Kcnk16 (potassium two pore domain channel subfamily K member 16) - Rat Genome Database

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Gene: Kcnk16 (potassium two pore domain channel subfamily K member 16) Rattus norvegicus
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Symbol: Kcnk16
Name: potassium two pore domain channel subfamily K member 16
RGD ID: 1582911
Description: Predicted to enable identical protein binding activity; potassium channel activity; and protein heterodimerization activity. Predicted to be involved in several processes, including endoplasmic reticulum calcium ion homeostasis; potassium ion transmembrane transport; and regulation of peptide hormone secretion. Predicted to act upstream of or within potassium ion transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Orthologous to human KCNK16 (potassium two pore domain channel subfamily K member 16); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688996; potassium channel subfamily K member 16; potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; similar to potassium channel, subfamily K, member 16
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Kcnk16-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,069,495 - 4,098,836 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,091,691 - 4,098,834 (+)EnsemblGRCr8
mRatBN7.2154,042,506 - 4,049,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,042,506 - 4,049,652 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx154,052,610 - 4,059,749 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,439,032 - 5,446,172 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,051,427 - 4,058,567 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,474,732 - 4,482,196 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,475,051 - 4,482,194 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,574,694 - 8,582,657 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,287,010 - 4,294,153 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15547,096 - 554,173 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11263999   PMID:12724142  


Genomics

Comparative Map Data
Kcnk16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,069,495 - 4,098,836 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,091,691 - 4,098,834 (+)EnsemblGRCr8
mRatBN7.2154,042,506 - 4,049,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,042,506 - 4,049,652 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx154,052,610 - 4,059,749 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,439,032 - 5,446,172 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,051,427 - 4,058,567 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,474,732 - 4,482,196 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,475,051 - 4,482,194 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,574,694 - 8,582,657 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,287,010 - 4,294,153 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15547,096 - 554,173 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNK16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,314,570 - 39,322,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,314,698 - 39,322,968 (-)Ensemblhg38GRCh38
GRCh37639,282,474 - 39,290,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,390,460 - 39,398,294 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34639,390,459 - 39,398,294NCBI
Celera640,835,738 - 40,843,594 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef639,000,935 - 39,008,791 (-)NCBIHuRef
CHM1_1639,285,120 - 39,292,976 (-)NCBICHM1_1
T2T-CHM13v2.0639,139,109 - 39,147,515 (-)NCBIT2T-CHM13v2.0
Kcnk16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,311,443 - 20,319,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,311,444 - 20,319,267 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381420,261,375 - 20,269,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,261,376 - 20,269,199 (-)Ensemblmm10GRCm38
MGSCv371421,081,978 - 21,088,384 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361419,051,308 - 19,057,714 (-)NCBIMGSCv36mm8
Celera1416,643,909 - 16,650,315 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.49NCBI
KCNK16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,811,177 - 53,819,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,680,775 - 49,689,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,903,546 - 38,911,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1640,214,325 - 40,222,171 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl640,214,325 - 40,222,171 (-)EnsemblpanPan2panpan1.1
Kcnk16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,627,366 - 43,633,167 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,327,086 - 20,332,752 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,327,086 - 20,332,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,727,793 - 34,734,771 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1734,727,771 - 34,734,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,812,306 - 39,817,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11732,815,592 - 32,823,313 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604439,318,493 - 39,325,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,195,440 - 21,200,885 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk16
284 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:188
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000008461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
13 8 86 47 52 22 10 22 6 110 30 72 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000008461   ⟹   ENSRNOP00000008461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl154,091,691 - 4,098,834 (+)Ensembl
mRatBN7.2 Ensembl154,042,506 - 4,049,652 (+)Ensembl
Rnor_6.0 Ensembl154,475,051 - 4,482,194 (+)Ensembl
RefSeq Acc Id: NM_001109520   ⟹   NP_001102990
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,091,691 - 4,098,834 (+)NCBI
mRatBN7.2154,042,506 - 4,049,652 (+)NCBI
Rnor_6.0154,475,051 - 4,482,194 (+)NCBI
Rnor_5.0158,574,694 - 8,582,657 (+)NCBI
RGSC_v3.4154,287,010 - 4,294,153 (+)RGD
Celera15547,096 - 554,173 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274661   ⟹   XP_063130731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,069,495 - 4,098,836 (+)NCBI
RefSeq Acc Id: XM_063274662   ⟹   XP_063130732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,069,495 - 4,098,836 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102990 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130731 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130732 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008461
  ENSRNOP00000008461.3
RefSeq Acc Id: NP_001102990   ⟸   NM_001109520
- UniProtKB: D3ZLR9 (UniProtKB/TrEMBL),   A6KKL7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008461   ⟸   ENSRNOT00000008461
RefSeq Acc Id: XP_063130732   ⟸   XM_063274662
- Peptide Label: isoform X1
- UniProtKB: A6KKL7 (UniProtKB/TrEMBL),   D3ZLR9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130731   ⟸   XM_063274661
- Peptide Label: isoform X1
- UniProtKB: A6KKL7 (UniProtKB/TrEMBL),   D3ZLR9 (UniProtKB/TrEMBL)
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLR9-F1-model_v2 AlphaFold D3ZLR9 1-292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582911 AgrOrtholog
BioCyc Gene G2FUF-14528 BioCyc
Ensembl Genes ENSRNOG00000006422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008461 ENTREZGENE
  ENSRNOT00000008461.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro Ion_trans_2 UniProtKB/TrEMBL
  K_chnl_2pore UniProtKB/TrEMBL
  K_chnl_2pore_TASK UniProtKB/TrEMBL
KEGG Report rno:688996 UniProtKB/TrEMBL
NCBI Gene 688996 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 16 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PhenoGen Kcnk16 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006422 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A6KKL7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLR9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk16  potassium two pore domain channel subfamily K member 16  Kcnk16  potassium channel, two pore domain subfamily K, member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk16  potassium channel, two pore domain subfamily K, member 16  Kcnk16  potassium channel, subfamily K, member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Kcnk16  potassium channel, subfamily K, member 16  LOC688996  similar to potassium channel, subfamily K, member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC688996  similar to potassium channel, subfamily K, member 16  LOC682965  similar to potassium channel, subfamily K, member 16  Data merged from RGD:1592779 1643240 APPROVED
2006-11-20 LOC682965  similar to potassium channel, subfamily K, member 16      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688996  similar to potassium channel, subfamily K, member 16      Symbol and Name status set to provisional 70820 PROVISIONAL