Phldb2 (pleckstrin homology-like domain, family B, member 2) - Rat Genome Database

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Gene: Phldb2 (pleckstrin homology-like domain, family B, member 2) Rattus norvegicus
Analyze
Symbol: Phldb2
Name: pleckstrin homology-like domain, family B, member 2
RGD ID: 1591402
Description: Predicted to be involved in several processes, including basement membrane organization; negative regulation of cellular component organization; and negative regulation of wound healing, spreading of epidermal cells. Predicted to be located in several cellular components, including cell leading edge; focal adhesion; and podosome. Predicted to be active in basal cortex. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC685611; NEWGENE_1591402; pleckstrin homology like domain family B member 2; pleckstrin homology-like domain family B member 2; similar to pleckstrin homology-like domain, family B, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,321,738 - 68,540,724 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1168,355,959 - 68,540,734 (+)EnsemblGRCr8
mRatBN7.21154,859,173 - 55,078,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,859,135 - 55,078,467 (+)EnsemblmRatBN7.2
Rnor_6.01160,042,879 - 60,051,229 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1157,265,732 - 57,481,589 (+)Ensemblrn6Rnor6.0
Rnor_5.01160,429,481 - 60,646,262 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,484,223 - 56,564,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,388,307 - 54,601,451 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
naled  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basal cortex  (IBA,IEA,ISO)
cell cortex  (IEA,ISO)
cell leading edge  (IEA,ISO)
cytosol  (IEA,ISO)
focal adhesion  (IEA,ISO)
plasma membrane  (IEA,ISO)
podosome  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23940118   PMID:24859005   PMID:25468996  


Genomics

Comparative Map Data
Phldb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,321,738 - 68,540,724 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1168,355,959 - 68,540,734 (+)EnsemblGRCr8
mRatBN7.21154,859,173 - 55,078,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,859,135 - 55,078,467 (+)EnsemblmRatBN7.2
Rnor_6.01160,042,879 - 60,051,229 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1157,265,732 - 57,481,589 (+)Ensemblrn6Rnor6.0
Rnor_5.01160,429,481 - 60,646,262 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,484,223 - 56,564,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,388,307 - 54,601,451 (+)NCBICelera
Cytogenetic Map11q21NCBI
PHLDB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383111,732,496 - 111,976,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3111,732,403 - 111,976,837 (+)Ensemblhg38GRCh38
GRCh373111,451,343 - 111,695,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,085,500 - 113,177,826 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343113,085,499 - 113,177,809NCBI
Celera3109,851,286 - 110,094,444 (+)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3108,826,722 - 109,070,708 (+)NCBIHuRef
CHM1_13111,415,675 - 111,659,409 (+)NCBICHM1_1
T2T-CHM13v2.03114,453,343 - 114,697,610 (+)NCBIT2T-CHM13v2.0
Phldb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391645,566,593 - 45,773,961 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1645,566,606 - 45,773,961 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381645,746,230 - 45,953,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,746,243 - 45,953,598 (-)Ensemblmm10GRCm38
MGSCv371645,746,346 - 45,844,491 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361645,665,575 - 45,763,715 (-)NCBIMGSCv36mm8
Celera1646,122,635 - 46,220,830 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.08NCBI
Phldb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542712,273,062 - 12,388,217 (+)Ensembl
ChiLan1.0NW_00495542712,284,100 - 12,385,755 (+)NCBIChiLan1.0ChiLan1.0
PHLDB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22109,844,347 - 109,975,856 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13109,849,118 - 109,980,637 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03108,878,798 - 109,120,501 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13115,803,869 - 116,044,586 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3115,745,634 - 116,044,586 (+)EnsemblpanPan2panpan1.1
PHLDB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13316,521,087 - 16,615,774 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3316,497,202 - 16,614,132 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3316,500,237 - 16,717,632 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03316,635,502 - 16,853,682 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3316,737,741 - 16,853,566 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13316,446,434 - 16,663,884 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03316,492,184 - 16,707,808 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,037,057 - 17,254,141 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phldb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,792,508 - 137,991,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936834592,584 - 793,386 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936834592,688 - 791,533 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLDB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,778,370 - 147,879,794 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113147,778,420 - 148,025,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PHLDB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,821,958 - 69,059,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2268,821,742 - 69,059,087 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604197,417,840 - 97,653,649 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phldb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473136,593,871 - 36,872,200 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473136,596,812 - 36,871,963 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Phldb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1430,469,268 - 30,566,278 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Phldb2
1337 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:80
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000034097, ENSRNOT00000042754
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH143382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,033,616 - 55,033,794 (+)MAPPERmRatBN7.2
Rnor_6.01157,438,982 - 57,439,159NCBIRnor6.0
Rnor_5.01160,601,717 - 60,601,894UniSTSRnor5.0
RGSC_v3.41156,521,549 - 56,521,726UniSTSRGSC3.4
Celera1154,559,131 - 54,559,308UniSTS
RH 3.4 Map11714.0UniSTS
Cytogenetic Map11q21UniSTS
RH141831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,076,683 - 55,076,888 (+)MAPPERmRatBN7.2
Rnor_6.01157,481,709 - 57,481,913NCBIRnor6.0
Rnor_6.01160,049,780 - 60,049,984NCBIRnor6.0
Rnor_5.01160,644,477 - 60,644,681UniSTSRnor5.0
RGSC_v3.41156,564,101 - 56,564,305UniSTSRGSC3.4
RH 3.4 Map4622.53UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 29 59 6 293 129 11 137 81 92 31 14 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034097   ⟹   ENSRNOP00000038800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,766 - 68,540,733 (+)Ensembl
mRatBN7.2 Ensembl1154,998,343 - 55,077,164 (+)Ensembl
Rnor_6.0 Ensembl1157,404,196 - 57,481,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000042754   ⟹   ENSRNOP00000049406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,742 - 68,539,731 (+)Ensembl
mRatBN7.2 Ensembl1154,981,191 - 55,077,164 (+)Ensembl
Rnor_6.0 Ensembl1157,404,196 - 57,481,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086178   ⟹   ENSRNOP00000077973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,766 - 68,540,733 (+)Ensembl
mRatBN7.2 Ensembl1154,981,197 - 55,078,467 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093174   ⟹   ENSRNOP00000076223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,355,959 - 68,540,733 (+)Ensembl
mRatBN7.2 Ensembl1154,859,135 - 55,078,464 (+)Ensembl
Rnor_6.0 Ensembl1157,265,732 - 57,405,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093201   ⟹   ENSRNOP00000076159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,766 - 68,540,733 (+)Ensembl
mRatBN7.2 Ensembl1154,981,197 - 55,078,467 (+)Ensembl
Rnor_6.0 Ensembl1157,430,166 - 57,481,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114570   ⟹   ENSRNOP00000097614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,762 - 68,540,734 (+)Ensembl
mRatBN7.2 Ensembl1154,981,191 - 55,078,126 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131917   ⟹   ENSRNOP00000102982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1168,443,766 - 68,540,733 (+)Ensembl
RefSeq Acc Id: XM_039088877   ⟹   XP_038944805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,173 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088878   ⟹   XP_038944806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,443,775 - 68,540,724 (+)NCBI
mRatBN7.21154,981,160 - 55,078,191 (+)NCBI
RefSeq Acc Id: XM_039088879   ⟹   XP_038944807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088880   ⟹   XP_038944808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088882   ⟹   XP_038944810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088883   ⟹   XP_038944811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088884   ⟹   XP_038944812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088885   ⟹   XP_038944813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088888   ⟹   XP_038944816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,174 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_039088889   ⟹   XP_038944817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
mRatBN7.21154,859,175 - 55,078,212 (+)NCBI
RefSeq Acc Id: XM_063270856   ⟹   XP_063126926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
RefSeq Acc Id: XM_063270857   ⟹   XP_063126927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
RefSeq Acc Id: XM_063270858   ⟹   XP_063126928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,443,466 - 68,540,724 (+)NCBI
RefSeq Acc Id: XM_063270859   ⟹   XP_063126929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
RefSeq Acc Id: XM_063270860   ⟹   XP_063126930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
RefSeq Acc Id: XM_063270861   ⟹   XP_063126931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,321,738 - 68,540,724 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419426 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419427 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419428 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419429 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419430 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419431 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419432 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944805 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944806 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944807 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944808 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944810 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944811 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944812 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944813 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944817 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126926 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126927 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126928 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126929 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126930 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038800.8
  ENSRNOP00000049406.7
  ENSRNOP00000076159.3
  ENSRNOP00000076223
  ENSRNOP00000076223.2
  ENSRNOP00000077973
  ENSRNOP00000077973.2
  ENSRNOP00000097614
  ENSRNOP00000097614.2
  ENSRNOP00000102982
  ENSRNOP00000102982.1
Ensembl Acc Id: ENSRNOP00000038800   ⟸   ENSRNOT00000034097
Ensembl Acc Id: ENSRNOP00000076223   ⟸   ENSRNOT00000093174
Ensembl Acc Id: ENSRNOP00000076159   ⟸   ENSRNOT00000093201
Ensembl Acc Id: ENSRNOP00000049406   ⟸   ENSRNOT00000042754
RefSeq Acc Id: XP_038944805   ⟸   XM_039088877
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y6J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944807   ⟸   XM_039088879
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944808   ⟸   XM_039088880
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944810   ⟸   XM_039088882
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944811   ⟸   XM_039088883
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944812   ⟸   XM_039088884
- Peptide Label: isoform X8
- UniProtKB: D3ZTL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944816   ⟸   XM_039088888
- Peptide Label: isoform X13
- UniProtKB: D3ZTL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944813   ⟸   XM_039088885
- Peptide Label: isoform X9
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944817   ⟸   XM_039088889
- Peptide Label: isoform X15
- UniProtKB: D3ZTL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944806   ⟸   XM_039088878
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y6J7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097614   ⟸   ENSRNOT00000114570
Ensembl Acc Id: ENSRNOP00000077973   ⟸   ENSRNOT00000086178
RefSeq Acc Id: XP_063126927   ⟸   XM_063270857
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063126926   ⟸   XM_063270856
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126929   ⟸   XM_063270859
- Peptide Label: isoform X12
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126930   ⟸   XM_063270860
- Peptide Label: isoform X14
- UniProtKB: A0A8I6GM52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126931   ⟸   XM_063270861
- Peptide Label: isoform X16
- UniProtKB: D3ZTL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126928   ⟸   XM_063270858
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000102982   ⟸   ENSRNOT00000131917
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A779-F1-model_v2 AlphaFold D4A779 1-1304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591402 AgrOrtholog
BioCyc Gene G2FUF-21391 BioCyc
Ensembl Genes ENSRNOG00000002171 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034097.9 UniProtKB/TrEMBL
  ENSRNOT00000042754.7 UniProtKB/TrEMBL
  ENSRNOT00000086178 ENTREZGENE
  ENSRNOT00000086178.3 UniProtKB/TrEMBL
  ENSRNOT00000093174 ENTREZGENE
  ENSRNOT00000093174.3 UniProtKB/TrEMBL
  ENSRNOT00000093201.3 UniProtKB/TrEMBL
  ENSRNOT00000114570 ENTREZGENE
  ENSRNOT00000114570.2 UniProtKB/TrEMBL
  ENSRNOT00000131917 ENTREZGENE
  ENSRNOT00000131917.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH-like_domain UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PHLDB1/2/3_PH UniProtKB/TrEMBL
NCBI Gene 685611 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PhenoGen Phldb2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002171 RatGTEx
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A1W2Q667 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y6J7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM52 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LE48_RAT UniProtKB/TrEMBL
  D3ZTL3 ENTREZGENE, UniProtKB/TrEMBL
  D4A779_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Phldb2  pleckstrin homology-like domain, family B, member 2  NEWGENE_1591402  pleckstrin homology like domain family B member 2  Data merged from RGD:11480351 737654 PROVISIONAL
2016-08-02 NEWGENE_1591402  pleckstrin homology like domain family B member 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Phldb2  pleckstrin homology-like domain, family B, member 2  LOC360713  similar to pleckstrin homology-like domain, family B, member 2  Data merged from RGD:1590884 1643240 APPROVED
2008-03-05 Phldb2  pleckstrin homology-like domain, family B, member 2  LOC685611  similar to pleckstrin homology-like domain, family B, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685611  similar to pleckstrin homology-like domain, family B, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC360713  similar to pleckstrin homology-like domain, family B, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL