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Gene: Mbtps2 (membrane-bound transcription factor peptidase, site 2) Rattus norvegicus

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Symbol:

Mbtps2 (Ensembl: Yy2)

Name:

membrane-bound transcription factor peptidase, site 2 (Ensembl:YY2 transcription factor)

RGD ID:

1566171

Description:

Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LRRGT00063; membrane-bound transcription factor protease, site 2; membrane-bound transcription factor site-2 protease

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	41,225,956 - 41,290,030 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	41,254,335 - 41,277,701 (+)	Ensembl				GRCr8
mRatBN7.2	X	37,410,914 - 37,461,130 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	37,410,811 - 37,464,430 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	38,609,601 - 38,657,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	42,076,796 - 42,124,460 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	39,761,507 - 39,809,169 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	40,258,933 - 40,309,047 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	40,258,493 - 40,310,563 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	40,569,195 - 40,619,334 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	58,708,065 - 58,757,022 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	38,039,020 - 38,086,670 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

BCARD syndrome (ISO)

Desbuquois dysplasia (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

ichthyosis follicularis-alopecia-photophobia syndrome 1 (ISO)

osteogenesis imperfecta (ISO)

osteogenesis imperfecta type 19 (ISO)

osteoporosis-pseudoglioma syndrome (ISO)

X-linked keratosis follicularis spinulosa decalvans (ISO)

X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,10-phenanthroline (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-sulfonyldiphenol (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

endosulfan (EXP)

gamma-hexachlorocyclohexane (EXP)

GSK-J4 (ISO)

nelfinavir (ISO)

paracetamol (EXP)

pirinixic acid (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

bone maturation (IEA,ISO)

membrane protein intracellular domain proteolysis (IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (ISO)

positive regulation of cholesterol biosynthetic process (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

protein maturation (IEA,ISO)

proteolysis (IEA)

response to endoplasmic reticulum stress (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

endomembrane system (IEA)

membrane (IEA)

Molecular Function

metalloendopeptidase activity (IEA,ISO)

transcription regulator activator activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

sterol regulatory element-binding protein signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.	Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11163209	PMID:19361614	PMID:27380894	PMID:33738762

Genomics

Comparative Map Data

Mbtps2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	41,225,956 - 41,290,030 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	41,254,335 - 41,277,701 (+)	Ensembl				GRCr8
mRatBN7.2	X	37,410,914 - 37,461,130 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	37,410,811 - 37,464,430 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	38,609,601 - 38,657,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	42,076,796 - 42,124,460 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	39,761,507 - 39,809,169 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	40,258,933 - 40,309,047 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	40,258,493 - 40,310,563 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	40,569,195 - 40,619,334 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	58,708,065 - 58,757,022 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	38,039,020 - 38,086,670 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

MBTPS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	21,839,617 - 21,885,423 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	21,839,610 - 21,885,423 (+)	Ensembl			hg38	GRCh38
GRCh37	X	21,857,735 - 21,903,541 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	21,767,675 - 21,810,794 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	21,617,410 - 21,660,530	NCBI
Celera	X	25,979,352 - 26,025,249 (+)	NCBI		Celera
Cytogenetic Map	X	p22.12	NCBI
HuRef	X	19,598,870 - 19,644,630 (+)	NCBI		HuRef
CHM1_1	X	21,888,082 - 21,933,974 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	21,422,918 - 21,468,735 (+)	NCBI		T2T-CHM13v2.0

Mbtps2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	156,330,818 - 156,381,711 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	156,318,367 - 156,381,711 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	157,547,822 - 157,598,715 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	157,535,371 - 157,598,715 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	153,985,754 - 154,036,647 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	152,894,045 - 152,942,755 (-)	NCBI		MGSCv36	mm8
Celera	X	140,799,978 - 140,850,843 (-)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	72.55	NCBI

Mbtps2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955509	2,184,522 - 2,222,505 (+)	Ensembl
ChiLan1.0	NW_004955509	2,185,054 - 2,222,497 (+)	NCBI	ChiLan1.0	ChiLan1.0

MBTPS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	23,648,185 - 23,742,670 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	23,651,590 - 23,713,273 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	14,470,268 - 14,529,854 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	21,825,780 - 21,871,381 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	21,825,780 - 21,883,550 (+)	Ensembl			panPan2	panpan1.1

MBTPS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	17,655,295 - 17,718,960 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	17,655,363 - 17,710,288 (+)	Ensembl			canFam3	CanFam3.1
ROS_Cfam_1.0	X	17,614,672 - 17,678,632 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	17,614,677 - 17,668,420 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	17,648,868 - 17,712,816 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	17,670,607 - 17,734,262 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	17,730,821 - 17,794,521 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mbtps2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	10,646,920 - 10,693,763 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936624	2,463,909 - 2,511,158 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936624	2,464,152 - 2,510,984 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MBTPS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	18,013,360 - 18,054,250 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	19,216,635 - 19,252,134 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MBTPS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	20,319,731 - 20,364,603 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	20,319,807 - 20,361,847 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666056	22,172,318 - 22,218,601 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mbtps2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	6,795,528 - 6,834,604 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624829	6,795,563 - 6,839,416 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mbtps2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	35,252,114 - 35,298,749 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mbtps2
314 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	245
Count of miRNA genes:	154
Interacting mature miRNAs:	184
Transcripts:	ENSRNOT00000033010
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	24470360	44931007	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	24470360	45082063	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat

Markers in Region

AU048074

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	37,458,722 - 37,458,858 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	40,306,640 - 40,306,775	NCBI	Rnor6.0
Rnor_5.0	X	40,616,927 - 40,617,062	UniSTS	Rnor5.0
RGSC_v3.4	X	58,757,126 - 58,757,261	UniSTS	RGSC3.4
Celera	X	38,086,774 - 38,086,909	UniSTS
Cytogenetic Map	X	q21	UniSTS

UniSTS:530593

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	37,439,829 - 37,440,033 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	40,287,328 - 40,287,531	NCBI	Rnor6.0
Rnor_5.0	X	40,597,615 - 40,597,818	UniSTS	Rnor5.0
RGSC_v3.4	X	58,737,996 - 58,738,199	UniSTS	RGSC3.4
Celera	X	38,067,881 - 38,068,084	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001035007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033010 ⟹ ENSRNOP00000031616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,919 - 37,464,430 (+)	Ensembl
Rnor_6.0 Ensembl	X	40,258,493 - 40,309,278 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087898 ⟹ ENSRNOP00000071961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,439,094 - 37,458,619 (+)	Ensembl
Rnor_6.0 Ensembl	X	40,286,592 - 40,310,563 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099895 ⟹ ENSRNOP00000081160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,919 - 37,442,047 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105689 ⟹ ENSRNOP00000078442

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,811 - 37,442,047 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108352 ⟹ ENSRNOP00000095286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,927 - 37,458,619 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110665 ⟹ ENSRNOP00000087347

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,919 - 37,438,974 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117269 ⟹ ENSRNOP00000089986

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	37,410,907 - 37,442,047 (+)	Ensembl

RefSeq Acc Id:

NM_001035007 ⟹ NP_001030179

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	41,225,985 - 41,273,675 (+)	NCBI
mRatBN7.2	X	37,410,927 - 37,458,619 (+)	NCBI
Rnor_6.0	X	40,258,933 - 40,306,536 (+)	NCBI
Rnor_5.0	X	40,569,195 - 40,619,334 (+)	NCBI
RGSC_v3.4	X	58,708,065 - 58,757,022 (+)	RGD
Celera	X	38,039,020 - 38,086,670 (+)	RGD

Sequence:

