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Gene: Bend4 (BEN domain containing 4) Rattus norvegicus

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Symbol:

Bend4

Name:

BEN domain containing 4

RGD ID:

1584735

Description:

Predicted to enable DNA binding activity. Orthologous to human BEND4 (BEN domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BEN domain-containing protein 4; BEN domain-containing protein 4-like; hypothetical protein LOC681008; LOC102551043; LOC681008; serine/arginine repetitive matrix protein 3-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BEND4 (BEN domain containing 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Bend4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bend4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BEND4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BEND4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bend4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BEND4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BEND4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bend4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Bend4 (BEN domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BEND4 (BEN domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bend4 (BEN domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bend4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bend4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	41,106,206 - 41,142,572 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	41,106,763 - 41,136,979 (+)	Ensembl				GRCr8
mRatBN7.2	14	40,753,048 - 40,788,686 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	40,753,077 - 40,783,504 (+)	Ensembl				mRatBN7.2
Rnor_6.0	14	42,399,359 - 42,401,643 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	14	42,401,665 - 42,437,957 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	42,401,706 - 42,431,480 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	42,198,936 - 42,233,813 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	43,358,184 - 43,388,464 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	39,905,910 - 39,943,725 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 3 (ISO)

lung non-small cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

copper atom (ISO)

copper(0) (ISO)

dorsomorphin (ISO)

entinostat (ISO)

fenvalerate (EXP)

fulvestrant (ISO)

mercury dibromide (ISO)

methoxychlor (EXP)

p-chloromercuribenzoic acid (ISO)

PCB138 (ISO)

pentanal (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

DNA binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Bend4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	41,106,206 - 41,142,572 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	41,106,763 - 41,136,979 (+)	Ensembl				GRCr8
mRatBN7.2	14	40,753,048 - 40,788,686 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	40,753,077 - 40,783,504 (+)	Ensembl				mRatBN7.2
Rnor_6.0	14	42,399,359 - 42,401,643 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	14	42,401,665 - 42,437,957 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	42,401,706 - 42,431,480 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	42,198,936 - 42,233,813 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	43,358,184 - 43,388,464 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	39,905,910 - 39,943,725 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

BEND4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	42,110,853 - 42,152,655 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	42,110,853 - 42,152,878 (-)	Ensembl			hg38	GRCh38
GRCh37	4	42,112,870 - 42,154,672 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	41,807,714 - 41,849,652 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	42,560,029 - 42,602,526 (-)	NCBI		Celera
Cytogenetic Map	4	p13	NCBI
HuRef	4	41,434,821 - 41,476,819 (-)	NCBI		HuRef
CHM1_1	4	42,113,137 - 42,155,162 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	42,084,790 - 42,126,591 (-)	NCBI		T2T-CHM13v2.0

Bend4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	67,549,490 - 67,585,471 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	67,549,490 - 67,585,653 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	67,392,147 - 67,428,128 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	67,392,147 - 67,428,310 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	67,783,386 - 67,819,038 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	67,677,371 - 67,707,536 (-)	NCBI		MGSCv36	mm8
Celera	5	64,687,804 - 64,713,730 (-)	NCBI		Celera
Cytogenetic Map	5	C3.1	NCBI
cM Map	5	36.06	NCBI

Bend4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	5,592,714 - 5,610,703 (+)	Ensembl
ChiLan1.0	NW_004955443	5,593,351 - 5,613,569 (+)	NCBI	ChiLan1.0	ChiLan1.0

BEND4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	42,290,520 - 42,337,084 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	42,483,963 - 42,530,249 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	36,436,006 - 36,478,066 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	42,283,229 - 42,316,250 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

BEND4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	39,157,121 - 39,188,309 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	39,162,575 - 39,186,008 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	39,132,814 - 39,168,007 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	39,647,864 - 39,683,047 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	39,653,317 - 39,683,303 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	39,336,640 - 39,371,785 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	39,448,308 - 39,483,449 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	39,913,842 - 39,949,072 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bend4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	36,940,750 - 36,979,367 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	9,327,469 - 9,346,905 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	9,318,875 - 9,352,735 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BEND4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	33,143,262 - 33,177,814 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	33,137,738 - 33,177,702 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	34,791,866 - 34,832,423 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BEND4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	8,186,086 - 8,230,604 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	8,186,960 - 8,223,874 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	54,487,981 - 54,534,568 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bend4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	24,801,893 - 24,833,825 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624761	24,801,813 - 24,839,981 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bend4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	24,503,776 - 24,534,584 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bend4
162 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	33
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000043639
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	10	65	157	75	74	43	65	43	6	305	162	11	136	78	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006221735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000090148 ⟹ ENSRNOP00000073618

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	41,106,763 - 41,136,979 (+)	Ensembl
mRatBN7.2 Ensembl	14	40,753,077 - 40,783,504 (+)	Ensembl
Rnor_6.0 Ensembl	14	42,401,706 - 42,431,360 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092933 ⟹ ENSRNOP00000076013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	42,402,081 - 42,431,480 (+)	Ensembl

RefSeq Acc Id:

XM_006250982 ⟹ XP_006251044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	41,106,962 - 41,142,572 (+)	NCBI
mRatBN7.2	14	40,753,048 - 40,788,686 (+)	NCBI
Rnor_6.0	14	42,401,665 - 42,437,957 (+)	NCBI
Rnor_5.0	14	42,198,936 - 42,233,813 (+)	NCBI

Sequence:

