Pikfyve (phosphoinositide kinase, FYVE-type zinc finger containing) - Rat Genome Database

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Pathways
Gene: Pikfyve (phosphoinositide kinase, FYVE-type zinc finger containing) Rattus norvegicus
Analyze
Symbol: Pikfyve
Name: phosphoinositide kinase, FYVE-type zinc finger containing
RGD ID: 1592067
Description: Predicted to enable phosphatidylinositol kinase activity; protein serine/threonine kinase activity; and zinc ion binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; phosphatidylinositol metabolic process; and vesicle organization. Predicted to act upstream of or within myelin assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle and vesicle membrane. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; LOC316457; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; Pip5k3; similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,057,488 - 74,151,610 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl974,057,514 - 74,151,610 (+)EnsemblGRCr8
mRatBN7.2966,563,747 - 66,657,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)EnsemblmRatBN7.2
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)Ensemblrn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9858586   PMID:11112776   PMID:12477932   PMID:14551253   PMID:15046600   PMID:15546921   PMID:16448788   PMID:16954148   PMID:17556371   PMID:17909029   PMID:19056739   PMID:19841139  
PMID:20110679   PMID:22028665   PMID:23793062   PMID:25578879   PMID:26232680   PMID:32221306  


Genomics

Comparative Map Data
Pikfyve
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,057,488 - 74,151,610 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl974,057,514 - 74,151,610 (+)EnsemblGRCr8
mRatBN7.2966,563,747 - 66,657,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)EnsemblmRatBN7.2
Rnor_6.0971,911,744 - 72,005,816 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)Ensemblrn6Rnor6.0
Rnor_5.0970,566,016 - 70,660,374 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4963,798,743 - 63,890,905 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera963,959,029 - 64,052,994 (+)NCBICelera
Cytogenetic Map9q32NCBI
PIKFYVE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,266,056 - 208,358,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,266,234 - 208,358,755 (+)Ensemblhg38GRCh38
GRCh372209,130,979 - 209,223,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,839,236 - 208,931,720 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2202,898,915 - 202,991,410 (+)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2200,978,970 - 201,070,591 (+)NCBIHuRef
CHM1_12209,136,843 - 209,229,320 (+)NCBICHM1_1
T2T-CHM13v2.02208,744,537 - 208,838,556 (+)NCBIT2T-CHM13v2.0
Pikfyve
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,225,796 - 65,317,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,225,842 - 65,317,854 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)Ensemblmm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBIMGSCv36mm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map132.94NCBI
Pikfyve
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,748,534 - 6,842,489 (-)Ensembl
ChiLan1.0NW_0049554576,749,226 - 6,841,855 (-)NCBIChiLan1.0ChiLan1.0
PIKFYVE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,875,873 - 110,968,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,891,072 - 110,983,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,505,376 - 95,597,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,628,997 - 213,721,299 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,628,997 - 213,721,299 (+)EnsemblpanPan2panpan1.1
PIKFYVE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,537,095 - 16,620,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,541,562 - 16,619,554 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3717,419,766 - 17,503,074 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03716,472,780 - 16,556,108 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,472,913 - 16,554,451 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,416,782 - 16,500,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,390,154 - 16,473,467 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,399,401 - 16,482,715 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pikfyve
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,903,831 - 164,987,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936950242,522 - 320,078 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936950242,071 - 323,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIKFYVE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,372,173 - 111,467,899 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115111,372,148 - 111,468,720 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,893,751 - 122,991,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIKFYVE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,051,096 - 94,144,968 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1094,056,923 - 94,145,268 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040105,226,813 - 105,319,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pikfyve
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247657,681,875 - 7,790,704 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247657,684,770 - 7,806,381 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pikfyve
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14139,063,298 - 139,145,732 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pikfyve
688 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:45
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000020447, ENSRNOT00000058045
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Rat176  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8974,098,215 - 74,098,435 (+)Marker Load Pipeline
mRatBN7.2966,604,477 - 66,604,697 (+)MAPPERmRatBN7.2
Rnor_6.0971,952,431 - 71,952,650NCBIRnor6.0
Rnor_5.0970,619,305 - 70,619,524UniSTSRnor5.0
RGSC_v3.4963,839,862 - 63,840,081UniSTSRGSC3.4
RGSC_v3.4963,839,861 - 63,840,081RGDRGSC3.4
Celera963,999,670 - 63,999,889UniSTS
RGSC_v3.1963,986,843 - 63,987,063RGD
SHRSP x BN Map945.5498UniSTS
SHRSP x BN Map945.5498RGD
Cytogenetic Map9q32UniSTS
RH130569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,569,205 - 66,569,418 (+)MAPPERmRatBN7.2
Rnor_6.0971,917,194 - 71,917,406NCBIRnor6.0
Rnor_5.0970,654,670 - 70,654,882UniSTSRnor5.0
RGSC_v3.4963,804,093 - 63,804,305UniSTSRGSC3.4
Celera963,964,479 - 63,964,691UniSTS
RH 3.4 Map9580.1UniSTS
Cytogenetic Map9q32UniSTS
RH143099  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,564,203 - 66,564,380 (+)MAPPERmRatBN7.2
Rnor_6.0971,912,193 - 71,912,369NCBIRnor6.0
Rnor_5.0970,659,707 - 70,659,883UniSTSRnor5.0
RGSC_v3.4963,799,092 - 63,799,268UniSTSRGSC3.4
Celera963,959,478 - 63,959,654UniSTS
RH 3.4 Map9569.1UniSTS
Cytogenetic Map9q32UniSTS
AI179196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,612,624 - 66,612,783 (+)MAPPERmRatBN7.2
Rnor_6.0971,960,578 - 71,960,736NCBIRnor6.0
Rnor_5.0970,611,219 - 70,611,377UniSTSRnor5.0
RGSC_v3.4963,848,009 - 63,848,167UniSTSRGSC3.4
Celera964,007,817 - 64,007,975UniSTS
RH 3.4 Map9581.7UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020447   ⟹   ENSRNOP00000020447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl974,057,514 - 74,151,610 (+)Ensembl
mRatBN7.2 Ensembl966,563,778 - 66,657,868 (+)Ensembl
Rnor_6.0 Ensembl971,915,421 - 72,005,838 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100337   ⟹   ENSRNOP00000088892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl974,057,686 - 74,151,610 (+)Ensembl
mRatBN7.2 Ensembl966,563,727 - 66,657,868 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117064   ⟹   ENSRNOP00000078503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl974,057,514 - 74,151,610 (+)Ensembl
mRatBN7.2 Ensembl966,563,734 - 66,657,868 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117606   ⟹   ENSRNOP00000076715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl974,057,755 - 74,151,610 (+)Ensembl
mRatBN7.2 Ensembl966,564,088 - 66,657,868 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163654   ⟹   ENSRNOP00000099448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl974,057,755 - 74,151,610 (+)Ensembl
RefSeq Acc Id: NM_001427277   ⟹   NP_001414206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,514 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_006245071   ⟹   XP_006245133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245072   ⟹   XP_006245134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245073   ⟹   XP_006245135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245074   ⟹   XP_006245136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,540 - 74,151,610 (+)NCBI
mRatBN7.2966,563,780 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245076   ⟹   XP_006245138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
mRatBN7.2966,563,747 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245077   ⟹   XP_006245139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,509 - 74,151,610 (+)NCBI
mRatBN7.2966,563,748 - 66,657,873 (+)NCBI
Rnor_6.0971,911,744 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245079   ⟹   XP_006245141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
Rnor_6.0971,911,934 - 72,005,816 (+)NCBI
Rnor_5.0970,566,016 - 70,660,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084595   ⟹   XP_038940523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,547 - 74,151,610 (+)NCBI
mRatBN7.2966,563,795 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_039084596   ⟹   XP_038940524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
mRatBN7.2966,563,945 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_039084597   ⟹   XP_038940525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,112,229 - 74,151,610 (+)NCBI
mRatBN7.2966,618,084 - 66,657,873 (+)NCBI
RefSeq Acc Id: XM_063267219   ⟹   XP_063123289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267220   ⟹   XP_063123290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267221   ⟹   XP_063123291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267222   ⟹   XP_063123292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,488 - 74,151,610 (+)NCBI
RefSeq Acc Id: XM_063267223   ⟹   XP_063123293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,128,204 (+)NCBI
RefSeq Acc Id: XM_063267224   ⟹   XP_063123294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,092,015 (+)NCBI
RefSeq Acc Id: XM_063267225   ⟹   XP_063123295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8974,057,872 - 74,092,015 (+)NCBI
RefSeq Acc Id: XP_006245138   ⟸   XM_006245076
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245139   ⟸   XM_006245077
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245136   ⟸   XM_006245074
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245135   ⟸   XM_006245073
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245141   ⟸   XM_006245079
- Peptide Label: isoform X8
- UniProtKB: A6IPK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245134   ⟸   XM_006245072
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245133   ⟸   XM_006245071
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YBG1 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020447   ⟸   ENSRNOT00000020447
RefSeq Acc Id: XP_038940523   ⟸   XM_039084595
- Peptide Label: isoform X4
- UniProtKB: D3ZYT8 (UniProtKB/TrEMBL),   A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940524   ⟸   XM_039084596
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940525   ⟸   XM_039084597
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000076715   ⟸   ENSRNOT00000117606
Ensembl Acc Id: ENSRNOP00000088892   ⟸   ENSRNOT00000100337
Ensembl Acc Id: ENSRNOP00000078503   ⟸   ENSRNOT00000117064
RefSeq Acc Id: XP_063123289   ⟸   XM_063267219
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123290   ⟸   XM_063267220
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123292   ⟸   XM_063267222
- Peptide Label: isoform X10
- UniProtKB: A6IPK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414206   ⟸   NM_001427277
- UniProtKB: A0A8I5ZL06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123291   ⟸   XM_063267221
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AAS9 (UniProtKB/TrEMBL),   A6IPK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123293   ⟸   XM_063267223
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063123294   ⟸   XM_063267224
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063123295   ⟸   XM_063267225
- Peptide Label: isoform X14
Ensembl Acc Id: ENSRNOP00000099448   ⟸   ENSRNOT00000163654
Protein Domains
DEP   FYVE-type   PIPK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYT8-F1-model_v2 AlphaFold D3ZYT8 1-2109 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592067 AgrOrtholog
BioCyc Gene G2FUF-27299 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000015158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020447 ENTREZGENE
  ENSRNOT00000020447.10 UniProtKB/TrEMBL
  ENSRNOT00000100337 ENTREZGENE
  ENSRNOT00000100337.2 UniProtKB/TrEMBL
  ENSRNOT00000117064 ENTREZGENE
  ENSRNOT00000117064.2 UniProtKB/TrEMBL
  ENSRNOT00000117606 ENTREZGENE
  ENSRNOT00000117606.2 UniProtKB/TrEMBL
  ENSRNOT00000163654 ENTREZGENE
  ENSRNOT00000163654.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2-Layer Sandwich UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.800.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Cpn60/TCP-1 UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  GroEL-like_apical_dom UniProtKB/TrEMBL
  PIKfyve UniProtKB/TrEMBL
  PIKfyve_DEP UniProtKB/TrEMBL
  PIKfyve_PIPKc UniProtKB/TrEMBL
  PInositol-4-P-4/5-kinase_C_sf UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/TrEMBL
  TCP-1-like_intermed UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 316457 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE UniProtKB/TrEMBL
  PTHR46715 UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  PIP5K UniProtKB/TrEMBL
PhenoGen Pikfyve PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  PIPK UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015158 RatGTEx
SMART DEP UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  PIPKc UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SAICAR synthase-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt A0A8I5YBG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAS9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEC2_RAT UniProtKB/TrEMBL
  A6IPK0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYT8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Pikfyve  phosphoinositide kinase, FYVE-type zinc finger containing  Pikfyve  phosphoinositide kinase, FYVE finger containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pikfyve  phosphoinositide kinase, FYVE finger containing  Pip5k3  phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Pip5k3  phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III  LOC316457  similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC316457  similar to phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL