Fam124b (family with sequence similarity 124 member B) - Rat Genome Database

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Gene: Fam124b (family with sequence similarity 124 member B) Rattus norvegicus
Analyze
Symbol: Fam124b
Name: family with sequence similarity 124 member B
RGD ID: 1589866
Description: Predicted to be located in mitochondrion. Predicted to be active in nucleoplasm. Orthologous to human FAM124B (family with sequence similarity 124 member B); INTERACTS WITH bisphenol A; Cuprizon; titanium dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: family with sequence similarity 124B; hypothetical protein LOC690912; LOC690912; NEWGENE_1589866
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,961,377 - 88,981,976 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,961,377 - 88,981,976 (-)EnsemblGRCr8
mRatBN7.2981,513,018 - 81,533,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,515,399 - 81,533,341 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,942,959 - 89,963,576 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,071,852 - 95,092,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,454,372 - 93,474,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,967,784 - 85,986,283 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,968,059 - 85,986,208 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl990,787,787 - 90,806,126 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,717,672 - 85,736,427 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0990,528,050 - 90,546,943 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,496,861 - 79,542,840 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,993,260 - 79,011,898 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Fam124b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,961,377 - 88,981,976 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl988,961,377 - 88,981,976 (-)EnsemblGRCr8
mRatBN7.2981,513,018 - 81,533,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,515,399 - 81,533,341 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx989,942,959 - 89,963,576 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,071,852 - 95,092,466 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,454,372 - 93,474,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,967,784 - 85,986,283 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,968,059 - 85,986,208 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl990,787,787 - 90,806,126 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,717,672 - 85,736,427 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0990,528,050 - 90,546,943 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,496,861 - 79,542,840 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera978,993,260 - 79,011,898 (-)NCBICelera
Cytogenetic Map9q34NCBI
FAM124B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,378,698 - 224,402,107 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,376,821 - 224,402,107 (-)Ensemblhg38GRCh38
GRCh372225,243,415 - 225,266,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,951,659 - 224,974,955 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2219,009,190 - 219,032,486 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,095,545 - 217,119,523 (-)NCBIHuRef
CHM1_12225,250,082 - 225,273,370 (-)NCBICHM1_1
T2T-CHM13v2.02224,861,847 - 224,885,253 (-)NCBIT2T-CHM13v2.0
Fam124b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,176,416 - 80,192,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,176,423 - 80,196,190 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38180,198,699 - 80,214,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,198,706 - 80,218,473 (-)Ensemblmm10GRCm38
MGSCv37180,195,274 - 80,210,519 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36180,077,730 - 80,092,968 (-)NCBIMGSCv36mm8
MGSCv36181,068,921 - 81,084,159 (-)NCBIMGSCv36mm8
Cytogenetic Map1C5NCBI
cM Map141.19NCBI
Fam124b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,675,179 - 9,696,022 (+)Ensembl
ChiLan1.0NW_0049554539,675,671 - 9,698,266 (+)NCBIChiLan1.0ChiLan1.0
FAM124B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213126,993,929 - 127,017,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,008,898 - 127,032,380 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,620,077 - 111,643,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,194,747 - 230,218,064 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,194,747 - 230,218,518 (-)EnsemblpanPan2panpan1.1
FAM124B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,657,369 - 37,677,682 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2538,262,444 - 38,284,810 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,893,534 - 37,912,140 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,893,687 - 37,911,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,834,431 - 37,853,077 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,675,048 - 37,693,673 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,849,765 - 37,868,388 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam124b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,638,605 - 179,661,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,981,558 - 6,003,968 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365695,981,532 - 6,003,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM124B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,112,448 - 126,127,547 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115126,112,445 - 126,127,658 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,543,747 - 139,557,613 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM124B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,328,049 - 110,355,647 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,325,884 - 110,351,541 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604089,062,566 - 89,086,414 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam124b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823916,380 - 937,979 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624823916,144 - 937,952 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam124b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14153,226,260 - 153,242,252 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fam124b
184 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000072054, ENSRNOT00000073128
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 6 57 106 46 51 16 28 16 12 216 120 11 74 61 80 35 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000072054   ⟹   ENSRNOP00000065080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl990,787,787 - 90,806,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073128   ⟹   ENSRNOP00000067143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,961,377 - 88,981,976 (-)Ensembl
mRatBN7.2 Ensembl981,515,399 - 81,533,341 (-)Ensembl
Rnor_6.0 Ensembl985,968,059 - 85,986,208 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127510   ⟹   ENSRNOP00000105720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl988,961,377 - 88,981,895 (-)Ensembl
RefSeq Acc Id: NM_001401942   ⟹   NP_001388871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,961,377 - 88,981,976 (-)NCBI
mRatBN7.2981,513,018 - 81,533,621 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388871 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75492 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067143
  ENSRNOP00000067143.1
  ENSRNOP00000105720.1
Ensembl Acc Id: ENSRNOP00000067143   ⟸   ENSRNOT00000073128
Ensembl Acc Id: ENSRNOP00000065080   ⟸   ENSRNOT00000072054
RefSeq Acc Id: NP_001388871   ⟸   NM_001401942
- UniProtKB: A6JW84 (UniProtKB/TrEMBL),   D4ACJ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105720   ⟸   ENSRNOT00000127510
Protein Domains
FAM124

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACJ9-F1-model_v2 AlphaFold D4ACJ9 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589866 AgrOrtholog
Ensembl Genes ENSRNOG00000054416 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000058883 Ensembl
Ensembl Transcript ENSRNOT00000073128 ENTREZGENE
  ENSRNOT00000073128.4 UniProtKB/TrEMBL
  ENSRNOT00000127510.1 UniProtKB/TrEMBL
InterPro FAM124 UniProtKB/TrEMBL
  FAM124_dom UniProtKB/TrEMBL
NCBI Gene Fam124b ENTREZGENE
PANTHER PROTEIN FAM124B UniProtKB/TrEMBL
  PTHR14715 UniProtKB/TrEMBL
Pfam FAM124 UniProtKB/TrEMBL
PhenoGen Fam124b PhenoGen
RatGTEx ENSRNOG00000054416 RatGTEx
  ENSRNOG00000058883 RatGTEx
UniProt A0ABK0LLA9_RAT UniProtKB/TrEMBL
  A6JW84 ENTREZGENE, UniProtKB/TrEMBL
  D4ACJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fam124b  family with sequence similarity 124 member B  NEWGENE_1589866  family with sequence similarity 124B  Data merged from RGD:9095683 737654 PROVISIONAL
2015-11-12 Fam124b  family with sequence similarity 124 member B  Fam124b  family with sequence similarity 124B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 NEWGENE_1589866  family with sequence similarity 124B      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Fam124b  family with sequence similarity 124B  LOC690912  hypothetical protein LOC690912  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690912  hypothetical protein LOC690912  LOC682221  hypothetical protein LOC682221  Data merged from RGD:1585768 1643240 APPROVED
2006-11-20 LOC690912  hypothetical protein LOC690912      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682221  hypothetical protein LOC682221      Symbol and Name status set to provisional 70820 PROVISIONAL