Alkbh7 (Alkbh7 RNA demethylase) - Rat Genome Database

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Gene: Alkbh7 (Alkbh7 RNA demethylase) Rattus norvegicus
Analyze
Symbol: Alkbh7
Name: Alkbh7 RNA demethylase (Ensembl:alkB homolog 7)
RGD ID: 1598126
Description: Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be involved in several processes, including fatty acid metabolic process; regulation of lipid storage; and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alkB homolog 7; alkB, alkylation repair homolog 7; alkB, alkylation repair homolog 7 (E. coli); AlkB-like protein 7; alkylated DNA repair protein alkB homolog 7; alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; LOC679944; similar to spermatogenesis associated 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,925,896 - 1,928,048 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,925,743 - 1,928,048 (+)EnsemblGRCr8
mRatBN7.291,838,886 - 1,841,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,272,791 - 2,274,925 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,622,150 - 7,624,284 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,578,011 - 6,580,146 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,045,375 - 10,047,507 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)Ensemblrn6Rnor6.0
Rnor_5.099,046,025 - 9,048,175 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,676,245 - 6,678,377 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial matrix  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16174769   PMID:18614015   PMID:23572141   PMID:23666923  


Genomics

Comparative Map Data
Alkbh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,925,896 - 1,928,048 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,925,743 - 1,928,048 (+)EnsemblGRCr8
mRatBN7.291,838,886 - 1,841,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,272,791 - 2,274,925 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,622,150 - 7,624,284 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,578,011 - 6,580,146 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,045,375 - 10,047,507 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)Ensemblrn6Rnor6.0
Rnor_5.099,046,025 - 9,048,175 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera96,676,245 - 6,678,377 (-)NCBICelera
Cytogenetic Map9q11NCBI
ALKBH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,372,794 - 6,375,250 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,372,763 - 6,375,250 (+)Ensemblhg38GRCh38
GRCh37196,372,805 - 6,375,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,323,444 - 6,326,040 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34196,323,443 - 6,326,040NCBI
Celera196,311,231 - 6,314,048 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,132,589 - 6,135,406 (+)NCBIHuRef
CHM1_1196,372,069 - 6,374,886 (+)NCBICHM1_1
T2T-CHM13v2.0196,361,696 - 6,364,152 (+)NCBIT2T-CHM13v2.0
Alkbh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,304,339 - 57,306,340 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,304,339 - 57,306,322 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,997,339 - 56,999,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,997,339 - 56,999,322 (+)Ensemblmm10GRCm38
MGSCv371757,136,776 - 57,138,745 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,682,477 - 56,684,446 (+)NCBIMGSCv36mm8
Celera1761,345,279 - 61,347,248 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.61NCBI
Alkbh7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,220,994 - 3,223,551 (-)Ensembl
ChiLan1.0NW_0049554953,220,994 - 3,222,675 (-)NCBIChiLan1.0ChiLan1.0
ALKBH7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,770,082 - 10,775,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,999,342 - 10,001,637 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,393,317 - 5,395,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,315,604 - 6,318,174 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,315,604 - 6,318,170 (+)EnsemblpanPan2panpan1.1
ALKBH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,783,948 - 53,785,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,783,993 - 53,785,524 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,530,856 - 53,532,460 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,438,215 - 54,439,821 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,438,223 - 54,439,826 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,504,678 - 53,506,283 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,953,017 - 53,954,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,182,768 - 54,184,373 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Alkbh7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,100,011 - 214,101,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,732,526 - 3,737,219 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,733,103 - 3,734,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKBH7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,698,529 - 72,703,736 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,702,077 - 72,703,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,215,582 - 73,218,234 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALKBH7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,988,610 - 5,991,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,988,371 - 5,991,136 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660812,032,188 - 2,034,764 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alkbh7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,507,657 - 3,509,314 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,507,657 - 3,509,314 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Alkbh7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1488,378,362 - 88,380,249 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Alkbh7
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:106
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000072118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
RH129643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,840,583 - 1,840,772 (-)MAPPERmRatBN7.2
Rnor_6.0910,045,646 - 10,045,834NCBIRnor6.0
Rnor_5.099,046,296 - 9,046,484UniSTSRnor5.0
Celera96,676,516 - 6,676,704UniSTS
RH130001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,837,474 - 1,837,671 (-)MAPPERmRatBN7.2
Rnor_6.0910,048,746 - 10,048,942NCBIRnor6.0
Rnor_5.099,049,396 - 9,049,592UniSTSRnor5.0
Celera96,679,616 - 6,679,812UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072118   ⟹   ENSRNOP00000065514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,925,916 - 1,928,048 (+)Ensembl
mRatBN7.2 Ensembl91,838,910 - 1,841,044 (+)Ensembl
Rnor_6.0 Ensembl910,045,375 - 10,047,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097182   ⟹   ENSRNOP00000087380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,925,743 - 1,928,048 (+)Ensembl
mRatBN7.2 Ensembl91,838,811 - 1,841,044 (+)Ensembl
RefSeq Acc Id: NM_001109384   ⟹   NP_001102854
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,925,916 - 1,928,048 (+)NCBI
mRatBN7.291,838,910 - 1,841,044 (+)NCBI
Rnor_6.0910,045,375 - 10,047,507 (-)NCBI
Rnor_5.099,046,025 - 9,048,175 (-)NCBI
Celera96,676,245 - 6,678,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084196   ⟹   XP_038940124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,925,896 - 1,927,794 (+)NCBI
mRatBN7.291,838,886 - 1,840,794 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102854 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940124 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83594 (Get FASTA)   NCBI Sequence Viewer  
  EDL83595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065514
  ENSRNOP00000065514.1
  ENSRNOP00000087380
  ENSRNOP00000087380.1
GenBank Protein QST76990 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102854   ⟸   NM_001109384
- UniProtKB: M0R7T2 (UniProtKB/TrEMBL),   A6KQT7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065514   ⟸   ENSRNOT00000072118
RefSeq Acc Id: XP_038940124   ⟸   XM_039084196
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7M8 (UniProtKB/TrEMBL),   A6KQT6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087380   ⟸   ENSRNOT00000097182
Protein Domains
Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7T2-F1-model_v2 AlphaFold M0R7T2 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696444
Promoter ID:EPDNEW_R6969
Type:multiple initiation site
Name:Alkbh7_1
Description:alkB homolog 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,047,502 - 10,047,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598126 AgrOrtholog
BioCyc Gene G2FUF-28499 BioCyc
Ensembl Genes ENSRNOG00000047089 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072118 ENTREZGENE
  ENSRNOT00000072118.3 UniProtKB/TrEMBL
  ENSRNOT00000097182 ENTREZGENE
  ENSRNOT00000097182.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.590 UniProtKB/TrEMBL
InterPro AlkB-like UniProtKB/TrEMBL
  AlkB-like_sf UniProtKB/TrEMBL
  ALKBH7 UniProtKB/TrEMBL
KEGG Report rno:679944 UniProtKB/TrEMBL
NCBI Gene 679944 ENTREZGENE
PANTHER ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR21052 UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_2 UniProtKB/TrEMBL
PhenoGen Alkbh7 PhenoGen
RatGTEx ENSRNOG00000047089 RatGTEx
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt A0A8A1U9H3_RAT UniProtKB/TrEMBL
  A0A8I6A7M8 ENTREZGENE, UniProtKB/TrEMBL
  A6KQT6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQT7 ENTREZGENE, UniProtKB/TrEMBL
  M0R7T2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-12-11 Alkbh7  Alkbh7 RNA demethylase  Alkbh7  alkB homolog 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-02 Alkbh7  alkB homolog 7  Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  LOC681562  similar to spermatogenesis associated 11  Data merged from RGD:1594076 1643240 APPROVED
2008-03-05 Alkbh7  alkB, alkylation repair homolog 7 (E. coli)  LOC679944  similar to spermatogenesis associated 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679944  similar to spermatogenesis associated 11      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681562  similar to spermatogenesis associated 11      Symbol and Name status set to provisional 70820 PROVISIONAL