crybb2
Name: crystallin, beta B2
RGD ID: 2417
Description: Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Involved in camera-type eye development. Human ortholog(s) of this gene implicated in cataract and cataract 3 multiple types. Orthologous to human CRYBB2 (crystallin beta B2); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; alendronic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-B2 crystallin; beta-crystallin B2; beta-crystallin Bp; R.norvegicus CRYBB2 gene (crystallin beta B2); R.norvegicus CRYBB2 gene (crystallin, beta B2)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,230,192 - 49,240,116 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1249,230,192 - 49,240,116 (+)EnsemblGRCr8
mRatBN7.21243,569,747 - 43,579,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,569,747 - 43,579,671 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1244,736,097 - 44,746,023 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,348,959 - 45,358,883 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,409,487 - 44,419,411 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,577,580 - 49,588,555 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,578,633 - 49,588,555 (+)Ensemblrn6Rnor6.0
Rnor_5.01251,351,267 - 51,361,440 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1245,165,513 - 45,175,496 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Crystallin gene expression during rat lens development. Aarts HJ, etal., Eur J Biochem 1989 Jul 15;183(1):31-6.
2. The N-terminal domain of betaB2-crystallin resembles the putative ancestral homodimer. Clout NJ, etal., J Mol Biol. 2000 Dec 1;304(3):253-7.
3. The cooperation between two silencers creates an enhancer element that controls both the lens-preferred and the differentiation stage-specific expression of the rat beta B2-crystallin gene. Dirks RP, etal., Eur J Biochem 1996 Jul 1;239(1):23-32.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2. Litt M, etal., Hum Mol Genet. 1997 May;6(5):665-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. A unique form of autosomal dominant cataract explained by gene conversion between beta-crystallin B2 and its pseudogene. Vanita, etal., J Med Genet 2001 Jun;38(6):392-6.
Additional References at PubMed
PMID:3943659   PMID:7363969   PMID:8405363   PMID:9655330   PMID:11381063   PMID:11773034   PMID:14717595   PMID:16319073   PMID:17264069   PMID:17662718  


Genomics

Comparative Map Data
Crybb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,230,192 - 49,240,116 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1249,230,192 - 49,240,116 (+)EnsemblGRCr8
mRatBN7.21243,569,747 - 43,579,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,569,747 - 43,579,671 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1244,736,097 - 44,746,023 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,348,959 - 45,358,883 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,409,487 - 44,419,411 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,577,580 - 49,588,555 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,578,633 - 49,588,555 (+)Ensemblrn6Rnor6.0
Rnor_5.01251,351,267 - 51,361,440 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1245,165,513 - 45,175,496 (+)NCBICelera
Cytogenetic Map12q16NCBI
CRYBB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382225,211,661 - 25,231,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2225,212,564 - 25,231,870 (+)Ensemblhg38GRCh38
GRCh372225,615,606 - 25,627,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,945,612 - 23,957,836 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342223,941,938 - 23,952,378NCBI
Celera229,419,940 - 9,432,156 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef228,563,281 - 8,575,505 (+)NCBIHuRef
CHM1_12225,574,214 - 25,586,439 (+)NCBICHM1_1
T2T-CHM13v2.02225,672,859 - 25,693,033 (+)NCBIT2T-CHM13v2.0
Crybb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,206,124 - 113,217,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,206,124 - 113,217,983 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385113,058,258 - 113,070,117 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,058,258 - 113,070,117 (-)Ensemblmm10GRCm38
MGSCv375113,487,285 - 113,497,786 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365113,298,568 - 113,309,069 (-)NCBIMGSCv36mm8
MGSCv365110,764,656 - 110,774,989 (-)NCBIMGSCv36mm8
Celera5110,185,744 - 110,188,631 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.38NCBI
LOC100978249
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22335,091,568 - 35,130,667 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,790,037 - 37,829,122 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0226,153,824 - 6,186,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12223,832,570 - 24,266,719 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2223,819,784 - 23,827,265 (+)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2223,819,784 - 23,827,265 (+)NCBIpanPan2panpan1.1
CRYBB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,298,947 - 19,308,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,298,863 - 19,308,400 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2619,164,624 - 19,174,125 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02619,664,244 - 19,673,750 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,664,160 - 19,673,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,369,483 - 19,378,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,635,278 - 19,644,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,704,621 - 19,714,129 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crybb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,534,233 - 115,543,847 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936657326,882 - 336,556 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936657326,888 - 336,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYBB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1443,209,311 - 43,220,837 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11443,206,138 - 43,220,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,029,737 - 46,043,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223077
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,318,486 - 8,331,632 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,321,039 - 8,331,929 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045118,521,373 - 118,558,745 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crybb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,851,248 - 1,867,573 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247471,851,242 - 1,867,650 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Crybb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11640,909,927 - 40,919,533 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:69
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000072683
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
BB094356  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81249,240,023 - 49,240,116 (+)Marker Load Pipeline
mRatBN7.21243,579,577 - 43,579,671 (+)MAPPERmRatBN7.2
Rnor_6.01249,588,462 - 49,588,555NCBIRnor6.0
Rnor_5.01251,361,347 - 51,361,440UniSTSRnor5.0
Celera1245,175,403 - 45,175,496UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 3 12 7 6 4 1 4 20 4 12 1 24 2 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000072683   ⟹   ENSRNOP00000067708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1249,230,192 - 49,240,116 (+)Ensembl
mRatBN7.2 Ensembl1243,569,747 - 43,579,671 (+)Ensembl
Rnor_6.0 Ensembl1249,578,633 - 49,588,555 (+)Ensembl
RefSeq Acc Id: NM_012937   ⟹   NP_037069
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81249,230,192 - 49,240,116 (+)NCBI
mRatBN7.21243,569,747 - 43,579,671 (+)NCBI
Rnor_6.01249,578,633 - 49,588,555 (+)NCBI
Rnor_5.01251,351,267 - 51,361,440 (+)NCBI
Celera1245,165,513 - 45,175,496 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037069 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA34204 (Get FASTA)   NCBI Sequence Viewer  
  CAA58645 (Get FASTA)   NCBI Sequence Viewer  
  EDM13982 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067708
  ENSRNOP00000067708.1
GenBank Protein P62697 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037069   ⟸   NM_012937
- UniProtKB: P62697 (UniProtKB/Swiss-Prot),   A6J243 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067708   ⟸   ENSRNOT00000072683
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62697-F1-model_v2 AlphaFold P62697 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2417 AgrOrtholog
BioCyc Gene G2FUF-18880 BioCyc
Ensembl Genes ENSRNOG00000050023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072683 ENTREZGENE
  ENSRNOT00000072683.2 UniProtKB/Swiss-Prot
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot
InterPro Beta/Gamma-Crystallin UniProtKB/Swiss-Prot
  Beta/gamma_crystallin UniProtKB/Swiss-Prot
  G_crystallin-like UniProtKB/Swiss-Prot
KEGG Report rno:25422 UniProtKB/Swiss-Prot
NCBI Gene 25422 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot
  PTHR11818:SF11 UniProtKB/Swiss-Prot
Pfam Crystall UniProtKB/Swiss-Prot
PhenoGen Crybb2 PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050023 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot
TIGR TC217497
UniProt A6J243 ENTREZGENE, UniProtKB/TrEMBL
  CRBB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70635_RAT UniProtKB/TrEMBL
UniProt Secondary P19942 UniProtKB/Swiss-Prot
  P26775 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-07-23 Crybb2  crystallin, beta B2      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Crybb2  R.norvegicus CRYBB2 gene (crystallin, beta B2)      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lens fibre cells of the eye during the differentiation period when basic fibroblast growth factor is present 1298813
gene_regulation regulatory elements that control transient expression are in the -750/-123 region and in the first intron 1298813