Dnajb3 (DnaJ heat shock protein family (Hsp40) member B3) - Rat Genome Database

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Gene: Dnajb3 (DnaJ heat shock protein family (Hsp40) member B3) Rattus norvegicus
Analyze
Symbol: Dnajb3
Name: DnaJ heat shock protein family (Hsp40) member B3
RGD ID: 1594215
Description: Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in acrosomal vesicle and centrosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human DNAJB3 (DnaJ heat shock protein family (Hsp40) member B3); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily B, member 3; dnaJ homolog subfamily B member 3; LOC680216; similar to DnaJ (Hsp40) homolog, subfamily B, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,243,345 - 96,244,358 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,243,071 - 96,244,408 (-)EnsemblGRCr8
mRatBN7.2988,795,542 - 88,796,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,795,488 - 88,796,560 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,219,362 - 97,220,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,355,554 - 102,356,567 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,723,739 - 100,724,752 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,289,918 - 95,290,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,289,918 - 95,290,931 (-)Ensemblrn6Rnor6.0
Rnor_5.0994,977,133 - 94,978,146 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,085,458 - 87,086,471 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,356,834 - 86,357,847 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
acrosomal vesicle  (ISO)
centrosome  (ISO)
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11466217   PMID:23376485   PMID:25446099  


Genomics

Comparative Map Data
Dnajb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,243,345 - 96,244,358 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,243,071 - 96,244,408 (-)EnsemblGRCr8
mRatBN7.2988,795,542 - 88,796,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,795,488 - 88,796,560 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,219,362 - 97,220,375 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,355,554 - 102,356,567 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,723,739 - 100,724,752 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,289,918 - 95,290,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,289,918 - 95,290,931 (-)Ensemblrn6Rnor6.0
Rnor_5.0994,977,133 - 94,978,146 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,085,458 - 87,086,471 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,356,834 - 86,357,847 (-)NCBICelera
Cytogenetic Map9q35NCBI
DNAJB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,742,750 - 233,743,998 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,743,188 - 233,743,916 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl2233,742,750 - 233,744,015 (-)Ensemblhg38GRCh38
GRCh372234,651,396 - 234,652,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,316,135 - 234,317,400 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2228,372,015 - 228,373,280 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,451,239 - 226,452,504 (-)NCBIHuRef
CHM1_12234,657,210 - 234,658,475 (-)NCBICHM1_1
T2T-CHM13v2.02234,231,381 - 234,232,629 (-)NCBIT2T-CHM13v2.0
Dnajb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,132,454 - 88,133,470 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,132,454 - 88,133,504 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38188,204,732 - 88,205,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,204,732 - 88,205,782 (-)Ensemblmm10GRCm38
MGSCv37190,101,307 - 90,102,323 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36190,035,906 - 90,036,919 (-)NCBIMGSCv36mm8
Celera191,165,798 - 91,166,814 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.55NCBI
Dnajb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554532,399,155 - 2,400,158 (+)NCBIChiLan1.0ChiLan1.0
DNAJB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12545,143,010 - 45,144,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2545,640,030 - 45,641,372 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02545,489,849 - 45,491,191 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2545,490,404 - 45,491,120 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12545,382,741 - 45,384,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02545,190,977 - 45,192,321 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02545,419,905 - 45,421,247 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnajb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303187,307,840 - 187,309,209 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365253,630,599 - 3,631,315 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365253,630,584 - 3,631,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115134,027,252 - 134,028,266 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215148,140,831 - 148,143,655 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Dnajb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14160,238,891 - 160,239,934 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnajb3
1 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:105
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025300
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 150 88 87 56 75 56 6 334 174 11 129 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000025300   ⟹   ENSRNOP00000024845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl996,243,071 - 96,244,408 (-)Ensembl
mRatBN7.2 Ensembl988,795,488 - 88,796,560 (-)Ensembl
Rnor_6.0 Ensembl995,289,918 - 95,290,931 (-)Ensembl
RefSeq Acc Id: NM_001109396   ⟹   NP_001102866
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,243,345 - 96,244,358 (-)NCBI
mRatBN7.2988,795,542 - 88,796,555 (-)NCBI
Rnor_6.0995,289,918 - 95,290,931 (-)NCBI
Rnor_5.0994,977,133 - 94,978,146 (-)NCBI
RGSC_v3.4987,085,458 - 87,086,471 (-)RGD
Celera986,356,834 - 86,357,847 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102866 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92111 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024845
  ENSRNOP00000024845.1
RefSeq Acc Id: NP_001102866   ⟸   NM_001109396
- UniProtKB: D3ZAC5 (UniProtKB/TrEMBL),   A6JQI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024845   ⟸   ENSRNOT00000025300
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAC5-F1-model_v2 AlphaFold D3ZAC5 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696844
Promoter ID:EPDNEW_R7369
Type:initiation region
Name:Dnajb3_1
Description:DnaJ heat shock protein family member B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,290,907 - 95,290,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594215 AgrOrtholog
BioCyc Gene G2FUF-26817 BioCyc
Ensembl Genes ENSRNOG00000023172 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025300 ENTREZGENE
  ENSRNOT00000025300.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
InterPro DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
  DNJB2/6-like UniProtKB/TrEMBL
  Heat_shock_DnaJ_CS UniProtKB/TrEMBL
KEGG Report rno:680216 UniProtKB/TrEMBL
NCBI Gene 680216 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY B MEMBER 2 UniProtKB/TrEMBL
  SIMILAR TO DNAJ HOMOLOG SUBFAMILY B MEMBER 6 (HEAT SHOCK PROTEIN J2) (HSJ-2) (MRJ) (MDJ4) UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
PhenoGen Dnajb3 PhenoGen
PRINTS JDOMAIN UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023172 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
UniProt A6JQI3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Dnajb3  DnaJ heat shock protein family (Hsp40) member B3  Dnajb3  DnaJ (Hsp40) homolog, subfamily B, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dnajb3  DnaJ (Hsp40) homolog, subfamily B, member 3  LOC680216  similar to DnaJ (Hsp40) homolog, subfamily B, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680216  similar to DnaJ (Hsp40) homolog, subfamily B, member 3  LOC683083  similar to DnaJ (Hsp40) homolog, subfamily B, member 3  Data merged from RGD:1591526 1643240 APPROVED
2006-11-20 LOC680216  similar to DnaJ (Hsp40) homolog, subfamily B, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC683083  similar to DnaJ (Hsp40) homolog, subfamily B, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL