Tmem70 (transmembrane protein 70) - Rat Genome Database

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Gene: Tmem70 (transmembrane protein 70) Rattus norvegicus
Analyze
Symbol: Tmem70
Name: transmembrane protein 70
RGD ID: 1566224
Description: Predicted to enable mitochondrial proton-transporting ATP synthase complex binding activity. Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial respiratory chain complex I assembly; and protein homooligomerization. Predicted to be located in mitochondrial crista. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500384; RGD1566224; similar to RIKEN cDNA 2210416J16; transmembrane protein 70, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr857,420,396 - 7,438,023 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl57,420,396 - 7,438,023 (-)EnsemblGRCr8
mRatBN7.252,637,102 - 2,654,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,637,102 - 2,654,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx54,755,660 - 4,773,292 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,394,524 - 6,412,156 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,093,125 - 6,110,745 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,019,852 - 2,037,038 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl52,019,852 - 2,037,038 (-)Ensemblrn6Rnor6.0
Rnor_5.052,019,520 - 2,036,983 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.451,983,166 - 2,007,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera52,258,902 - 2,277,040 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:18953340   PMID:27914986  


Genomics

Comparative Map Data
Tmem70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr857,420,396 - 7,438,023 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl57,420,396 - 7,438,023 (-)EnsemblGRCr8
mRatBN7.252,637,102 - 2,654,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,637,102 - 2,654,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx54,755,660 - 4,773,292 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,394,524 - 6,412,156 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,093,125 - 6,110,745 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,019,852 - 2,037,038 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl52,019,852 - 2,037,038 (-)Ensemblrn6Rnor6.0
Rnor_5.052,019,520 - 2,036,983 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.451,983,166 - 2,007,544 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera52,258,902 - 2,277,040 (-)NCBICelera
Cytogenetic Map5q11NCBI
TMEM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38873,976,195 - 73,982,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl873,972,437 - 73,982,783 (+)Ensemblhg38GRCh38
GRCh37874,888,430 - 74,895,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,050,984 - 75,057,570 (+)NCBIBuild 36Build 36hg18NCBI36
Celera870,886,069 - 70,892,868 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef870,379,298 - 70,385,926 (+)NCBIHuRef
CHM1_1874,940,306 - 74,946,947 (+)NCBICHM1_1
T2T-CHM13v2.0874,405,457 - 74,412,045 (+)NCBIT2T-CHM13v2.0
Tmem70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,735,415 - 16,748,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,735,431 - 16,748,499 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38116,665,191 - 16,678,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,665,207 - 16,678,275 (+)Ensemblmm10GRCm38
MGSCv37116,655,272 - 16,668,356 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36116,650,432 - 16,663,487 (+)NCBIMGSCv36mm8
Celera116,597,042 - 16,611,752 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.1NCBI
Tmem70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554446,393,227 - 6,397,118 (-)Ensembl
ChiLan1.0NW_0049554446,393,023 - 6,397,115 (-)NCBIChiLan1.0ChiLan1.0
TMEM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2789,718,029 - 89,724,599 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1865,346,042 - 65,352,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0870,509,897 - 70,515,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1872,154,872 - 72,161,500 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl872,154,872 - 72,163,239 (+)EnsemblpanPan2panpan1.1
TMEM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12922,475,961 - 22,487,920 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2922,478,941 - 22,487,741 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2922,741,251 - 22,752,935 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02922,586,852 - 22,598,751 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12922,645,846 - 22,657,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02922,680,708 - 22,692,691 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02922,964,370 - 22,976,052 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,798,273 - 56,811,914 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366482,636,667 - 2,650,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl461,958,605 - 61,966,024 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1461,958,605 - 61,966,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2467,664,533 - 67,671,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1869,576,786 - 69,582,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl869,576,808 - 69,583,308 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603971,789,274 - 71,794,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474417,259,245 - 17,266,115 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474417,256,749 - 17,265,507 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem70
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11136,180,253 - 136,191,632 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem70
92 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:70
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000008680
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat

Markers in Region
RH134630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.252,637,816 - 2,638,009 (+)MAPPERmRatBN7.2
Rnor_6.052,020,567 - 2,020,759NCBIRnor6.0
Rnor_5.052,020,235 - 2,020,427UniSTSRnor5.0
RGSC_v3.452,007,241 - 2,007,433UniSTSRGSC3.4
Celera52,259,617 - 2,259,809UniSTS
Cytogenetic Map5q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008680   ⟹   ENSRNOP00000008680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl57,420,396 - 7,438,023 (-)Ensembl
mRatBN7.2 Ensembl52,637,102 - 2,654,729 (-)Ensembl
Rnor_6.0 Ensembl52,019,852 - 2,037,038 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169875   ⟹   ENSRNOP00000111856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl57,420,496 - 7,438,023 (-)Ensembl
RefSeq Acc Id: NM_001109258   ⟹   NP_001102728
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,420,396 - 7,438,023 (-)NCBI
mRatBN7.252,637,102 - 2,654,729 (-)NCBI
Rnor_6.052,019,852 - 2,037,038 (-)NCBI
Rnor_5.052,019,520 - 2,036,983 (-)NCBI
RGSC_v3.451,983,166 - 2,007,544 (+)RGD
Celera52,258,902 - 2,277,040 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102728 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11493 (Get FASTA)   NCBI Sequence Viewer  
  EDM11494 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008680
  ENSRNOP00000008680.4
  ENSRNOP00000111856.1
RefSeq Acc Id: NP_001102728   ⟸   NM_001109258
- UniProtKB: D3Z946 (UniProtKB/TrEMBL),   A6JF97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008680   ⟸   ENSRNOT00000008680
Ensembl Acc Id: ENSRNOP00000111856   ⟸   ENSRNOT00000169875

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z946-F1-model_v2 AlphaFold D3Z946 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693522
Promoter ID:EPDNEW_R4046
Type:initiation region
Name:Tmem70_1
Description:transmembrane protein 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.052,037,006 - 2,037,066EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566224 AgrOrtholog
BioCyc Gene G2FUF-42314 BioCyc
Ensembl Genes ENSRNOG00000006608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008680 ENTREZGENE
  ENSRNOT00000008680.7 UniProtKB/TrEMBL
  ENSRNOT00000169875.1 UniProtKB/TrEMBL
InterPro DUF1301 UniProtKB/TrEMBL
  TMEM70/TMEM186/TMEM223 UniProtKB/TrEMBL
KEGG Report rno:500384 UniProtKB/TrEMBL
NCBI Gene 500384 ENTREZGENE
PANTHER DUF1301 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam DUF1301 UniProtKB/TrEMBL
PhenoGen Tmem70 PhenoGen
RatGTEx ENSRNOG00000006608 RatGTEx
UniProt A0ABK0LLN5_RAT UniProtKB/TrEMBL
  A6JF97 ENTREZGENE, UniProtKB/TrEMBL
  D3Z946 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Tmem70  transmembrane protein 70  RGD1566224_predicted  similar to RIKEN cDNA 2210416J16 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566224_predicted  similar to RIKEN cDNA 2210416J16 (predicted)  LOC500384  similar to RIKEN cDNA 2210416J16  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500384  similar to RIKEN cDNA 2210416J16      Symbol and Name status set to provisional 70820 PROVISIONAL