Treml2 (triggering receptor expressed on myeloid cells-like 2) - Rat Genome Database

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Gene: Treml2 (triggering receptor expressed on myeloid cells-like 2) Rattus norvegicus
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Symbol: Treml2
Name: triggering receptor expressed on myeloid cells-like 2
RGD ID: 1587039
Description: Predicted to enable signaling receptor activity. Predicted to be involved in T cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Orthologous to human TREML2 (triggering receptor expressed on myeloid cells like 2); INTERACTS WITH alpha-Zearalanol; bisphenol A; acrylamide (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC680844; similar to triggering receptor expressed on myeloid cells-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,192,292 - 20,202,981 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,193,687 - 20,202,286 (-)EnsemblGRCr8
mRatBN7.2912,694,453 - 12,705,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)EnsemblmRatBN7.2
Rnor_6.0914,659,967 - 14,668,313 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,581,327 - 13,590,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,107,688 - 8,115,759 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,468,458 - 10,476,804 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
T cell activation  (IBA,ISO)

Cellular Component
cell surface  (IBA,ISO)
plasma membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18650384  


Genomics

Comparative Map Data
Treml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,192,292 - 20,202,981 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,193,687 - 20,202,286 (-)EnsemblGRCr8
mRatBN7.2912,694,453 - 12,705,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)EnsemblmRatBN7.2
Rnor_6.0914,659,967 - 14,668,313 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,581,327 - 13,590,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,107,688 - 8,115,759 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,468,458 - 10,476,804 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,189,749 - 41,201,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,189,749 - 41,201,149 (-)Ensemblhg38GRCh38
GRCh37641,157,487 - 41,168,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,266,206 - 41,276,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34641,266,205 - 41,276,902NCBI
Celera642,710,254 - 42,721,629 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,875,346 - 40,886,723 (-)NCBIHuRef
CHM1_1641,160,464 - 41,171,828 (-)NCBICHM1_1
T2T-CHM13v2.0641,018,309 - 41,029,701 (-)NCBIT2T-CHM13v2.0
Treml2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,606,419 - 48,619,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,606,526 - 48,619,561 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381748,299,390 - 48,312,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,299,498 - 48,312,533 (+)Ensemblmm10GRCm38
MGSCv371748,439,363 - 48,451,859 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,765,507 - 47,776,716 (+)NCBIMGSCv36mm8
Celera1751,729,007 - 51,741,509 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Treml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554377,812,005 - 7,824,344 (-)NCBIChiLan1.0ChiLan1.0
TREML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,674,472 - 55,685,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,544,432 - 51,555,915 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,766,713 - 40,778,115 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,075,101 - 42,086,477 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,075,101 - 42,086,477 (-)EnsemblpanPan2panpan1.1
TREML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,948,309 - 9,958,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,950,133 - 9,959,478 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha129,978,286 - 9,988,881 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01210,427,899 - 10,438,498 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,428,677 - 10,438,672 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,959,997 - 9,970,595 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,041,737 - 10,052,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,136,772 - 10,147,368 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Treml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,326,414 - 45,335,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,625,573 - 18,632,228 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,625,573 - 18,632,228 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,482,058 - 36,493,906 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,478,339 - 36,494,348 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,779,258 - 41,786,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,949,709 - 30,962,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,950,860 - 30,959,703 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,197,970 - 41,209,962 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Treml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,613,812 - 17,623,436 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Treml2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1481,617,907 - 81,627,349 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Treml2
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000042404
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 159 91 90 59 92 59 6 353 191 11 132 80 91 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000042404   ⟹   ENSRNOP00000043394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,193,687 - 20,202,286 (-)Ensembl
mRatBN7.2 Ensembl912,694,697 - 12,705,324 (-)Ensembl
Rnor_6.0 Ensembl914,660,738 - 14,668,297 (-)Ensembl
RefSeq Acc Id: XM_001059150   ⟹   XP_001059150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,981 (-)NCBI
mRatBN7.2912,694,453 - 12,705,379 (-)NCBI
Rnor_6.0914,659,967 - 14,668,313 (-)NCBI
Rnor_5.0913,581,327 - 13,590,040 (-)NCBI
RGSC_v3.498,107,688 - 8,115,759 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084467   ⟹   XP_038940395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,981 (-)NCBI
mRatBN7.2912,694,453 - 12,705,379 (-)NCBI
RefSeq Acc Id: XM_039084468   ⟹   XP_038940396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,192,292 - 20,202,003 (-)NCBI
mRatBN7.2912,694,453 - 12,704,399 (-)NCBI
RefSeq Acc Id: XP_001059150   ⟸   XM_001059150
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000043394   ⟸   ENSRNOT00000042404
RefSeq Acc Id: XP_038940395   ⟸   XM_039084467
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940396   ⟸   XM_039084468
- Peptide Label: isoform X2
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF32-F1-model_v2 AlphaFold D3ZF32 1-322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587039 AgrOrtholog
BioCyc Gene G2FUF-28299 BioCyc
Ensembl Genes ENSRNOG00000013554 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042404 ENTREZGENE
  ENSRNOT00000042404.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immune_rcpt_domain UniProtKB/TrEMBL
KEGG Report rno:680844 UniProtKB/TrEMBL
NCBI Gene 680844 ENTREZGENE
PANTHER TREM-LIKE TRANSCRIPT 2 PROTEIN UniProtKB/TrEMBL
  TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Treml2 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013554 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt D3ZF32 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Treml2  triggering receptor expressed on myeloid cells-like 2  LOC680844  similar to triggering receptor expressed on myeloid cells-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680844  similar to triggering receptor expressed on myeloid cells-like 2  LOC682922  similar to triggering receptor expressed on myeloid cells-like 2  Data merged from RGD:1592821 1643240 APPROVED
2006-11-20 LOC682922  similar to triggering receptor expressed on myeloid cells-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC680844  similar to triggering receptor expressed on myeloid cells-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL