Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) - Rat Genome Database

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Gene: Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh4a1
Name: aldehyde dehydrogenase 4 family, member A1
RGD ID: 1624206
Description: Predicted to enable L-glutamate gamma-semialdehyde dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in L-proline catabolic process to L-glutamate. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; LOC641316; P5C dehydrogenase; similar to aldehyde dehydrogenase 4 family, member A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85157,163,189 - 157,188,673 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5157,162,945 - 157,188,673 (+)EnsemblGRCr8
mRatBN7.25151,880,002 - 151,905,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,830,701 - 151,925,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5154,578,425 - 154,603,973 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,352,798 - 156,378,348 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,333,760 - 156,359,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05158,090,238 - 158,115,725 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5158,042,587 - 158,135,733 (+)Ensemblrn6Rnor6.0
Rnor_5.05161,829,323 - 161,854,796 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45158,437,691 - 158,453,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5150,256,652 - 150,282,086 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hesperetin  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
nitrofen  (EXP)
nobiletin  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
triadimefon  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:4015840   PMID:8621661   PMID:12477932   PMID:14651853   PMID:15057822   PMID:18614015   PMID:22516612   PMID:23928095  


Genomics

Comparative Map Data
Aldh4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85157,163,189 - 157,188,673 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5157,162,945 - 157,188,673 (+)EnsemblGRCr8
mRatBN7.25151,880,002 - 151,905,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,830,701 - 151,925,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5154,578,425 - 154,603,973 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,352,798 - 156,378,348 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,333,760 - 156,359,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05158,090,238 - 158,115,725 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5158,042,587 - 158,135,733 (+)Ensemblrn6Rnor6.0
Rnor_5.05161,829,323 - 161,854,796 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45158,437,691 - 158,453,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5150,256,652 - 150,282,086 (+)NCBICelera
Cytogenetic Map5q36NCBI
ALDH4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38118,871,430 - 18,902,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl118,871,425 - 18,902,799 (-)Ensemblhg38GRCh38
GRCh37119,197,924 - 19,229,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,070,513 - 19,101,659 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34118,943,231 - 18,974,378NCBI
Celera117,525,220 - 17,556,609 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,442,100 - 17,473,468 (-)NCBIHuRef
CHM1_1119,307,273 - 19,338,658 (-)NCBICHM1_1
T2T-CHM13v2.0118,691,214 - 18,722,363 (-)NCBIT2T-CHM13v2.0
Aldh4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394139,348,404 - 139,377,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4139,350,177 - 139,377,001 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384139,622,871 - 139,649,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,622,866 - 139,649,690 (+)Ensemblmm10GRCm38
MGSCv374139,178,809 - 139,205,606 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364138,895,086 - 138,921,763 (+)NCBIMGSCv36mm8
Celera4141,417,063 - 141,444,074 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.79NCBI
Aldh4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955527338,593 - 372,872 (+)Ensembl
ChiLan1.0NW_004955527338,593 - 369,528 (+)NCBIChiLan1.0ChiLan1.0
ALDH4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21208,212,985 - 208,244,303 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11207,329,575 - 207,360,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0117,829,723 - 17,861,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1118,878,421 - 18,909,615 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl118,878,421 - 18,909,615 (-)EnsemblpanPan2panpan1.1
ALDH4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,688,078 - 79,712,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,688,086 - 79,710,540 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha276,202,258 - 76,226,797 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0280,311,305 - 80,335,987 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl280,311,248 - 80,335,984 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1277,070,827 - 77,093,559 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0278,080,932 - 78,105,430 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,151,584 - 79,176,100 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,392,819 - 39,421,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364745,218,686 - 5,246,664 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364745,217,601 - 5,246,718 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,374,002 - 77,404,036 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1677,373,999 - 77,404,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,494,105 - 71,512,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,661,850 - 113,693,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660332,463,684 - 2,495,495 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,051,178 - 4,082,142 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247644,051,999 - 4,081,954 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh4a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1118,534,343 - 18,561,573 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh4a1
148 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
RH133354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,905,182 - 151,905,385 (+)MAPPERmRatBN7.2
Rnor_6.05158,115,417 - 158,115,619NCBIRnor6.0
Rnor_5.05161,854,488 - 161,854,690UniSTSRnor5.0
RGSC_v3.45158,453,519 - 158,453,721UniSTSRGSC3.4
Celera5150,281,778 - 150,281,980UniSTS
RH 3.4 Map51046.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077863   ⟹   ENSRNOP00000072481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,909,648 - 151,925,345 (+)Ensembl
Rnor_6.0 Ensembl5158,119,894 - 158,135,733 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079516   ⟹   ENSRNOP00000069536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,905,482 (+)Ensembl
Rnor_6.0 Ensembl5158,090,238 - 158,115,725 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080108   ⟹   ENSRNOP00000069221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,831,503 - 151,918,134 (+)Ensembl
Rnor_6.0 Ensembl5158,069,725 - 158,128,523 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088766   ⟹   ENSRNOP00000075011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,901,630 (+)Ensembl
Rnor_6.0 Ensembl5158,090,173 - 158,115,751 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090593   ⟹   ENSRNOP00000069936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,830,701 - 151,873,075 (+)Ensembl
Rnor_6.0 Ensembl5158,042,587 - 158,083,311 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092026   ⟹   ENSRNOP00000069040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,904,072 (+)Ensembl
Rnor_6.0 Ensembl5158,090,268 - 158,114,306 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095029   ⟹   ENSRNOP00000077405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,858,983 - 151,918,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101164   ⟹   ENSRNOP00000083484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,858,038 - 151,876,946 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117654   ⟹   ENSRNOP00000085310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,909,648 - 151,925,345 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120748   ⟹   ENSRNOP00000098374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5157,162,945 - 157,187,254 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120749   ⟹   ENSRNOP00000098375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5157,162,945 - 157,188,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134841   ⟹   ENSRNOP00000110221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5157,162,945 - 157,184,817 (+)Ensembl
RefSeq Acc Id: NM_001134698   ⟹   NP_001128170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85157,163,189 - 157,188,673 (+)NCBI
mRatBN7.25151,880,002 - 151,905,491 (+)NCBI
Rnor_6.05158,090,238 - 158,115,725 (+)NCBI
Rnor_5.05161,829,323 - 161,854,796 (+)NCBI
RGSC_v3.45158,437,691 - 158,453,827 (+)RGD
Celera5150,256,652 - 150,282,086 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68153 (Get FASTA)   NCBI Sequence Viewer  
  EDL80928 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098375
GenBank Protein P0C2X9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001128170   ⟸   NM_001134698
- UniProtKB: B4F768 (UniProtKB/TrEMBL),   A6ITM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069040   ⟸   ENSRNOT00000092026
Ensembl Acc Id: ENSRNOP00000069221   ⟸   ENSRNOT00000080108
Ensembl Acc Id: ENSRNOP00000069536   ⟸   ENSRNOT00000079516
Ensembl Acc Id: ENSRNOP00000069936   ⟸   ENSRNOT00000090593
Ensembl Acc Id: ENSRNOP00000072481   ⟸   ENSRNOT00000077863
Ensembl Acc Id: ENSRNOP00000075011   ⟸   ENSRNOT00000088766
Ensembl Acc Id: ENSRNOP00000077405   ⟸   ENSRNOT00000095029
Ensembl Acc Id: ENSRNOP00000083484   ⟸   ENSRNOT00000101164
Ensembl Acc Id: ENSRNOP00000085310   ⟸   ENSRNOT00000117654
Ensembl Acc Id: ENSRNOP00000098375   ⟸   ENSRNOT00000120749
Ensembl Acc Id: ENSRNOP00000110221   ⟸   ENSRNOT00000134841
Ensembl Acc Id: ENSRNOP00000098374   ⟸   ENSRNOT00000120748
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C2X9-F1-model_v2 AlphaFold P0C2X9 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1624206 AgrOrtholog
BioCyc Gene G2FUF-39408 BioCyc
BioCyc Pathway ARGASEDEG-PWY [L-arginine degradation I (arginase pathway)] BioCyc
  PROUT-PWY [L-proline degradation I] BioCyc
BioCyc Pathway Image ARGASEDEG-PWY BioCyc
  PROUT-PWY BioCyc
Ensembl Genes ENSRNOG00000061876 Ensembl
  ENSRNOG00000071265 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000120749 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
  P5CDH/ALDH4A1 UniProtKB/Swiss-Prot
NCBI Gene 641316 ENTREZGENE
PANTHER 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER UniProtKB/Swiss-Prot
  DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh4a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061876 RatGTEx
  ENSRNOG00000071265 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0ABK0L3W9_RAT UniProtKB/TrEMBL
  A0ABK0LED7_RAT UniProtKB/TrEMBL
  A0ABK0M052_RAT UniProtKB/TrEMBL
  A6ITM7 ENTREZGENE, UniProtKB/TrEMBL
  AL4A1_RAT UniProtKB/Swiss-Prot
  B4F768 ENTREZGENE, UniProtKB/TrEMBL
  P0C2X9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-02 Aldh4a1   aldehyde dehydrogenase 4 family, member A1  LOC641316  similar to aldehyde dehydrogenase 4 family, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-03 LOC641316  similar to aldehyde dehydrogenase 4 family, member A1      Symbol and Name status set to provisional 70820 PROVISIONAL