Pram1 (PML-RARA regulated adaptor molecule 1) - Rat Genome Database

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Gene: Pram1 (PML-RARA regulated adaptor molecule 1) Rattus norvegicus
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Symbol: Pram1
Name: PML-RARA regulated adaptor molecule 1
RGD ID: 1564330
Description: Orthologous to human PRAM1 (PML-RARA regulated adaptor molecule 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC362848; PML-RAR alpha-regulated adaptor molecule 1; PML-RARA-regulated adapter molecule 1; RGD1564330; similar to PML-RAR alpha-regulated adaptor molecule-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,125,813 - 15,142,494 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2714,428,548 - 14,438,081 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)EnsemblmRatBN7.2
Rnor_6.0718,507,878 - 18,516,321 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,510,354 - 18,515,503 (+)Ensemblrn6Rnor6.0
Rnor_5.0718,685,469 - 18,693,921 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4716,143,455 - 16,149,438 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,329,032 - 13,337,475 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15572693   PMID:20873783  


Genomics

Comparative Map Data
Pram1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,125,813 - 15,142,494 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2714,428,548 - 14,438,081 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)EnsemblmRatBN7.2
Rnor_6.0718,507,878 - 18,516,321 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,510,354 - 18,515,503 (+)Ensemblrn6Rnor6.0
Rnor_5.0718,685,469 - 18,693,921 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4716,143,455 - 16,149,438 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,329,032 - 13,337,475 (+)NCBICelera
Cytogenetic Map7q13NCBI
PRAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,490,056 - 8,502,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,490,056 - 8,502,647 (-)Ensemblhg38GRCh38
GRCh37198,554,940 - 8,567,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,460,940 - 8,473,495 (-)NCBIBuild 36Build 36hg18NCBI36
Celera198,412,603 - 8,425,203 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,210,376 - 8,222,977 (-)NCBIHuRef
CHM1_1198,554,008 - 8,566,604 (-)NCBICHM1_1
T2T-CHM13v2.0198,477,638 - 8,490,223 (-)NCBIT2T-CHM13v2.0
Pram1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,857,030 - 33,864,680 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,857,030 - 33,864,680 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381733,638,056 - 33,645,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,638,056 - 33,645,706 (+)Ensemblmm10GRCm38
MGSCv371733,775,001 - 33,782,651 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361733,244,828 - 33,252,394 (+)NCBIMGSCv36mm8
Celera1736,393,427 - 36,401,056 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Pram1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955563926,765 - 933,183 (+)Ensembl
ChiLan1.0NW_004955563924,365 - 933,198 (+)NCBIChiLan1.0ChiLan1.0
PRAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22013,157,540 - 13,178,259 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,275,091 - 12,289,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,775,887 - 7,789,657 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,624,974 - 8,638,214 (-)NCBIPanPan1.1PanPan1.1panPan2
PRAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,035,389 - 53,047,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,836,491 - 52,843,565 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,563,520 - 53,570,590 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,563,527 - 53,570,461 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,765,320 - 52,772,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,211,676 - 53,218,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,442,813 - 53,449,885 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pram1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,539,537 - 212,550,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365885,284,621 - 5,292,520 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365885,284,001 - 5,294,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,804,721 - 70,813,230 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,803,092 - 70,812,859 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,163,231 - 71,180,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,840,452 - 7,857,049 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607412,403,515 - 12,420,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pram1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,251,815 - 1,256,314 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248281,251,566 - 1,259,032 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pram1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11158,759,747 - 158,767,071 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pram1
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000060002
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011094   ⟹   ENSRNOP00000011094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl715,122,878 - 15,125,040 (+)Ensembl
mRatBN7.2 Ensembl714,420,244 - 14,422,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060002   ⟹   ENSRNOP00000056752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl715,122,401 - 15,125,755 (+)Ensembl
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)Ensembl
Rnor_6.0 Ensembl718,510,354 - 18,515,503 (+)Ensembl
RefSeq Acc Id: XM_006241132   ⟹   XP_006241194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,132,531 - 15,142,494 (+)NCBI
mRatBN7.2714,428,550 - 14,438,081 (+)NCBI
Rnor_6.0718,507,878 - 18,516,299 (+)NCBI
Rnor_5.0718,685,469 - 18,693,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080064   ⟹   XP_038935992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,125,813 - 15,142,494 (+)NCBI
mRatBN7.2714,428,548 - 14,438,081 (+)NCBI
RefSeq Acc Id: XM_039080065   ⟹   XP_038935993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,125,813 - 15,142,494 (+)NCBI
mRatBN7.2714,428,549 - 14,438,081 (+)NCBI
Protein Sequences
Protein RefSeqs XP_006241194 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935992 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935993 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056752.6
RefSeq Acc Id: XP_006241194   ⟸   XM_006241132
- Peptide Label: isoform X3
- UniProtKB: F1M121 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056752   ⟸   ENSRNOT00000060002
RefSeq Acc Id: XP_038935992   ⟸   XM_039080064
- Peptide Label: isoform X1
- UniProtKB: F1M121 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935993   ⟸   XM_039080065
- Peptide Label: isoform X2
- UniProtKB: F1M121 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000011094   ⟸   ENSRNOT00000011094

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M121-F1-model_v2 AlphaFold F1M121 1-668 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564330 AgrOrtholog
BioCyc Gene G2FUF-34714 BioCyc
Ensembl Genes ENSRNOG00000008378 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000039204 Ensembl
Ensembl Transcript ENSRNOT00000060002.6 UniProtKB/TrEMBL
Gene3D-CATH SH3 Domains UniProtKB/TrEMBL
InterPro FYB1/2-like UniProtKB/TrEMBL
  hSH3 UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 362848 ENTREZGENE
PANTHER PML-RARA-REGULATED ADAPTER MOLECULE 1 UniProtKB/TrEMBL
  PTHR16830 UniProtKB/TrEMBL
Pfam hSH3 UniProtKB/TrEMBL
PhenoGen Pram1 PhenoGen
PROSITE SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008378 RatGTEx
  ENSRNOG00000039204 RatGTEx
Superfamily-SCOP SH3 UniProtKB/TrEMBL
UniProt F1M121 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-15 Pram1  PML-RARA regulated adaptor molecule 1  Pram1  PML-RAR alpha-regulated adaptor molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Pram1  PML-RAR alpha-regulated adaptor molecule 1  RGD1564330_predicted  similar to PML-RAR alpha-regulated adaptor molecule-1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564330_predicted  similar to PML-RAR alpha-regulated adaptor molecule-1 (predicted)  LOC362848  similar to PML-RAR alpha-regulated adaptor molecule-1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362848  similar to PML-RAR alpha-regulated adaptor molecule-1      Symbol and Name status set to provisional 70820 PROVISIONAL