Fmo9 (flavin containing monooxygenase 9) - Rat Genome Database

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Gene: Fmo9 (flavin containing monooxygenase 9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fmo9
Name: flavin containing monooxygenase 9
RGD ID: 1595083
Description: Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: flavin containing monooxygenase 9 pseudogene; Fmo9p; LOC685365; similar to flavin containing monooxygenase 5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81381,353,044 - 81,374,033 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1381,353,044 - 81,374,033 (-)EnsemblGRCr8
mRatBN7.21378,820,080 - 78,841,075 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,820,080 - 78,841,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1381,439,561 - 81,460,585 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01382,753,103 - 82,774,124 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01379,991,404 - 80,012,416 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01384,774,274 - 84,795,081 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1384,774,274 - 84,795,081 (-)Ensemblrn6Rnor6.0
Rnor_5.01389,648,149 - 89,668,956 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41382,305,221 - 82,326,535 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1378,527,996 - 78,549,015 (-)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Fmo9
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:110
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000029706
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
37 1 8 1 34 1 38 33 25 8

Sequence


Ensembl Acc Id: ENSRNOT00000029706   ⟹   ENSRNOP00000036759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1381,353,044 - 81,374,033 (-)Ensembl
mRatBN7.2 Ensembl1378,820,080 - 78,841,075 (-)Ensembl
Rnor_6.0 Ensembl1384,774,274 - 84,795,081 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076083   ⟹   ENSRNOP00000068061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1384,774,754 - 84,795,070 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076886   ⟹   ENSRNOP00000068224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1384,774,754 - 84,793,463 (-)Ensembl
RefSeq Acc Id: NM_001109466   ⟹   NP_001102936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81381,353,044 - 81,374,033 (-)NCBI
mRatBN7.21378,820,080 - 78,841,075 (-)NCBI
Rnor_6.01384,774,274 - 84,795,081 (-)NCBI
Rnor_5.01389,648,149 - 89,668,956 (-)NCBI
RGSC_v3.41382,305,221 - 82,326,535 (-)RGD
Celera1378,527,996 - 78,549,015 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102936 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036759
  ENSRNOP00000036759.4
RefSeq Acc Id: NP_001102936   ⟸   NM_001109466
- UniProtKB: D3ZD07 (UniProtKB/TrEMBL),   A6IDK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068224   ⟸   ENSRNOT00000076886
Ensembl Acc Id: ENSRNOP00000036759   ⟸   ENSRNOT00000029706
Ensembl Acc Id: ENSRNOP00000068061   ⟸   ENSRNOT00000076083

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD07-F1-model_v2 AlphaFold D3ZD07 1-543 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595083 AgrOrtholog
BioCyc Gene G2FUF-17535 BioCyc
Ensembl Genes ENSRNOG00000025119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029706 ENTREZGENE
  ENSRNOT00000029706.8 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_5 UniProtKB/TrEMBL
  FMO UniProtKB/TrEMBL
KEGG Report rno:685365 UniProtKB/TrEMBL
NCBI Gene 685365 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PhenoGen Fmo9 PhenoGen
PIRSF FMO UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025119 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A6IDK6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZD07 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-05 Fmo9  flavin containing monooxygenase 9  Fmo9p  flavin containing monooxygenase 9 pseudogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Fmo9  flavin containing monooxygenase 9  LOC686830  similar to flavin containing monooxygenase 5  Data merged from RGD:1592519 1643240 APPROVED
2008-03-05 Fmo9  flavin containing monooxygenase 9  LOC685365  similar to flavin containing monooxygenase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685365  similar to flavin containing monooxygenase 5      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686830  similar to flavin containing monooxygenase 5      Symbol and Name status set to provisional 70820 PROVISIONAL