Drc7 (dynein regulatory complex subunit 7) - Rat Genome Database

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Pathways
Gene: Drc7 (dynein regulatory complex subunit 7) Rattus norvegicus
Analyze
Symbol: Drc7
Name: dynein regulatory complex subunit 7
RGD ID: 1565601
Description: Predicted to be involved in sperm axoneme assembly. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in motile cilium. Orthologous to human DRC7 (dynein regulatory complex subunit 7); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccdc135; coiled-coil domain containing 135; coiled-coil domain-containing protein 135; coiled-coil domain-containing protein lobo homolog; hypothetical protein LOC291853; LOC291853; RGD1565601; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,949,484 - 9,967,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl199,949,486 - 9,967,192 (-)EnsemblGRCr8
mRatBN7.2199,943,452 - 9,961,266 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,943,456 - 9,961,163 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,907,019 - 9,924,764 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,673,860 - 10,691,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,960,748 - 9,978,484 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,363,012 - 10,380,822 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,363,108 - 10,380,809 (-)Ensemblrn6Rnor6.0
Rnor_5.01910,342,364 - 10,360,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,377,415 - 10,395,121 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera199,831,376 - 9,849,084 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
motile cilium  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Drc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,949,484 - 9,967,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl199,949,486 - 9,967,192 (-)EnsemblGRCr8
mRatBN7.2199,943,452 - 9,961,266 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,943,456 - 9,961,163 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,907,019 - 9,924,764 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,673,860 - 10,691,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,960,748 - 9,978,484 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,363,012 - 10,380,822 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,363,108 - 10,380,809 (-)Ensemblrn6Rnor6.0
Rnor_5.01910,342,364 - 10,360,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41910,377,415 - 10,395,121 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera199,831,376 - 9,849,084 (-)NCBICelera
Cytogenetic Map19p13NCBI
DRC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,694,806 - 57,731,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,694,793 - 57,731,805 (+)Ensemblhg38GRCh38
GRCh371657,728,718 - 57,765,717 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,286,227 - 56,322,868 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1642,224,749 - 42,262,676 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,596,311 - 43,632,296 (+)NCBIHuRef
CHM1_11659,134,320 - 59,172,147 (+)NCBICHM1_1
T2T-CHM13v2.01663,490,013 - 63,527,011 (+)NCBIT2T-CHM13v2.0
Drc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,781,731 - 95,804,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,781,731 - 95,804,769 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38895,055,103 - 95,078,141 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,055,103 - 95,078,141 (+)Ensemblmm10GRCm38
MGSCv37897,579,003 - 97,602,041 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36897,579,003 - 97,602,041 (+)NCBIMGSCv36mm8
Celera899,381,092 - 99,404,172 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map847.12NCBI
Drc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,322,508 - 15,340,525 (+)Ensembl
ChiLan1.0NW_00495543315,319,829 - 15,340,525 (+)NCBIChiLan1.0ChiLan1.0
DRC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,165,046 - 67,202,389 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,085,895 - 73,123,319 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,970,908 - 38,008,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,103,720 - 57,139,220 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,103,720 - 57,139,220 (+)EnsemblpanPan2panpan1.1
DRC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,758,644 - 58,775,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,758,655 - 58,774,080 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha255,388,430 - 55,405,244 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,297,005 - 59,313,845 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,297,016 - 59,312,442 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,128,727 - 56,145,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,136,216 - 57,153,027 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,029,533 - 58,046,352 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Drc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934949,854,328 - 49,873,417 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,715,858 - 9,734,627 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,715,858 - 9,734,627 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,603,399 - 19,629,172 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1619,603,413 - 19,629,175 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,574,087 - 17,586,852 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,627,591 - 43,662,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,627,577 - 43,664,702 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366653027,871 - 51,241 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,385,320 - 28,404,416 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474628,386,638 - 28,406,276 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Drc7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1171,935,874 - 1,952,135 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Drc7
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:85
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000031064
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
MARC_14789-14790:1010672522:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2199,958,352 - 9,959,635 (+)MAPPERmRatBN7.2
Rnor_6.01910,377,996 - 10,379,278NCBIRnor6.0
Rnor_5.01910,357,258 - 10,358,540UniSTSRnor5.0
RGSC_v3.41910,392,311 - 10,393,593UniSTSRGSC3.4
Celera199,846,274 - 9,847,556UniSTS
Cytogenetic Map19p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 2 6 101 12 25 4 22 4 2 48 30 2 97 11 57 21 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000031064   ⟹   ENSRNOP00000032646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,949,486 - 9,967,192 (-)Ensembl
mRatBN7.2 Ensembl199,943,456 - 9,961,163 (-)Ensembl
Rnor_6.0 Ensembl1910,363,108 - 10,380,809 (-)Ensembl
RefSeq Acc Id: NM_001106169   ⟹   NP_001099639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,949,486 - 9,967,192 (-)NCBI
mRatBN7.2199,943,456 - 9,961,163 (-)NCBI
Rnor_6.01910,363,100 - 10,380,806 (-)NCBI
Rnor_5.01910,342,364 - 10,360,097 (-)NCBI
RGSC_v3.41910,377,415 - 10,395,121 (-)RGD
Celera199,831,376 - 9,849,084 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255079   ⟹   XP_006255141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,949,484 - 9,967,295 (-)NCBI
mRatBN7.2199,943,456 - 9,961,265 (-)NCBI
Rnor_6.01910,363,012 - 10,380,822 (-)NCBI
Rnor_5.01910,342,364 - 10,360,097 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255081   ⟹   XP_006255143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,949,484 - 9,967,296 (-)NCBI
mRatBN7.2199,943,452 - 9,961,266 (-)NCBI
Rnor_6.01910,363,012 - 10,380,822 (-)NCBI
Rnor_5.01910,342,364 - 10,360,097 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005496624
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,956,292 - 9,967,296 (-)NCBI
mRatBN7.2199,950,266 - 9,961,266 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099639 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421007 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255141 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87308 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032646
  ENSRNOP00000032646.4
RefSeq Acc Id: NP_001099639   ⟸   NM_001106169
- UniProtKB: D3ZZ82 (UniProtKB/TrEMBL),   A6JY30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255143   ⟸   XM_006255081
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006255141   ⟸   XM_006255079
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000032646   ⟸   ENSRNOT00000031064
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ82-F1-model_v2 AlphaFold D3ZZ82 1-874 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700934
Promoter ID:EPDNEW_R11458
Type:single initiation site
Name:Drc7_1
Description:dynein regulatory complex subunit 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01910,380,801 - 10,380,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565601 AgrOrtholog
BioCyc Gene G2FUF-6523 BioCyc
Ensembl Genes ENSRNOG00000025860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031064 ENTREZGENE
  ENSRNOT00000031064.7 UniProtKB/TrEMBL
InterPro CEPT76/DRC7_peptidase-like_dom UniProtKB/TrEMBL
  DRC7/lobo UniProtKB/TrEMBL
  DRC7_C UniProtKB/TrEMBL
  MORN_DRC7 UniProtKB/TrEMBL
  Papain_like_cys_pep_sf UniProtKB/TrEMBL
KEGG Report rno:291853 UniProtKB/TrEMBL
NCBI Gene 291853 ENTREZGENE
PANTHER DYNEIN REGULATORY COMPLEX SUBUNIT 7 UniProtKB/TrEMBL
  PTHR35249 UniProtKB/TrEMBL
Pfam CEPT76_peptidase UniProtKB/TrEMBL
  DRC7_C UniProtKB/TrEMBL
  MORN_DRC7 UniProtKB/TrEMBL
PhenoGen Drc7 PhenoGen
RatGTEx ENSRNOG00000025860 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6JY30 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-10 Drc7  dynein regulatory complex subunit 7  Ccdc135  coiled-coil domain containing 135  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Ccdc135  coiled-coil domain containing 135  RGD1565601  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565601  similar to hypothetical protein   RGD1565601_predicted  similar to hypothetical protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565601_predicted  similar to hypothetical protein (predicted)  LOC291853  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC291853  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL