Zfp78 (zinc finger protein 78) - Rat Genome Database

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Gene: Zfp78 (zinc finger protein 78) Rattus norvegicus
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Symbol: Zfp78
Name: zinc finger protein 78
RGD ID: 1586242
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZFP28 (ZFP28 zinc finger protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; paracetamol; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC691269; similar to Zinc finger protein 471 (EZFIT-related protein 1); zinc finger protein 471; Znf471
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,543,519 - 76,558,052 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2167,508,627 - 67,524,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,494,544 - 67,524,881 (-)EnsemblmRatBN7.2
Rnor_6.0171,183,115 - 71,196,978 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,183,171 - 71,190,423 (-)Ensemblrn6Rnor6.0
RGSC_v3.4165,935,591 - 65,943,189 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,254,527 - 65,270,952 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear lumen  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp78
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,543,519 - 76,558,052 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2167,508,627 - 67,524,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,494,544 - 67,524,881 (-)EnsemblmRatBN7.2
Rnor_6.0171,183,115 - 71,196,978 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,183,171 - 71,190,423 (-)Ensemblrn6Rnor6.0
RGSC_v3.4165,935,591 - 65,943,189 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,254,527 - 65,270,952 (-)NCBICelera
Cytogenetic Map1q12NCBI
ZNF471
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381956,507,855 - 56,530,212 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1956,507,731 - 56,530,221 (+)Ensemblhg38GRCh38
GRCh371957,019,224 - 57,041,581 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361961,711,024 - 61,732,082 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341961,711,023 - 61,732,079NCBI
Celera1954,062,199 - 54,083,259 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1953,329,184 - 53,350,211 (+)NCBIHuRef
CHM1_11957,012,840 - 57,033,893 (+)NCBICHM1_1
T2T-CHM13v2.01959,602,138 - 59,624,646 (+)NCBIT2T-CHM13v2.0
Zfp78
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3976,365,812 - 6,385,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl76,366,279 - 6,385,604 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3876,362,809 - 6,382,606 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl76,363,280 - 6,382,605 (+)Ensemblmm10GRCm38
MGSCv3776,316,015 - 6,335,315 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3675,967,500 - 5,986,607 (+)NCBIMGSCv36mm8
Celera76,093,158 - 6,112,595 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map73.69NCBI
ZNF471
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22062,794,460 - 62,817,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11964,585,967 - 64,607,827 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01953,532,255 - 53,554,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11962,297,288 - 62,348,730 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1962,326,353 - 62,348,724 (+)EnsemblpanPan2panpan1.1
LOC119863933
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1101,671,154 - 101,683,878 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01102,130,224 - 102,143,692 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11101,769,573 - 101,783,041 (-)NCBIUMICH_Zoey_3.1
ZNF471
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl660,789,561 - 60,802,097 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1660,783,564 - 60,802,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2656,025,583 - 56,043,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF471
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1649,044,098 - 49,069,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl649,050,920 - 49,070,547 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660452,050,685 - 2,081,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp78
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000035184, ENSRNOT00000035217
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035184   ⟹   ENSRNOP00000037545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl171,183,171 - 71,190,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000035217   ⟹   ENSRNOP00000036346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl171,183,171 - 71,190,423 (-)Ensembl
RefSeq Acc Id: NM_001427789   ⟹   NP_001414718
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,543,519 - 76,557,985 (-)NCBI
RefSeq Acc Id: XM_063286996   ⟹   XP_063143066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,543,525 - 76,558,004 (-)NCBI
RefSeq Acc Id: XM_063286999   ⟹   XP_063143069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,543,525 - 76,558,052 (-)NCBI
Ensembl Acc Id: ENSRNOP00000036346   ⟸   ENSRNOT00000035217
Ensembl Acc Id: ENSRNOP00000037545   ⟸   ENSRNOT00000035184
RefSeq Acc Id: NP_001414718   ⟸   NM_001427789
- UniProtKB: D3ZXJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143069   ⟸   XM_063286999
- Peptide Label: isoform X2
- UniProtKB: D3ZXJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143066   ⟸   XM_063286996
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXJ3-F1-model_v2 AlphaFold D3ZXJ3 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586242 AgrOrtholog
BioCyc Gene G2FUF-60927 BioCyc
Ensembl Genes ENSRNOG00000015322 Ensembl
  ENSRNOG00000042777 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000083797 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035184 ENTREZGENE
  ENSRNOT00000035184.7 UniProtKB/TrEMBL
  ENSRNOT00000035217.6 UniProtKB/TrEMBL
  ENSRNOT00000096770.2 UniProtKB/TrEMBL
  ENSRNOT00000129126 ENTREZGENE
  ENSRNOT00000129126.1 UniProtKB/TrEMBL
  ENSRNOT00000130311.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene Zfp78 ENTREZGENE
PANTHER C2H2-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ZFP14 ZINC FINGER PROTEIN-RELATED UniProtKB/TrEMBL
  ZINC FINGER AND BTB DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Zfp78 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015322 RatGTEx
  ENSRNOG00000042777 RatGTEx
  ENSRNOG00000083797 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6ASG2_RAT UniProtKB/TrEMBL
  A0ABK0LPP0_RAT UniProtKB/TrEMBL
  A0ABK0LX52_RAT UniProtKB/TrEMBL
  D3ZB41_RAT UniProtKB/TrEMBL
  D3ZXJ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Zfp78  zinc finger protein 78  Znf471  zinc finger protein 471  Data merged from RGD:9386210 737654 APPROVED
2015-11-30 Zfp78  zinc finger protein 78  Zfp78  zinc finger protein 78  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2014-08-25 Znf471  zinc finger protein 471      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Zfp78  zinc finger protein 78  LOC691269  similar to Zinc finger protein 471 (EZFIT-related protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691269  similar to Zinc finger protein 471 (EZFIT-related protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL