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Gene: Snx3 (sorting nexin 3) Rattus norvegicus

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Symbol:

Snx3

Name:

sorting nexin 3

RGD ID:

1595151

Description:

Predicted to enable phosphatidylinositol phosphate binding activity; protein phosphatase binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; host-mediated suppression of symbiont invasion; and negative regulation of transport. Predicted to act upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Orthologous to human SNX3 (sorting nexin 3); PARTICIPATES IN retromer-mediated pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC684097; similar to sorting nexin 3; sorting nexin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SNX3 (sorting nexin 3)	RGD	RGD
Mus musculus (house mouse):	Snx3 (sorting nexin 3)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Snx3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SNX3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SNX3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Snx3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SNX3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SNX3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Snx3 (sorting nexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SNX12 (sorting nexin 12)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SNX3 (sorting nexin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SNX3 (sorting nexin 3)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Snx3 (sorting nexin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Snx3 (sorting nexin 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	snx3 (sorting nexin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	snx3 (sorting nexin 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Snx3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Snx3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SNX3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	snx-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	snx-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	snx3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	snx3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	47,574,051 - 47,607,577 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	47,574,900 - 47,615,430 (+)	Ensembl				GRCr8
mRatBN7.2	20	45,992,446 - 46,025,361 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	45,992,720 - 46,025,379 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	47,710,148 - 47,742,787 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	47,360,312 - 47,392,951 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	48,053,233 - 48,086,017 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	47,225,382 - 47,263,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	47,225,619 - 47,263,390 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	48,923,090 - 48,932,814 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	20	53,947,195 - 53,979,808 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dimethoxyphenol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

alpha-pinene (ISO)

amitrole (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

ethanol (ISO)

finasteride (EXP)

folic acid (ISO)

fumonisin B1 (ISO)

furfural (ISO)

ivermectin (ISO)

methimazole (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

ozone (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (EXP,ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

endocytic recycling (IBA)

hemoglobin biosynthetic process (ISO)

host-mediated suppression of symbiont invasion (ISO)

intralumenal vesicle formation (ISO)

late endosome to Golgi transport (IBA)

membrane invagination (ISO)

negative regulation of early endosome to late endosome transport (ISO)

negative regulation of phagocytosis (ISO,ISS)

negative regulation of protein catabolic process (ISO)

negative regulation of protein transport (ISO)

positive regulation of neuron projection development (ISO,ISS)

protein to membrane docking (ISO,ISS)

protein transport (IEA)

regulation of intracellular protein transport (ISO)

regulation of protein metabolic process (IEA,ISO)

regulation of protein transport (IEA)

regulation of Wnt signaling pathway (ISO,ISS)

response to bacterium (ISO)

transferrin transport (ISO)

Cellular Component

clathrin-coated vesicle (ISO,ISS)

cytoplasm (ISO)

cytoplasmic vesicle (IEA)

cytosol (ISO)

early endosome (IEA,ISO,ISS)

early endosome membrane (IBA,ISO)

early phagosome (ISO,ISS)

endosome membrane (ISO,ISS)

phagocytic vesicle (IEA)

retromer complex (IBA,ISO)

Molecular Function

lipid binding (IEA)

phosphatidylinositol binding (IEA)

phosphatidylinositol phosphate binding (IEA)

phosphatidylinositol-3,5-bisphosphate binding (ISO,ISS)

phosphatidylinositol-3-phosphate binding (IBA,ISO,ISS)

phosphatidylinositol-4-phosphate binding (ISO,ISS)

phosphatidylinositol-5-phosphate binding (ISO,ISS)

protein binding (ISO)

protein phosphatase binding (ISO)

retromer complex binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

retromer-mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Retromer and sorting nexins in endosomal sorting.	Gallon M and Cullen PJ, Biochem Soc Trans. 2015 Feb;43(1):33-47. doi: 10.1042/BST20140290.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9819414	PMID:11279102	PMID:11433298	PMID:12477932	PMID:15673616	PMID:17622474	PMID:18767904	PMID:19056867	PMID:19576982	PMID:20482551	PMID:21725319	PMID:22719997
PMID:22871113	PMID:23237080	PMID:23376485	PMID:23416069	PMID:24344282

Genomics

Comparative Map Data

Snx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	47,574,051 - 47,607,577 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	47,574,900 - 47,615,430 (+)	Ensembl				GRCr8
mRatBN7.2	20	45,992,446 - 46,025,361 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	45,992,720 - 46,025,379 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	47,710,148 - 47,742,787 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	47,360,312 - 47,392,951 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	48,053,233 - 48,086,017 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	47,225,382 - 47,263,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	47,225,619 - 47,263,390 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	48,923,090 - 48,932,814 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	20	53,947,195 - 53,979,808 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

SNX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	108,211,222 - 108,261,040 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	108,211,222 - 108,261,255 (-)	Ensembl			hg38	GRCh38
GRCh37	6	108,532,426 - 108,582,244 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	108,639,410 - 108,689,156 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	108,639,410 - 108,689,156	NCBI
Celera	6	109,279,209 - 109,328,955 (-)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	106,100,989 - 106,150,564 (-)	NCBI		HuRef
CHM1_1	6	108,795,674 - 108,845,435 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	109,388,338 - 109,438,159 (-)	NCBI		T2T-CHM13v2.0

Snx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	42,378,050 - 42,411,365 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	42,378,026 - 42,411,377 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	42,502,054 - 42,535,369 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	42,502,030 - 42,535,381 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	42,221,860 - 42,255,175 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	42,190,444 - 42,223,782 (+)	NCBI		MGSCv36	mm8
Celera	10	43,369,479 - 43,403,088 (+)	NCBI		Celera
Cytogenetic Map	10	B2	NCBI
cM Map	10	22.89	NCBI

Snx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	33,340,274 - 33,345,500 (-)	Ensembl
ChiLan1.0	NW_004955411	33,339,974 - 33,344,563 (-)	NCBI	ChiLan1.0	ChiLan1.0

SNX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	128,216,245 - 128,269,590 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	126,106,433 - 126,156,957 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	106,010,633 - 106,063,331 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	109,874,095 - 109,924,185 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	109,874,105 - 109,924,185 (-)	Ensembl			panPan2	panpan1.1

SNX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	65,252,175 - 65,294,620 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	65,252,175 - 65,294,611 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	65,067,774 - 65,110,209 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	66,127,936 - 66,170,477 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	66,127,942 - 66,170,467 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	65,483,130 - 65,525,574 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	65,329,591 - 65,371,812 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	65,602,544 - 65,644,998 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Snx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	100,197,614 - 100,245,855 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	4,471,652 - 4,520,785 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936564	4,472,171 - 4,520,732 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SNX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	74,306,455 - 74,349,335 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	74,306,450 - 74,349,735 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	83,576,787 - 83,585,208 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SNX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	65,590,413 - 65,640,368 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	65,589,801 - 65,640,876 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	37,916,042 - 37,966,796 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Snx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	14,043,003 - 14,080,380 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624780	14,043,002 - 14,080,380 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Snx3
573 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	375
Count of miRNA genes:	211
Interacting mature miRNAs:	248
Transcripts:	ENSRNOT00000074532
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26689362	56021148	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26792353	56021148	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26689362	56021148	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	26689362	56021148	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26689362	56021148	Rat

Markers in Region

REN49968

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	46,013,127 - 46,013,385 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	47,251,161 - 47,251,418	NCBI	Rnor6.0
Rnor_5.0	20	48,920,585 - 48,920,842	UniSTS	Rnor5.0
Celera	20	53,959,169 - 53,959,426	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000074532

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	47,575,160 - 47,607,591 (+)	Ensembl
mRatBN7.2 Ensembl	20	45,992,965 - 46,025,361 (+)	Ensembl
Rnor_6.0 Ensembl	20	47,225,619 - 47,263,389 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000075924

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	47,574,900 - 47,607,576 (+)	Ensembl
mRatBN7.2 Ensembl	20	45,992,720 - 46,025,379 (+)	Ensembl
Rnor_6.0 Ensembl	20	47,253,664 - 47,263,390 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103931 ⟹ ENSRNOP00000082616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	47,575,266 - 47,607,593 (+)	Ensembl
mRatBN7.2 Ensembl	20	45,993,047 - 46,025,361 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000137007 ⟹ ENSRNOP00000103816

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	47,574,900 - 47,615,430 (+)	Ensembl

RefSeq Acc Id:

NM_001044283 ⟹ NP_001037748

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,574,940 - 47,607,577 (+)	NCBI
mRatBN7.2	20	45,992,721 - 46,025,361 (+)	NCBI
Rnor_6.0	20	47,225,382 - 47,263,390 (+)	NCBI
Rnor_5.0	20	48,923,090 - 48,932,814 (+)	NCBI
Celera	20	53,947,195 - 53,979,808 (-)	RGD

Sequence:

show sequence

GTCTCCCGGTATCCTTGGCGCCCACCGTTCCGTGACGCCGCCGCCCCTCAGCCCCACCCCGCAG
TGTCCCTCCGGGGCCGCCGCGGGGCCTGCGAACCGGGCGCGGCGTTCAGGCCAGTCAGCTGTTT
CTCCTTGGGCAAAGGGCGGAAGCCCGAGCAGCCTGGGGCGGAGCTTCGCGTAGAGCGAACGCCC
ACCCGTCCTACGTGCTCGTTCGCCTCTGTTCGCTGCGCGCGAGCCGGGAGTCCCCCGCGGCGGG
CGGCGGCGGCGGCGTTGGCGGAAGGAGGCGGCGGTGGAGAGAAGCCCGCGGCTGCCGCGGCGAT
AGCGAAATGGCGGAGACCGTAGCGGACACCCGGCGGCTCATCACCAAGCCGCAGAACCTGAATG
ACGCCTACGGGCCGCCCAGCAACTTCCTCGAGATCGACGTGAGCAATCCGCAGACTGTGGGGGT
CGGCCGGGGCCGCTTCACCACCTACGAGATCAGGGTCAAGACCAATCTTCCTATCTTCAAGCTG
AAGGAATCTACTGTTAGAAGAAGATACAGTGACTTTGAGTGGCTTCGAAGTGAACTAGAGAGAG
AGAGCAAGGTTGTCGTTCCCCCACTCCCGGGGAAAGCATTTTTGCGGCAGCTTCCTTTTAGAGG
AGACGATGGAATATTTGACGATAATTTCATCGAGGAAAGGAAGCAAGGGCTGGAACAGTTCATA
AACAAGGTCGCTGGTCATCCTCTGGCCCAGAATGAACGTTGTCTTCACATGTTTTTACAGGATG
AAATCATAGATAAAAGCTATACTCCATCTAAAATAAGACATGCCTGAGTTTGGCAAGAAGAGGC
AAACCCCAAGACCATGAATGATTCGTCCGTACCAATGAAGACGTTGTAACTAACTTAGCATGCT
GCAGACACTGCTGTAACAAACGCGCACGCCCTGGATGTACTAACACTCACGCTCCCTTTCATTC
TGTCTGTTTGGCAAGACGTTCATTTGCTTTAGTGGAAACTCCCTCACTTCTCCAGCCTTTCTAA
GTAGCCCTTCCCACCGTGTCCCTCCGTGTGCACTGTAGCCTCAGCCCTGTAGACCTGCAGTGTT
CTGACTAAAGCTGCCGACTTGCTCGAATTTGCAGTTTCTGTGTCGTGTGCTTCTTGAATCTGAT
TGACTAGGATATTTCTCCCCACCCCTGATGTGTGATGTCACCACTTGGTCCTAATTTATGTGCA
GGAGCACGACACCATTTGTCTCCAGTGCCACACATACGAGGTGTACTTTGTGTGCAGAATGTGT
CTTCCTTCTGGCCTGTAATCCCCTTCACATGAGAGATTAATGAGGGAAATCTTTATATTCTGTA
TAAAACAAAATCAAATTTATATACTAAAATCATTTGTCTAAAATTTAAGTTGTTTTCAAATAAA
AGTTGAAATGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039099063 ⟹ XP_038954991

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,574,051 - 47,607,577 (+)	NCBI
mRatBN7.2	20	45,992,446 - 46,025,361 (+)	NCBI

RefSeq Acc Id:

XM_039099064 ⟹ XP_038954992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,574,051 - 47,607,577 (+)	NCBI
mRatBN7.2	20	45,992,446 - 46,025,361 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001037748	(Get FASTA)	NCBI Sequence Viewer
	XP_038954991	(Get FASTA)	NCBI Sequence Viewer
	XP_038954992	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86341	(Get FASTA)	NCBI Sequence Viewer
	AAI07919	(Get FASTA)	NCBI Sequence Viewer
	AAI58609	(Get FASTA)	NCBI Sequence Viewer
	EDL99706	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000087527
	ENSRNOP00000092005
	ENSRNOP00000092005.1
GenBank Protein	Q5U211	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001037748 ⟸ NM_001044283
- UniProtKB:	Q5U211 (UniProtKB/Swiss-Prot), A6K6Y8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKE STVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINK VAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA hide sequence

RefSeq Acc Id:	XP_038954991 ⟸ XM_039099063
- Peptide Label:	isoform X1
- UniProtKB:	B0BMY2 (UniProtKB/TrEMBL), A0A8I6A603 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954992 ⟸ XM_039099064
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000082616 ⟸ ENSRNOT00000103931

Ensembl Acc Id:

ENSRNOP00000103816 ⟸ ENSRNOT00000137007

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U211-F1-model_v2	AlphaFold	Q5U211	1-162	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1595151	AgrOrtholog
BioCyc Gene	G2FUF-3359	BioCyc
Ensembl Genes	ENSRNOG00000046705	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000074532	ENTREZGENE
	ENSRNOT00000074532.4	UniProtKB/Swiss-Prot
	ENSRNOT00000075924	ENTREZGENE
Gene3D-CATH	3.30.1520.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7301775	IMAGE-MGC_LOAD
	IMAGE:7301779	IMAGE-MGC_LOAD
	IMAGE:7458016	IMAGE-MGC_LOAD
InterPro	Phox	UniProtKB/Swiss-Prot
	PX_dom_sf	UniProtKB/Swiss-Prot
	PX_SNX3_Vert	UniProtKB/Swiss-Prot
	Sorting_Nexin	UniProtKB/Swiss-Prot
KEGG Report	rno:684097	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105945	IMAGE-MGC_LOAD
	MGC:125029	IMAGE-MGC_LOAD
	MGC:187477	IMAGE-MGC_LOAD
NCBI Gene	684097	ENTREZGENE
PANTHER	RE52028P	UniProtKB/Swiss-Prot
	SORTING NEXIN-3	UniProtKB/Swiss-Prot
Pfam	PF00787	UniProtKB/Swiss-Prot
PhenoGen	Snx3	PhenoGen
PROSITE	PS50195	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000046705	RatGTEx
SMART	SM00312	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF64268	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZVK8_RAT	UniProtKB/TrEMBL
	A0A8I6A603	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L3L6_RAT	UniProtKB/TrEMBL
	A6K6Y8	ENTREZGENE, UniProtKB/TrEMBL
	B0BMY2	ENTREZGENE, UniProtKB/TrEMBL
	Q5U211	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-12-08	Snx3	sorting nexin 3	LOC684097	similar to sorting nexin 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC684097	similar to sorting nexin 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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