Tbc1d8 (TBC1 domain family, member 8) - Rat Genome Database

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Gene: Tbc1d8 (TBC1 domain family, member 8) Rattus norvegicus
Analyze
Symbol: Tbc1d8
Name: TBC1 domain family, member 8
RGD ID: 1595491
Description: Predicted to enable GTPase activator activity. Predicted to be involved in system process. Orthologous to human TBC1D8 (TBC1 domain family member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; amphetamine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: IHoP; LOC680133; rCG22278-like; similar to TBC1 domain family, member 8; TBC1 domain family member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,147,109 - 49,257,140 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,147,109 - 49,257,118 (-)EnsemblGRCr8
mRatBN7.2941,651,394 - 41,761,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,651,395 - 41,761,409 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx950,147,376 - 50,257,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0955,270,124 - 55,380,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0953,552,121 - 53,662,122 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,090,613 - 46,206,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,090,019 - 46,206,605 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,778,864 - 45,893,710 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,443,425 - 38,554,183 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,400,963 - 39,510,757 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
chloroethene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
leflunomide  (EXP)
lithium chloride  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17646400   PMID:22143342  


Genomics

Comparative Map Data
Tbc1d8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,147,109 - 49,257,140 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,147,109 - 49,257,118 (-)EnsemblGRCr8
mRatBN7.2941,651,394 - 41,761,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,651,395 - 41,761,409 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx950,147,376 - 50,257,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0955,270,124 - 55,380,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0953,552,121 - 53,662,122 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,090,613 - 46,206,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,090,019 - 46,206,605 (-)Ensemblrn6Rnor6.0
Rnor_5.0945,778,864 - 45,893,710 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,443,425 - 38,554,183 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,400,963 - 39,510,757 (-)NCBICelera
Cytogenetic Map9q22NCBI
TBC1D8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,007,228 - 101,151,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2101,005,934 - 101,252,866 (-)Ensemblhg38GRCh38
GRCh372101,623,690 - 101,767,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,990,122 - 101,134,278 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342101,082,208 - 101,134,521NCBI
Celera295,827,603 - 95,971,825 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef295,387,733 - 95,470,953 (-)NCBIHuRef
CHM1_12101,628,017 - 101,772,187 (-)NCBICHM1_1
T2T-CHM13v2.02101,465,925 - 101,610,081 (-)NCBIT2T-CHM13v2.0
Tbc1d8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,410,576 - 39,517,860 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,410,573 - 39,517,836 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38139,371,495 - 39,478,778 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,371,492 - 39,478,755 (-)Ensemblmm10GRCm38
MGSCv37139,428,340 - 39,535,592 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36139,316,046 - 39,423,281 (-)NCBIMGSCv36mm8
Celera139,165,425 - 39,272,500 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.3NCBI
Tbc1d8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554706,917,119 - 6,977,937 (-)Ensembl
ChiLan1.0NW_0049554706,916,553 - 7,012,358 (-)NCBIChiLan1.0ChiLan1.0
TBC1D8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,073,870 - 27,218,653 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,076,735 - 27,223,060 (+)NCBINHGRI_mPanPan1
PanPan1.12A101,983,337 - 102,066,327 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A101,983,337 - 102,069,516 (-)EnsemblpanPan2panpan1.1
TBC1D8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,718,975 - 41,831,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1041,729,623 - 41,835,075 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1041,644,404 - 41,757,232 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01042,587,181 - 42,700,001 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1042,587,102 - 42,711,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,299,601 - 42,411,825 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01042,582,407 - 42,695,032 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,773,777 - 42,886,785 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tbc1d8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629286,483,440 - 86,545,257 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666124,274 - 85,657 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493666124,274 - 86,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBC1D8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,149,196 - 53,289,790 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1353,149,059 - 53,289,249 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2355,689,868 - 55,835,478 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBC1D8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,715,787 - 4,846,284 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl144,716,368 - 4,846,357 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041172,335,966 - 172,375,811 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbc1d8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247495,800,750 - 5,897,459 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247495,800,751 - 5,897,400 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tbc1d8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,613,511 - 115,721,112 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tbc1d8
915 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000018640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH143784  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,684,917 - 41,686,374 (+)MAPPERmRatBN7.2
Rnor_6.0946,124,478 - 46,125,934NCBIRnor6.0
Rnor_5.0945,812,244 - 45,813,700UniSTSRnor5.0
RGSC_v3.4938,477,437 - 38,478,893UniSTSRGSC3.4
Celera939,434,395 - 39,435,851UniSTS
RH 3.4 Map9450.59UniSTS
Cytogenetic Map9q21UniSTS
BE108075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,695,109 - 41,695,273 (+)MAPPERmRatBN7.2
Rnor_6.0946,134,681 - 46,134,844NCBIRnor6.0
Rnor_5.0945,822,447 - 45,822,610UniSTSRnor5.0
RGSC_v3.4938,487,629 - 38,487,792UniSTSRGSC3.4
Celera939,444,587 - 39,444,750UniSTS
RH 3.4 Map9388.1UniSTS
Cytogenetic Map9q21UniSTS
RH127697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,651,547 - 41,651,740 (+)MAPPERmRatBN7.2
Rnor_6.0946,091,106 - 46,091,298NCBIRnor6.0
Rnor_5.0945,779,018 - 45,779,210UniSTSRnor5.0
RGSC_v3.4938,443,578 - 38,443,770UniSTSRGSC3.4
Celera939,401,116 - 39,401,308UniSTS
Cytogenetic Map9q21UniSTS
BE118306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,651,203 - 41,651,378 (+)MAPPERmRatBN7.2
Rnor_6.0946,090,762 - 46,090,936NCBIRnor6.0
Rnor_5.0945,778,674 - 45,778,848UniSTSRnor5.0
RGSC_v3.4938,443,234 - 38,443,408UniSTSRGSC3.4
Celera939,400,772 - 39,400,946UniSTS
RH 3.4 Map9386.4UniSTS
Cytogenetic Map9q21UniSTS
TBC1D8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8949,148,864 - 49,149,196 (+)Marker Load Pipeline
mRatBN7.2941,653,150 - 41,653,482 (+)MAPPERmRatBN7.2
Rnor_6.0946,092,709 - 46,093,040NCBIRnor6.0
Rnor_5.0945,780,621 - 45,780,952UniSTSRnor5.0
RGSC_v3.4938,445,181 - 38,445,512UniSTSRGSC3.4
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018640   ⟹   ENSRNOP00000018640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,147,109 - 49,257,118 (-)Ensembl
mRatBN7.2 Ensembl941,651,395 - 41,761,409 (-)Ensembl
Rnor_6.0 Ensembl946,090,019 - 46,206,605 (-)Ensembl
RefSeq Acc Id: NM_001191067   ⟹   NP_001177996
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,147,109 - 49,257,118 (-)NCBI
mRatBN7.2941,651,395 - 41,761,409 (-)NCBI
Rnor_6.0946,090,953 - 46,206,653 (-)NCBI
Rnor_5.0945,778,864 - 45,893,710 (-)NCBI
Celera939,400,963 - 39,510,757 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244851   ⟹   XP_006244913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,147,109 - 49,257,139 (-)NCBI
mRatBN7.2941,651,394 - 41,761,431 (-)NCBI
Rnor_6.0946,090,613 - 46,206,672 (-)NCBI
Rnor_5.0945,778,864 - 45,893,710 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084197   ⟹   XP_038940125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,156,966 - 49,257,140 (-)NCBI
mRatBN7.2941,660,942 - 41,761,432 (-)NCBI
RefSeq Acc Id: XM_039084198   ⟹   XP_038940126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,157,492 - 49,257,140 (-)NCBI
mRatBN7.2941,661,779 - 41,761,432 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001177996 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244913 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940125 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940126 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018640
  ENSRNOP00000018640.6
RefSeq Acc Id: NP_001177996   ⟸   NM_001191067
- UniProtKB: F1LWZ7 (UniProtKB/TrEMBL),   A6INL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244913   ⟸   XM_006244851
- Peptide Label: isoform X1
- UniProtKB: A6INL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018640   ⟸   ENSRNOT00000018640
RefSeq Acc Id: XP_038940125   ⟸   XM_039084197
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940126   ⟸   XM_039084198
- Peptide Label: isoform X3
Protein Domains
EF-hand   Rab-GAP TBC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWZ7-F1-model_v2 AlphaFold F1LWZ7 1-1135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696625
Promoter ID:EPDNEW_R7149
Type:multiple initiation site
Name:Tbc1d8_1
Description:TBC1 domain family, member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,206,615 - 46,206,675EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595491 AgrOrtholog
BioCyc Gene G2FUF-27749 BioCyc
Ensembl Genes ENSRNOG00000013583 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018640 ENTREZGENE
  ENSRNOT00000018640.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  putative rabgap domain of human tbc1 domain family member 14 like domains UniProtKB/TrEMBL
  Ypt/Rab-GAP domain of gyp1p, domain 1 UniProtKB/TrEMBL
  Ypt/Rab-GAP domain of gyp1p, domain 3 UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  GRAM UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Rab-GTPase_TBC_sf UniProtKB/TrEMBL
  RabGAP/TBC_dom UniProtKB/TrEMBL
  TBC1D8_PH-GRAM1 UniProtKB/TrEMBL
  TBC1D8_PH-GRAM2 UniProtKB/TrEMBL
KEGG Report rno:680133 UniProtKB/TrEMBL
NCBI Gene 680133 ENTREZGENE
PANTHER PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC UniProtKB/TrEMBL
  TBC1 DOMAIN FAMILY MEMBER 8 ISOFORM X1 UniProtKB/TrEMBL
Pfam GRAM UniProtKB/TrEMBL
  TBC UniProtKB/TrEMBL
PhenoGen Tbc1d8 PhenoGen
PROSITE EF_HAND_2 UniProtKB/TrEMBL
  TBC_RABGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013583 RatGTEx
SMART GRAM UniProtKB/TrEMBL
  TBC UniProtKB/TrEMBL
Superfamily-SCOP RabGAP_TBC UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A6INL4 ENTREZGENE, UniProtKB/TrEMBL
  F1LWZ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tbc1d8  TBC1 domain family, member 8  LOC100364476  rCG22278-like  Data merged from RGD:2320984 1643240 APPROVED
2010-05-05 LOC100364476  rCG22278-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-21 Tbc1d8  TBC1 domain family, member 8  LOC680133  similar to TBC1 domain family, member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680133  similar to TBC1 domain family, member 8  LOC681648  similar to TBC1 domain family, member 8  Data merged from RGD:1592886 1643240 APPROVED
2006-11-20 LOC680133  similar to TBC1 domain family, member 8      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681648  similar to TBC1 domain family, member 8      Symbol and Name status set to provisional 70820 PROVISIONAL