Misp (mitotic spindle positioning) - Rat Genome Database

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Gene: Misp (mitotic spindle positioning) Rattus norvegicus
Analyze
Symbol: Misp
Name: mitotic spindle positioning
RGD ID: 1595680
Description: Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including establishment of centrosome localization; microtubule cytoskeleton organization involved in mitosis; and regulation of protein localization to cell cortex. Predicted to be located in cytoskeleton and focal adhesion. Orthologous to human MISP (mitotic spindle positioning); INTERACTS WITH acetamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC500797; hypothetical protein LOC500797; LOC500797; mitotic interactor and substrate of PLK1; uncharacterized protein LOC500797
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,526,980 - 10,537,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,503,209 - 10,537,159 (-)EnsemblGRCr8
mRatBN7.279,870,390 - 9,886,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,870,444 - 9,886,541 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,756,866 - 12,767,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,634,945 - 14,645,132 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,494,741 - 12,504,920 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,691,834 - 12,707,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,697,743 - 12,707,922 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,861,587 - 12,877,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,389,248 - 11,399,427 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,051,026 - 8,061,205 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23509069   PMID:23574715  


Genomics

Comparative Map Data
Misp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,526,980 - 10,537,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,503,209 - 10,537,159 (-)EnsemblGRCr8
mRatBN7.279,870,390 - 9,886,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,870,444 - 9,886,541 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,756,866 - 12,767,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,634,945 - 14,645,132 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,494,741 - 12,504,920 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,691,834 - 12,707,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,697,743 - 12,707,922 (-)Ensemblrn6Rnor6.0
Rnor_5.0712,861,587 - 12,877,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,389,248 - 11,399,427 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,051,026 - 8,061,205 (-)NCBICelera
Cytogenetic Map7q11NCBI
MISP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819748,438 - 764,318 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19748,404 - 764,363 (+)Ensemblhg38GRCh38
GRCh3719751,112 - 764,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619702,146 - 715,318 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3419702,145 - 715,319NCBI
Celera1952,059 - 65,229 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19520,795 - 533,963 (+)NCBIHuRef
CHM1_119750,590 - 763,759 (+)NCBICHM1_1
T2T-CHM13v2.019702,466 - 718,374 (+)NCBIT2T-CHM13v2.0
Misp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,656,853 - 79,666,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,656,823 - 79,666,324 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,821,019 - 79,830,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,820,989 - 79,830,490 (+)Ensemblmm10GRCm38
MGSCv371079,283,766 - 79,293,197 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,224,150 - 79,233,581 (+)NCBIMGSCv36mm8
Celera1080,835,820 - 80,845,252 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Misp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,032,876 - 7,038,916 (-)Ensembl
ChiLan1.0NW_0049554957,034,664 - 7,044,886 (-)NCBIChiLan1.0ChiLan1.0
MISP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,076,766 - 5,093,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,314,863 - 4,331,763 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019369,238 - 383,633 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119717,766 - 731,942 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19717,766 - 731,942 (+)EnsemblpanPan2panpan1.1
MISP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,839,423 - 57,847,013 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,838,731 - 57,843,219 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2057,641,618 - 57,647,893 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,581,930 - 58,588,205 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,581,165 - 58,585,729 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,636,448 - 57,642,628 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,115,878 - 58,122,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,319,170 - 58,325,443 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Misp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,540,716 - 217,550,768 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588290,662 - 294,248 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588290,620 - 294,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MISP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,602,142 - 77,619,087 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,607,185 - 77,619,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2278,316,218 - 78,324,105 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MISP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16505,841 - 520,758 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6506,482 - 520,827 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660818,403,707 - 8,451,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Misp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,800,424 - 7,812,035 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Misp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,044,198 - 155,054,456 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Misp
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:170
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000013857
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 66 151 84 83 52 70 52 6 321 167 9 127 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000013857   ⟹   ENSRNOP00000013857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,526,980 - 10,537,159 (-)Ensembl
mRatBN7.2 Ensembl79,876,361 - 9,886,541 (-)Ensembl
Rnor_6.0 Ensembl712,697,743 - 12,707,922 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109453   ⟹   ENSRNOP00000084852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,503,209 - 10,537,159 (-)Ensembl
mRatBN7.2 Ensembl79,870,444 - 9,886,541 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156023   ⟹   ENSRNOP00000104133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,520,367 - 10,537,159 (-)Ensembl
RefSeq Acc Id: NM_001109284   ⟹   NP_001102754
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,526,980 - 10,537,159 (-)NCBI
mRatBN7.279,876,361 - 9,886,541 (-)NCBI
Rnor_6.0712,697,743 - 12,707,922 (-)NCBI
Rnor_5.0712,861,587 - 12,877,644 (-)NCBI
RGSC_v3.4711,389,248 - 11,399,427 (-)RGD
Celera78,051,026 - 8,061,205 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595045   ⟹   XP_017450534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,526,983 - 10,533,217 (-)NCBI
mRatBN7.279,876,364 - 9,886,478 (-)NCBI
Rnor_6.0712,697,746 - 12,703,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264095   ⟹   XP_063120165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,526,983 - 10,535,613 (-)NCBI
RefSeq Acc Id: XM_063264096   ⟹   XP_063120166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,526,983 - 10,537,156 (-)NCBI
RefSeq Acc Id: NP_001102754   ⟸   NM_001109284
- UniProtKB: D3ZHV9 (UniProtKB/TrEMBL),   A6K8W8 (UniProtKB/TrEMBL),   A0A8I6GB45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450534   ⟸   XM_017595045
- Peptide Label: isoform X1
- UniProtKB: D3ZHV9 (UniProtKB/TrEMBL),   A6K8W8 (UniProtKB/TrEMBL),   A0A8I6GB45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013857   ⟸   ENSRNOT00000013857
Ensembl Acc Id: ENSRNOP00000084852   ⟸   ENSRNOT00000109453
RefSeq Acc Id: XP_063120166   ⟸   XM_063264096
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120165   ⟸   XM_063264095
- Peptide Label: isoform X1
- UniProtKB: A6K8W8 (UniProtKB/TrEMBL),   D3ZHV9 (UniProtKB/TrEMBL),   A0A8I6GB45 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104133   ⟸   ENSRNOT00000156023
Protein Domains
A-kinase anchor protein 2 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHV9-F1-model_v2 AlphaFold D3ZHV9 1-651 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695045
Promoter ID:EPDNEW_R5570
Type:single initiation site
Name:Misp_1
Description:mitotic spindle positioning
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,707,919 - 12,707,979EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595680 AgrOrtholog
BioCyc Gene G2FUF-34891 BioCyc
Ensembl Genes ENSRNOG00000010423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013857 ENTREZGENE
  ENSRNOT00000013857.7 UniProtKB/TrEMBL
  ENSRNOT00000109453.2 UniProtKB/TrEMBL
  ENSRNOT00000156023.1 UniProtKB/TrEMBL
InterPro AKAP2_C UniProtKB/TrEMBL
  MISP/MISP3 UniProtKB/TrEMBL
KEGG Report rno:500797 UniProtKB/TrEMBL
NCBI Gene 500797 ENTREZGENE
PANTHER MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 UniProtKB/TrEMBL
  PTHR18839 UniProtKB/TrEMBL
Pfam AKAP2_C UniProtKB/TrEMBL
PhenoGen Misp PhenoGen
RatGTEx ENSRNOG00000010423 RatGTEx
UniProt A0A8I6GB45 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFM5_RAT UniProtKB/TrEMBL
  A6K8W8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHV9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Misp  mitotic spindle positioning  LOC500797  hypothetical LOC500797  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC500797  hypothetical LOC500797      Symbol and Name status set to provisional 70820 PROVISIONAL