Creg2 (cellular repressor of E1A-stimulated genes 2) - Rat Genome Database

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Gene: Creg2 (cellular repressor of E1A-stimulated genes 2) Rattus norvegicus
Analyze
Symbol: Creg2
Name: cellular repressor of E1A-stimulated genes 2
RGD ID: 1564056
Description: Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human CREG2 (cellular repressor of E1A stimulated genes 2); INTERACTS WITH 17beta-estradiol; bisphenol A; furan.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cellular repressor of E1A-stimulated genes 2, pseudogene 1; Creg2-ps1; LOC316353; RGD1564056; similar to cellular repressor of E1A-stimulated genes 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,367,693 - 49,441,133 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,399,114 - 49,440,985 (-)EnsemblGRCr8
mRatBN7.2941,872,000 - 41,945,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,902,304 - 41,945,095 (-)EnsemblmRatBN7.2
Rnor_6.0946,328,088 - 46,402,237 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,360,061 - 46,401,911 (-)Ensemblrn6Rnor6.0
Rnor_5.0946,047,373 - 46,089,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,698,544 - 38,830,140 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,648,511 - 39,694,478 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12408961  


Genomics

Comparative Map Data
Creg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,367,693 - 49,441,133 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,399,114 - 49,440,985 (-)EnsemblGRCr8
mRatBN7.2941,872,000 - 41,945,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,902,304 - 41,945,095 (-)EnsemblmRatBN7.2
Rnor_6.0946,328,088 - 46,402,237 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,360,061 - 46,401,911 (-)Ensemblrn6Rnor6.0
Rnor_5.0946,047,373 - 46,089,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,698,544 - 38,830,140 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,648,511 - 39,694,478 (-)NCBICelera
Cytogenetic Map9q22NCBI
CREG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,345,550 - 101,387,503 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2101,345,550 - 101,387,503 (-)Ensemblhg38GRCh38
GRCh372101,962,012 - 102,003,965 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362101,331,655 - 101,370,489 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342101,423,742 - 101,462,575NCBI
Celera296,168,703 - 96,207,615 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef295,728,993 - 95,767,814 (-)NCBIHuRef
CHM1_12101,969,227 - 102,008,038 (-)NCBICHM1_1
T2T-CHM13v2.02101,804,250 - 101,846,207 (-)NCBIT2T-CHM13v2.0
Creg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,657,574 - 39,690,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,657,574 - 39,690,642 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38139,618,406 - 39,652,052 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,618,406 - 39,651,474 (-)Ensemblmm10GRCm38
MGSCv37139,675,251 - 39,708,027 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36139,562,952 - 39,595,728 (-)NCBIMGSCv36mm8
Celera139,415,441 - 39,449,617 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.37NCBI
Creg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554707,094,483 - 7,115,792 (-)NCBIChiLan1.0ChiLan1.0
CREG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,838,764 - 26,887,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,841,498 - 26,890,151 (+)NCBINHGRI_mPanPan1
PanPan1.12A102,324,445 - 102,363,730 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A102,324,445 - 102,363,735 (-)EnsemblpanPan2panpan1.1
CREG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,540,829 - 41,576,549 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1041,540,826 - 41,572,005 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1041,465,911 - 41,501,834 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01042,408,511 - 42,444,575 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1042,408,511 - 42,440,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,121,462 - 42,157,368 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01042,403,969 - 42,439,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,595,365 - 42,631,294 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Creg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,949,580 - 90,988,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936713149,678 - 183,459 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936713147,571 - 183,150 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl352,918,844 - 52,977,924 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1352,918,475 - 52,978,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2355,464,877 - 55,523,176 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,048,996 - 5,088,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,050,356 - 5,088,668 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041172,715,652 - 172,763,089 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Creg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,036,755 - 6,064,714 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247496,032,034 - 6,064,769 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Creg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,863,620 - 115,904,522 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Creg2
260 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:91
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000046557
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH142071  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0946,047,466 - 46,047,660NCBIRnor5.0
RGSC_v3.4938,698,124 - 38,698,315UniSTSRGSC3.4
Celera939,653,151 - 39,653,342UniSTS
RH 3.4 Map9389.5UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 3 33 145 31 33 12 18 12 6 168 76 11 130 68 78 21 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000046557   ⟹   ENSRNOP00000047210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,399,114 - 49,440,985 (-)Ensembl
mRatBN7.2 Ensembl941,902,304 - 41,945,095 (-)Ensembl
Rnor_6.0 Ensembl946,360,061 - 46,401,911 (-)Ensembl
RefSeq Acc Id: XM_008767069   ⟹   XP_008765291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,367,693 - 49,441,133 (-)NCBI
mRatBN7.2941,872,000 - 41,945,413 (-)NCBI
Rnor_6.0946,328,088 - 46,402,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084545   ⟹   XP_038940473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,395,055 - 49,441,096 (-)NCBI
mRatBN7.2941,899,904 - 41,945,383 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008765291 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940473 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99189 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047210
  ENSRNOP00000047210.6
RefSeq Acc Id: XP_008765291   ⟸   XM_008767069
- Peptide Label: isoform X2
- UniProtKB: A6INM1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047210   ⟸   ENSRNOT00000046557
RefSeq Acc Id: XP_038940473   ⟸   XM_039084545
- Peptide Label: isoform X1
- UniProtKB: D4A3H3 (UniProtKB/TrEMBL),   A6INM1 (UniProtKB/TrEMBL)
Protein Domains
CREG-like beta-barrel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3H3-F1-model_v2 AlphaFold D4A3H3 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564056 AgrOrtholog
BioCyc Gene G2FUF-27740 BioCyc
Ensembl Genes ENSRNOG00000013991 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046557 ENTREZGENE
  ENSRNOT00000046557.7 UniProtKB/TrEMBL
Gene3D-CATH Electron Transport, Fmn-binding Protein, Chain A UniProtKB/TrEMBL
InterPro CREG UniProtKB/TrEMBL
  CREG_beta-barrel UniProtKB/TrEMBL
  Split_barrel_FMN-bd UniProtKB/TrEMBL
NCBI Gene 316353 ENTREZGENE
PANTHER CREG1 PROTEIN UniProtKB/TrEMBL
  PROTEIN CREG2 UniProtKB/TrEMBL
Pfam Pyrid_oxidase_2 UniProtKB/TrEMBL
PhenoGen Creg2 PhenoGen
PIRSF CREG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013991 RatGTEx
Superfamily-SCOP FMN-binding split barrel UniProtKB/TrEMBL
UniProt A6INM1 ENTREZGENE, UniProtKB/TrEMBL
  D4A3H3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-05 Creg2  cellular repressor of E1A-stimulated genes 2  Creg2-ps1  cellular repressor of E1A-stimulated genes 2, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-08 Creg2-ps1  cellular repressor of E1A-stimulated genes 2, pseudogene 1  Creg2  cellular repressor of E1A-stimulated genes 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Creg2  cellular repressor of E1A-stimulated genes 2  RGD1564056_predicted  similar to cellular repressor of E1A-stimulated genes 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564056_predicted  similar to cellular repressor of E1A-stimulated genes 2 (predicted)  LOC316353  similar to cellular repressor of E1A-stimulated genes 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC316353  similar to cellular repressor of E1A-stimulated genes 2      Symbol and Name status set to provisional 70820 PROVISIONAL