show sequence

TCCGGAGCGCGCGCGGGGCGGGCAGGGCCTCAAGACTCGGCATGGAGCCCCGAGATGCAGGCGG
CGGAGAGGGGCCCAGCGCGCCCCGCATCTACAAGCAGCGCGGCCCCTACAGCGTCCTCAAGACG
TTCCCCAGCCGGCGGCCGGCGCTGGCCAAGCGCCTACGACAGACTCTCCTGCTAGAGCTGTCGC
CGCCCGCGGCCGTCCCGCTGCCGCCCCCGCCCGCCGCCGCCGCCGCCCTTCGCCTTCGCTCGCC
GCCGTGGCCCATCAGCAGCACGGAGCCGCCGCCGTTCCCCGACGCAGCCGTCCTATCCCGCCGG
GTCAGGCCGGGCCCGCCGCCGCCGCCGGCCTCCTCGTCGTCGCCGTCCTGCACACCCGCCGCCN
NCCCGGGCCACCCGAGGACTCCGGCGCCACCGCCGCCGCCGCCGCCGCCGCCGCCCCTCGCGGC
CCCCGCCGCCTCGTCGTCGTCGTCCTTCGCCGCCGTCGTCAGGTACGGCCCTGGCCCGGCGAGC
GGCGCGGGCAGCAGCGGCGCGGGTAGCGACGGCGCCAGCCTAGAGCTCAGTGCAGAGAGCCGGA
TGATCCTGGATGCCTTTGCCCAGCAGTGCAGTCGTGTTCTTAGTCTCTTAAATTGTGGAGGAAA
ACTTCTGGACTCCAGCCACTCTCAGTCCATGATTTCTTGCGTCAAGCAGGAAGGCTCTAGTTAT
AACGAAAGACAGGACCAGTGCCACATCGTAAAAGGGGTCCAAAGTCAGACCTCTGACAACATAG
ACATAGAAATGCAATATATGCAAAGAAAACAACAGACTTCTGCCTTTCTGAGAGTGTTCACCGA
CTCTCTCCAAAATTACCTGCTCTCGGGGAACTTCCCCACTCCGAACACCTCATCGGTCAGTGAG
TATGGCCACCTGGCTGATGTGGACCCTCTCTCAGCCTCCCCGGTGCACACGTTAGGTGGCTGGA
CCTCCCCGGCAACATCTGAGTCCCACGGTCACCCGTCCTCCTCCACACTGCCGGAGGAGGAGGA
GGAGGAAGAGGAAGGCTACTGCCCTCGGTGCCAGGAGCTGGAGCAGGAGGTTATCTCGCTGCAA
CAAGAAAATGAAGAACTCAGAAGAAAATTGGAGAGCATCCCAGTGCCCTGCCAGACCGTCCTAG
ATTACCTAAAGACAGTGCTGCTGCACCACAACCAGCTCCTGCCGCAGCCCGCCGAGCAGCCCAC
CGAGGGAAGCAAGCAGCTGTTGAACAGCTATCCTGTGTACATAACGAGCAAACAGTGGGACGAG
GCTGTGAACTCTTCCAAGAAGGACGGGAGGCGGCTTCTGCGCTACCTCATCAGATTCGTCTTCA
CCACCGACGAGCTTAAGTACTCATGCGGCCTTGGGAAAAGGAAAAGGTCAGTGCAGTCAGGAGA
GACAGGTCCCGAAAGACGCCCTCTGGATCCAGTTAAAGTCACGTGCCTCCGAGAATTCATTAGG
ATGCACTGTACCTCAAACCCTGATTGGTGGATGCCCTCGGAGGAGCAGATAAACAAAGTGTTCA
GCGATGCCGTAGGTCACGCCCGACAAGGGCGGGCAGTGGGGACTTTCCTGCACAACGGTGGCTC
GTTTTACGAAGGGATGGATCACCAGGCTTCCCAAGATGAGGTCTTCAACAAGAGCTCTCAGGAT
GGGTCTGGGGACTAGCGGACAGAACCTAGCAGTGGTGTTTTGGTTTTTTGTGTAAGAGCTCCAG
TTGTGAATGTCCATCCCCTTGTCTCTTAGAGTCCAAAGCATGGTATTCCGTCATACTTTACACA
TTCTTGACCCACTGCCACAGTTCCCAAATACGAATCCACTTTAGGATTCGGGGGGGAAATGAGC
AGCTGCAGTAGATTGGGGTGTATTCTATCACAGAGGAGAATGTACAGTTAACATGAAGTCATTA
CTAGCTGGTCATTGAGAGTGACTCCAGCCCCAGATCTTCAGGGAAGCCTGGCCTCCTGAGCAGA
GCTGGTCTCCAGGGAAGGTTCAGTTGGTGTTCCTGCACATGGGGGAAGGGAAGACAAGCAACGC
GTATTTTCTTTAATTCAAGTAAGCTGTCTTTCATTTTCCTAAGACTTGGTTTTAGAGTTCTCAG
CAAAGACACAAGCTAGGTGAGACTGTAAGCTTCCATCTGTTTTAAACTCTTACGATAAGCCAGA
ACAGAGGCCATGTCTGTAGAGGGTACTTGATGGAAGTCAGCTATTTTTCTGTTCTCTTACACGC
AAAACTCACTGTGTCAATCAGAAAGGCAACCTCATTGCTGTGGTTTACAAGCAGAGATTCTCTT
TACATCTTTAGGAAACATCCAAAGATTCAGACCCATTTTCAAATGCCTCATTTCATAAGTTCTA
ACACATAGCCTTCCATAGCCTTACATCATGCTTTGTTGACACAATGCCAGGGTGGTGGGTTCAC
TGAGAACCTCTACGAGCTAGCTATTTGGTAAGATCAAACACAGGGCATGAATGACAGTATCTGC
TGTTGATAAAGGGTCGGGTATTGTAGACACGTAGCTTCAGTGCCGTTCTGACAACTATGCAATG
GCTTATGGGTGATTTCTCTGAAATTTGAGGCCTTTTTCTGGGCTGAGTGAAGGTTTAGAATATA
TAAAACTTCTGTTCCCCACTGTCATGGATGAAAACACCTCAACCAGCTGTGCCTCTCCTTTTCC
CACAGTCCCTCTGTGGTCTAAGTTCTGAGTTACTGCTCTGCTTCCCTGCTTAATTTGCGGCATC
CATGTGAGAAGTCACACATGTTAGTGATGTCTAGTAAAGGCTACAGAGGTGCTGGAATTGTTCC
TGATGAAGGTTAAACTTTTGGACATGAGGAGAAGGCTAGTTTTATTTTTTTTAATCCCTCCCTC
CCCCGTTGGCTTTGTTAAACAAATCAAGATTACTGTGTTCTTTGTGGAACCAAAAGCTAAATGG
GCAGCATTTATGAAAATTATGAATGCCATCTACAAACACAGCAAAGAGCTTTGAAATGGGATAG
AAATTCAGACTGAGTATCCATTTAGAAAAGGTCTGTATGGGAGGCCAGTTTTGTCAGAATAAAT
CAGACATCCTTTATATTCAGTATTTAGCATCGGATTTTGAACAAATCGGCCAAACAGTTTAGAA
GTAAAAGAAATTAAACGAGTAAATGAGATGTCATTTACATGGACCGAAGACCAGTGTCTTTGGC
TGTCCAAGAGAAAGGGATGTTGTTTTCTTAATTAGGAAAGCTGTCTCCGGATAGCATCCAGGAC
AGCATGTTGATAGCTTCTTGCTGGTCTGGGGCACTCACTATCATCTTGTTTAAAATCCTCATCT
GCAGCACTGAAGACGTCTCTCATTGCTGTTTATCCACACGGCTGAGCCCCGTTCCTCTCTTTGG
TGGTTTATTTACTGCCTGCTCAACCTCATTGAGTTTGGTCAGTAAGTGTGAAAAGCTTTCTTTG
GTTGTCCTGTAGTCTTTAAACGATCCATCGAGTTTTCTCGTCCACAAGTTTGCAACTCTGCCTA
AGTATGGAAAGTTGGCAGGAGCAAGGCTCATGGCGCTGGAGCTTCAGAGCCCCCATGTGAGGAA
TCAGGAAGACCCCATGGAGTGATCCTCCTCCACCTCTTTAAAGGCTCTGATCTCAACACCAGCT
CGGGGTGCCCTGGGATAAGCTCTTGTCAGTGAAGCTTCTCATTGTCATCTGCATAGGCTGGTAC
TAGTTTTAGTTGAGCTTGTGCTGTGCTGTGCTGTGCTGTTCAGCCTACATCACCTTCCACATCA
AATGTAGCTTTAGAAGAGGGTATCTAAATCATTTGTGGGTACCATACGACTGCACCTCTCAAGC
CCACTGTCGGGTCAGGGTCAGCAGCTGGAAGAATTGATCCTTGATAGAGGGTTGCATACATCGC
TTTAAGTCTTCCACTTCACTTGTCGAGGTTTTCTGGTCACGTGATACAGTCGTCCTGATTCTGC
TTTTGCAGTCTTCACTTCTGGTCTCCTTAACTTCAGGGTTTTCCCAGGTCCGGGCTTACCGATT
TGGTTAAACTCCCCAGCTCCGTTGACATGTGAATAGGAACAAGACTTTCTTTCCTACTTACATA
AAGAAGGGAACAGCGTATAGACAAGTAGGCAATGATATACTCCACCAGGGGCTTTTGCCGCTTG
CCCAGATGTGCAAACGGCAACATCTGCTCCCTCTACTGCAAGGTCTAGGTAAGAAGTGCAGAGC
ACTCCTGATGGGCTGTTGTCATTTCCATCTGGTGACACGCTTGTCATAAACTCCACAGTGACAA
GCACTGTTGTGGGAGCGCTGTTCAATAGGATATTGAAAACGGTATTTCTTAGTGTGTGATCCAA
GGTCTGGGAAGTCTGACCTAGGAGGTCTCCAGTGTCAAGAAACCTTAGGTGGAGCCCGTCATCA
CCCACCTGCCATTACGTCATCAGTCTTGCACTGGGCCGCAGTTCCTCTTGCTGCTGGATATGTT
GACCCTGCTACAGCCGTAGTGCTTAGCAACTGCTTTTAGGGTACAGACTTGCAGGTTGTACCTC
TTTCCAGGAAGTTCGAGGGAACATTCTGTGCATCCATCTTGGAGCATTTTGGCCACCAACTCTT
TGAGCCTTTGACTTCCCACAAGTATGGGGCAGGGGCAGAAACCTGGCTGCTGTTTCTGCCACTT
GAAAGGACATCTGTGTCAGGCTTGCCACTGCATCTGCTCTGTCAGCACTTTCCCACAGTGGACA
TGATACTGGCTGTTGTCCTCAGCATCCTAGCCAGTCCTCACAGGTAATGACAGGAGGACCTGAA
CGCCTCAGCCCAGTCAGGTGTTCATTTTTCCTGCCTGTTTATGTGATTTCTGCTGTTTTCTTCA
GCTCAGTTCACCCCGATACCAGCAGTCGAACATTGAGGTTTGCTTCAGCATCCTGCTGGCTCTT
TCTTTGCCTTTGTGGATATCCAGTTAAGGCTGGGCTGCTACTCAAGTCAGCCTGTGAAAGGTGT
CACTTCTGAGAACTCACGATCAAACTGGCTACCCTGATTTCTGCACATGCCTTTGGCTTGCTCT
TGGAGGTCTGAAGATGTTGTCTGTCATTATTCTGGCAGTAAGACACATGGCTTCCACAAGGCAA
AAGCTAGTCCTCTGTCAACTTTTAGAATTACCCGAGCCACTCAGTGTTGGTTGGAAGTAGACTT
GAGTTAAAAATATCTCAGGATGGATGCAACTGTACCTTGTCCTTGGTGAGGAAACCGTGGTTGC
CAGGCTGGCGTAATTAAATGGCTTTTTCATCAGTGATTAGGCCGGTCCGGAGTCCCAGCATCAG
AGGCTCCATAGTTAACAGTGACGCTTTCCAAATTAAAATGCTTTCCCTCTCATGGGGATTTAAC
TCCCCAGGCACAGATCTTGCCAAGAGAATGATGAGCCCTCAGGGGATCAAGACCAGGAACCTGT
GGAGGGGAGCAGTGTTTAGATAAGGCCCCATTTCTCACCAGCCCATTTGTGGGTGTTCAGCCTC
TTGTGGTATCAAGAAAAGTGTAGCTGTTTCTACAAGTCCTTAACCCTGTTCCTCATCTGTCACA
GCATTTAGGAGACTGTCACCATGTATGTGTTTCATAAGGTTTCCCCAAGGCAGAGAGCAGAGGA
GTAAGAGGGTTGATCTCTTGGTGAGGTGTTGAGGAGTGTGTGTCCCTGCTAGACGCTGTGGTTT
ATGTAGACTGTCCCTTACCCTTCAGTGATCAGCATCAAGGCGAGGCCTTTGTCAGGATGATAAG
GAGACACAGTTAACTACAATCTTACTTGACACAGCCACTCTACACGGCATCAGGTGATCGGCAC
TGACAGCAATAGGACTGTGGTTTCCATCCAGTCCAATAGTGATTCTTGAATTATTTGCTGTTTA
CACAAAATTTACACAATAACTCAGACTTAGGAATCTGCAGGTGTGTGGTTTCTACATATCCCTG
CCATCTAATGACTTGTGCCTCTCATGCAACTCTGAGAAAGTGGATGGCATGCACTCCGTGGGAA
GATGTGAGTTATGTCTGGAACCCAAACATCGCCCTCATTTGAGTTCTGTGTTTTGTGGTACAGG
GGTCAACCATTATTCAGTATGTGCTCTAGACTAACCCTGACATCCACTGACTACCTCCTGAGTT
TCTGTATAAACCAGTTACATTTTTTAGTTTAAAGGTCATTTTTGGTGACTTAGAAAGAATTTTA
AATGTATCGTTTCCTCAGCTAGTGCTGTATCATCTCACAGTACAGATCTGTGTTAATTTGTGAC
AGGTTTCACGTGTGGGTTTGTAGAAGTGTAATAGAGAGTGGCTTTGCACATACGGTGTGAGTCT
TGCTGCTGTGTGCTTAATGTGGCGACACTTGCCAAAGCTGCTTGGCAAACACGTCAAAAGGGAT
GCTTGAGTCACAACTCAAATGCAAATGTGTCGCAACAGGAGTGTGTGTCACTATGATGTATTTT
TGTAAACACAGTGATGGCCTCTTTCAGTCATATAAGTACTGGATAAAAATAACCACTGGAGGGA
AATGTCACTTAACTGATGGCAAAGCTACTCATACTGTCAGCCAGGGGCGTGTGTGTGTGTGTGC
GCGTGCGTGCGTGCGTGCGTGCGTGCGTCATGGAGAGGGAAGAATTGACATCAGCAATATGGAG
GGCAAAAGTAATACCCCATCAAGTTAGAGGCCACTTGCACTCCCCATAGTATATGGATTTTAGG
AAATATTGAGAGAACTGGAATTCTCACACTAAATTACTGGCCTTGTCAGTTTGACTACTGAAGG
CAGTGGATTACCAAAAATTTTGCTTCTAAGCCTCCATAGCTGTCAGTAAGGGCTATGTCTTGTT
GAATCACCCCTTTCACCTGTTCCCCAAATTGCAATGAAAGTGATATGCTAGTGAGACGGACTCA
CAAACCTGGGTCACTCTGAACATGGCAGCAGTACAGGCAGGCAGATGCGCCTCAGCGTGCTGTA
GGAGATCACTCCCATAGCAATAGTAACTACACCACCTAAGTGTGACTCCTGACTCCTGCTAGTT
GCTTCCTCTCCTCTGCTTGGACCTCACAGCTGCCCTAAGAGCTGTTCCTGACAGGGCGCTCACC
TGAGCCTTCTCAGCTCAGTAAGCAGAATGGCCTCTTCTATCTGTGCCCGTCAGGCATAGTTCTC
AAAGTCTGCCAACACTTTGGAGTGAACGTTATTTGATTTTCTGATGCTATCAAGGGAAGGTTGG
CGTTCTATCACTAAATATGCAGGTGCTTAAATAACAAGCTTGTGAAGCCTCCAGGCCTCTCGGG
CCGGCATGAGGCGTGCCCTGAGTGGCATCCTGTGAGGGAGACCAGAAACCCTTAAAGGAAGTGG
GCACATCAGGAGTCTAGTCCCTCCCACCTTTCTAGATCCCCTGTACAAAGATGCAGGAACAAAG
GAAGACTTTGGATCTCGAGATTAGATCATTCACGTGACACCTGGTGATAGCTCTGGCTATTGGC
CAGTGTTCCCCCTCTGTGTGGCTGATTTTGCAGCCTCTGGTGACACTTCCAGTTCCGTGGGACG
TGAGGTTTTAGTTGACGATGTCACTGTGAGAACGGTAGAGGAGACTGTAAAGACTATAGTGACC
TGTTGGGTTTGCCCCTGTAGTCGAAAATTTAACATCCTTCAAACGCATGCCAAGGTCACGATGA
GCCTGGCTTGTGCCTCGGGAGCAAGGCCTGCCGGAAGCAGGCGGAGACTCAGTCACTGACCAGC
CTGCCCCTGCCCTGGCTAAGCCTTGCTTGCCCTCATGTTGCTCCTGTGCAGAACGGCATGTAGC
AGCTAACACTGGGGCCAGTTGCCTTTACTCTATTTTCTATGATGAATACTTGTGGAGAAACTGT
GACAAATCCATTGATCCTGATATTTTTATTGTTGGAGTCTTGTGGCTTCTCTGAATAATTTCTA
TTTGATTGTACTGTGTAGAGTTCATACACACTAGGGATATGTTAAAGAAGCTAAAATGCATAGT
ATAATATAGAATAGCAAAAAAATTTTTGTGAACAATTTATATAGAAGAGTGAGTTGTTTTTTAA
GTGTTAGGCCATTTCTTTTAGGAACCTAAAACGTTTTAAGAGTTTTTTAAACATTCAATATTTT
TAATTATGAGAGACATTTGTTACTAGAGCTGATTATTTCGGGTGTTCTAATTGGAATATTGATT
TTCTTACCTCATATACCTCTAGAATGCCACATGTTCTGTTGGGGGTAAAATTGCACAATAAATG
TCAAGTTATCTGTTAAA

hide sequence

RefSeq Acc Id:

XM_039092733 ⟹ XP_038948661

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	41,106,962 - 41,136,051 (+)	NCBI
mRatBN7.2	14	40,753,048 - 40,782,018 (+)	NCBI

RefSeq Acc Id:

XM_063273822 ⟹ XP_063129892

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	41,106,206 - 41,116,775 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_006251044	(Get FASTA)	NCBI Sequence Viewer
	XP_038948661	(Get FASTA)	NCBI Sequence Viewer
	XP_063129892	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073618
	ENSRNOP00000073618.2

RefSeq Acc Id:	XP_006251044 ⟸ XM_006250982
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K5Z6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPRDAGGGEGPSAPRIYKQRGPYSVLKTFPSRRPALAKRLRQTLLLELSPPAAVPLPPPPAAA AALRLRSPPWPISSTEPPPFPDAAVLSRRVRPGPPPPPASSSSPSCTPAAXPGHPRTPAPPPPP PPPPPLAAPAASSSSSFAAVVRYGPGPASGAGSSGAGSDGASLELSAESRMILDAFAQQCSRVL SLLNCGGKLLDSSHSQSMISCVKQEGSSYNERQDQCHIVKGVQSQTSDNIDIEMQYMQRKQQTS AFLRVFTDSLQNYLLSGNFPTPNTSSVSEYGHLADVDPLSASPVHTLGGWTSPATSESHGHPSS STLPEEEEEEEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKTVLLHHNQLL PQPAEQPTEGSKQLLNSYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKR KRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVG TFLHNGGSFYEGMDHQASQDEVFNKSSQDGSGD hide sequence

Ensembl Acc Id:

ENSRNOP00000073618 ⟸ ENSRNOT00000090148

Ensembl Acc Id:

ENSRNOP00000076013 ⟸ ENSRNOT00000092933

RefSeq Acc Id:	XP_038948661 ⟸ XM_039092733
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063129892 ⟸ XM_063273822
- Peptide Label:	isoform X3

Protein Domains

BEN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K5Z6-F1-model_v2	AlphaFold	A0A0G2K5Z6	1-543	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1584735	AgrOrtholog
BioCyc Gene	G2FUF-15777	BioCyc
Ensembl Genes	ENSRNOG00000053303	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000090148	ENTREZGENE
	ENSRNOT00000090148.3	UniProtKB/TrEMBL
InterPro	BEN_domain	UniProtKB/TrEMBL
	BEND4	UniProtKB/TrEMBL
NCBI Gene	681008	ENTREZGENE
PANTHER	BEN DOMAIN-CONTAINING PROTEIN 4	UniProtKB/TrEMBL
	PTHR35082	UniProtKB/TrEMBL
Pfam	BEN	UniProtKB/TrEMBL
PhenoGen	Bend4	PhenoGen
PROSITE	BEN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000053303	RatGTEx
SMART	BEN	UniProtKB/TrEMBL
UniProt	A0A0G2K5Z6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Bend4	BEN domain containing 4	LOC102551043	serine/arginine repetitive matrix protein 3-like	Data merged from RGD:7727148	737654	PROVISIONAL
2013-12-18	LOC102551043	serine/arginine repetitive matrix protein 3-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-05-24	Bend4	BEN domain containing 4	LOC100365335	BEN domain-containing protein 4-like	Data merged from RGD:2319243	1643240	APPROVED
2010-05-05	LOC100365335	BEN domain-containing protein 4-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-04-21	Bend4	BEN domain containing 4	LOC681008	hypothetical protein LOC681008	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC681008	hypothetical protein LOC681008	LOC687246	hypothetical protein LOC687246	Data merged from RGD:1587732	1643240	APPROVED
2006-11-19	LOC681008	hypothetical protein LOC681008			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC687246	hypothetical protein LOC687246			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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