Acer1 (alkaline ceramidase 1) - Rat Genome Database

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Gene: Acer1 (alkaline ceramidase 1) Rattus norvegicus
Analyze
Symbol: Acer1
Name: alkaline ceramidase 1
RGD ID: 1588582
Description: Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in several processes, including keratinocyte differentiation; response to alkaline pH; and sphingolipid metabolic process. Predicted to act upstream of or within regulation of lipid metabolic process and sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human ACER1 (alkaline ceramidase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Asah3; LOC301118; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; similar to N-acylsphingosine amidohydrolase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,881,361 - 1,911,439 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,881,361 - 1,919,416 (-)EnsemblGRCr8
mRatBN7.291,794,340 - 1,824,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,793,139 - 1,824,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,228,390 - 2,258,319 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,577,751 - 7,607,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,533,609 - 6,563,538 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,061,978 - 10,093,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,061,978 - 10,093,588 (+)Ensemblrn6Rnor6.0
Rnor_5.099,062,245 - 9,093,541 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,692,746 - 6,724,451 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12783875   PMID:16477081   PMID:17713573   PMID:20207939   PMID:20628055   PMID:27126290   PMID:29056331  


Genomics

Comparative Map Data
Acer1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,881,361 - 1,911,439 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,881,361 - 1,919,416 (-)EnsemblGRCr8
mRatBN7.291,794,340 - 1,824,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,793,139 - 1,824,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,228,390 - 2,258,319 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,577,751 - 7,607,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,533,609 - 6,563,538 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,061,978 - 10,093,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,061,978 - 10,093,588 (+)Ensemblrn6Rnor6.0
Rnor_5.099,062,245 - 9,093,541 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,692,746 - 6,724,451 (+)NCBICelera
Cytogenetic Map9q11NCBI
ACER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,306,142 - 6,360,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,306,142 - 6,333,612 (-)Ensemblhg38GRCh38
GRCh37196,306,153 - 6,333,623 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,257,725 - 6,284,562 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,257,724 - 6,284,562NCBI
Celera196,245,303 - 6,272,430 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,065,539 - 6,093,294 (-)NCBIHuRef
CHM1_1196,306,127 - 6,333,277 (-)NCBICHM1_1
T2T-CHM13v2.0196,294,362 - 6,349,269 (-)NCBIT2T-CHM13v2.0
Acer1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,260,490 - 57,289,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,260,490 - 57,289,126 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,953,490 - 56,982,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,953,490 - 56,982,126 (-)Ensemblmm10GRCm38
MGSCv371757,092,913 - 57,121,549 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,638,614 - 56,667,250 (-)NCBIMGSCv36mm8
Celera1761,301,415 - 61,330,050 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.59NCBI
Acer1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,247,083 - 3,271,720 (+)Ensembl
ChiLan1.0NW_0049554953,247,170 - 3,271,417 (+)NCBIChiLan1.0ChiLan1.0
ACER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,706,922 - 10,738,430 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,932,811 - 9,964,360 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,327,251 - 5,393,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,252,300 - 6,281,016 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,252,300 - 6,281,016 (-)EnsemblpanPan2panpan1.1
ACER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,819,224 - 53,838,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,819,074 - 53,838,438 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,566,184 - 53,584,788 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,473,745 - 54,491,643 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,473,658 - 54,491,842 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,540,193 - 53,558,067 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,988,319 - 54,007,142 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,218,116 - 54,237,024 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acer1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,128,914 - 214,148,773 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,688,244 - 3,705,831 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,688,244 - 3,705,831 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,743,643 - 72,769,570 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,704,603 - 72,767,474 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,283,294 - 73,331,148 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,949,286 - 5,978,282 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660812,050,460 - 2,092,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acer1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,041,875 - 4,045,675 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248284,022,288 - 4,046,235 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acer1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1488,335,268 - 88,364,285 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acer1
94 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:522
Count of miRNA genes:196
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000075180
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 1 13 90 68 67 36 32 36 6 147 65 72 30 82 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000075180   ⟹   ENSRNOP00000064840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,881,361 - 1,911,439 (-)Ensembl
mRatBN7.2 Ensembl91,793,139 - 1,824,434 (-)Ensembl
Rnor_6.0 Ensembl910,061,978 - 10,093,588 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128965   ⟹   ENSRNOP00000108535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,881,361 - 1,902,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142867   ⟹   ENSRNOP00000110685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,881,361 - 1,919,416 (-)Ensembl
RefSeq Acc Id: NM_001106875   ⟹   NP_001100345
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,881,361 - 1,911,439 (-)NCBI
mRatBN7.291,794,340 - 1,824,432 (-)NCBI
Rnor_6.0910,061,978 - 10,093,588 (+)NCBI
Rnor_5.099,062,245 - 9,093,541 (+)NCBI
Celera96,692,746 - 6,724,451 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83598 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064840
  ENSRNOP00000064840.1
  ENSRNOP00000108535.1
  ENSRNOP00000110685.1
RefSeq Acc Id: NP_001100345   ⟸   NM_001106875
- UniProtKB: M0R603 (UniProtKB/TrEMBL),   A6KQU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064840   ⟸   ENSRNOT00000075180
Ensembl Acc Id: ENSRNOP00000110685   ⟸   ENSRNOT00000142867
Ensembl Acc Id: ENSRNOP00000108535   ⟸   ENSRNOT00000128965

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R603-F1-model_v2 AlphaFold M0R603 1-273 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696446
Promoter ID:EPDNEW_R6971
Type:initiation region
Name:Acer1_1
Description:alkaline ceramidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,061,951 - 10,062,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588582 AgrOrtholog
BioCyc Gene G2FUF-28501 BioCyc
Ensembl Genes ENSRNOG00000047368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075180 ENTREZGENE
  ENSRNOT00000075180.4 UniProtKB/TrEMBL
  ENSRNOT00000128965.1 UniProtKB/TrEMBL
  ENSRNOT00000142867.1 UniProtKB/TrEMBL
InterPro Ceramidase UniProtKB/TrEMBL
KEGG Report rno:301118 UniProtKB/TrEMBL
NCBI Gene 301118 ENTREZGENE
PANTHER ALKALINE CERAMIDASE 1 UniProtKB/TrEMBL
  PTHR46139 UniProtKB/TrEMBL
Pfam Ceramidase UniProtKB/TrEMBL
PhenoGen Acer1 PhenoGen
RatGTEx ENSRNOG00000047368 RatGTEx
UniProt A0ABK0LY22_RAT UniProtKB/TrEMBL
  A0ABK0LZC2_RAT UniProtKB/TrEMBL
  A6KQU0 ENTREZGENE, UniProtKB/TrEMBL
  M0R603 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-01-05 Acer1  alkaline ceramidase 1  Asah3  N-acylsphingosine amidohydrolase (alkaline ceramidase) 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Asah3  N-acylsphingosine amidohydrolase (alkaline ceramidase) 3  LOC301118  similar to N-acylsphingosine amidohydrolase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301118  similar to N-acylsphingosine amidohydrolase 3      Symbol and Name status set to provisional 70820 PROVISIONAL