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Gene: Dcun1d2 (defective in cullin neddylation 1 domain containing 2) Rattus norvegicus

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Symbol:

Dcun1d2

Name:

defective in cullin neddylation 1 domain containing 2

RGD ID:

1582994

Description:

Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation and protein neddylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D2 (defective in cullin neddylation 1 domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DCN1, defective in cullin neddylation 1, domain containing 2; DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae); DCN1-like protein 2; LOC290879; LOC688913; NEWGENE_1582994; RGD1311743; similar to DCN1-like protein 2 (Defective in cullin neddylation protein 2-like protein 2) (DCUN1 domain-containing protein 2); similar to RP42 homolog; squamous cell carcinoma-related oncogene

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,956,493 - 82,983,308 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	82,956,339 - 82,983,307 (+)	Ensembl				GRCr8
mRatBN7.2	16	76,254,433 - 76,281,139 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,254,413 - 76,281,146 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	81,535,022 - 81,560,483 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,987,600 - 85,013,057 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,236,452 - 80,261,933 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,008,177 - 81,034,869 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,587,446 - 81,614,553 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,008,176 - 81,028,656 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	81,075,552 - 81,102,636 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	81,111,139 - 81,136,556 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	74,061,054 - 74,086,607 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Epidermolysis Bullosa Simplex 5D with Nail Dystrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cyclosporin A (ISO)

dioxygen (EXP)

doxorubicin (ISO)

gentamycin (EXP)

inulin (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

nitrofen (EXP)

nitrogen dioxide (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

testosterone (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of protein neddylation (IEA,ISO)

protein neddylation (IBA)

regulation of protein neddylation (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

nucleus (IEA,ISO)

ubiquitin ligase complex (IBA)

Molecular Function

cullin family protein binding (IBA,IEA,ISO)

protein binding (ISO)

ubiquitin conjugating enzyme binding (IBA)

ubiquitin-like protein binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15632090

Genomics

Comparative Map Data

Dcun1d2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,956,493 - 82,983,308 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	82,956,339 - 82,983,307 (+)	Ensembl				GRCr8
mRatBN7.2	16	76,254,433 - 76,281,139 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,254,413 - 76,281,146 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	81,535,022 - 81,560,483 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,987,600 - 85,013,057 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,236,452 - 80,261,933 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,008,177 - 81,034,869 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,587,446 - 81,614,553 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,008,176 - 81,028,656 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	81,075,552 - 81,102,636 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	81,111,139 - 81,136,556 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	74,061,054 - 74,086,607 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

DCUN1D2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,455,819 - 113,491,563 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,455,819 - 113,490,984 (-)	Ensembl			hg38	GRCh38
GRCh37	13	114,110,134 - 114,145,026 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	113,158,135 - 113,193,024 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	113,158,236 - 113,193,007	NCBI
Celera	13	94,938,125 - 94,973,014 (-)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,549,729 - 94,577,633 (-)	NCBI		HuRef
CHM1_1	13	114,077,877 - 114,112,768 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,714,662 - 112,750,406 (-)	NCBI		T2T-CHM13v2.0

Dcun1d2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,305,963 - 13,337,833 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,305,963 - 13,338,131 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	13,255,963 - 13,288,126 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,255,963 - 13,288,131 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	13,255,963 - 13,288,126 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,259,880 - 13,287,810 (-)	NCBI		MGSCv36	mm8
Celera	8	13,424,198 - 13,456,484 (-)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.73	NCBI

Dcun1d2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	463,238 - 493,047 (+)	Ensembl
ChiLan1.0	NW_004955404	463,238 - 491,385 (+)	NCBI	ChiLan1.0	ChiLan1.0

DCUN1D2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	114,962,363 - 114,998,210 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,651,709 - 113,687,615 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,601,936 - 94,635,866 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,660,823 - 113,693,748 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,660,823 - 113,693,689 (-)	Ensembl			panPan2	panpan1.1