show sequence

AGCGGATGCTGGAGCTGTAAGGCTCCGTGCAGGCGGCTGATTGTGGATCGCAGAAGGAGGACGC
TGGGGCCCGCCGTCCATCCGCTGCTACTATGATTCCGGTGTCGCTGGTGGTGGTGGTGGTGGGT
GGTTGGACTGCCGTCTACCTGGCCGACTTGGTGTTGAAGTCATCTGTGTATTTTAAACATTCTT
ATGAAGACTGGCTGGAAAACAATGGATTGAGCATCTCTCCTTTTCATATAAGATGGCAAACTTC
AATTTTTAATCGTGCCTTTTACAGTTGGGGACGGCGGAAAGCAAGGATGCTTTACCAATGGTTC
AATTTTGGAATGGTGTTTGGTGTGATTGCCATGTTCAGCTCTTTTTTTCTCCTTGGAAAAACAC
TGATGCAGACTTTGGCACAAATGATGGCTGACTCTCCCTCTCCTTATTCTTCCTCTTCTTCCTC
TTCCTCTTCCTCTTCCTCTTCCTCTTCCTCTTCTTCTTCCTCCTCCTCCTCTCTTCACAATGAT
CAGGTGTTGCAAGTTGTGGTTCCTGGTATAAATTTACCTGTCAATCAGCTGACTTACTTCTTCG
CTGCAGTCCTCATTAGTGGTGTTGTACATGAAATTGGACACGGTATAGCAGCCATTAGGGAACA
AGTTCGATTTAATGGCTTTGGAATTTTCCTCTTCATTATTTATCCTGGAGCATTTGTTGATCTG
TTCACCACCCATTTGCAACTTATATCACCAGTCCAGCAGCTAAGGATATTTTGTGCAGGTATAT
GGCATAATTTTGTCCTTGCTCTCCTTGGTATTTTAGCTCTTGTTCTCCTCCCAGTAATCCTCTT
GCCTTTTTACTACACTGGAGTTGGGGTACTTATCACTGAAGTCGCAGAGGACTCACCTGCCATT
GGACCCAGAGGCCTTTTTGTGGGAGACCTTGTTACTCATCTACAGGATTGTCCCGTTACTAATG
TGCAAGATTGGAACGAATGTTTAGACACCATTGCATATGAGCCCCAAATTGGGTACTGTATAAG
TGCATCAACGTTACAACAATTAAGCTTCCCAGTTAGAGCATACAAACGACTAGATGGTTCTACT
GAATGCTGTAACAATCACAGCCTCACAGATGTGTGCTTTTCCTACAGAAATAATTTTAATAAAC
GTTTGCATACATGTCTACCTGCCCGGAAAGCAGTTGAAGCCACTCAAGTTTGTAGAAGCAATAA
AGATTGCAAAAGCAGCTCAAGCTCAAGCTTCTGTATAGTGCCATCCTTGGAAACTCACACTCGG
TTAATAAAGGTGAAACACCCCCCACAGATTGATATGCTCTATGTAGGGCACCCACTGCACCTTC
ACTACACAGTGAGCATTACAAGTTTTATCCCACGTTTCAACTTTCTAAGCATAGATCTGCCAGT
AATTGTGGAGACATTTGTCAAATACCTGATTTCTCTTTCTGGAGCCCTGGCTATTGTTAATGCA
GTGCCCTGCTTTGCCTTGGACGGTCAATGGATTTTAAACTCTTTCCTGGATGCTACCCTGACTT
CAGTGATTGGAGACAACGATGTCAAAGATCTAATAGGATTTTTCATCCTGCTTGGTGGCAGTGT
ACTTTTGGCTGCCAATGTGACACTGGGACTCTGGATGGTTACAGCACGGTAATATTTGCTCTTA
TCCAACAGAATTAAAAAGTATAGCTACATGGTAATATCTGTTGCCATTGAAATTCTTACTAGGT
ATGAAATGTAAAGTGTTTCCTTAAAACATCTTGGCCAACCTCTTTGAGCTCCTAATATCTAGAG
AATCCAAAAACTCTGTAAAAGACAAATGGAGGAAATGAAAAACATAATTCCTGACTACATTCTA
CTCTGAAAGATTGAATGTGAAAACTCTGAATGTCTGTTGAATAATTTGTAAACAAGTGAAAATT
CATTCATGCAATACCATTTTGTGTGACTATATAGCATTTTGAAGTAGTAAAAGGAAAAGCAGAA
AACGTGTGTGCACGCATATATGCGTGCGTGCATGTGTTCTACTAGTATTTGAAACCAGCTTGCC
TATCCCAGGTAAAATGTACTGAAAAGTGCAATTAAGATGATGT

hide sequence

RefSeq Acc Id:

XM_063279940 ⟹ XP_063136010

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	41,225,956 - 41,290,030 (+)	NCBI

RefSeq Acc Id:

XM_063279941 ⟹ XP_063136011

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	41,225,956 - 41,281,431 (+)	NCBI

RefSeq Acc Id:

XM_063279942 ⟹ XP_063136012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	41,233,011 - 41,290,030 (+)	NCBI

RefSeq Acc Id:

XM_063279943 ⟹ XP_063136013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	41,232,965 - 41,276,186 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001030179	(Get FASTA)	NCBI Sequence Viewer
	XP_063136010	(Get FASTA)	NCBI Sequence Viewer
	XP_063136011	(Get FASTA)	NCBI Sequence Viewer
	XP_063136012	(Get FASTA)	NCBI Sequence Viewer
	XP_063136013	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97391	(Get FASTA)	NCBI Sequence Viewer
	EDL96114	(Get FASTA)	NCBI Sequence Viewer
	EDL96115	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071961.3
	ENSRNOP00000087347.1
	ENSRNOP00000100822.1

RefSeq Acc Id:

NP_001030179 ⟸ NM_001035007

- UniProtKB:

A0A8I6AN61 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIPVSLVVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTSIFNRAFYSW
GRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSSSS
SSSSSSSSLHNDQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIF
LFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGV
LITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSF
PVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSSSSSS
FCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYL
ISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLG
LWMVTAR

hide sequence

Ensembl Acc Id:

ENSRNOP00000031616 ⟸ ENSRNOT00000033010

Ensembl Acc Id:

ENSRNOP00000071961 ⟸ ENSRNOT00000087898

Ensembl Acc Id:

ENSRNOP00000078442 ⟸ ENSRNOT00000105689

Ensembl Acc Id:

ENSRNOP00000081160 ⟸ ENSRNOT00000099895

Ensembl Acc Id:

ENSRNOP00000095286 ⟸ ENSRNOT00000108352

Ensembl Acc Id:

ENSRNOP00000089986 ⟸ ENSRNOT00000117269

Ensembl Acc Id:

ENSRNOP00000087347 ⟸ ENSRNOT00000110665

RefSeq Acc Id:	XP_063136010 ⟸ XM_063279940
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063136011 ⟸ XM_063279941
- Peptide Label:	isoform X2
- UniProtKB:	D3ZDS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136013 ⟸ XM_063279943
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063136012 ⟸ XM_063279942
- Peptide Label:	isoform X3

Protein Domains

Peptidase M50

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDS6-F1-model_v2	AlphaFold	D3ZDS6	1-519	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566171	AgrOrtholog
BioCyc Gene	G2FUF-2466	BioCyc
Ensembl Genes	ENSRNOG00000007644	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000076532	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087898.3	UniProtKB/TrEMBL
	ENSRNOT00000110665.2	UniProtKB/TrEMBL
	ENSRNOT00000154456.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7453173	IMAGE-MGC_LOAD
InterPro	PDZ_sf	UniProtKB/TrEMBL
	Peptidase_M50	UniProtKB/TrEMBL
	SREBP_intramem_Prtase	UniProtKB/TrEMBL
MGC_CLONE	MGC:114434	IMAGE-MGC_LOAD
NCBI Gene	302705	ENTREZGENE
PANTHER	MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE	UniProtKB/TrEMBL
	PTHR13325	UniProtKB/TrEMBL
Pfam	Peptidase_M50	UniProtKB/TrEMBL
PhenoGen	Mbtps2	PhenoGen
PRINTS	SREBPS2PTASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007644	RatGTEx
	ENSRNOG00000076532	RatGTEx
Superfamily-SCOP	SSF50156	UniProtKB/TrEMBL
UniProt	A0A8I6A7T1_RAT	UniProtKB/TrEMBL
	A0A8I6AN61	ENTREZGENE
	A0ABK0LHM2_RAT	UniProtKB/TrEMBL
	A6IPP8_RAT	UniProtKB/TrEMBL
	A6IPP9_RAT	UniProtKB/TrEMBL
	D3ZDS6	ENTREZGENE
	Q4V8H3_RAT	UniProtKB/TrEMBL
UniProt Secondary	A0A0G2K1S2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-02-09	Mbtps2	membrane-bound transcription factor peptidase, site 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)