Advanced Search (OLGA)

Gene: Tmem181 (transmembrane protein 181) Rattus norvegicus

Analyze

Symbol:

Tmem181

Name:

transmembrane protein 181

RGD ID:

1566403

Description:

Predicted to enable toxic substance binding activity. Predicted to be located in membrane. Orthologous to human TMEM181 (transmembrane protein 181); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC502228; LOC502228; RGD1566403; similar to OTTHUMP00000040081

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM181 (transmembrane protein 181)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Tmem181a (transmembrane protein 181A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem181 (transmembrane protein 181)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMEM181 (transmembrane protein 181)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem181a (transmembrane protein 181A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem181 (transmembrane protein 181)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG13409	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem181	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	49,235,923 - 49,290,244 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	49,236,025 - 49,290,616 (+)	Ensembl				GRCr8
mRatBN7.2	1	46,830,812 - 46,885,173 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	46,830,710 - 46,884,295 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	47,391,496 - 47,431,636 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	53,378,752 - 53,418,898 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	47,466,929 - 47,507,071 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	47,162,394 - 47,202,554 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	47,162,394 - 47,202,549 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	48,465,874 - 48,508,264 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	41,044,202 - 41,092,834 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	42,531,766 - 42,570,322 (+)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

epoxiconazole (ISO)

ethanol (ISO)

methapyrilene (ISO)

methimazole (EXP)

paracetamol (EXP)

PCB138 (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

thiram (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

Molecular Function

toxic substance binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:19965467

Genomics

Comparative Map Data

Tmem181
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	49,235,923 - 49,290,244 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	49,236,025 - 49,290,616 (+)	Ensembl				GRCr8
mRatBN7.2	1	46,830,812 - 46,885,173 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	46,830,710 - 46,884,295 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	47,391,496 - 47,431,636 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	53,378,752 - 53,418,898 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	47,466,929 - 47,507,071 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	47,162,394 - 47,202,554 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	47,162,394 - 47,202,549 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	48,465,874 - 48,508,264 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	41,044,202 - 41,092,834 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	42,531,766 - 42,570,322 (+)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

TMEM181
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	158,536,640 - 158,635,429 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	158,536,436 - 158,635,435 (+)	Ensembl			hg38	GRCh38
GRCh37	6	158,957,672 - 159,056,461 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	158,877,456 - 158,976,455 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	6	159,605,468 - 159,704,461 (+)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	156,428,842 - 156,527,319 (+)	NCBI		HuRef
CHM1_1	6	159,220,227 - 159,319,025 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	159,781,619 - 159,880,620 (+)	NCBI		T2T-CHM13v2.0

Tmem181a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	6,307,001 - 6,358,589 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	6,307,135 - 6,358,589 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	6,256,726 - 6,308,314 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	6,256,860 - 6,308,314 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	6,270,475 - 6,305,783 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	6,380,413 - 6,407,591 (+)	NCBI		MGSCv36	mm8
MGSCv36	13	45,856,164 - 45,867,098 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	17	A1	NCBI
cM Map	17	3.85	NCBI

Tmem181
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	3,843,823 - 3,900,108 (-)	Ensembl
ChiLan1.0	NW_004955439	3,843,823 - 3,914,702 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM181
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	178,644,912 - 178,743,035 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	176,548,880 - 176,646,934 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	156,431,076 - 156,529,012 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	161,469,469 - 161,540,603 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	161,445,828 - 161,539,535 (+)	Ensembl			panPan2	panpan1.1