DCUN1D2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	60,750,547 - 60,778,245 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	60,752,283 - 60,778,038 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,462,189 - 60,496,249 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,435,654 - 61,463,394 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,435,663 - 61,464,629 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	60,874,424 - 60,908,458 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	60,876,493 - 60,910,549 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	60,907,666 - 60,935,412 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dcun1d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,644,032 - 195,666,235 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	285,990 - 308,164 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	285,927 - 308,123 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCUN1D2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,679,039 - 78,708,846 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	78,673,582 - 78,708,959 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,426,427 - 86,442,483 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCUN1D2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,426,580 - 91,466,594 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,428,821 - 91,458,863 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666046	48,493,314 - 48,532,638 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dcun1d2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	565,681 - 596,260 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624793	565,690 - 596,175 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dcun1d2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	70,419,532 - 70,442,932 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dcun1d2
314 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	287
Count of miRNA genes:	177
Interacting mature miRNAs:	233
Transcripts:	ENSRNOT00000026370
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	59428714	91442908	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	59428714	91442908	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	59428714	91442908	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat

Markers in Region

AW495713

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,279,830 - 76,279,929 (-)	MAPPER	mRatBN7.2
mRatBN7.2	16	76,279,830 - 76,279,929 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,613,236 - 81,613,334	NCBI	Rnor6.0
Rnor_6.0	16	81,009,387 - 81,009,485	NCBI	Rnor6.0
Rnor_5.0	16	81,101,328 - 81,101,426	UniSTS	Rnor5.0
RGSC_v3.4	16	81,136,487 - 81,136,585	UniSTS	RGSC3.4
Celera	16	74,086,538 - 74,086,636	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH133394

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,280,829 - 76,281,021 (-)	MAPPER	mRatBN7.2
mRatBN7.2	16	76,280,829 - 76,281,021 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,614,235 - 81,614,426	NCBI	Rnor6.0
Rnor_6.0	16	81,008,295 - 81,008,486	NCBI	Rnor6.0
Rnor_5.0	16	81,102,327 - 81,102,518	UniSTS	Rnor5.0
RGSC_v3.4	16	81,137,486 - 81,137,677	UniSTS	RGSC3.4
Celera	16	74,087,537 - 74,087,728	UniSTS
RH 3.4 Map	16	743.3	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
19	1	38	142	68	62	36	79	36	12	263	151	11	117	57	80	26	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026370 ⟹ ENSRNOP00000026370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,956,339 - 82,982,442 (+)	Ensembl
mRatBN7.2 Ensembl	16	76,260,649 - 76,281,139 (+)	Ensembl
Rnor_6.0 Ensembl	16	81,593,532 - 81,614,553 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091296 ⟹ ENSRNOP00000070767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,956,597 - 82,983,307 (+)	Ensembl
mRatBN7.2 Ensembl	16	76,254,413 - 76,281,146 (+)	Ensembl
Rnor_6.0 Ensembl	16	81,008,176 - 81,028,656 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092680 ⟹ ENSRNOP00000075757

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,956,603 - 82,983,307 (+)	Ensembl
mRatBN7.2 Ensembl	16	76,254,413 - 76,281,137 (+)	Ensembl
Rnor_6.0 Ensembl	16	81,587,446 - 81,614,544 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096712 ⟹ ENSRNOP00000097667

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,956,339 - 82,980,382 (+)	Ensembl
mRatBN7.2 Ensembl	16	76,254,413 - 76,279,272 (+)	Ensembl

RefSeq Acc Id:

NM_001134798 ⟹ NP_001128270

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	82,956,617 - 82,982,069 (+)	NCBI
mRatBN7.2	16	76,254,441 - 76,279,900 (+)	NCBI
Rnor_6.0	16	81,009,416 - 81,034,869 (-)	NCBI
Rnor_5.0	16	81,075,552 - 81,102,636 (+)	NCBI
RGSC_v3.4	16	81,111,139 - 81,136,556 (+)	RGD
Celera	16	74,061,054 - 74,086,607 (+)	RGD

Sequence:

show sequence

AGCATTGGGGAGCATGCATAAACTTAAATCAGCTCAGAAGGACAAGGTCCGCCAGTTCATGGCA
TGCACTCAGGCTAGTGAGAAGACTGCCATCTACTGCCTGACACAGAATGAGTGGAAACTAGACG
AGGCCACGGACAGTTTCTTCCAGAACCCAGAGGCGTTCCACCGAGAGTCTATGAAGAGCAGTGT
GGACCAGAAGAAGCTGGAGCAGCTCTACAGCAGGTACAAAGACCCGCAGGACGAAAACAAGATC
GGAATCGATGGGATCCAGCAGTTCTGCGATGACCTGAGCCTGGACCCGGCCAGTATCAGTGTTT
TGGTCATAGCATGGAGGTTCAGGGCCGCCACTCAGTGCGAATTTAGCAAGAAGGAATTTGTGGA
CGGCATGACAGAGCTGGGGTGTGATAGCACAGAGAGGCTGAAAGCTCTTCTCCCCAAACTGGAG
CAAGAGCTTAAGGACTCAGCTAAGTTCAAGGACTTTTACCAGTTTACCTTCACCTTCGCCAAGA
ACCCTGGGCAGAAGGGCTTAGATTTAGAAATGGCTGTTGCATATTGGAAGTTAGTATTGTCTGG
AAGGTTTAAATTTTTAGATCTTTGGAACACATTTCTGCTGGAGCATCACAAAAGATCAATTCCA
AGGGACACTTGGAACCTTCTCCTAGATTTTGGAAACATGATTGCAGACGATTTGTCTAACTACG
ATGAAGAAGGAGCATGGCCTGTCCTTATAGATGACTTTGTAGAATATGCACGGCCAGTAGTCAC
AGGAGGGAGACGTGGCCCTCTCTAGACGGAAACGCCAGAGACGCCAGACAGAGGGCATGTCCTG
GAGGAGACGGCTGCGTGGGTTGCTGTGTGCATTTGTCGCTGACCTCAGAGTCTTCCTCATCCAT
TCATGAAGCAAATCCTCACTCTGCTTAAAGGCTGCAGTGGCTGACAGCGCAGACACGAAGAAGC
TCCTCGGGGCGTGAGGGACATTGGCAAAGCTATTGCTTTAGGAGACGCCTGCATGACTTGTCTT
TATAGAGAGCAACACAGACCCTGTTTGCAGGGCTGAAAGCATGTTGTTCAGTTGATGACGTTAA
GGTGAGCACCAGCCGTTTCCAAACTGGAATCATGTTACAGTTATGCTTCAAAGTAGCATCCGTG
TCCCCAGAATGATGTGTCTTTTATACAAGCCCAAACCTCTTGAAGATGGCCTTGTCAGAGAGCC
CACTGCTTTTAATCTTGGTATTCAAGATGGATAGTTTTAAATCATCAAATCTCTAGATTTACTA
GATGTCTTGCTTTCATTTTCTCTAGAAGATACCGTTGCAGTTTGCACGGGGTGGGGGGGCACAG
GACGCAATCCAGCAGGTTCATATCAAACTGTTTACAAGCCGGTAGGCCTGGTTCACTTCTACTG
AGGTTACTACTAT

hide sequence

RefSeq Acc Id:

XM_063275742 ⟹ XP_063131812

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	82,956,493 - 82,983,308 (+)	NCBI

RefSeq Acc Id:

XM_063275743 ⟹ XP_063131813

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	82,956,493 - 82,983,308 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128270	(Get FASTA)	NCBI Sequence Viewer
	XP_063131812	(Get FASTA)	NCBI Sequence Viewer
	XP_063131813	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM08887	(Get FASTA)	NCBI Sequence Viewer
	EDM08888	(Get FASTA)	NCBI Sequence Viewer
	EDM08889	(Get FASTA)	NCBI Sequence Viewer
	EDM08890	(Get FASTA)	NCBI Sequence Viewer
	EDM08891	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026370
	ENSRNOP00000026370.7
	ENSRNOP00000070767
	ENSRNOP00000070767.2
	ENSRNOP00000075757
	ENSRNOP00000075757.3
	ENSRNOP00000097667.2

RefSeq Acc Id:

NP_001128270 ⟸ NM_001134798

- UniProtKB:

D4AD48 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHKLKSAQKDKVRQFMACTQASEKTAIYCLTQNEWKLDEATDSFFQNPEAFHRESMKSSVDQKK
LEQLYSRYKDPQDENKIGIDGIQQFCDDLSLDPASISVLVIAWRFRAATQCEFSKKEFVDGMTE
LGCDSTERLKALLPKLEQELKDSAKFKDFYQFTFTFAKNPGQKGLDLEMAVAYWKLVLSGRFKF
LDLWNTFLLEHHKRSIPRDTWNLLLDFGNMIADDLSNYDEEGAWPVLIDDFVEYARPVVTGGRR
GPL

hide sequence

Ensembl Acc Id:

ENSRNOP00000075757 ⟸ ENSRNOT00000092680

Ensembl Acc Id:

ENSRNOP00000026370 ⟸ ENSRNOT00000026370

Ensembl Acc Id:

ENSRNOP00000070767 ⟸ ENSRNOT00000091296

Ensembl Acc Id:

ENSRNOP00000097667 ⟸ ENSRNOT00000096712

RefSeq Acc Id:	XP_063131812 ⟸ XM_063275742
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYS0 (UniProtKB/TrEMBL), A6IWI1 (UniProtKB/TrEMBL), A6IWI3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131813 ⟸ XM_063275743
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AWN0 (UniProtKB/TrEMBL), A6IWI2 (UniProtKB/TrEMBL)

Protein Domains

DCUN1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0U1RRP2-F1-model_v2	AlphaFold	A0A0U1RRP2	1-259	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1582994	AgrOrtholog
BioCyc Gene	G2FUF-10716	BioCyc
Ensembl Genes	ENSRNOG00000019473	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000052837	Ensembl
Ensembl Transcript	ENSRNOT00000026370	ENTREZGENE
	ENSRNOT00000026370.8	UniProtKB/TrEMBL
	ENSRNOT00000091296	ENTREZGENE
	ENSRNOT00000091296.3	UniProtKB/TrEMBL
	ENSRNOT00000092680	ENTREZGENE
	ENSRNOT00000092680.3	UniProtKB/TrEMBL
	ENSRNOT00000096712.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.238.200	UniProtKB/TrEMBL
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	DCN-prot	UniProtKB/TrEMBL
	DCN1-like_PONY	UniProtKB/TrEMBL
	DUF298	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
NCBI Gene	688913	ENTREZGENE
PANTHER	DCN1-LIKE PROTEIN 2	UniProtKB/TrEMBL
	DUF298	UniProtKB/TrEMBL
Pfam	Cullin_binding	UniProtKB/TrEMBL
	UBA_4	UniProtKB/TrEMBL
PhenoGen	Dcun1d2	PhenoGen
PROSITE	DCUN1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019473	RatGTEx
	ENSRNOG00000052837	RatGTEx
Superfamily-SCOP	SSF46934	UniProtKB/TrEMBL
UniProt	A0A0G2JYS0	ENTREZGENE, UniProtKB/TrEMBL
	A0A0U1RRP2_RAT	UniProtKB/TrEMBL
	A0A8I6AWN0	ENTREZGENE, UniProtKB/TrEMBL
	A6IWI1	ENTREZGENE, UniProtKB/TrEMBL
	A6IWI2	ENTREZGENE, UniProtKB/TrEMBL
	A6IWI3	ENTREZGENE, UniProtKB/TrEMBL
	D4AD48	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Dcun1d2	defective in cullin neddylation 1 domain containing 2	NEWGENE_1582994	DCN1, defective in cullin neddylation 1, domain containing 2	Data merged from RGD:9432541	737654	PROVISIONAL
2016-01-20	Dcun1d2	defective in cullin neddylation 1 domain containing 2	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	NEWGENE_1582994	DCN1, defective in cullin neddylation 1, domain containing 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-07-09	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-15	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	RGD1311743	similar to RP42 homolog; squamous cell carcinoma-related oncogene	Data merged from RGD:1311743	1643240	APPROVED
2008-04-30	RGD1311743	similar to RP42 homolog; squamous cell carcinoma-related oncogene	RGD1311743_predicted	similar to RP42 homolog; squamous cell carcinoma-related oncogene (predicted)	'predicted' is removed	2292626	APPROVED
2008-03-06	Dcun1d2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	LOC688913	similar to DCN1-like protein 2 (Defective in cullin neddylation protein 2-like protein 2) (DCUN1 domain-containing protein 2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC688913	similar to DCN1-like protein 2 (Defective in cullin neddylation protein 2-like protein 2) (DCUN1 domain-containing protein 2)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	RGD1311743_predicted	similar to RP42 homolog; squamous cell carcinoma-related oncogene (predicted)	LOC290879_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC290879_predicted	similar to RP42 homolog; squamous cell carcinoma-related oncogene (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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