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Gene: Gpr75 (G protein-coupled receptor 75) Rattus norvegicus

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Symbol:

Gpr75

Name:

G protein-coupled receptor 75

RGD ID:

1566385

Description:

Predicted to enable C-C chemokine receptor activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to act upstream of or within ERK1 and ERK2 cascade. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR75 (G protein-coupled receptor 75); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor GPR75; LOC498434; probable G-protein coupled receptor 75; RGD1566385; similar to G protein-coupled receptor GPR75

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR75 (G protein-coupled receptor 75)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPR75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr75	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr75	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	108,817,086 - 108,821,926 (+)	Ensembl				GRCr8
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	108,928,518 - 108,931,127 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	110,161,479 - 110,164,088 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	106,633,916 - 106,636,525 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	103,454,448 - 103,457,057 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

gentamycin (EXP)

Moniliformin (ISO)

niclosamide (ISO)

nitrogen dioxide (ISO)

okadaic acid (ISO)

ozone (ISO)

PCB138 (ISO)

potassium chloride (ISO)

titanium dioxide (ISO)

triclosan (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemokine-mediated signaling pathway (IEA,ISO)

G protein-coupled receptor signaling pathway (IBA,IEA,ISO)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

C-C chemokine receptor activity (IBA,IEA,ISO)

G protein-coupled receptor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17001303	PMID:23979485

Genomics

Comparative Map Data

Gpr75
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	108,817,086 - 108,821,926 (+)	Ensembl				GRCr8
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	108,928,518 - 108,931,127 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	110,161,479 - 110,164,088 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	106,633,916 - 106,636,525 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	103,454,448 - 103,457,057 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

GPR75
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	53,852,912 - 53,859,967 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	53,852,912 - 53,859,967 (-)	Ensembl			hg38	GRCh38
GRCh37	2	54,080,049 - 54,087,104 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	53,933,554 - 53,940,572 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	53,991,700 - 53,998,719	NCBI
Celera	2	53,920,904 - 53,927,988 (-)	NCBI		Celera
Cytogenetic Map	2	p16.2	NCBI
HuRef	2	53,814,122 - 53,821,237 (-)	NCBI		HuRef
CHM1_1	2	54,010,915 - 54,018,039 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	53,849,132 - 53,856,193 (-)	NCBI		T2T-CHM13v2.0

Gpr75
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	30,834,636 - 30,846,090 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	30,835,358 - 30,843,729 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	30,884,633 - 30,896,090 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	30,885,358 - 30,893,729 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	30,791,097 - 30,792,719 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	30,791,097 - 30,792,719 (+)	NCBI		MGSCv36	mm8
Celera	11	33,296,506 - 33,298,128 (+)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI
cM Map	11	18.16	NCBI

Gpr75
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	19,576,967 - 19,578,571 (-)	Ensembl
ChiLan1.0	NW_004955441	19,576,490 - 19,579,447 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPR75
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	72,498,538 - 72,509,305 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	72,502,488 - 72,513,270 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	53,996,008 - 54,003,134 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	54,908,210 - 54,915,172 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	54,908,736 - 54,910,358 (-)	Ensembl			panPan2	panpan1.1

GPR75
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	54,858,380 - 54,862,734 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	54,813,033 - 54,815,018 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	55,860,403 - 55,862,384 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	55,860,403 - 55,861,929 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	55,553,039 - 55,554,936 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	55,839,677 - 55,841,765 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	56,126,156 - 56,128,140 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gpr75
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	28,171,339 - 28,180,452 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	391,144 - 400,001 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	391,022 - 400,394 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR75
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	87,341,345 - 87,350,637 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	87,341,562 - 87,350,664 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	92,492,876 - 92,499,138 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR75
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	53,112,773 - 53,119,964 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	53,117,915 - 53,119,537 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	58,583,166 - 58,590,309 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr75
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	8,026,168 - 8,033,382 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624833	8,023,796 - 8,033,355 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gpr75
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	98,389,718 - 98,391,763 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	322
Count of miRNA genes:	205
Interacting mature miRNAs:	240
Transcripts:	ENSRNOT00000033437
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat

Markers in Region

RH144409

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	104,618,470 - 104,618,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	115,278,096 - 115,278,300	NCBI	Rnor6.0
Rnor_5.0	14	114,935,599 - 114,935,803	UniSTS	Rnor5.0
RGSC_v3.4	14	112,006,239 - 112,006,443	UniSTS	RGSC3.4
Celera	14	103,456,650 - 103,456,854	UniSTS
Cytogenetic Map	14	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	11	66	153	56	55	26	48	26	6	269	146	11	132	78	91	29	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033437 ⟹ ENSRNOP00000029471

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	108,817,086 - 108,821,926 (+)	Ensembl
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl

RefSeq Acc Id:

NM_001109096 ⟹ NP_001102566

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	108,817,185 - 108,819,794 (+)	NCBI
mRatBN7.2	14	104,616,269 - 104,618,878 (+)	NCBI
Rnor_6.0	14	115,275,894 - 115,278,503 (+)	NCBI
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	RGD
Celera	14	103,454,448 - 103,457,057 (+)	RGD

Sequence:

show sequence

ATGAATTCAAGTGCCCCGCTTCAGAATGTTCCCAATGCCACCTTGCTATACACACCTCCCCTGC
AGGGAGGAAATAACACTTCTCTCCAGGAGGGTCTTCGAGATTTTATCCACACAGCCACCTTGGT
GACCTGCACGGTCCTGCTTGCCATCATCTTCTGTCTAGGCTCTTATGGAAATTTTATTGTCTTC
TTGTCTTTCTTTGACCCGGCCTTCAGAAAGTTCAGAACTAACTTTGATTTCATGATCTTGAACC
TGTCTTTCTGTGATCTGTTCATCTGTGGGGCCACAGCCCCCATGTTCACCTTTGTGCTGTTCTT
CAGCTCAGCCAGGAGCATCCCAGACAGTTTCTGCTTCACCTTCCACCTTACCAGCTCAGGTTTC
ATCATCATGTCCCTCAAGATGGTAGCTGTGATTGCCCTGCACCGGCTCCGGATGGTGATGGGGA
AGCAGCCTAATTGCACCGCTTCCTTTTCCTGCATCTTGCTCCTTACCCTTCTTCTCTGGGCCAC
CAGCTTTACACTTGCCACCTTGGCTACACTGAGAACCAGTAAGTCCCACCTGTGTCTCCCCATG
TCCAGTCTTATGGACGGGGAAGGGAAGGCCATTCTGTCTCTGTATGTTGTTGACTTTACCTTCT
GTGTGGCCGTGGTGTCTGTCTCTTATATCATGATTGCTCAAACCCTTCGGAAGAATGCCCAAGT
AAAAAAGTGCCCCCCTGTGATCACAGTTGATGCTTCCAGACCACAGCCATTCATGGGGGCCTCT
GTGAAGGGAAATGGAGATCCCATCCAGTGCACCATGCCAGCTCTGTATAGGAACCAGAATTATA
ACAAACTGCAGCACAATCAAACTCATGGATACACTAAGAATGCCAACCAGATGCCAATCCCCTC
AGCCAGTCGGCTCCAGCTGGTATCAGCGGTCAACCTCTCTACTGCCAAGGATTCCAAAGCTGTG
GTCACCTGCATGGTCATCGTGTTGTCGGTTCTAGTGTGCTGTCTTCCTCTGGGGATTTCCCTGC
TGCAAGTGGTTCTGTCTGACAGTGGCAGCTTCATCCTTTACCAGTTTGAGTTATTTGGATTTAC
TCTGATATTTTTCAAGTCAGGATTAAATCCTTTTATATATTCTCGGAACAGTGCTGGGCTGAGA
AGGAAAGTGCTCTGGTGCCTGCGATACACTGGCCTGGGCTTCCTCTGCTGCAAACAGAAAACTC
GACTTCGGGCCATGGGGAAAGGGAACCTTGAAATCAATAGAAACAAATCCTCCCATCATGAGAC
AAACTCTGCCTACATGCTGTCTCCAAAACCACAGAAGAAATTTGTAGACCAGGCTTGTGGCCCA
AGTCATTCAAAAGAAAGTGTAGCAAGTCCCAAAGTCTCTGCTGGACATCACCCCTGTGGGCAGA
GCAGCTCGACACCCATCAACACTCGGATTGAACCTTACTATAGCATCTATAACAGCAGCCCGTC
CCAGCAGGAGAGCAGCCCAGCAAACCTGCAGCCAGTGAACTCTTTTGGTTTCGCCAGTTCCTAC
ATCGCCATGCACTATTACACCACCAATGACTTGATGCAGGACTATGACAGCACGTCGGCAAAAC
AGATCCCTATCCCTTCTGTTTAATACAGCCAGAGAATCTGGAGGGAATGGTTTTCTCTCTGGAC
TGAACAAACCTTTAAAAGAGCTTGAGTTCCATGGCAAAACAAAACCTGGAATCAACTGAAGACT
TGACTTTCTTTCACCTGAAGTATTAGTATCCGGGTTGGCTTCATGGTTTCTTGACATTTTAAGA
TTTAGTGTAAAAGTTTAGTTCAATTTATACTCTGACCCATGTCCCAATACTTTATACTAAACTG
CTAAAAAGATGTCAGGGACTATTCTATTAATGACACCCTTTTAAGTCAGTATTATGGGATTTTA
GATATGTATTGACTACATTTTCTTTCTTTCCACTAATTTATTTATTTATTCACTTTACATCCCG
ATTGAAGCCCCACCTCTCCTCCCAGTACTCCCTCTCATGGTCCCTCTCCCAATTTCTCCTCCCC
TTTATTTCTGAGGAGGAGGAGGTCCCTCCTGGGGAAACAACCTTCCTCAAGTCACTGAAGGACT
AGGTACATCCTCTGCCACTGAGGCCAGACGTGCTAGCCCAATTAGGAGCAGGATTCACAGACAG
GAAACAGTCAGGGACAGTCAGCACTCTACTCATTGGGGGACCCATATAAAGACCAAGCTGCACC
TCTGTTACAAATGTGCTGGTGGGCCTAGGACCAGCCTCTTTGGCTAGTGGTTCAGTACCTGGGA
GCCTTCAAGGATCCAGGTTAGTTGGTATTCTGAAGGAGTACCTGTTCCCTCCAGGTTCCTCTAT
CCTTTCTCCAACCCTTCCACAAGACTTCCCAAGCTCCAGTCTAATGTTTGGCTGTGGGACTGCA
TTTGTTTCTGTCAACTGCTGTAATTTGGCTACATTTTTAAAATGGTGTTTGAAAAAAATTATCT
TTCTGAAGTGTTATTTTTATAAAAATATGGAATTAGTGTCTTTGAAGTACTGAAACAGCAAACA
GTGTACTTTTTTGGTGGCAAGTGGTTTAAATAAAAAACTTACTGTTAAAA

