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Gene: Dstn (destrin, actin depolymerizing factor) Rattus norvegicus

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Symbol:

Dstn

Name:

destrin, actin depolymerizing factor

RGD ID:

1588366

Description:

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to act upstream of or within cell motility and positive regulation of actin filament depolymerization. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in several cellular components, including actin cytoskeleton; glutamatergic synapse; and postsynapse. Orthologous to human DSTN (destrin, actin depolymerizing factor); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

actin-depolymerizing factor; ADF; destrin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DSTN (destrin, actin depolymerizing factor)	RGD	RGD
Mus musculus (house mouse):	Dstn (destrin)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Dstn (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DSTN (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DSTN (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dstn (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DSTN (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DSTN (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dstn (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dstn (destrin, actin depolymerizing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DSTN (destrin, actin depolymerizing factor)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	DSTN (destrin, actin depolymerizing factor)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dstn (destrin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cfl1l (cofilin 1 (non-muscle), like)	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6873	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6873	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	COF1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	COF1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	tsr	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	tsr	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-60	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F53E2.2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F53E2.2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cfl1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dstn	Alliance	DIOPT (OrthoFinder\|PANTHER)

Related Pseudogenes:

Dstnl1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	151,737,711 - 151,764,752 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	151,737,849 - 151,764,769 (+)	Ensembl				GRCr8
mRatBN7.2	3	131,284,647 - 131,311,361 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	131,284,648 - 131,311,379 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	135,208,521 - 135,235,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	143,792,606 - 143,819,083 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	141,495,807 - 141,522,288 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	138,024,508 - 138,051,304 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	138,024,508 - 138,051,298 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	144,462,864 - 144,489,660 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	132,358,484 - 132,385,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	130,182,499 - 130,209,162 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Otitis Media (ISO)

Animal Disease Models (ISO)

congestive heart failure (ISO)

Ventricular Remodeling (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dimethoxyphenol (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furfural (ISO)

genistein (EXP)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

hydrogen sulfide (ISO)

isoflavones (EXP)

isoflurane (ISO)

ivermectin (ISO)

kojic acid (ISO)

lead diacetate (ISO)

leflunomide (EXP)

lovastatin (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

Monobutylphthalate (ISO)

monoethyl phthalate (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

nitrates (ISO)

Nutlin-3 (ISO)

okadaic acid (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (EXP)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

T-2 toxin (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

warfarin (ISO)

zearalenone (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament depolymerization (IEA,ISO)

actin filament fragmentation (IBA,ISO)

actin filament severing (IBA)

cell motility (ISO)

positive regulation of actin filament depolymerization (ISO)

Cellular Component

actin cytoskeleton (IBA,IEA)

cortical actin cytoskeleton (ISO)

cytoplasm (IBA,ISO)

glutamatergic synapse (ISO)

postsynapse (ISO)

presynapse (ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA,IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8399167	PMID:9877327	PMID:11809832	PMID:11812157	PMID:12947022	PMID:15548599	PMID:19056867	PMID:23376485	PMID:24093776	PMID:31400829

Genomics

Comparative Map Data

Dstn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	151,737,711 - 151,764,752 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	151,737,849 - 151,764,769 (+)	Ensembl				GRCr8
mRatBN7.2	3	131,284,647 - 131,311,361 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	131,284,648 - 131,311,379 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	135,208,521 - 135,235,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	143,792,606 - 143,819,083 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	141,495,807 - 141,522,288 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	138,024,508 - 138,051,304 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	138,024,508 - 138,051,298 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	144,462,864 - 144,489,660 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	132,358,484 - 132,385,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	130,182,499 - 130,209,162 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

DSTN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	17,570,075 - 17,609,919 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	17,569,152 - 17,609,919 (+)	Ensembl			hg38	GRCh38
GRCh37	20	17,550,720 - 17,590,564 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	17,498,599 - 17,536,652 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	17,498,598 - 17,536,651	NCBI
Celera	20	17,625,081 - 17,663,141 (+)	NCBI		Celera
Cytogenetic Map	20	p12.1	NCBI
HuRef	20	17,513,288 - 17,551,352 (+)	NCBI		HuRef
CHM1_1	20	17,550,604 - 17,588,662 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	17,616,166 - 17,660,584 (+)	NCBI		T2T-CHM13v2.0

Dstn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	143,757,251 - 143,785,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	143,757,240 - 143,785,244 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	143,915,331 - 143,943,324 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	143,915,320 - 143,943,324 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	143,741,067 - 143,769,060 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	143,607,052 - 143,634,765 (+)	NCBI		MGSCv36	mm8
Celera	2	145,097,359 - 145,125,469 (+)	NCBI		Celera
Cytogenetic Map	2	G1	NCBI
cM Map	2	70.89	NCBI

