Defb26 (defensin beta 26) - Rat Genome Database

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Gene: Defb26 (defensin beta 26) Rattus norvegicus
Analyze
Symbol: Defb26
Name: defensin beta 26
RGD ID: 1564413
Description: Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in extracellular region. Orthologous to human DEFB125 (defensin beta 125); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 125; beta-defensin 125-like; beta-defensin 26; LOC100911232
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Defb26em1Mlit
Genetic Models: SD-Defb26em1Mlit
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,437,500 - 161,441,234 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,437,500 - 161,441,234 (-)EnsemblGRCr8
mRatBN7.23140,977,214 - 140,980,949 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,977,489 - 140,980,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,882,773 - 144,886,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,466,618 - 153,469,993 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,206,621 - 151,210,014 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,982,213 - 147,985,616 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,982,213 - 147,985,616 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,391,632 - 154,395,035 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,834,066 - 142,837,469 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,728,349 - 139,731,744 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Comparative Map Data
Defb26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,437,500 - 161,441,234 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,437,500 - 161,441,234 (-)EnsemblGRCr8
mRatBN7.23140,977,214 - 140,980,949 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,977,489 - 140,980,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,882,773 - 144,886,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,466,618 - 153,469,993 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,206,621 - 151,210,014 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,982,213 - 147,985,616 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,982,213 - 147,985,616 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,391,632 - 154,395,035 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,834,066 - 142,837,469 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,728,349 - 139,731,744 (-)NCBICelera
Cytogenetic Map3q41NCBI
DEFB125
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382087,672 - 97,094 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2087,250 - 97,094 (+)Ensemblhg38GRCh38
GRCh372068,313 - 77,735 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362016,351 - 25,296 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342016,362 - 25,174NCBI
Celera20163,193 - 172,141 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef2021,385 - 30,334 (+)NCBIHuRef
CHM1_12068,360 - 77,306 (+)NCBICHM1_1
T2T-CHM13v2.020130,104 - 139,527 (+)NCBIT2T-CHM13v2.0
Defb26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,349,490 - 152,353,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,349,718 - 152,353,612 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,507,756 - 152,511,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,507,798 - 152,511,692 (-)Ensemblmm10GRCm38
MGSCv372152,333,492 - 152,337,472 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362152,199,239 - 152,203,133 (-)NCBIMGSCv36mm8
Celera2158,323,236 - 158,327,152 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.18NCBI
LOC100977930
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28146,343,038 - 146,358,954 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110146,351,826 - 146,365,641 (-)NCBINHGRI_mPanPan1
PanPan1.12093,610 - 102,449 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2093,610 - 102,449 (+)EnsemblpanPan2panpan1.1
DEFB125
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,743,519 - 20,757,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,743,523 - 20,820,628 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2420,390,886 - 20,404,939 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02421,431,588 - 21,445,845 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,431,592 - 21,445,790 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,707,797 - 20,721,860 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,812,951 - 20,826,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,243,559 - 21,257,625 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Defb125
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,874,544 - 169,881,917 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648518,305,908 - 18,320,197 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEFB125
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,003,914 - 35,010,677 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11735,003,914 - 35,010,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,810,453 - 39,817,216 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DEFB125
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1235,657,282 - 35,658,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl235,658,224 - 35,658,640 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660787,440,872 - 7,442,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Defb26
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000070900, ENSRNOT00000073514
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat


Genetic Models
This gene Defb26 is modified in the following models/strains:
SD-Defb26em1Mlit    


Expression

RNA-SEQ Expression

circulatory system
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
reproductive system
2 2 2 2 2 4 2 19

Sequence


Ensembl Acc Id: ENSRNOT00000087431   ⟹   ENSRNOP00000071709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,437,500 - 161,441,234 (-)Ensembl
mRatBN7.2 Ensembl3140,977,489 - 140,980,893 (-)Ensembl
Rnor_6.0 Ensembl3147,982,213 - 147,985,616 (-)Ensembl
RefSeq Acc Id: NM_001037506   ⟹   NP_001032595
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,437,500 - 161,441,234 (-)NCBI
mRatBN7.23140,977,214 - 140,980,949 (-)NCBI
Rnor_6.03147,982,213 - 147,985,616 (-)NCBI
Rnor_5.03154,391,632 - 154,395,035 (-)NCBI
RGSC_v3.43142,834,066 - 142,837,469 (-)RGD
Celera3139,728,349 - 139,731,744 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032595 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51896 (Get FASTA)   NCBI Sequence Viewer  
  ACU80894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071709
  ENSRNOP00000071709.1
RefSeq Acc Id: NP_001032595   ⟸   NM_001037506
- Peptide Label: precursor
- UniProtKB: Q32ZG6 (UniProtKB/TrEMBL),   C8CKX5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071709   ⟸   ENSRNOT00000087431
Protein Domains
Beta-defensin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZG6-F1-model_v2 AlphaFold Q32ZG6 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564413 AgrOrtholog
BioCyc Gene G2FUF-47266 BioCyc
Ensembl Genes ENSRNOG00000053114 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087431 ENTREZGENE
  ENSRNOT00000087431.3 UniProtKB/TrEMBL
InterPro Beta-defensin UniProtKB/TrEMBL
  Beta_defensin UniProtKB/TrEMBL
KEGG Report rno:641629 UniProtKB/TrEMBL
NCBI Gene 641629 ENTREZGENE
PANTHER BETA-DEFENSIN 123-RELATED UniProtKB/TrEMBL
  BETA-DEFENSIN 125 UniProtKB/TrEMBL
Pfam Defensin_beta_2 UniProtKB/TrEMBL
PhenoGen Defb26 PhenoGen
RatGTEx ENSRNOG00000053114 RatGTEx
UniProt C8CKX5 ENTREZGENE, UniProtKB/TrEMBL
  Q32ZG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Defb26  defensin beta 26  LOC100911232  beta-defensin 125-like  Data merged from RGD:6494431 737654 PROVISIONAL
2012-07-05 LOC100911232  beta-defensin 125-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-07 Defb26  defensin beta 26    beta-defensin 26  Name updated 1299863 APPROVED
2006-02-09 Defb26  beta-defensin 26      Symbol and Name status set to provisional 70820 PROVISIONAL