Ppa1 (inorganic pyrophosphatase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ppa1 (inorganic pyrophosphatase 1) Rattus norvegicus
Analyze
Symbol: Ppa1
Name: inorganic pyrophosphatase 1
RGD ID: 1589773
Description: Predicted to enable inorganic diphosphate phosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Orthologous to human PPA1 (inorganic pyrophosphatase 1); PARTICIPATES IN oxidative phosphorylation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inorganic pyrophosphatase; Pp; Pyp; Pyp_mapped; pyrophosphatase; pyrophosphatase (inorganic) 1; pyrophosphatase (mapped); pyrophosphatase 1; Pyrophosphatase, inorganic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,132,088 - 30,160,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,133,504 - 30,160,489 (+)EnsemblGRCr8
mRatBN7.22029,590,733 - 29,617,711 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,590,707 - 29,619,215 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,601,761 - 30,628,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,992,971 - 30,019,903 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,735,457 - 30,762,391 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,265,519 - 31,292,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,265,483 - 31,310,674 (+)Ensemblrn6Rnor6.0
Rnor_5.02033,048,139 - 33,089,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42029,015,647 - 29,042,399 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2031,018,425 - 31,045,357 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bufalin  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
microcystin RR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
Pyridostigmine bromide  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium phosphate  (ISO)
sulforaphane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:656444   PMID:1914521   PMID:4130389   PMID:12477932   PMID:17415680   PMID:17933215   PMID:20458337   PMID:23376485  


Genomics

Comparative Map Data
Ppa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,132,088 - 30,160,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,133,504 - 30,160,489 (+)EnsemblGRCr8
mRatBN7.22029,590,733 - 29,617,711 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,590,707 - 29,619,215 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,601,761 - 30,628,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,992,971 - 30,019,903 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,735,457 - 30,762,391 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,265,519 - 31,292,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,265,483 - 31,310,674 (+)Ensemblrn6Rnor6.0
Rnor_5.02033,048,139 - 33,089,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42029,015,647 - 29,042,399 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2031,018,425 - 31,045,357 (+)NCBICelera
Cytogenetic Map20q11NCBI
PPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,202,835 - 70,233,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,202,831 - 70,233,911 (-)Ensemblhg38GRCh38
GRCh371071,962,591 - 71,993,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,632,592 - 71,663,196 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341071,632,591 - 71,663,177NCBI
Celera1065,241,716 - 65,272,852 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1065,955,053 - 65,986,358 (-)NCBIHuRef
CHM1_11072,244,637 - 72,275,007 (-)NCBICHM1_1
T2T-CHM13v2.01071,071,720 - 71,102,270 (-)NCBIT2T-CHM13v2.0
Ppa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,484,400 - 61,509,944 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,484,331 - 61,509,947 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381061,648,621 - 61,674,165 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,648,552 - 61,674,168 (+)Ensemblmm10GRCm38
MGSCv371061,111,369 - 61,136,913 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361061,043,978 - 61,069,522 (+)NCBIMGSCv36mm8
Celera1062,750,078 - 62,775,671 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.25NCBI
Ppa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,027,518 - 21,057,612 (+)Ensembl
ChiLan1.0NW_00495543721,027,516 - 21,057,712 (+)NCBIChiLan1.0ChiLan1.0
PPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,356,853 - 82,387,261 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,362,174 - 82,392,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,677,005 - 66,707,345 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,205,263 - 69,235,475 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,205,263 - 69,235,475 (-)EnsemblpanPan2panpan1.1
PPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,145,547 - 21,189,985 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,145,547 - 21,182,748 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha421,278,096 - 21,314,338 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0421,421,370 - 21,457,344 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,421,370 - 21,457,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,318,886 - 21,354,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,524,023 - 21,560,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,874,985 - 21,911,180 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,893,600 - 59,898,451 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,377,198 - 8,401,324 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,386,325 - 8,391,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,132,375 - 73,167,689 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11473,132,368 - 73,167,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,052,544 - 79,087,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,071,315 - 61,101,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604821,810,884 - 21,840,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,348,288 - 4,379,649 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247544,348,278 - 4,379,643 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11827,470,238 - 27,493,500 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppa1
173 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:167
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000000674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH129670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,617,421 - 29,617,617 (+)MAPPERmRatBN7.2
mRatBN7.22029,617,421 - 29,619,121 (+)MAPPERmRatBN7.2
Rnor_6.02031,292,162 - 31,293,861NCBIRnor6.0
Rnor_6.02031,292,162 - 31,292,357NCBIRnor6.0
Rnor_5.02033,089,636 - 33,089,832NCBIRnor5.0
Rnor_5.02033,089,636 - 33,091,336NCBIRnor5.0
RGSC_v3.42029,042,110 - 29,043,809UniSTSRGSC3.4
RGSC_v3.42029,042,110 - 29,042,305UniSTSRGSC3.4
Celera2031,045,068 - 31,045,263UniSTS
Celera2031,045,068 - 31,046,767UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 24 83 34 30 18 73 18 6 196 119 11 70 46 51 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000673   ⟹   ENSRNOP00000000673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,166,334 - 30,178,710 (+)Ensembl
mRatBN7.2 Ensembl2029,623,553 - 29,635,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000000674   ⟹   ENSRNOP00000000674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,133,504 - 30,160,488 (+)Ensembl
mRatBN7.2 Ensembl2029,590,800 - 29,617,695 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079584   ⟹   ENSRNOP00000069053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,590,763 - 29,619,169 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096267   ⟹   ENSRNOP00000086305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,595,978 - 29,619,215 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099561   ⟹   ENSRNOP00000097301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,623,564 - 29,635,926 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107042   ⟹   ENSRNOP00000091904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,133,508 - 30,160,489 (+)Ensembl
mRatBN7.2 Ensembl2029,590,707 - 29,617,684 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107711   ⟹   ENSRNOP00000092973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,133,572 - 30,157,484 (+)Ensembl
mRatBN7.2 Ensembl2029,590,707 - 29,614,703 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117131   ⟹   ENSRNOP00000078264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,590,787 - 29,617,705 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119581   ⟹   ENSRNOP00000081890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,166,364 - 30,178,710 (+)Ensembl
mRatBN7.2 Ensembl2029,623,618 - 29,635,806 (+)Ensembl
RefSeq Acc Id: NM_001100834   ⟹   NP_001094304
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,133,560 - 30,160,492 (+)NCBI
mRatBN7.22029,590,774 - 29,617,711 (+)NCBI
Rnor_6.02031,265,519 - 31,292,451 (+)NCBI
Rnor_5.02033,048,139 - 33,089,926 (+)NCBI
RGSC_v3.42029,015,647 - 29,042,399 (+)RGD
Celera2031,018,425 - 31,045,357 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098610   ⟹   XP_038954538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,133,508 - 30,160,492 (+)NCBI
mRatBN7.22029,590,733 - 29,617,711 (+)NCBI
RefSeq Acc Id: XM_063279069   ⟹   XP_063135139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,133,483 - 30,158,631 (+)NCBI
RefSeq Acc Id: XM_063279070   ⟹   XP_063135140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,132,088 - 30,160,492 (+)NCBI
RefSeq Acc Id: XM_063279071   ⟹   XP_063135141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,140,279 - 30,160,492 (+)NCBI
RefSeq Acc Id: NP_001094304   ⟸   NM_001100834
- UniProtKB: F7EPH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038954538   ⟸   XM_039098610
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUD2 (UniProtKB/TrEMBL),   F7EPH4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078264   ⟸   ENSRNOT00000117131
Ensembl Acc Id: ENSRNOP00000086305   ⟸   ENSRNOT00000096267
Ensembl Acc Id: ENSRNOP00000091904   ⟸   ENSRNOT00000107042
Ensembl Acc Id: ENSRNOP00000092973   ⟸   ENSRNOT00000107711
Ensembl Acc Id: ENSRNOP00000000674   ⟸   ENSRNOT00000000674
Ensembl Acc Id: ENSRNOP00000069053   ⟸   ENSRNOT00000079584
Ensembl Acc Id: ENSRNOP00000081890   ⟸   ENSRNOT00000119581
Ensembl Acc Id: ENSRNOP00000000673   ⟸   ENSRNOT00000000673
Ensembl Acc Id: ENSRNOP00000097301   ⟸   ENSRNOT00000099561
RefSeq Acc Id: XP_063135140   ⟸   XM_063279070
- Peptide Label: isoform X3
- UniProtKB: F7EPH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135139   ⟸   XM_063279069
- Peptide Label: isoform X2
- UniProtKB: F7EPH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135141   ⟸   XM_063279071
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GET1 (UniProtKB/TrEMBL),   F7EPH4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUD2-F1-model_v2 AlphaFold A0A0G2JUD2 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701605
Promoter ID:EPDNEW_R12129
Type:initiation region
Name:Ppa1_1
Description:pyrophosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12130  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02031,265,531 - 31,265,591EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589773 AgrOrtholog
BioCyc Gene G2FUF-3717 BioCyc
Ensembl Genes ENSRNOG00000000557 Ensembl
  ENSRNOG00000063854 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000674 ENTREZGENE
  ENSRNOT00000000674.8 UniProtKB/TrEMBL
  ENSRNOT00000107042 ENTREZGENE
  ENSRNOT00000107042.2 UniProtKB/TrEMBL
  ENSRNOT00000107711.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.80.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7935440 IMAGE-MGC_LOAD
InterPro Pyrophosphatase UniProtKB/TrEMBL
  Pyrophosphatase_sf UniProtKB/TrEMBL
KEGG Report rno:294504 UniProtKB/TrEMBL
MGC_CLONE MGC:124712 IMAGE-MGC_LOAD
NCBI Gene 294504 ENTREZGENE
PANTHER Pyrophosphatase UniProtKB/TrEMBL
Pfam Pyrophosphatase UniProtKB/TrEMBL
PhenoGen Ppa1 PhenoGen
PROSITE PPASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000557 RatGTEx
  ENSRNOG00000063854 RatGTEx
Superfamily-SCOP Pyrophosphatase UniProtKB/TrEMBL
UniProt A0A0G2JUD2 ENTREZGENE
  A0A8I6AI23_RAT UniProtKB/TrEMBL
  A0A8I6GET1 ENTREZGENE
  A0A8I6GJY5_RAT UniProtKB/TrEMBL
  A6K403_RAT UniProtKB/TrEMBL
  A6K404_RAT UniProtKB/TrEMBL
  F7EPH4 ENTREZGENE, UniProtKB/TrEMBL
  Q499R7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-09 Ppa1  inorganic pyrophosphatase 1  Ppa1  pyrophosphatase (inorganic) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ppa1  pyrophosphatase (inorganic) 1  Pyp  pyrophosphatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   pyrophosphatase  Pyp  pyrophosphatase (mapped)  Name updated 737654 APPROVED
2007-04-11 Pyp  pyrophosphatase (mapped)  Pyp_mapped  pyrophosphatase (mapped)  Data merged from RGD:3368 737654 APPROVED
2006-11-20 Pyp  pyrophosphatase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Pyp_mapped  pyrophosphatase (mapped)  Pp  pyrophosphatase  Symbol and Name updated 1556543 APPROVED
2003-04-09 Pp  pyrophosphatase    Pyrophosphatase, inorganic  Name updated 629478 APPROVED
2002-06-10 Pp  Pyrophosphatase, inorganic      Symbol and Name status set to approved 70586 APPROVED