hide sequence

RefSeq Acc Id:

XM_006251616 ⟹ XP_006251678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI

Sequence:

show sequence

TATCAGCGGCCAGTTCTCCGGCAGCCCTGGCAGGTCTGAGTGCACACCCACCAGGCTGAGGCCC
GCAGGCAGGGAGGGTGACGACAGGCGGGGCGGCCACGGTCAGAGGGAGGGGCTGCGCCCCGGGT
TCTGTGACTGCGCCGCCGGCCCGGCTCGCCTAGGCTCCCGGGATGCGTGGAGGCGGCGGCGATG
ACGGTGATGACTCTAGCCCGGCAGCATCCAGGCCACCGGGCGCAGATAGGGTCGAGCATCCAGG
CCACCGGGCGCAGATAGGGTCGCTGCTGCGACATGGAGGAGGAAGGGCGGCGCTGCGGCCAGCT
GGCAGGCTTATCTTCCTCCGCCATACATGCCCATCGTCTGTGAGCTGAGATCCTGACTCTCTTC
CTGCTGATGTTTTTAAAACACAAGAGACACTTCTCTGAAGATGAATTCAAGTGCCCCGCTTCAG
AATGTTCCCAATGCCACCTTGCTATACACACCTCCCCTGCAGGGAGGAAATAACACTTCTCTCC
AGGAGGGTCTTCGAGATTTTATCCACACAGCCACCTTGGTGACCTGCACGGTCCTGCTTGCCAT
CATCTTCTGTCTAGGCTCTTATGGAAATTTTATTGTCTTCTTGTCTTTCTTTGACCCGGCCTTC
AGAAAGTTCAGAACTAACTTTGATTTCATGATCTTGAACCTGTCTTTCTGTGATCTGTTCATCT
GTGGGGCCACAGCCCCCATGTTCACCTTTGTGCTGTTCTTCAGCTCAGCCAGGAGCATCCCAGA
CAGTTTCTGCTTCACCTTCCACCTTACCAGCTCAGGTTTCATCATCATGTCCCTCAAGATGGTA
GCTGTGATTGCCCTGCACCGGCTCCGGATGGTGATGGGGAAGCAGCCTAATTGCACCGCTTCCT
TTTCCTGCATCTTGCTCCTTACCCTTCTTCTCTGGGCCACCAGCTTTACACTTGCCACCTTGGC
TACACTGAGAACCAGTAAGTCCCACCTGTGTCTCCCCATGTCCAGTCTTATGGACGGGGAAGGG
AAGGCCATTCTGTCTCTGTATGTTGTTGACTTTACCTTCTGTGTGGCCGTGGTGTCTGTCTCTT
ATATCATGATTGCTCAAACCCTTCGGAAGAATGCCCAAGTAAAAAAGTGCCCCCCTGTGATCAC
AGTTGATGCTTCCAGACCACAGCCATTCATGGGGGCCTCTGTGAAGGGAAATGGAGATCCCATC
CAGTGCACCATGCCAGCTCTGTATAGGAACCAGAATTATAACAAACTGCAGCACAATCAAACTC
ATGGATACACTAAGAATGCCAACCAGATGCCAATCCCCTCAGCCAGTCGGCTCCAGCTGGTATC
AGCGGTCAACCTCTCTACTGCCAAGGATTCCAAAGCTGTGGTCACCTGCATGGTCATCGTGTTG
TCGGTTCTAGTGTGCTGTCTTCCTCTGGGGATTTCCCTGCTGCAAGTGGTTCTGTCTGACAGTG
GCAGCTTCATCCTTTACCAGTTTGAGTTATTTGGATTTACTCTGATATTTTTCAAGTCAGGATT
AAATCCTTTTATATATTCTCGGAACAGTGCTGGGCTGAGAAGGAAAGTGCTCTGGTGCCTGCGA
TACACTGGCCTGGGCTTCCTCTGCTGCAAACAGAAAACTCGACTTCGGGCCATGGGGAAAGGGA
ACCTTGAAATCAATAGAAACAAATCCTCCCATCATGAGACAAACTCTGCCTACATGCTGTCTCC
AAAACCACAGAAGAAATTTGTAGACCAGGCTTGTGGCCCAAGTCATTCAAAAGAAAGTGTAGCA
AGTCCCAAAGTCTCTGCTGGACATCACCCCTGTGGGCAGAGCAGCTCGACACCCATCAACACTC
GGATTGAACCTTACTATAGCATCTATAACAGCAGCCCGTCCCAGCAGGAGAGCAGCCCAGCAAA
CCTGCAGCCAGTGAACTCTTTTGGTTTCGCCAGTTCCTACATCGCCATGCACTATTACACCACC
AATGACTTGATGCAGGACTATGACAGCACGTCGGCAAAACAGATCCCTATCCCTTCTGTTTAAT
ACAGCCAGAGAATCTGGAGGGAATGGTTTTCTCTCTGGACTGAACAAACCTTTAAAAGAGCTTG
AGTTCCATGGCAAAACAAAACCTGGAATCAACTGAAGACTTGACTTTCTTTCACCTGAAGTATT
AGTATCCGGGTTGGCTTCATGGTTTCTTGACATTTTAAGATTTAGTGTAAAAGTTTAGTTCAAT
TTATACTCTGACCCATGTCCCAATACTTTATACTAAACTGCTAAAAAGATGTCAGGGACTATTC
TATTAATGACACCCTTTTAAGTCAGTATTATGGGATTTTAGATATGTATTGACTACATTTTCTT
TCTTTCCACTAATTTATTTATTTATTCACTTTACATCCCGATTGAAGCCCCACCTCTCCTCCCA
GTACTCCCTCTCATGGTCCCTCTCCCAATTTCTCCTCCCCTTTATTTCTGAGGAGGAGGAGGTC
CCTCCTGGGGAAACAACCTTCCTCAAGTCACTGAAGGACTAGGTACATCCTCTGCCACTGAGGC
CAGACGTGCTAGCCCAATTAGGAGCAGGATTCACAGACAGGAAACAGTCAGGGACAGTCAGCAC
TCTACTCATTGGGGGACCCATATAAAGACCAAGCTGCACCTCTGTTACAAATGTGCTGGTGGGC
CTAGGACCAGCCTCTTTGGCTAGTGGTTCAGTACCTGGGAGCCTTCAAGGATCCAGGTTAGTTG
GTATTCTGAAGGAGTACCTGTTCCCTCCAGGTTCCTCTATCCTTTCTCCAACCCTTCCACAAGA
CTTCCCAAGCTCCAGTCTAATGTTTGGCTGTGGGACTGCATTTGTTTCTGTCAACTGCTGTAAT
TTGGCTACATTTTTAAAATGGTGTTTGAAAAAAATTATCTTTCTGAAGTGTTATTTTTATAAAA
ATATGGAATTAGTGTCTTTGAAGTACTGAAACAGCAAACAGTGTACTTTTTTGGTGGCAAGTGG
TTTAAATAAAAAACTTACTGTTAAAACAGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102566	(Get FASTA)	NCBI Sequence Viewer
	XP_006251678	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98049	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029471
	ENSRNOP00000029471.4

RefSeq Acc Id:

NP_001102566 ⟸ NM_001109096

- UniProtKB:

D3Z826 (UniProtKB/TrEMBL), A6JQD2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNSSAPLQNVPNATLLYTPPLQGGNNTSLQEGLRDFIHTATLVTCTVLLAIIFCLGSYGNFIVF
LSFFDPAFRKFRTNFDFMILNLSFCDLFICGATAPMFTFVLFFSSARSIPDSFCFTFHLTSSGF
IIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTSKSHLCLPM
SSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGAS
VKGNGDPIQCTMPALYRNQNYNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAV
VTCMVIVLSVLVCCLPLGISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLR
RKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQACGP
SHSKESVASPKVSAGHHPCGQSSSTPINTRIEPYYSIYNSSPSQQESSPANLQPVNSFGFASSY
IAMHYYTTNDLMQDYDSTSAKQIPIPSV

hide sequence

RefSeq Acc Id:

XP_006251678 ⟸ XM_006251616

- Peptide Label:

isoform X1

- Sequence:

show sequence

MNSSAPLQNVPNATLLYTPPLQGGNNTSLQEGLRDFIHTATLVTCTVLLAIIFCLGSYGNFIVF
LSFFDPAFRKFRTNFDFMILNLSFCDLFICGATAPMFTFVLFFSSARSIPDSFCFTFHLTSSGF
IIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTSKSHLCLPM
SSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGAS
VKGNGDPIQCTMPALYRNQNYNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAV
VTCMVIVLSVLVCCLPLGISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLR
RKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQACGP
SHSKESVASPKVSAGHHPCGQSSSTPINTRIEPYYSIYNSSPSQQESSPANLQPVNSFGFASSY
IAMHYYTTNDLMQDYDSTSAKQIPIPSV

hide sequence

Ensembl Acc Id:

ENSRNOP00000029471 ⟸ ENSRNOT00000033437

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z826-F1-model_v2	AlphaFold	D3Z826	1-540	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566385	AgrOrtholog
BioCyc Gene	G2FUF-14627	BioCyc
Ensembl Genes	ENSRNOG00000022176	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033437	ENTREZGENE
	ENSRNOT00000033437.6	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
KEGG Report	rno:498434	UniProtKB/TrEMBL
NCBI Gene	498434	ENTREZGENE
PANTHER	B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR	UniProtKB/TrEMBL
	G-PROTEIN COUPLED RECEPTOR 75-RELATED	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Gpr75	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022176	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A6JQD2	ENTREZGENE, UniProtKB/TrEMBL
	D3Z826	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Gpr75	G protein-coupled receptor 75	RGD1566385_predicted	similar to G protein-coupled receptor GPR75 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1566385_predicted	similar to G protein-coupled receptor GPR75 (predicted)	LOC498434	similar to G protein-coupled receptor GPR75	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498434	similar to G protein-coupled receptor GPR75			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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