Rrm1-ps1 (ribonucleotide reductase M1, pseudogene 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rrm1-ps1 (ribonucleotide reductase M1, pseudogene 1) Rattus norvegicus
Analyze
Symbol: Rrm1-ps1
Name: ribonucleotide reductase M1, pseudogene 1
RGD ID: 1598288
Description: INTERACTS WITH leflunomide
Type: pseudo
RefSeq Status: INFERRED
Previously known as: Ribonucleotide reductase 1; ribonucleotide reductase M1; ribonucleotide reductase M1 (mapped); Rrm1; Rrm1_mapped
Related Functional Gene: Rrm1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,389,709 - 76,392,646 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21472,177,386 - 72,180,323 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1476,619,065 - 76,622,002 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01477,859,922 - 77,862,859 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,299,985 - 74,302,922 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1476,918,825 - 76,921,762 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1475,547,574 - 75,550,511 (+)NCBILyon_Normotensive
Lyon_Hypertensive1477,066,374 - 77,069,311 (+)NCBILyon_Hypertensive
F344_StmMcwi1475,990,472 - 75,993,409 (+)NCBIF344_StmMcwi
Rnor_6.01476,909,379 - 76,912,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01476,893,771 - 76,896,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41477,408,781 - 77,411,150 (+)ENTREZGENERGSC_v3.4RGSC_v3.4rn4
Celera1471,129,676 - 71,132,613 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
leflunomide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Rrm1-ps1
20 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
BI279462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,847,740 - 156,847,913 (+)MAPPERmRatBN7.2
mRatBN7.21472,179,804 - 72,179,977 (+)MAPPERmRatBN7.2
Rnor_6.01476,911,798 - 76,911,970NCBIRnor6.0
Rnor_6.01167,562,167 - 167,562,339NCBIRnor6.0
Rnor_5.01476,896,190 - 76,896,362UniSTSRnor5.0
Rnor_5.01173,750,774 - 173,750,946UniSTSRnor5.0
RGSC_v3.41477,411,056 - 77,411,228UniSTSRGSC3.4
Celera1471,132,095 - 71,132,267UniSTS
Celera1154,914,652 - 154,914,824UniSTS
RH 3.4 Map11275.7UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Sequences
Protein Domains
ATP-cone


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-15394 BioCyc
IMAGE_CLONE IMAGE:7193834 IMAGE-MGC_LOAD
InterPro ATP-cone_dom UniProtKB/TrEMBL
  RNR_R1-su_N UniProtKB/TrEMBL
  Rrm1 UniProtKB/TrEMBL
MGC_CLONE MGC:94742 IMAGE-MGC_LOAD
NCBI Gene 365320 ENTREZGENE
PANTHER RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT UniProtKB/TrEMBL
Pfam ATP-cone UniProtKB/TrEMBL
PharmGKB RRM1 RGD
PhenoGen Rrm1-ps1 PhenoGen
PROSITE ATP_CONE UniProtKB/TrEMBL
Superfamily-SCOP R1 subunit of ribonucleotide reductase, N-terminal domain UniProtKB/TrEMBL
UniProt A6I740_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-01-26 Rrm1-ps1  ribonucleotide reductase M1, pseudogene 1  Rrm1  ribonucleotide reductase M1  Symbol and Name updated 1299863 APPROVED
2007-04-12   ribonucleotide reductase M1  Rrm1  ribonucleotide reductase M1 (mapped)  Symbol updated 737654 APPROVED
2007-04-12 Rrm1  ribonucleotide reductase M1 (mapped)  Rrm1_mapped  ribonucleotide reductase M1 (mapped)  Data merged from RGD:3603 737654 APPROVED
2006-11-20 Rrm1  ribonucleotide reductase M1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Rrm1_mapped  ribonucleotide reductase M1 (mapped)      Symbol and Name updated 1556543 APPROVED
2003-04-09 Rrm1  ribonucleotide reductase M1    Ribonucleotide reductase 1  Name updated 629478 APPROVED
2002-06-10 Rrm1  Ribonucleotide reductase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process human homolog encodes an enzyme required for production of deoxyribonucleotides prior to DNA synthesis 704405