Arhgef4 (Rho guanine nucleotide exchange factor 4) - Rat Genome Database

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Gene: Arhgef4 (Rho guanine nucleotide exchange factor 4) Rattus norvegicus
Analyze
Symbol: Arhgef4
Name: Rho guanine nucleotide exchange factor 4
RGD ID: 1586179
Description: Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be located in cytoplasm. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301334; Rho guanine nucleotide exchange factor (GEF) 4; similar to Rho guanine nucleotide exchange factor 4 isoform a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl944,357,736 - 44,501,550 (+)EnsemblGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)Ensemblrn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amosite asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clobetasol  (ISO)
crocidolite asbestos  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10947987   PMID:17599059   PMID:30125942   PMID:34022264  


Genomics

Comparative Map Data
Arhgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl944,357,736 - 44,501,550 (+)EnsemblGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)Ensemblrn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
ARHGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,836,914 - 131,047,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,836,914 - 131,047,263 (+)Ensemblhg38GRCh38
GRCh372131,594,487 - 131,804,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,390,694 - 131,521,306 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342131,507,955 - 131,638,568NCBI
Celera2124,772,847 - 124,903,056 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2123,744,169 - 123,803,670 (+)NCBIHuRef
CHM1_12131,678,231 - 131,808,841 (+)NCBICHM1_1
T2T-CHM13v2.02131,271,158 - 131,481,546 (+)NCBIT2T-CHM13v2.0
Arhgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,717,263 - 34,851,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,717,269 - 34,852,390 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38134,677,949 - 34,812,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,678,188 - 34,813,309 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl134,801,794 - 34,801,964 (+)Ensemblmm10GRCm38
MGSCv37134,858,567 - 34,869,599 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36134,746,268 - 34,757,300 (+)NCBIMGSCv36mm8
Celera134,571,295 - 34,582,266 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.34NCBI
Arhgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955459321,659 - 533,172 (+)Ensembl
ChiLan1.0NW_004955459321,683 - 534,108 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21344,598,671 - 44,805,585 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B44,613,644 - 44,820,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B29,583,389 - 29,716,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B131,669,743 - 131,800,705 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B131,594,345 - 131,800,705 (+)EnsemblpanPan2panpan1.1
ARHGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,618,860 - 20,734,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,150,254 - 100,308,313 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646941,373,517 - 41,469,187 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646941,352,361 - 41,467,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,115,853 - 57,374,612 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037568,740 - 772,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473214,885,119 - 15,110,134 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgef4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14110,930,080 - 111,021,826 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgef4
911 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:165
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000018935
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
D9Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8944,458,256 - 44,458,488 (+)Marker Load Pipeline
mRatBN7.2936,962,359 - 36,962,591 (+)MAPPERmRatBN7.2
Rnor_6.0941,261,034 - 41,261,265NCBIRnor6.0
Rnor_5.0940,929,725 - 40,929,956UniSTSRnor5.0
RGSC_v3.4933,496,795 - 33,497,026UniSTSRGSC3.4
RGSC_v3.4933,496,794 - 33,497,026RGDRGSC3.4
Celera934,746,702 - 34,746,933UniSTS
RGSC_v3.1933,498,209 - 33,498,440RGD
RH 3.4 Map9352.2RGD
RH 3.4 Map9352.2UniSTS
RH 2.0 Map9356.8RGD
SHRSP x BN Map932.0698RGD
FHH x ACI Map924.71RGD