Dstn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	26,569,264 - 26,600,862 (+)	Ensembl
ChiLan1.0	NW_004955415	26,567,457 - 26,598,978 (+)	NCBI	ChiLan1.0	ChiLan1.0

DSTN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	18,457,549 - 18,496,854 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	18,454,524 - 18,493,692 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	17,528,574 - 17,566,925 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	17,506,262 - 17,545,331 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	17,506,262 - 17,545,331 (+)	Ensembl			panPan2	panpan1.1

DSTN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	5,394,972 - 5,402,443 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	5,356,464 - 5,432,574 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	5,327,813 - 5,364,670 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	5,803,229 - 5,840,053 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	5,803,229 - 5,840,657 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	5,416,513 - 5,453,319 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	5,510,480 - 5,547,273 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	5,786,183 - 5,822,988 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	154,073,128 - 154,105,932 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	2,504,234 - 2,538,203 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	2,504,492 - 2,537,507 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DSTN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	26,043,079 - 26,050,353 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	25,998,830 - 26,050,354 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	29,448,874 - 29,455,841 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DSTN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	46,636,111 - 46,672,771 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	46,635,954 - 46,673,165 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666078	1,303,906 - 1,339,785 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dstn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	18,728,705 - 18,759,094 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	18,728,734 - 18,758,281 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dstn
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	123,570,808 - 123,597,321 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dstn
148 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	146
Count of miRNA genes:	103
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000007794
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	136091420	155634702	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

RH130919

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	20	p12	UniSTS
Cytogenetic Map	3	q41	UniSTS

AU042046

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	705,464 - 705,629 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	131,311,080 - 131,311,245 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	846,286 - 846,450	NCBI	Rnor6.0
Rnor_6.0	3	138,051,024 - 138,051,188	NCBI	Rnor6.0
Rnor_5.0	20	830,647 - 830,811	UniSTS	Rnor5.0
Rnor_5.0	3	144,489,380 - 144,489,544	UniSTS	Rnor5.0
RGSC_v3.4	3	132,384,918 - 132,385,082	UniSTS	RGSC3.4
RGSC_v3.4	20	663,415 - 663,579	UniSTS	RGSC3.4
Celera	20	1,479,338 - 1,479,502	UniSTS
Celera	3	130,208,882 - 130,209,046	UniSTS
Cytogenetic Map	3	q41	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CB785930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF111187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007794 ⟹ ENSRNOP00000007794

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	151,737,849 - 151,764,769 (+)	Ensembl
mRatBN7.2 Ensembl	3	131,284,648 - 131,311,379 (+)	Ensembl
Rnor_6.0 Ensembl	3	138,024,508 - 138,051,298 (+)	Ensembl

RefSeq Acc Id:

NM_001033666 ⟹ NP_001028838

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	151,738,039 - 151,764,752 (+)	NCBI
mRatBN7.2	3	131,284,647 - 131,311,361 (+)	NCBI
Rnor_6.0	3	138,024,508 - 138,051,304 (+)	NCBI
Rnor_5.0	3	144,462,864 - 144,489,660 (+)	NCBI
RGSC_v3.4	3	132,358,484 - 132,385,198 (+)	RGD
Celera	3	130,182,499 - 130,209,162 (+)	RGD

Sequence:

show sequence

GCCCTTAATAAGCTCGAGCTGCCGCGTCCGCCCTGCGCTTCCTCTCCTGCTTTTGCTACCGCGA
GGAAGAAGGTGCACAGACTTTCCGCCAGGTTCCTAGCTCTCCTCCCGATCCGCGAACATGGCCT
CAGGAGTTCAAGTTGCAGATGAAGTATGTCGTATTTTCTACGACATGAAAGTTCGGAAATGCTC
CACACCTGAAGAAATCAAGAAAAGAAAGAAGGCTGTCATTTTTTGTCTCAGTGCAGACAAAAAG
TGCATAGTCGTTGAAGAAGGCAAAGAGATCTTGGTTGGAGATGTCGGCGTTACCATAACTGATC
CTTTCAAGCATTTTGTGGGAATGCTTCCTGAAAAAGATTGTCGCTACGCTTTGTATGATGCCAG
CTTTGAAACCAAGGAGTCCAGAAAAGAAGAGCTCATGTTCTTCTTGTGGGCACCAGAACAAGCA
CCTCTGAAAAGTAAAATGATCTATGCAAGCTCGAAGGACGCCATCAAGAAGAAATTTCCAGGTA
TAAAGCACGAGTATCAAGCAAATGGGCCAGAAGACCTCAATCGGACTAGTATTGCTGAAAAGCT
AGGTGGCTCCTTAATTGTAGCGTTCGAAGGATCCCCTGTGTAGATTATCAGTCAGTGCCACGAA
TTGAAAGCTTCCATATTTAACACTATCCTTTCACTATATAAGTAAAGCAAATATATTAGGCCAG
GATCTCACTGAGGGGAATTTGTCTTGTCATCTTTTAGAGTAAACTAAAAATTTTATAGTGTCTG
CAAATACTACCCTACATAAATCTAGCCTCTAAAGTTTCATTGGTGTGGAATTAAATTCTTATTG
GCCAAATGCCTATTTTCATGAAGTGACTTGTAAAGATTTTGTTAAGCTCAGGATTTTTAATAAC
ACAGTTCACAAAACAGTACAAGGCAATGTGAGGGGAACTACTAATCTTTGCTAACCTCAGCAGT
TACTTTGTTTCTTTTGTTTAGAAAAGTGATTGTAATCTGTGTATCATTTTGACCCAAATTCTCT
ATTTTTCCTTGACTTAAACAGAATAATGAGATATAATTTTCTTTATACTGTGTACAACACCTAA
TCTATACTAACAGCAATAAGACTAAGCCAGGCAGTCTTAATTCTATCAGATGTGTCATGAGACT
GTTTCAGACTCGCGTCTGCTTAAAGTTCACGCTCATCTTGCAAAGCGCCAGAGCACCGTGCTGG
AGTGCAGTCAGTGCCCTGTACCTGCCGCAAGAGGCTCGCTGGGCTGGGAGATGGCGTAGAGCAA
CTTTCTGTCTTAGAAATCATGGTGATCCTCAGGAGAATGCTCCGTGTCTTGTAACAACTAATTA
CATTGCAAATTAGGGCTTCATTGTAATCTACTTTATTAATGAAAAATGACAAGGCAGTGTACTG
ATAAGCCAAGGTGCTTTCGATCTGTAATCTCTTCTTCAAAACTGCTGTGTCTGGTACAGTAGAC
TGGAAAGAGTGTTGATTATGTTTCCTCTGGGGCCTGGTAGGGTGCAAATGCCTAGAGCAGTTTA
CCAGCTGTGTGTGAGACAGAAGCAGTACCATGGATGACACAGGGGACTGCCCAACAACACTTGG
AAATGATGGTTACCATCACAGGCATGACACTGAACACTGTAGAGGTGCACAGTCAGTTGAACTT
AGTAGCAGTGCTGGCTTTATGTAATAAA

hide sequence

RefSeq Acc Id:

XR_010064687

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	151,737,711 - 151,763,751 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001028838	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95182	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007794
	ENSRNOP00000007794.5
GenBank Protein	Q7M0E3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001028838 ⟸ NM_001033666
- UniProtKB:	Q7M0E3 (UniProtKB/Swiss-Prot), A6K737 (UniProtKB/TrEMBL), A6K738 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIVVEEGKEILVGDVGVTI TDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPEQAPLKSKMIYASSKDAIKKKF PGIKHEYQANGPEDLNRTSIAEKLGGSLIVAFEGSPV hide sequence

Ensembl Acc Id:

ENSRNOP00000007794 ⟸ ENSRNOT00000007794

Protein Domains

ADF-H

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7M0E3-F1-model_v2	AlphaFold	Q7M0E3	1-165	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692479

Promoter ID:

EPDNEW_R3002

Type:

initiation region

Name:

Dstn_1

Description:

destrin, actin depolymerizing factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	138,024,542 - 138,024,602	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588366	AgrOrtholog
BioCyc Gene	G2FUF-47622	BioCyc
Ensembl Genes	ENSRNOG00000005924	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000007794	ENTREZGENE
	ENSRNOT00000007794.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.20.10	UniProtKB/Swiss-Prot
InterPro	ADF-H	UniProtKB/Swiss-Prot
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot
	ADF/Cofilin	UniProtKB/Swiss-Prot
KEGG Report	rno:502674	UniProtKB/Swiss-Prot
NCBI Gene	502674	ENTREZGENE
PANTHER	PTHR11913	UniProtKB/Swiss-Prot
Pfam	Cofilin_ADF	UniProtKB/Swiss-Prot
PhenoGen	Dstn	PhenoGen
PRINTS	COFILIN	UniProtKB/Swiss-Prot
PROSITE	ADF_H	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005924	RatGTEx
SMART	ADF	UniProtKB/Swiss-Prot
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/Swiss-Prot
UniProt	A6K737	ENTREZGENE, UniProtKB/TrEMBL
	A6K738	ENTREZGENE, UniProtKB/TrEMBL
	DEST_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-11	Dstn	destrin, actin depolymerizing factor	Dstn	destrin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	Dstn	destrin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD