Cd81 (Cd81 molecule) - Rat Genome Database

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Gene: Cd81 (Cd81 molecule) Rattus norvegicus
Analyze
Symbol: Cd81
Name: Cd81 molecule
RGD ID: 2315
Description: Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in regulation of cell population proliferation and regulation of growth. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule); PARTICIPATES IN B cell receptor signaling pathway; hepatitis C pathway; malaria pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 26 kDa cell surface protein TAPA-1; CD 81 antigen; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); Tapa1; target of the antiproliferative antibody 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,665,274 - 207,681,094 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,664,885 - 207,681,092 (+)EnsemblGRCr8
mRatBN7.21198,235,861 - 198,251,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,614,397 - 206,630,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,700,545 - 213,716,337 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,374,702 - 206,390,494 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,237,663 - 216,253,460 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,099,328 - 223,114,942 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,327,287 - 203,342,901 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,804,757 - 195,820,558 (+)NCBICelera
RGSC_v3.11203,480,739 - 203,496,354 (+)NCBI
Cytogenetic Map1q41-q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chloropicrin  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clotrimazole  (EXP)
cocaine  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
linuron  (EXP)
Mesaconitine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
monosodium L-glutamate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
pyrene  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
CD4-positive, alpha-beta T cell costimulation  (ISO,ISS)
cellular response to low-density lipoprotein particle stimulus  (ISO,ISS)
humoral immune response mediated by circulating immunoglobulin  (ISO,ISS)
immune system process  (IEA)
immunological synapse formation  (ISO,ISS)
macrophage fusion  (ISO,ISS)
myoblast fusion involved in skeletal muscle regeneration  (ISO,ISS)
osteoclast fusion  (ISO,ISS)
positive regulation of adaptive immune memory response  (ISO)
positive regulation of B cell activation  (ISO,ISS)
positive regulation of B cell proliferation  (ISO)
positive regulation of B cell receptor signaling pathway  (ISO,ISS)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO,ISS)
positive regulation of inflammatory response to antigenic stimulus  (ISO,ISS)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of protein catabolic process in the vacuole  (ISO)
positive regulation of protein exit from endoplasmic reticulum  (ISO,ISS)
positive regulation of receptor clustering  (ISO,ISS)
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO,ISS)
positive regulation of T cell receptor signaling pathway  (ISO,ISS)
positive regulation of T-helper 2 cell cytokine production  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to lysosome  (ISO)
protein localization to plasma membrane  (ISO,ISS)
receptor internalization  (ISO,ISS)
regulation of cell motility  (ISO)
regulation of cell population proliferation  (IDA,IEA)
regulation of growth  (IEP)
regulation of macrophage migration  (ISO,ISS)
regulation of protein stability  (ISO)
symbiont entry into host cell  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. Charrin S, etal., J Biol Chem. 2001 Apr 27;276(17):14329-37. Epub 2001 Jan 18.
3. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. Crotta S, etal., J Exp Med 2002 Jan 7;195(1):35-41.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Retinal pigment epithelium of the rat express CD81, the target of the anti-proliferative antibody (TAPA). Geisert EE Jr, etal., Invest Ophthalmol Vis Sci 2002 Jan;43(1):274-80.
6. Astrocyte growth, reactivity, and the target of the antiproliferative antibody, TAPA. Geisert EE Jr, etal., J Neurosci 1996 Sep 1;16(17):5478-87.
7. A novel cell adhesion molecule, G-CAM, found on cultured rat glia. Geisert EE Jr, etal., Neurosci Lett 1991 Dec 9;133(2):262-6.
8. The upregulation of a glial cell surface antigen at the astrocytic scar in the rat. Irwin MH and Geisert EE Jr, Neurosci Lett 1993 May 14;154(1-2):57-60.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8409388   PMID:8766544   PMID:9360996   PMID:10400713   PMID:11046035   PMID:11673522   PMID:12565133   PMID:12796480   PMID:14676841   PMID:15908444   PMID:16449649   PMID:16557522  
PMID:17327823   PMID:17481908   PMID:18662991   PMID:19028452   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20237408   PMID:20375010   PMID:20407874   PMID:20458337   PMID:21235781  
PMID:21276792   PMID:21423176   PMID:21930792   PMID:22307619   PMID:23376485   PMID:23395392   PMID:23499492   PMID:23533145   PMID:23575678   PMID:23858057   PMID:24038174   PMID:25002582  
PMID:25635054   PMID:27881302   PMID:27993971   PMID:28167787   PMID:28871089   PMID:30871575   PMID:32830152   PMID:36961378  


Genomics

Comparative Map Data
Cd81
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,665,274 - 207,681,094 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,664,885 - 207,681,092 (+)EnsemblGRCr8
mRatBN7.21198,235,861 - 198,251,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,614,397 - 206,630,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,700,545 - 213,716,337 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,374,702 - 206,390,494 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,237,663 - 216,253,460 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,099,328 - 223,114,942 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,327,287 - 203,342,901 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,804,757 - 195,820,558 (+)NCBICelera
RGSC_v3.11203,480,739 - 203,496,354 (+)NCBI
Cytogenetic Map1q41-q42NCBI
CD81
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,376,180 - 2,397,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,376,166 - 2,397,802 (+)Ensemblhg38GRCh38
GRCh37112,397,410 - 2,418,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,355,123 - 2,375,225 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34112,355,315 - 2,375,202NCBI
Celera112,433,431 - 2,453,456 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef112,188,870 - 2,209,001 (+)NCBIHuRef
CHM1_1112,397,498 - 2,417,522 (+)NCBICHM1_1
T2T-CHM13v2.0112,465,548 - 2,486,747 (+)NCBIT2T-CHM13v2.0
Cd81
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,606,487 - 142,621,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,606,476 - 142,621,671 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387143,052,750 - 143,067,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,052,739 - 143,067,934 (+)Ensemblmm10GRCm38
MGSCv377150,238,655 - 150,253,835 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,862,185 - 142,877,314 (+)NCBIMGSCv36mm8
Celera7142,808,354 - 142,823,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.1NCBI
Cd81
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,155,682 - 14,175,181 (+)Ensembl
ChiLan1.0NW_00495542214,155,682 - 14,175,181 (+)NCBIChiLan1.0ChiLan1.0
CD81
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,780,374 - 4,806,793 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,992,792 - 4,018,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,400,503 - 2,421,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,442,322 - 2,449,308 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,437,991 - 2,449,308 (+)EnsemblpanPan2panpan1.1
CD81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,466,484 - 46,474,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,466,499 - 46,473,868 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1845,067,559 - 45,083,899 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,137,460 - 47,153,838 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,888,521 - 47,153,823 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,585,393 - 46,601,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,165,925 - 46,182,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,912,742 - 46,929,121 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd81
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,718,486 - 2,727,090 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794664,115 - 669,800 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936794664,089 - 670,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD81
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,625,736 - 1,641,663 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,625,728 - 1,641,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD81
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,190,896 - 2,211,838 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12,190,845 - 2,211,389 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,392,792 - 99,413,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd81
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,192,452 - 15,210,922 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476715,192,446 - 15,210,923 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd81
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v126,635,177 - 6,651,199 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd81
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:174
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000027760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH127728  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,251,331 - 198,251,548 (+)MAPPERmRatBN7.2
Rnor_6.01216,253,132 - 216,253,348NCBIRnor6.0
Rnor_5.01223,114,763 - 223,114,979UniSTSRnor5.0
RGSC_v3.41203,342,722 - 203,342,938UniSTSRGSC3.4
Celera1195,820,230 - 195,820,446UniSTS
Cytogenetic Map1q41UniSTS
RH94618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,251,329 - 198,251,507 (+)MAPPERmRatBN7.2
Rnor_6.01216,253,130 - 216,253,307NCBIRnor6.0
Rnor_5.01223,114,761 - 223,114,938UniSTSRnor5.0
RGSC_v3.41203,342,720 - 203,342,897UniSTSRGSC3.4
Celera1195,820,228 - 195,820,405UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027760   ⟹   ENSRNOP00000027760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,672,148 - 207,681,092 (+)Ensembl
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)Ensembl
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166633   ⟹   ENSRNOP00000102299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,664,885 - 207,681,092 (+)Ensembl
RefSeq Acc Id: NM_013087   ⟹   NP_037219
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,665,297 - 207,681,094 (+)NCBI
mRatBN7.21198,235,861 - 198,251,660 (+)NCBI
Rnor_6.01216,237,663 - 216,253,460 (+)NCBI
Rnor_5.01223,099,328 - 223,114,942 (+)NCBI
RGSC_v3.41203,327,287 - 203,342,901 (+)RGD
Celera1195,804,757 - 195,820,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282108   ⟹   XP_063138178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,665,274 - 207,681,094 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037219 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138178 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53103 (Get FASTA)   NCBI Sequence Viewer  
  AAH60583 (Get FASTA)   NCBI Sequence Viewer  
  EDM12179 (Get FASTA)   NCBI Sequence Viewer  
  Q62745 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037219   ⟸   NM_013087
- UniProtKB: Q62745 (UniProtKB/Swiss-Prot),   Q6P9V1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027760   ⟸   ENSRNOT00000027760
RefSeq Acc Id: XP_063138178   ⟸   XM_063282108
- Peptide Label: isoform X1
- UniProtKB: Q62745 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000102299   ⟸   ENSRNOT00000166633

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62745-F1-model_v2 AlphaFold Q62745 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690569
Promoter ID:EPDNEW_R1094
Type:multiple initiation site
Name:Cd81_1
Description:Cd81 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01216,237,698 - 216,237,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2315 AgrOrtholog
BioCyc Gene G2FUF-56880 BioCyc
Ensembl Genes ENSRNOG00000020451 Ensembl
Gene3D-CATH 1.10.1450.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918296 IMAGE-MGC_LOAD
InterPro Tetraspanin UniProtKB/Swiss-Prot
  Tetraspanin/Peripherin UniProtKB/Swiss-Prot
  Tetraspanin_CS UniProtKB/Swiss-Prot
  Tetraspanin_EC2_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:72925 IMAGE-MGC_LOAD
NCBI Gene 25621 ENTREZGENE
PANTHER CD81 ANTIGEN UniProtKB/Swiss-Prot
  PTHR19282 UniProtKB/Swiss-Prot
Pfam Tetraspanin UniProtKB/Swiss-Prot
PhenoGen Cd81 PhenoGen
PIRSF Tetraspanin UniProtKB/Swiss-Prot
PRINTS TMFOUR UniProtKB/Swiss-Prot
PROSITE TM4_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020451 RatGTEx
Superfamily-SCOP SSF48652 UniProtKB/Swiss-Prot
TIGR TC216937
UniProt A0ABK0LB52_RAT UniProtKB/TrEMBL
  CD81_RAT UniProtKB/Swiss-Prot
  F7EXZ2_RAT UniProtKB/TrEMBL
  Q62745 ENTREZGENE
  Q6P9V1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd81  Cd81 molecule  Cd81  CD 81 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd81  CD 81 antigen    CD81 antigen (target of antiproliferative antibody 1)  Name updated 625702 APPROVED
2002-06-10 Cd81  CD81 antigen (target of antiproliferative antibody 1)      Symbol and Name status set to approved 70586 APPROVED