Cytogenetic Map9q21UniSTS
D9Rat58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2936,919,457 - 36,919,672 (+)MAPPERmRatBN7.2
Rnor_6.0941,218,155 - 41,218,369NCBIRnor6.0
Rnor_5.0940,887,557 - 40,887,771UniSTSRnor5.0
RGSC_v3.4933,453,530 - 33,453,744UniSTSRGSC3.4
RGSC_v3.4933,453,529 - 33,453,744RGDRGSC3.4
Celera934,704,373 - 34,704,587UniSTS
RGSC_v3.1933,454,944 - 33,455,158RGD
RH 3.4 Map9352.9RGD
RH 3.4 Map9352.9UniSTS
RH 2.0 Map9353.5RGD
FHH x ACI Map924.71RGD
Cytogenetic Map9q21UniSTS
D9Got46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2936,865,773 - 36,865,913 (+)MAPPERmRatBN7.2
Rnor_6.0941,164,475 - 41,164,614NCBIRnor6.0
Rnor_5.0940,833,877 - 40,834,016UniSTSRnor5.0
RGSC_v3.4933,399,848 - 33,399,988RGDRGSC3.4
RGSC_v3.4933,399,849 - 33,399,988UniSTSRGSC3.4
Celera934,650,705 - 34,650,844UniSTS
RGSC_v3.1933,401,263 - 33,401,402RGD
RH 3.4 Map9348.0UniSTS
RH 3.4 Map9348.0RGD
RH 2.0 Map9352.4RGD
Cytogenetic Map9q21UniSTS
BG381432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2937,001,257 - 37,001,418 (+)MAPPERmRatBN7.2
Rnor_6.0941,299,598 - 41,299,758NCBIRnor6.0
Rnor_5.0940,968,286 - 40,968,446UniSTSRnor5.0
RGSC_v3.4933,535,791 - 33,535,951UniSTSRGSC3.4
Celera934,785,215 - 34,785,375UniSTS
RH 3.4 Map9353.2UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 162 85 84 53 91 53 6 347 189 10 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018935   ⟹   ENSRNOP00000018935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl944,357,736 - 44,500,958 (+)Ensembl
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)Ensembl
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135503   ⟹   ENSRNOP00000103915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl944,434,581 - 44,501,550 (+)Ensembl
RefSeq Acc Id: NM_001427642   ⟹   NP_001414571
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,758 - 44,500,959 (+)NCBI
RefSeq Acc Id: XM_017596787   ⟹   XP_017452276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,499,976 (+)NCBI
mRatBN7.2936,861,800 - 37,003,508 (+)NCBI
Rnor_6.0941,160,562 - 41,302,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084525   ⟹   XP_038940453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,500,959 (+)NCBI
mRatBN7.2936,861,800 - 37,005,079 (+)NCBI
RefSeq Acc Id: XM_063266889   ⟹   XP_063122959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,493,548 (+)NCBI
RefSeq Acc Id: XM_063266890   ⟹   XP_063122960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,500,959 (+)NCBI
RefSeq Acc Id: XM_063266891   ⟹   XP_063122961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,434,115 - 44,500,959 (+)NCBI
RefSeq Acc Id: XP_017452276   ⟸   XM_017596787
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000018935   ⟸   ENSRNOT00000018935
RefSeq Acc Id: XP_038940453   ⟸   XM_039084525
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122960   ⟸   XM_063266890
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122959   ⟸   XM_063266889
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414571   ⟸   NM_001427642
- UniProtKB: D3ZKB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122961   ⟸   XM_063266891
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000103915   ⟸   ENSRNOT00000135503
Protein Domains
DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKB4-F1-model_v2 AlphaFold D3ZKB4 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586179 AgrOrtholog
BioCyc Gene G2FUF-27851 BioCyc
Ensembl Genes ENSRNOG00000014035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018935 ENTREZGENE
  ENSRNOT00000018935.9 UniProtKB/TrEMBL
  ENSRNOT00000135503 ENTREZGENE
  ENSRNOT00000135503.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
NCBI Gene 301334 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Arhgef4 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014035 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt A0ABK0LPM7_RAT UniProtKB/TrEMBL
  A6INA8_RAT UniProtKB/TrEMBL
  D3ZKB4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef4  Rho guanine nucleotide exchange factor 4  Arhgef4  Rho guanine nucleotide exchange factor (GEF) 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Arhgef4  Rho guanine nucleotide exchange factor (GEF) 4  LOC301334  similar to Rho guanine nucleotide exchange factor 4 isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301334  similar to Rho guanine nucleotide exchange factor 4 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL