Defb105b (defensin beta 105B) - Rat Genome Database

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Gene: Defb105b (defensin beta 105B) Rattus norvegicus
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Symbol: Defb105b
Name: defensin beta 105B
RGD ID: 1564879
Description: Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in extracellular region. Orthologous to several human genes including DEFB105B (defensin beta 105B); INTERACTS WITH aflatoxin B1 (ortholog); propanal (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-12; beta-defensin 12; beta-defensin 12-like; Defb12; defensin beta 12; defensin, beta 12
RGD Orthologs
Human
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,428,110 - 77,431,282 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,428,110 - 77,431,282 (+)EnsemblGRCr8
mRatBN7.21670,725,687 - 70,728,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,136,218 - 70,138,633 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1670,725,701 - 70,728,143 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,409,907 - 75,412,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,872,772 - 78,875,216 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,122,186 - 74,124,630 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,118,002 - 75,120,417 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,118,002 - 75,120,417 (-)Ensemblrn6Rnor6.0
Rnor_5.01674,737,487 - 74,739,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,813,231 - 74,815,646 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,590,526 - 68,592,947 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
aflatoxin B1  (ISO)
propanal  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Comparative Map Data
Defb105b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,428,110 - 77,431,282 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,428,110 - 77,431,282 (+)EnsemblGRCr8
mRatBN7.21670,725,687 - 70,728,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,136,218 - 70,138,633 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1670,725,701 - 70,728,143 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,409,907 - 75,412,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,872,772 - 78,875,216 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,122,186 - 74,124,630 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,118,002 - 75,120,417 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,118,002 - 75,120,417 (-)Ensemblrn6Rnor6.0
Rnor_5.01674,737,487 - 74,739,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,813,231 - 74,815,646 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,590,526 - 68,592,947 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
DEFB105B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,487,679 - 7,489,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,487,679 - 7,489,593 (+)Ensemblhg38GRCh38
GRCh38.p14 Ensembl87,821,004 - 7,823,880 (-)Ensemblhg38GRCh38
GRCh3787,345,201 - 7,347,115 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,332,653 - 7,334,483 (+)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map8p23.1NCBI
HuRef86,962,782 - 6,964,605 (-)NCBIHuRef
CHM1_187,280,720 - 7,282,550 (-)NCBICHM1_1
T2T-CHM13v2.087,216,697 - 7,218,608 (+)NCBIT2T-CHM13v2.0
LOC106506206
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11537,982,133 - 37,989,094 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21543,180,220 - 43,183,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Defb105b
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000044094
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat


Expression

RNA-SEQ Expression

ectoderm
mesenchyme
nervous system
renal system
reproductive system
1 36 1 36 23

Sequence


Ensembl Acc Id: ENSRNOT00000044094   ⟹   ENSRNOP00000045210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,136,218 - 70,138,633 (-)Ensembl
Rnor_6.0 Ensembl1675,118,002 - 75,120,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106638   ⟹   ENSRNOP00000083375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,725,701 - 70,728,143 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128035   ⟹   ENSRNOP00000111491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1677,428,110 - 77,431,282 (+)Ensembl
RefSeq Acc Id: NM_001037514   ⟹   NP_001032603
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,428,110 - 77,431,282 (+)NCBI
mRatBN7.21670,725,687 - 70,728,859 (+)NCBI
Rnor_6.01675,118,002 - 75,120,417 (-)NCBI
Rnor_5.01674,737,487 - 74,739,902 (-)NCBI
RGSC_v3.41674,813,231 - 74,815,646 (-)RGD
Celera1668,590,526 - 68,592,947 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032603 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51883 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045210.3
  ENSRNOP00000111491
RefSeq Acc Id: NP_001032603   ⟸   NM_001037514
- Peptide Label: precursor
- UniProtKB: Q32ZH9 (UniProtKB/Swiss-Prot),   A0A8I5ZVS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045210   ⟸   ENSRNOT00000044094
Ensembl Acc Id: ENSRNOP00000083375   ⟸   ENSRNOT00000106638
Ensembl Acc Id: ENSRNOP00000111491   ⟸   ENSRNOT00000128035

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZH9-F1-model_v2 AlphaFold Q32ZH9 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564879 AgrOrtholog
BioCyc Gene G2FUF-10815 BioCyc
Ensembl Genes ENSRNOG00000038155 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000065258 Ensembl
  ENSRNOG00000083461 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044094.4 UniProtKB/Swiss-Prot
  ENSRNOT00000128035 ENTREZGENE
InterPro Beta_defensin UniProtKB/Swiss-Prot
KEGG Report rno:641643 UniProtKB/Swiss-Prot
NCBI Gene 641643 ENTREZGENE
Pfam Defensin_beta_2 UniProtKB/Swiss-Prot
PhenoGen Defb105b PhenoGen
RatGTEx ENSRNOG00000038155 RatGTEx
  ENSRNOG00000065258 RatGTEx
  ENSRNOG00000083461 RatGTEx
UniProt A0A8I5ZVS0 ENTREZGENE
  DFB12_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-13 Defb105b  defensin beta 105B  Defb12  defensin beta 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Defb12  defensin beta 12  LOC100362695  beta-defensin 12-like  Data merged from RGD:2324263 1643240 APPROVED
2010-05-06 LOC100362695  beta-defensin 12-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-07 Defb12  defensin beta 12    beta-defensin 12  Name updated 1299863 APPROVED
2006-02-09 Defb12  beta-defensin 12      Symbol and Name status set to provisional 70820 PROVISIONAL