Fpr3 (formyl peptide receptor 3) - Rat Genome Database

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Gene: Fpr3 (formyl peptide receptor 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fpr3
Name: formyl peptide receptor 3
RGD ID: 1566044
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and chemotaxis. Predicted to be located in plasma membrane. Orthologous to human FPR3 (formyl peptide receptor 3); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: formyl peptide receptor 2; formyl peptide receptor 2-like; LOC292413; RGD1566044; similar to N-formylpeptide receptor-like 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,557,464 - 67,566,509 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,518,199 - 67,566,519 (+)EnsemblGRCr8
mRatBN7.2158,884,427 - 58,893,472 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,845,118 - 58,893,467 (+)EnsemblmRatBN7.2
Rnor_6.01116,152,526 - 116,161,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,152,667 - 116,153,722 (-)Ensemblrn6Rnor6.0
Rnor_5.01117,322,134 - 117,331,195 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4156,730,912 - 56,783,230 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera155,024,311 - 55,064,284 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12218158   PMID:12470609  


Genomics

Variants

.
Variants in Fpr3
103 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:76
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000064917
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 2 20 60 44 44 17 82 17 6 201 129 10 35 50 17 27 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000041605   ⟹   ENSRNOP00000042428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,557,424 - 67,566,519 (+)Ensembl
mRatBN7.2 Ensembl158,845,118 - 58,893,467 (+)Ensembl
Rnor_6.0 Ensembl1116,152,667 - 116,153,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064917   ⟹   ENSRNOP00000061936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,518,199 - 67,566,512 (+)Ensembl
mRatBN7.2 Ensembl158,845,167 - 58,893,467 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097361   ⟹   ENSRNOP00000096636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl158,845,118 - 58,893,467 (+)Ensembl
RefSeq Acc Id: NM_001408716   ⟹   NP_001395645
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,557,464 - 67,566,509 (+)NCBI
mRatBN7.2158,884,427 - 58,893,472 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99791 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042428
  ENSRNOP00000042428.2
  ENSRNOP00000061936.4
Ensembl Acc Id: ENSRNOP00000042428   ⟸   ENSRNOT00000041605
Ensembl Acc Id: ENSRNOP00000061936   ⟸   ENSRNOT00000064917
Ensembl Acc Id: ENSRNOP00000096636   ⟸   ENSRNOT00000097361
RefSeq Acc Id: NP_001395645   ⟸   NM_001408716
- UniProtKB: F1M670 (UniProtKB/TrEMBL),   D4A8L8 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8L8-F1-model_v2 AlphaFold D4A8L8 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566044 AgrOrtholog
BioCyc Gene G2FUF-61243 BioCyc
Ensembl Genes ENSRNOG00000031331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041605 ENTREZGENE
  ENSRNOT00000041605.4 UniProtKB/TrEMBL
  ENSRNOT00000064917.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Frt_met_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene 292413 ENTREZGENE
PANTHER N-FORMYL PEPTIDE RECEPTOR 2 UniProtKB/TrEMBL
  PTHR24225 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Fpr3 PhenoGen
PRINTS FMETLEUPHER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031331 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D4A8L8 ENTREZGENE, UniProtKB/TrEMBL
  F1M670 ENTREZGENE
UniProt Secondary F1M670 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-11 Fpr3  formyl peptide receptor 3   RGD1566044  similar to N-formylpeptide receptor-like 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566044  similar to N-formylpeptide receptor-like 2   RGD1566044_predicted  similar to N-formylpeptide receptor-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566044_predicted  similar to N-formylpeptide receptor-like 2 (predicted)  LOC292413  similar to N-formylpeptide receptor-like 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292413  similar to N-formylpeptide receptor-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL