Ampd3 (adenosine monophosphate deaminase 3) - Rat Genome Database

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Gene: Ampd3 (adenosine monophosphate deaminase 3) Rattus norvegicus
Analyze
Symbol: Ampd3
Name: adenosine monophosphate deaminase 3
RGD ID: 2111
Description: Enables AMP deaminase activity. Predicted to be involved in erythrocyte homeostasis and purine ribonucleotide metabolic process. Predicted to act upstream of or within ADP metabolic process; ATP metabolic process; and energy homeostasis. Predicted to be active in cytosol. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 3,7-dihydropurine-6-thione; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AMP deaminase 3; Ampd; Ampd isoform C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,319,526 - 174,364,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1174,294,867 - 174,364,608 (+)EnsemblGRCr8
mRatBN7.21164,884,823 - 164,929,899 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1173,223,024 - 173,267,566 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,409,049 - 180,453,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,093,501 - 173,137,978 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,585,301 - 175,630,479 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)Ensemblrn6Rnor6.0
Rnor_5.01182,573,239 - 182,618,415 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41168,519,462 - 168,568,291 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,776,701 - 162,820,660 (+)NCBICelera
RGSC_v3.11168,644,154 - 168,678,954 (+)NCBI
RH 3.4 Map11330.8RGD
Cytogenetic Map1q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7beta-aminocephalosporanic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
graphite  (EXP)
hexamethylene diisocyanate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
mechlorethamine  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular biology of AMP deaminase deficiency. Gross M Pharm World Sci 1994 Apr 15;16(2):55-61.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type. Mahnke-Zizelman DK, etal., Biochem J 1997 Sep 1;326 ( Pt 2):521-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1429593   PMID:7287721   PMID:9133604   PMID:9857047   PMID:16751776   PMID:23078545   PMID:23439682   PMID:23542464   PMID:23911318   PMID:24066180   PMID:24940686   PMID:29733818  
PMID:30053369   PMID:36815317  


Genomics

Comparative Map Data
Ampd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,319,526 - 174,364,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1174,294,867 - 174,364,608 (+)EnsemblGRCr8
mRatBN7.21164,884,823 - 164,929,899 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1173,223,024 - 173,267,566 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,409,049 - 180,453,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,093,501 - 173,137,978 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,585,301 - 175,630,479 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)Ensemblrn6Rnor6.0
Rnor_5.01182,573,239 - 182,618,415 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41168,519,462 - 168,568,291 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,776,701 - 162,820,660 (+)NCBICelera
RGSC_v3.11168,644,154 - 168,678,954 (+)NCBI
RH 3.4 Map11330.8RGD
Cytogenetic Map1q33NCBI
AMPD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,450,388 - 10,507,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,308,162 - 10,507,877 (+)Ensemblhg38GRCh38
GRCh371110,471,935 - 10,529,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,428,800 - 10,485,702 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341110,428,799 - 10,485,247NCBI
Celera1110,593,627 - 10,650,868 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef1110,144,687 - 10,201,742 (+)NCBIHuRef
CHM1_11110,469,929 - 10,527,173 (+)NCBICHM1_1
T2T-CHM13v2.01110,534,888 - 10,592,054 (+)NCBIT2T-CHM13v2.0
Ampd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,367,291 - 110,411,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,367,413 - 110,411,612 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387110,767,790 - 110,812,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,768,206 - 110,812,405 (+)Ensemblmm10GRCm38
MGSCv377117,916,118 - 117,955,909 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367110,563,781 - 110,603,572 (+)NCBIMGSCv36mm8
Celera7110,746,081 - 110,786,296 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.85NCBI
Ampd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541426,072,855 - 26,116,448 (+)Ensembl
ChiLan1.0NW_00495541426,073,192 - 26,116,448 (+)NCBIChiLan1.0ChiLan1.0
AMPD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2912,889,967 - 12,946,561 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,852,321 - 12,911,287 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,581,730 - 10,638,777 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,309,436 - 10,365,369 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,309,436 - 10,365,369 (+)EnsemblpanPan2panpan1.1
AMPD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02134,487,335 - 34,534,074 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,487,920 - 34,534,063 (+)EnsemblROS_Cfam_1.0 Ensembl
Ampd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,814,360 - 51,857,818 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365287,848,096 - 7,890,627 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365287,847,156 - 7,891,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMPD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,028,923 - 49,083,590 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1249,026,695 - 49,084,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,377,794 - 52,432,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMPD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,318,746 - 54,374,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,316,334 - 54,373,619 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038151,984,708 - 152,040,518 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ampd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247662,545,932 - 2,587,025 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247662,542,021 - 2,586,912 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ampd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1290,635,723 - 90,680,923 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ampd3
174 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:137
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000024933
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1174182140176235262Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH142177  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81174,363,473 - 174,363,670 (+)Marker Load Pipeline
mRatBN7.21164,928,760 - 164,928,957 (+)MAPPERmRatBN7.2
Rnor_6.01175,629,341 - 175,629,537NCBIRnor6.0
Rnor_5.01182,617,277 - 182,617,473UniSTSRnor5.0
RGSC_v3.41168,567,165 - 168,567,361UniSTSRGSC3.4
Celera1162,819,534 - 162,819,730UniSTS
RH 3.4 Map11330.8UniSTS
Cytogenetic Map1q35-q36UniSTS
D1Bda34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,929,146 - 164,929,673 (+)MAPPERmRatBN7.2
Rnor_6.01175,629,727 - 175,630,253NCBIRnor6.0
Rnor_5.01182,617,663 - 182,618,189UniSTSRnor5.0
RGSC_v3.41168,567,551 - 168,568,077UniSTSRGSC3.4
Celera1162,819,920 - 162,820,446UniSTS
Cytogenetic Map1q35-q36UniSTS
RH139645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,929,564 - 164,929,766 (+)MAPPERmRatBN7.2
Rnor_6.01175,630,145 - 175,630,346NCBIRnor6.0
Rnor_5.01182,618,081 - 182,618,282UniSTSRnor5.0
RGSC_v3.41168,567,969 - 168,568,170UniSTSRGSC3.4
Celera1162,820,338 - 162,820,539UniSTS
RH 3.4 Map11330.8UniSTS
Cytogenetic Map1q35-q36UniSTS
MARC_44785-45781:1101739916:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,922,360 - 164,923,531 (+)MAPPERmRatBN7.2
Rnor_6.01175,622,943 - 175,624,113NCBIRnor6.0
Rnor_5.01182,610,879 - 182,612,049UniSTSRnor5.0
RGSC_v3.41168,560,767 - 168,561,937UniSTSRGSC3.4
Celera1162,813,170 - 162,814,340UniSTS
Cytogenetic Map1q35-q36UniSTS
MARC_45777-45778:1101741591:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,920,109 - 164,920,658 (+)MAPPERmRatBN7.2
Rnor_6.01175,620,692 - 175,621,240NCBIRnor6.0
Rnor_5.01182,608,628 - 182,609,176UniSTSRnor5.0
RGSC_v3.41168,558,516 - 168,559,064UniSTSRGSC3.4
Celera1162,810,919 - 162,811,467UniSTS
Cytogenetic Map1q35-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 13 80 211 91 90 59 151 59 6 467 274 22 188 105 123 31 33 33

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ604380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024933   ⟹   ENSRNOP00000024933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1174,319,967 - 174,364,604 (+)Ensembl
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)Ensembl
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106719   ⟹   ENSRNOP00000088165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1174,325,730 - 174,364,608 (+)Ensembl
mRatBN7.2 Ensembl1164,890,847 - 164,929,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112866   ⟹   ENSRNOP00000084681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1174,320,355 - 174,364,604 (+)Ensembl
mRatBN7.2 Ensembl1164,885,765 - 164,929,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135140   ⟹   ENSRNOP00000109764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1174,294,867 - 174,364,608 (+)Ensembl
RefSeq Acc Id: NM_031544   ⟹   NP_113732
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,320,033 - 174,364,600 (+)NCBI
mRatBN7.21164,885,320 - 164,929,887 (+)NCBI
Rnor_6.01175,586,097 - 175,630,467 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
RGSC_v3.41168,519,462 - 168,568,291 (+)RGD
Celera1162,776,701 - 162,820,660 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230010   ⟹   XP_006230072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,325,518 - 174,364,605 (+)NCBI
mRatBN7.21164,890,819 - 164,929,899 (+)NCBI
Rnor_6.01175,591,107 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230011   ⟹   XP_006230073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,320,219 - 174,364,605 (+)NCBI
mRatBN7.21164,885,599 - 164,929,899 (+)NCBI
Rnor_6.01175,586,576 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230012   ⟹   XP_006230074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,323,320 - 174,364,605 (+)NCBI
mRatBN7.21164,889,741 - 164,929,899 (+)NCBI
Rnor_6.01175,590,172 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230013   ⟹   XP_006230075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,323,320 - 174,364,605 (+)NCBI
mRatBN7.21164,889,741 - 164,929,899 (+)NCBI
Rnor_6.01175,590,172 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230014   ⟹   XP_006230076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,319,526 - 174,364,605 (+)NCBI
mRatBN7.21164,884,823 - 164,929,899 (+)NCBI
Rnor_6.01175,585,301 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230015   ⟹   XP_006230077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,321,453 - 174,364,605 (+)NCBI
mRatBN7.21164,886,741 - 164,929,896 (+)NCBI
Rnor_6.01175,587,167 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101357   ⟹   XP_038957285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,325,873 - 174,364,605 (+)NCBI
mRatBN7.21164,890,819 - 164,929,899 (+)NCBI
RefSeq Acc Id: XM_039101372   ⟹   XP_038957300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,346,238 - 174,364,605 (+)NCBI
mRatBN7.21164,911,522 - 164,929,899 (+)NCBI
RefSeq Acc Id: XM_063281242   ⟹   XP_063137312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,319,898 - 174,362,069 (+)NCBI
RefSeq Acc Id: NP_113732   ⟸   NM_031544
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   F1M7Q5 (UniProtKB/TrEMBL),   A6I819 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230076   ⟸   XM_006230014
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230073   ⟸   XM_006230011
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0N2 (UniProtKB/TrEMBL),   A6I820 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230077   ⟸   XM_006230015
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230074   ⟸   XM_006230012
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230075   ⟸   XM_006230013
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230072   ⟸   XM_006230010
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9F8 (UniProtKB/TrEMBL),   A6I820 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024933   ⟸   ENSRNOT00000024933
RefSeq Acc Id: XP_038957285   ⟸   XM_039101357
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957300   ⟸   XM_039101372
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000088165   ⟸   ENSRNOT00000106719
Ensembl Acc Id: ENSRNOP00000084681   ⟸   ENSRNOT00000112866
RefSeq Acc Id: XP_063137312   ⟸   XM_063281242
- Peptide Label: isoform X4
- UniProtKB: O09178 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000109764   ⟸   ENSRNOT00000135140

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09178-F1-model_v2 AlphaFold O09178 1-765 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2111 AgrOrtholog
BioCyc Gene G2FUF-57826 BioCyc
Ensembl Genes ENSRNOG00000018262 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024933 ENTREZGENE
  ENSRNOT00000106719 ENTREZGENE
  ENSRNOT00000112866 ENTREZGENE
  ENSRNOT00000135140 ENTREZGENE
Gene3D-CATH 4.10.800.20 UniProtKB/Swiss-Prot
  Metal-dependent hydrolases UniProtKB/Swiss-Prot
InterPro A/AMP_deam_AS UniProtKB/Swiss-Prot
  AMPD UniProtKB/Swiss-Prot
  Metal_Hydrolase UniProtKB/Swiss-Prot
KEGG Report rno:25095 UniProtKB/Swiss-Prot
NCBI Gene 25095 ENTREZGENE
PANTHER PTHR11359 UniProtKB/Swiss-Prot
  PTHR11359:SF2 UniProtKB/Swiss-Prot
Pfam AMP_deaminase UniProtKB/Swiss-Prot
PhenoGen Ampd3 PhenoGen
PIRSF AMP_deaminase_met UniProtKB/Swiss-Prot
PROSITE A_DEAMINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018262 RatGTEx
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot
UniProt A0A8I6A0N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9F8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LG52_RAT UniProtKB/TrEMBL
  A6I819 ENTREZGENE, UniProtKB/TrEMBL
  A6I820 ENTREZGENE, UniProtKB/TrEMBL
  A6I821 ENTREZGENE, UniProtKB/TrEMBL
  AMPD3_RAT UniProtKB/Swiss-Prot
  F1M7Q5 ENTREZGENE, UniProtKB/TrEMBL
  O09178 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ampd3  Adenosine monophosphate deaminase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of AMP to IMP 632203
gene_transcript contains several transcripts with heterogeneity in the 5 sequence 632203