Mzt1 (mitotic spindle organizing protein 1) - Rat Genome Database

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Gene: Mzt1 (mitotic spindle organizing protein 1) Rattus norvegicus
Analyze
Symbol: Mzt1
Name: mitotic spindle organizing protein 1
RGD ID: 1592140
Description: Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be located in cytoplasm and microtubule organizing center. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Orthologous to human MZT1 (mitotic spindle organizing protein 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; oxaliplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC692032; LOC692032; mitotic-spindle organizing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,195,128 - 82,205,436 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1582,195,128 - 82,205,436 (-)EnsemblGRCr8
mRatBN7.21575,787,281 - 75,797,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1579,770,343 - 79,780,634 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,846,961 - 80,857,252 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,794,504 - 77,804,795 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,429,437 - 83,442,118 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)Ensemblrn6Rnor6.0
Rnor_5.01586,941,556 - 86,953,251 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41582,820,060 - 82,828,971 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map15q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20360068  


Genomics

Comparative Map Data
Mzt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,195,128 - 82,205,436 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1582,195,128 - 82,205,436 (-)EnsemblGRCr8
mRatBN7.21575,787,281 - 75,797,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1579,770,343 - 79,780,634 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,846,961 - 80,857,252 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,794,504 - 77,804,795 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,429,437 - 83,442,118 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)Ensemblrn6Rnor6.0
Rnor_5.01586,941,556 - 86,953,251 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41582,820,060 - 82,828,971 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map15q21NCBI
MZT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,708,367 - 72,727,629 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1372,708,367 - 72,727,629 (-)Ensemblhg38GRCh38
GRCh371373,282,505 - 73,301,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,180,496 - 72,199,826 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1354,180,988 - 54,200,426 (-)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1353,980,057 - 53,999,481 (-)NCBIHuRef
CHM1_11373,250,244 - 73,269,658 (-)NCBICHM1_1
T2T-CHM13v2.01371,929,913 - 71,949,154 (-)NCBIT2T-CHM13v2.0
Mzt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,271,980 - 99,283,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,271,980 - 99,283,570 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381499,034,544 - 99,046,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,034,544 - 99,046,134 (-)Ensemblmm10GRCm38
MGSCv371499,433,763 - 99,445,355 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361497,917,684 - 97,929,214 (-)NCBIMGSCv36mm8
Celera1497,708,854 - 97,714,991 (-)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.22NCBI
Mzt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,944,833 - 33,962,729 (+)Ensembl
ChiLan1.0NW_00495540433,945,576 - 33,961,922 (+)NCBIChiLan1.0ChiLan1.0
MZT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,288,827 - 74,307,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11372,880,043 - 72,899,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01353,937,689 - 53,956,954 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11372,713,799 - 72,733,057 (-)NCBIPanPan1.1PanPan1.1panPan2
MZT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,862,454 - 26,880,213 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,863,674 - 26,880,126 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2226,718,302 - 26,736,061 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02227,193,817 - 27,211,586 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,192,928 - 27,211,465 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,855,994 - 26,873,687 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,895,506 - 26,913,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02226,966,775 - 26,984,527 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mzt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,717,380 - 132,732,578 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365118,134,607 - 8,149,390 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365118,134,607 - 8,149,923 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MZT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1144,999,320 - 45,018,862 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11145,000,735 - 45,019,009 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,548,170 - 49,565,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MZT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1351,840,354 - 51,860,248 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl351,842,167 - 51,860,164 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660467,934,397 - 7,954,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mzt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,814,973 - 27,832,343 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475127,815,065 - 27,851,738 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mzt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11225,467,171 - 25,479,191 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mzt1
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000039400
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH127426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21575,787,384 - 75,787,629 (+)MAPPERmRatBN7.2
Rnor_6.01583,429,541 - 83,429,785NCBIRnor6.0
Rnor_5.01586,941,660 - 86,941,904UniSTSRnor5.0
RGSC_v3.41582,818,982 - 82,819,226UniSTSRGSC3.4
Celera1575,025,513 - 75,025,757UniSTS
RH 3.4 Map15517.4UniSTS
Cytogenetic Map15q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000039400   ⟹   ENSRNOP00000030357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1583,431,178 - 83,442,008 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095807   ⟹   ENSRNOP00000083391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1582,195,128 - 82,205,436 (-)Ensembl
mRatBN7.2 Ensembl1575,786,994 - 75,797,589 (-)Ensembl
RefSeq Acc Id: NM_001399557   ⟹   NP_001386486
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,195,128 - 82,205,436 (-)NCBI
mRatBN7.21575,787,281 - 75,797,589 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083391
  ENSRNOP00000083391.1
Ensembl Acc Id: ENSRNOP00000030357   ⟸   ENSRNOT00000039400
Ensembl Acc Id: ENSRNOP00000083391   ⟸   ENSRNOT00000095807
RefSeq Acc Id: NP_001386486   ⟸   NM_001399557
- UniProtKB: A0A8I5ZZ71 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4N1-F1-model_v2 AlphaFold D4A4N1 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699861
Promoter ID:EPDNEW_R10382
Type:initiation region
Name:Mzt1_1
Description:mitotic spindle organizing protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01583,442,055 - 83,442,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592140 AgrOrtholog
BioCyc Gene G2FUF-12790 BioCyc
Ensembl Genes ENSRNOG00000024813 Ensembl
  ENSRNOG00000068487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095807 ENTREZGENE
  ENSRNOT00000095807.2 UniProtKB/TrEMBL
InterPro MZT1 UniProtKB/TrEMBL
NCBI Gene 692032 ENTREZGENE
PANTHER MITOTIC-SPINDLE ORGANIZING PROTEIN 1 UniProtKB/TrEMBL
  PTHR28520 UniProtKB/TrEMBL
Pfam MOZART1 UniProtKB/TrEMBL
PhenoGen Mzt1 PhenoGen
RatGTEx ENSRNOG00000024813 RatGTEx
  ENSRNOG00000068487 RatGTEx
UniProt A0A8I5ZZ71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mzt1  mitotic spindle organizing protein 1  Mzt1  mitotic spindle organizing protein 1  Data merged from RGD:149736527 737654 PROVISIONAL
2021-08-09 Mzt1  mitotic spindle organizing protein 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2011-08-02 Mzt1  mitotic spindle organizing protein 1  LOC692032  hypothetical protein LOC692032  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC692032  hypothetical protein LOC692032      Symbol and Name status set to provisional 70820 PROVISIONAL