Rad21 (RAD21 cohesin complex component) - Rat Genome Database

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Gene: Rad21 (RAD21 cohesin complex component) Rattus norvegicus
Analyze
Symbol: Rad21
Name: RAD21 cohesin complex component
RGD ID: 1594529
Description: Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be part of meiotic cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: double-strand-break repair protein rad21 homolog; MGC116373; RAD21 homolog; RAD21 homolog (S. pombe); similar to HR21spA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,177,715 - 85,204,657 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl785,177,716 - 85,204,657 (-)EnsemblGRCr8
mRatBN7.2783,287,867 - 83,314,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,287,870 - 83,314,817 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx785,183,451 - 85,210,398 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,384,656 - 87,411,603 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,211,563 - 87,238,505 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd787,266,803 - 87,293,733 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive788,129,067 - 88,156,014 (-)NCBILyon_Normotensive
Lyon_Hypertensive788,268,175 - 88,295,122 (-)NCBILyon_Hypertensive
F344_StmMcwi786,742,928 - 86,769,867 (-)NCBIF344_StmMcwi
Rnor_6.0791,511,755 - 91,538,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,511,756 - 91,538,673 (-)Ensemblrn6Rnor6.0
Rnor_5.0792,155,546 - 92,182,749 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4788,267,648 - 88,294,703 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera780,164,565 - 80,191,459 (-)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
finasteride  (EXP)
genistein  (ISO)
glafenine  (EXP)
glycyrrhizinic acid  (ISO)
GSK-J4  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
Mezerein  (ISO)
microcystin-LR  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
saccharin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
chromosome  (IEA)
chromosome, centromeric region  (IEA,ISO)
cohesin complex  (IEA,ISO)
condensed nuclear chromosome  (IEA,ISO)
nuclear matrix  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PPARγ/RAD21 alleviates peripheral secondary brain injury in rat cerebral hemorrhage model through promoting M2 polarization of microglial cells. Jiao Y, etal., Int Immunopharmacol. 2023 Jan;114:109572. doi: 10.1016/j.intimp.2022.109572. Epub 2022 Dec 18.
3. Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion. Kang H and Lieberman PM, J Virol. 2011 Nov;85(21):11159-69. doi: 10.1128/JVI.00720-11. Epub 2011 Aug 31.
4. Polymorphisms in mitotic checkpoint-related genes can influence survival outcomes of early-stage non-small cell lung cancer. Kang HG, etal., Oncotarget. 2017 Jun 27;8(37):61777-61785. doi: 10.18632/oncotarget.18693. eCollection 2017 Sep 22.
5. [Endometrial cancer in young women--clinical and molecular aspects]. Lapińska-Szumczyk S, etal., Ginekol Pol. 2014 Oct;85(10):754-9.
6. LncRNA MIAT activates vascular endothelial growth factor A through RAD21 to promote nerve injury repair in acute spinal cord injury. Li D, etal., Mol Cell Endocrinol. 2021 May 15;528:111244. doi: 10.1016/j.mce.2021.111244. Epub 2021 Mar 17.
7. Cell Cycle Genes Are Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma. Liping X, etal., Biomed Res Int. 2020 Jun 7;2020:6206157. doi: 10.1155/2020/6206157. eCollection 2020.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. MiR-320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling. Wang J, etal., Cancer Sci. 2021 Feb;112(2):575-588. doi: 10.1111/cas.14751. Epub 2020 Dec 31.
14. Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. Yamamoto G, etal., Virchows Arch. 2006 Apr;448(4):435-41. doi: 10.1007/s00428-005-0132-y. Epub 2006 Jan 14.
15. Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis. Zhou B and Guo R, Sci Rep. 2018 Dec 13;8(1):17836. doi: 10.1038/s41598-018-36168-8.
Additional References at PubMed
PMID:10375619   PMID:11590136   PMID:12477932   PMID:18499658   PMID:19468298   PMID:19946888   PMID:21111234   PMID:22419665   PMID:22628566   PMID:22780989   PMID:23242214   PMID:23920377  
PMID:24797475   PMID:31505169  


Genomics

Comparative Map Data
Rad21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,177,715 - 85,204,657 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl785,177,716 - 85,204,657 (-)EnsemblGRCr8
mRatBN7.2783,287,867 - 83,314,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,287,870 - 83,314,817 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx785,183,451 - 85,210,398 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,384,656 - 87,411,603 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,211,563 - 87,238,505 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd787,266,803 - 87,293,733 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive788,129,067 - 88,156,014 (-)NCBILyon_Normotensive
Lyon_Hypertensive788,268,175 - 88,295,122 (-)NCBILyon_Hypertensive
F344_StmMcwi786,742,928 - 86,769,867 (-)NCBIF344_StmMcwi
Rnor_6.0791,511,755 - 91,538,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,511,756 - 91,538,673 (-)Ensemblrn6Rnor6.0
Rnor_5.0792,155,546 - 92,182,749 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4788,267,648 - 88,294,703 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera780,164,565 - 80,191,459 (-)NCBICelera
Cytogenetic Map7q31NCBI
RAD21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388116,845,934 - 116,874,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8116,845,934 - 116,874,849 (-)Ensemblhg38GRCh38
GRCh378117,858,173 - 117,887,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368117,927,355 - 117,956,182 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348117,927,354 - 117,956,182NCBI
Celera8114,046,862 - 114,075,794 (-)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8113,184,591 - 113,213,523 (-)NCBIHuRef
CHM1_18117,898,409 - 117,927,335 (-)NCBICHM1_1
T2T-CHM13v2.08117,974,085 - 118,002,938 (-)NCBIT2T-CHM13v2.0
Rad21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391551,826,000 - 51,856,934 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1551,825,636 - 51,855,143 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381551,962,604 - 51,993,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1551,962,240 - 51,991,747 (-)Ensemblmm10GRCm38
MGSCv371551,794,150 - 51,823,306 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361551,792,680 - 51,821,636 (-)NCBIMGSCv36mm8
Celera1553,535,633 - 53,555,853 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1519.54NCBI
Rad21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541722,941,479 - 22,966,837 (-)Ensembl
ChiLan1.0NW_00495541722,941,549 - 22,966,395 (-)NCBIChiLan1.0ChiLan1.0
RAD21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27134,252,362 - 134,281,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18109,767,758 - 109,796,718 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08113,520,456 - 113,549,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18116,063,503 - 116,092,421 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8116,063,503 - 116,092,421 (-)EnsemblpanPan2panpan1.1
RAD21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11316,337,563 - 16,368,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1316,338,972 - 16,368,035 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1316,338,678 - 16,369,154 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01316,626,236 - 16,656,848 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1316,626,236 - 16,656,850 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11316,369,666 - 16,400,273 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01316,469,992 - 16,500,602 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01316,711,252 - 16,741,853 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rad21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530321,951,734 - 21,978,780 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647029,377,734 - 29,407,312 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647029,377,793 - 29,403,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl421,772,855 - 21,802,715 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1421,772,821 - 21,802,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2423,059,570 - 23,262,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18111,486,356 - 111,515,641 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8111,486,048 - 111,507,729 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603928,811,005 - 28,840,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476315,131,005 - 15,158,155 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476315,131,106 - 15,157,512 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rad21
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11226,305,500 - 226,332,431 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rad21
233 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:149
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000006209
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH131367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,293,712 - 83,293,892 (+)MAPPERmRatBN7.2
Rnor_6.0791,517,601 - 91,517,780NCBIRnor6.0
Rnor_5.0792,161,392 - 92,161,571UniSTSRnor5.0
RGSC_v3.4788,273,494 - 88,273,673UniSTSRGSC3.4
Celera780,170,411 - 80,170,590UniSTS
RH 3.4 Map7550.3UniSTS
Cytogenetic Map7q31UniSTS
RH137734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,288,539 - 83,288,693 (+)MAPPERmRatBN7.2
Rnor_6.0791,512,428 - 91,512,581NCBIRnor6.0
Rnor_5.0792,156,219 - 92,156,372UniSTSRnor5.0
RGSC_v3.4788,268,321 - 88,268,474UniSTSRGSC3.4
Celera780,165,238 - 80,165,391UniSTS
RH 3.4 Map7550.4UniSTS
Cytogenetic Map7q31UniSTS
RH134178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,287,932 - 83,288,113 (+)MAPPERmRatBN7.2
Rnor_6.0791,511,821 - 91,512,001NCBIRnor6.0
Rnor_5.0792,155,612 - 92,155,792UniSTSRnor5.0
RGSC_v3.4788,267,714 - 88,267,894UniSTSRGSC3.4
Celera780,164,631 - 80,164,811UniSTS
RH 3.4 Map7549.1UniSTS
Cytogenetic Map7q31UniSTS
RH139481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,288,539 - 83,288,756 (+)MAPPERmRatBN7.2
Rnor_6.0791,512,428 - 91,512,644NCBIRnor6.0
Rnor_5.0792,156,219 - 92,156,435UniSTSRnor5.0
RGSC_v3.4788,268,321 - 88,268,537UniSTSRGSC3.4
Celera780,165,238 - 80,165,454UniSTS
RH 3.4 Map7551.8UniSTS
Cytogenetic Map7q31UniSTS
AW530029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,316,640 - 83,316,791 (+)MAPPERmRatBN7.2
Rnor_6.0791,540,504 - 91,540,654NCBIRnor6.0
Rnor_5.0792,184,580 - 92,184,730UniSTSRnor5.0
RGSC_v3.4788,296,534 - 88,296,684UniSTSRGSC3.4
Celera780,193,290 - 80,193,440UniSTS
RH 3.4 Map7541.8UniSTS
Cytogenetic Map7q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006209   ⟹   ENSRNOP00000006209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl785,177,716 - 85,204,657 (-)Ensembl
mRatBN7.2 Ensembl783,287,870 - 83,314,817 (-)Ensembl
Rnor_6.0 Ensembl791,511,756 - 91,538,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116638   ⟹   ENSRNOP00000095133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl783,288,697 - 83,314,805 (-)Ensembl
RefSeq Acc Id: NM_001025701   ⟹   NP_001020872
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8785,177,715 - 85,204,657 (-)NCBI
mRatBN7.2783,287,867 - 83,314,810 (-)NCBI
Dahl_SR_JrHsd787,266,803 - 87,293,733 (-)NCBI
Lyon_Normotensive788,129,067 - 88,156,014 (-)NCBI
Lyon_Hypertensive788,268,175 - 88,295,122 (-)NCBI
F344_StmMcwi786,742,928 - 86,769,867 (-)NCBI
Rnor_6.0791,511,755 - 91,538,673 (-)NCBI
Rnor_5.0792,155,546 - 92,182,749 (-)NCBI
RGSC_v3.4788,267,648 - 88,294,703 (-)RGD
Celera780,164,565 - 80,191,459 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99200 (Get FASTA)   NCBI Sequence Viewer  
  EDM16276 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006209
  ENSRNOP00000006209.7
RefSeq Acc Id: NP_001020872   ⟸   NM_001025701
- UniProtKB: Q4KLH7 (UniProtKB/TrEMBL),   A0A8I6ANZ0 (UniProtKB/TrEMBL),   F7EK71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006209   ⟸   ENSRNOT00000006209
Ensembl Acc Id: ENSRNOP00000095133   ⟸   ENSRNOT00000116638
Protein Domains
Rad21/Rec8-like protein C-terminal eukaryotic   Rad21/Rec8-like protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLH7-F1-model_v2 AlphaFold Q4KLH7 1-635 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695323
Promoter ID:EPDNEW_R5848
Type:initiation region
Name:Rad21_1
Description:RAD21 cohesin complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0791,538,660 - 91,538,720EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594529 AgrOrtholog
BioCyc Gene G2FUF-33427 BioCyc
Ensembl Genes ENSRNOG00000004420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006209 ENTREZGENE
  ENSRNOT00000006209.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.580 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384021 IMAGE-MGC_LOAD
InterPro NXP1_M-like UniProtKB/TrEMBL
  Rad21/Rec8-like UniProtKB/TrEMBL
  Rad21/Rec8_C UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/TrEMBL
  ScpA-like_C UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:314949 UniProtKB/TrEMBL
MGC_CLONE MGC:116373 IMAGE-MGC_LOAD
NCBI Gene 314949 ENTREZGENE
PANTHER DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG UniProtKB/TrEMBL
  PTHR12585 UniProtKB/TrEMBL
Pfam Rad21_Rec8 UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/TrEMBL
PhenoGen Rad21 PhenoGen
RatGTEx ENSRNOG00000004420 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A8I6ANZ0 ENTREZGENE, UniProtKB/TrEMBL
  F7EK71 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLH7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Rad21  RAD21 cohesin complex component  Rad21  RAD21 homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Rad21  RAD21 homolog (S. pombe)  MGC116373  similar to HR21spA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 MGC116373  similar to HR21spA      Symbol and Name status set to provisional 70820 PROVISIONAL