TMEM181
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	47,969,247 - 48,058,207 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	47,983,174 - 48,055,111 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	48,828,692 - 48,903,310 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	48,171,364 - 48,244,345 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	48,171,282 - 48,244,285 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	48,046,502 - 48,121,066 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	47,916,956 - 47,991,632 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	48,476,703 - 48,551,267 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem181
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	143,023,754 - 143,076,109 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	10,275,924 - 10,328,071 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	10,275,739 - 10,328,102 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM181
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	8,562,844 - 8,635,462 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	8,564,752 - 8,642,358 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	10,372,389 - 10,384,560 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM181
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	86,102,912 - 86,206,815 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	58,475,644 - 58,591,334 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem181
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624929	979,523 - 1,040,057 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624929	977,896 - 1,053,590 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem181
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	192,503,788 - 192,557,571 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem181
305 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	220
Count of miRNA genes:	164
Interacting mature miRNAs:	177
Transcripts:	ENSRNOT00000068457
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	7746118	52746118	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	29409279	74409279	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	6941022	51941022	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	6909353	51909353	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	17315378	51816258	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	6909353	51909353	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	7e-07	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	6909353	51909353	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	20508326	65508326	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	11684464	56684464	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	7746121	52746121	Rat
1558642	Prcr2	Prostate cancer resistance QTL 2	4.3		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	1	10379492	55379492	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	12820494	57820494	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20656420	65656420	Rat

Markers in Region

D1Ztm7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	47,200,222 - 47,200,455	NCBI	Rnor6.0
Rnor_5.0	1	48,503,432 - 48,503,665	UniSTS	Rnor5.0
RGSC_v3.4	1	41,090,502 - 41,090,735	UniSTS	RGSC3.4
Celera	1	42,567,990 - 42,568,223	UniSTS
Cytogenetic Map	1	q11	UniSTS

RH129044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	46,882,350 - 46,882,530 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	47,202,227 - 47,202,406	NCBI	Rnor6.0
Rnor_5.0	1	48,505,437 - 48,505,616	UniSTS	Rnor5.0
RGSC_v3.4	1	41,092,507 - 41,092,686	UniSTS	RGSC3.4
Celera	1	42,569,995 - 42,570,174	UniSTS
Cytogenetic Map	1	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001130939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001444177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001444178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000068457 ⟹ ENSRNOP00000059824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,247,576 - 49,289,362 (+)	Ensembl
mRatBN7.2 Ensembl	1	46,842,517 - 46,882,673 (+)	Ensembl
Rnor_6.0 Ensembl	1	47,162,394 - 47,202,549 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098929 ⟹ ENSRNOP00000093316

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,258,115 - 49,289,362 (+)	Ensembl
mRatBN7.2 Ensembl	1	46,852,752 - 46,884,295 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104987 ⟹ ENSRNOP00000097066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,248,221 - 49,289,362 (+)	Ensembl
mRatBN7.2 Ensembl	1	46,843,049 - 46,882,673 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112360 ⟹ ENSRNOP00000085718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,253,232 - 49,289,362 (+)	Ensembl
mRatBN7.2 Ensembl	1	46,830,710 - 46,882,673 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000137115 ⟹ ENSRNOP00000109249

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,236,042 - 49,289,362 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161806 ⟹ ENSRNOP00000102101

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	49,236,025 - 49,290,616 (+)	Ensembl

RefSeq Acc Id:

NM_001130939 ⟹ NP_001124411

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	49,247,604 - 49,287,754 (+)	NCBI
mRatBN7.2	1	46,842,517 - 46,882,678 (+)	NCBI
Rnor_6.0	1	47,162,394 - 47,202,554 (+)	NCBI
Rnor_5.0	1	48,465,874 - 48,508,264 (+)	NCBI
RGSC_v3.4	1	41,044,202 - 41,092,834 (+)	RGD
Celera	1	42,531,766 - 42,570,322 (+)	RGD

Sequence:

show sequence

GCCGGCTGCTCGGCCTCACGGGTGGCTCTGGCGGCGGCTGCGGGACGCCGGGCGAGCTCGGGAC
GCACCGGCGGGGGCCGGGGACCCGGGTCTCCGAGATGGAACCACTGGCACCCATGCGGCTCTAC
ACGCTCTCCAAGCGCCACTTTGTCCTCGTGTTTGTTGTCTTCTTCATCTGTTTTGGGCTGACCG
TCTTCGTTGGCATCGAGGGACCCAGAGTGATCCAGACTTCGGCTGCTAATTTTTCACTGAATAA
TAGCAAAAAGCTAAAACCAGTTCAAATCCGTTCAAACCCACTGTCCACATATAACCAGCAGCTA
TGGCTGACGTGCGTTGTGGAACTGGAGCCCTCAGAAGAAACATCTATTCAAACCAGCTTTCCCA
TGACTGTGAAAGTCGATGGTGTGTCTCAAGATGCAACCACAATGTACATCCATAACAAAGTTCA
CAATCGGACGAGGACCCTCACATGTGCAGGGAAATGCGCAGAAATCATTGTGGCCCACCTTGGC
TACCTGAATTACACGCAGTACAGAGTGACTGTGGGATTTGAGCACCTGAACCAGCCCATCAAGG
AGATGAACTTCACATGGAAGACATACAACCCTGCGTTTTCCCAGCTGGAGATCTGGTTCCGCTT
CGTGTTTGTGGTGCTCACCTTCATCGTCATCTGCCTGTTTGTGCATTCCCTGCGCAAGTTCTCC
ATGAGGGACTGGGGCATCGAGCAGAAGTGGATGTCTGTCCTCCTGCTACTGCTGCTGCTCTACA
ATGACCCTTTCTTCCCACTCTCCTTCCTGGTGAACAGCTGGTTCCCAGGGATGCTGGACGACTT
CTTCCAGTCTCTGTTCCTGTGTGCCCTGCTGCTCTTCTGGCTCTGCGTGTATCATGGGATACGG
GTCCAGGGAGAAAGAAAATGTTTAACTTTCTATTTGCCTAAATTCTTCATCGTTGGACTGCTGT
GGCTGGCTTCTGTTACGCTGGGAATATGGCAAACATTTAATGAATTAAATGACCCCATGTACCA
GTATCGGGTTGACACCGGAAACTTTCAGGGCATGAAGGTCTTCTTCATGGTGGTGGCTGCTGTA
TACATTTTATACCTACTATTCTTGATAGTGCGGGCATGCTCCGAGCTCCGTCATATGCCTTACG
TGGATCTTAGGTTAAAGTTTTTGACTGCGTTGACCTTTGTAGTGCTTGTTATTAGCATCGTCAT
CCTCTACCTAAGGTTTGGAGCACAAGTGCTACAGGACAACTTCGTAGCAGAACTGTCCGCTCAC
TACCAGAACTCAGCTGAATTCCTGTCTTTCTATGGCCTGTTGAACTTTTACCTCTACACGCTGG
CCTTTGTGTACTCTCCATCAAAGAATGCTCTGTATGAGTCCCAGCTGAAAGACAATCCTGCATT
TTCCATGCTCAACGACTCTGATGATGATGTGATTTACGGGAGTGACTATGAAGAAATGCCCCTG
CAGAATGGCCAGGCCATCCGAGCCAAGTGCAGGGAAGAGTCGGACAGTGACTGAGCCCCGGACA
GCAGATGGGACAGCAAGGGGGCCAGAGACCTGCCTGAGTGATGCGTTCTGGCCCTTTTCTTCTA
TCCGTCTGTGTCTGGACTCCTCTGTAAGCAAGTTTCCTGTTCCTTATTTGTTTACATATTTTTA
AAAGAGAAACCAAATGGATTGACATGTATTTGCTGTGAGGGTAGCCCCACGTTTTAAGAAGAGG
GGCTGGCTGATAGAGAAGCCAAAGGCATTCCCTTACGTCGATAGCAGGTGAGATGGAGCCTATG
TGCAGTCATGAGAAGATATTACCCATTTTTAATAAAAAGAATTATGTACTTTTTTCCCTTTTAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088219 ⟹ XP_038944147

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	49,235,943 - 49,290,244 (+)	NCBI
mRatBN7.2	1	46,830,818 - 46,885,173 (+)	NCBI

RefSeq Acc Id:

XM_039088223 ⟹ XP_038944151

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	49,235,923 - 49,287,425 (+)	NCBI
mRatBN7.2	1	46,830,812 - 46,885,173 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001124411	(Get FASTA)	NCBI Sequence Viewer
	NP_001431106	(Get FASTA)	NCBI Sequence Viewer
	NP_001431107	(Get FASTA)	NCBI Sequence Viewer
	XP_038944147	(Get FASTA)	NCBI Sequence Viewer
	XP_038944151	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68231	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059824
	ENSRNOP00000059824.1
	ENSRNOP00000085718.2
	ENSRNOP00000093316.2
	ENSRNOP00000097066.1
	ENSRNOP00000102101
	ENSRNOP00000102101.1
	ENSRNOP00000109249.1

RefSeq Acc Id:

NP_001124411 ⟸ NM_001130939

- UniProtKB:

B4F7D5 (UniProtKB/TrEMBL), A0A8I6GKL8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTVFVGIEGPRVIQTSAANFSLNNSKKLKPVQIRS
NPLSTYNQQLWLTCVVELEPSEETSIQTSFPMTVKVDGVSQDATTMYIHNKVHNRTRTLTCAGK
CAEIIVAHLGYLNYTQYRVTVGFEHLNQPIKEMNFTWKTYNPAFSQLEIWFRFVFVVLTFIVIC
LFVHSLRKFSMRDWGIEQKWMSVLLLLLLLYNDPFFPLSFLVNSWFPGMLDDFFQSLFLCALLL
FWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTFNELNDPMYQYRVDTGNFQGM
KVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIVILYLRFGAQVLQ
DNFVAELSAHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVI
YGSDYEEMPLQNGQAIRAKCREESDSD

hide sequence

Ensembl Acc Id:

ENSRNOP00000059824 ⟸ ENSRNOT00000068457

RefSeq Acc Id:	XP_038944151 ⟸ XM_039088223
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038944147 ⟸ XM_039088219
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GD86 (UniProtKB/TrEMBL), A0A8I6GKL8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000097066 ⟸ ENSRNOT00000104987

Ensembl Acc Id:

ENSRNOP00000085718 ⟸ ENSRNOT00000112360

Ensembl Acc Id:

ENSRNOP00000093316 ⟸ ENSRNOT00000098929

Ensembl Acc Id:

ENSRNOP00000109249 ⟸ ENSRNOT00000137115

Ensembl Acc Id:

ENSRNOP00000102101 ⟸ ENSRNOT00000161806

Protein Domains

TMEM181 GOLD Wntless-like transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B4F7D5-F1-model_v2	AlphaFold	B4F7D5	1-475	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689608

Promoter ID:

EPDNEW_R130

Type:

initiation region

Name:

Tmem181_1

Description:

transmembrane protein 181

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	47,162,384 - 47,162,444	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566403	AgrOrtholog
BioCyc Gene	G2FUF-61617	BioCyc
Ensembl Genes	ENSRNOG00000018158	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068457	ENTREZGENE
	ENSRNOT00000068457.4	UniProtKB/TrEMBL
	ENSRNOT00000098929.2	UniProtKB/TrEMBL
	ENSRNOT00000104987.2	UniProtKB/TrEMBL
	ENSRNOT00000112360.2	UniProtKB/TrEMBL
	ENSRNOT00000137115.1	UniProtKB/TrEMBL
	ENSRNOT00000161806	ENTREZGENE
	ENSRNOT00000161806.1	UniProtKB/TrEMBL
InterPro	TMEM181	UniProtKB/TrEMBL
	TMEM181_GOLD	UniProtKB/TrEMBL
	WLS-like_TM	UniProtKB/TrEMBL
KEGG Report	rno:502228	UniProtKB/TrEMBL
NCBI Gene	502228	ENTREZGENE
PANTHER	PTHR31918	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 181	UniProtKB/TrEMBL
Pfam	MIG-14_Wnt-bd	UniProtKB/TrEMBL
	TMEM181_GOLD	UniProtKB/TrEMBL
PhenoGen	Tmem181	PhenoGen
RatGTEx	ENSRNOG00000018158	RatGTEx
UniProt	A0A8I6AUF9_RAT	UniProtKB/TrEMBL
	A0A8I6GD86	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GKL8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LKI7_RAT	UniProtKB/TrEMBL
	A0ABK0LXP5_RAT	UniProtKB/TrEMBL
	B4F7D5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-05-05	Tmem181	transmembrane protein 181	RGD1566403	similar to OTTHUMP00000040081	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1566403	similar to OTTHUMP00000040081	RGD1566403_predicted	similar to OTTHUMP00000040081 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1566403_predicted	similar to OTTHUMP00000040081 (predicted)	LOC502228	similar to OTTHUMP00000040081	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502228	similar to OTTHUMP00000040081			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message