Frg2 (FSHD region gene 2) - Rat Genome Database

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Gene: Frg2 (FSHD region gene 2) Rattus norvegicus
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Symbol: Frg2
Name: FSHD region gene 2
RGD ID: 1592623
Description: Orthologous to human FRG2 (FSHD region gene 2); INTERACTS WITH atrazine; Cuprizon; indole-3-methanol.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: MODEL
Previously known as: Frg2b; FSHD region gene 2 family, member B; LOC685524; similar to FSHD region gene 2 protein
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,641,245 - 84,643,565 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,641,658 - 84,643,166 (+)EnsemblGRCr8
mRatBN7.21480,427,260 - 80,429,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,427,673 - 80,429,181 (+)EnsemblmRatBN7.2
Rnor_6.01485,779,927 - 85,792,527 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,791,159 - 85,792,257 (+)Ensemblrn6Rnor6.0
Rnor_5.01486,450,035 - 86,462,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41486,188,923 - 86,190,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1479,302,524 - 79,315,124 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Frg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,641,245 - 84,643,565 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,641,658 - 84,643,166 (+)EnsemblGRCr8
mRatBN7.21480,427,260 - 80,429,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,427,673 - 80,429,181 (+)EnsemblmRatBN7.2
Rnor_6.01485,779,927 - 85,792,527 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,791,159 - 85,792,257 (+)Ensemblrn6Rnor6.0
Rnor_5.01486,450,035 - 86,462,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41486,188,923 - 86,190,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1479,302,524 - 79,315,124 (+)NCBICelera
Cytogenetic Map14q21NCBI
FRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384190,024,367 - 190,027,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4190,024,367 - 190,027,257 (-)Ensemblhg38GRCh38
GRCh374190,945,522 - 190,948,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364191,182,516 - 191,185,406 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map4q35.2NCBI
CHM1_14190,930,255 - 190,933,142 (-)NCBICHM1_1
T2T-CHM13v2.04193,392,577 - 193,395,463 (-)NCBIT2T-CHM13v2.0
FRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23187,730,569 - 187,732,912 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14188,091,130 - 188,093,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04182,168,388 - 182,169,720 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC119619667
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037116,206,544 - 116,207,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Frg2
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000041857
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
reproductive system
respiratory system
1 1 5 18 19 18 26 18 48 28 3 3 31 1

Sequence


Ensembl Acc Id: ENSRNOT00000041857   ⟹   ENSRNOP00000041859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,641,658 - 84,643,166 (+)Ensembl
mRatBN7.2 Ensembl1480,427,673 - 80,429,181 (+)Ensembl
Rnor_6.0 Ensembl1485,791,159 - 85,792,257 (+)Ensembl
RefSeq Acc Id: XM_063273883   ⟹   XP_063129953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,641,245 - 84,643,565 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063129953 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000041859   ⟸   ENSRNOT00000041857
RefSeq Acc Id: XP_063129953   ⟸   XM_063273883

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWQ0-F1-model_v2 AlphaFold F1LWQ0 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592623 AgrOrtholog
BioCyc Gene G2FUF-15137 BioCyc
Ensembl Genes ENSRNOG00000034011 Ensembl
NCBI Gene 685524 ENTREZGENE
PhenoGen Frg2 PhenoGen
RatGTEx ENSRNOG00000034011 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-29 Frg2  FSHD region gene 2  Frg2b  FSHD region gene 2 family, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-21 Frg2b  FSHD region gene 2 family, member B  LOC685524  similar to FSHD region gene 2 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685524  similar to FSHD region gene 2 protein  LOC684005  similar to FSHD region gene 2 protein  Data merged from RGD:1595239 1643240 APPROVED
2006-11-20 LOC685524  similar to FSHD region gene 2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684005  similar to FSHD region gene 2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL