Asb14 (ankyrin repeat and SOCS box-containing 14) - Rat Genome Database

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Gene: Asb14 (ankyrin repeat and SOCS box-containing 14) Rattus norvegicus
Analyze
Symbol: Asb14
Name: ankyrin repeat and SOCS box-containing 14
RGD ID: 1596812
Description: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and SOCS box protein 14; Ankyrin repeat and SOCS box-containing protein 14; LOC680076; similar to ankyrin repeat and SOCS box-containing protein 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,102,303 - 2,131,379 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl162,102,363 - 2,130,590 (+)EnsemblGRCr8
mRatBN7.2162,095,567 - 2,123,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,095,644 - 2,115,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx162,102,250 - 2,121,773 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,247,937 - 3,267,460 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,108,637 - 2,127,986 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,537,209 - 2,556,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,537,248 - 2,556,735 (+)Ensemblrn6Rnor6.0
Rnor_5.0162,511,969 - 2,531,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4162,162,243 - 2,175,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera162,063,524 - 2,083,013 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822  


Genomics

Comparative Map Data
Asb14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,102,303 - 2,131,379 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl162,102,363 - 2,130,590 (+)EnsemblGRCr8
mRatBN7.2162,095,567 - 2,123,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,095,644 - 2,115,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx162,102,250 - 2,121,773 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,247,937 - 3,267,460 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,108,637 - 2,127,986 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,537,209 - 2,556,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,537,248 - 2,556,735 (+)Ensemblrn6Rnor6.0
Rnor_5.0162,511,969 - 2,531,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4162,162,243 - 2,175,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera162,063,524 - 2,083,013 (+)NCBICelera
Cytogenetic Map16p16NCBI
ASB14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,268,342 - 57,292,685 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,268,342 - 57,292,685 (-)Ensemblhg38GRCh38
GRCh37357,302,370 - 57,326,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,277,419 - 57,288,020 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34357,277,418 - 57,288,020NCBI
Celera357,267,953 - 57,292,330 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,351,544 - 57,375,919 (-)NCBIHuRef
CHM1_1357,252,526 - 57,276,848 (-)NCBICHM1_1
T2T-CHM13v2.0357,308,608 - 57,332,970 (-)NCBIT2T-CHM13v2.0
Asb14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,616,547 - 26,638,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,616,514 - 26,637,215 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381426,894,590 - 26,915,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,894,557 - 26,915,258 (+)Ensemblmm10GRCm38
MGSCv371427,707,790 - 27,728,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361425,730,127 - 25,742,142 (+)NCBIMGSCv36mm8
Celera1423,133,157 - 23,154,948 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Asb14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,020,823 - 7,038,057 (-)Ensembl
ChiLan1.0NW_0049554307,014,091 - 7,038,751 (-)NCBIChiLan1.0ChiLan1.0
ASB14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,241,429 - 57,260,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,246,640 - 57,265,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,209,408 - 57,225,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,418,243 - 58,434,409 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,418,243 - 58,434,409 (-)EnsemblpanPan2panpan1.1
ASB14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,110,930 - 33,137,249 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,110,992 - 33,133,695 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2033,038,555 - 33,065,206 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02033,383,368 - 33,410,033 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,383,438 - 33,408,610 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,832,425 - 32,859,045 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02033,190,899 - 33,217,541 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,361,952 - 33,388,842 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Asb14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,478,515 - 174,494,626 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,610,783 - 7,632,249 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,616,912 - 7,633,100 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,123,650 - 39,146,914 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11339,121,461 - 39,147,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ASB14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,595,768 - 18,613,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,596,107 - 18,612,536 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041148,257,866 - 148,274,769 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482219,813 - 29,974 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Asb14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1132,646,740 - 2,660,714 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Asb14
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000017995
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161177108157035Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168392304234212Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat

Markers in Region
RH140174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,115,175 - 2,115,372 (+)MAPPERmRatBN7.2
Rnor_6.0162,556,776 - 2,556,972NCBIRnor6.0
Rnor_5.0162,531,524 - 2,531,720UniSTSRnor5.0
RGSC_v3.4162,175,865 - 2,176,061UniSTSRGSC3.4
Celera162,083,054 - 2,083,250UniSTS
RH 3.4 Map164.1UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 127 51 50 19 87 19 6 284 185 11 106 56 72 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017995   ⟹   ENSRNOP00000017995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl162,102,363 - 2,122,169 (+)Ensembl
mRatBN7.2 Ensembl162,095,644 - 2,115,135 (+)Ensembl
Rnor_6.0 Ensembl162,537,248 - 2,556,735 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164434   ⟹   ENSRNOP00000098971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl162,102,365 - 2,130,590 (+)Ensembl
RefSeq Acc Id: NM_001170749   ⟹   NP_001164220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,376 - 2,121,866 (+)NCBI
mRatBN7.2162,095,644 - 2,115,135 (+)NCBI
Rnor_6.0162,537,248 - 2,556,735 (+)NCBI
Rnor_5.0162,511,969 - 2,531,658 (+)NCBI
Celera162,063,524 - 2,083,013 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063275709   ⟹   XP_063131779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,340 - 2,121,869 (+)NCBI
RefSeq Acc Id: XM_063275710   ⟹   XP_063131780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,303 - 2,121,869 (+)NCBI
RefSeq Acc Id: XM_063275711   ⟹   XP_063131781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,335 - 2,131,379 (+)NCBI
RefSeq Acc Id: XM_063275712   ⟹   XP_063131782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,345 - 2,121,869 (+)NCBI
RefSeq Acc Id: XM_063275713   ⟹   XP_063131783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,108,322 - 2,121,869 (+)NCBI
RefSeq Acc Id: XR_010058318
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,102,335 - 2,131,379 (+)NCBI
RefSeq Acc Id: NP_001164220   ⟸   NM_001170749
- UniProtKB: P0C927 (UniProtKB/Swiss-Prot),   F1M704 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017995   ⟸   ENSRNOT00000017995
RefSeq Acc Id: XP_063131780   ⟸   XM_063275710
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131781   ⟸   XM_063275711
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131779   ⟸   XM_063275709
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131782   ⟸   XM_063275712
- Peptide Label: isoform X2
- UniProtKB: P0C927 (UniProtKB/Swiss-Prot),   F1M704 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131783   ⟸   XM_063275713
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000098971   ⟸   ENSRNOT00000164434
Protein Domains
SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C927-F1-model_v2 AlphaFold P0C927 1-596 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596812 AgrOrtholog
BioCyc Gene G2FUF-12248 BioCyc
Ensembl Genes ENSRNOG00000013346 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017995 ENTREZGENE
  ENSRNOT00000164434 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Multifunctional_ANK_Repeat UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 680076 ENTREZGENE
PANTHER ANKYRIN REPEAT-CONTAINING UniProtKB/Swiss-Prot
  PROTEIN HOS4 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
PhenoGen Asb14 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013346 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt A0ABK0L6B7_RAT UniProtKB/TrEMBL
  ASB14_RAT UniProtKB/Swiss-Prot
  F1M704 ENTREZGENE, UniProtKB/TrEMBL
  P0C927 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Asb14  ankyrin repeat and SOCS box-containing 14  LOC680076  similar to ankyrin repeat and SOCS box-containing protein 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680076  similar to ankyrin repeat and SOCS box-containing protein 14      Symbol and Name status set to provisional 70820 PROVISIONAL